The gene/protein map for NC_010793 is currently unavailable.
Definition Mycobacterium leprae Br4923 chromosome, complete genome.
Accession NC_011896
Length 3,268,071

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The map label for this gene is ispG

Identifier: 221230306

GI number: 221230306

Start: 1905686

End: 1906864

Strand: Reverse

Name: ispG

Synonym: MLBr_01581

Alternate gene names: 221230306

Gene position: 1906864-1905686 (Counterclockwise)

Preceding gene: 221230307

Following gene: 221230305

Centisome position: 58.35

GC content: 61.41

Gene sequence:

>1179_bases
GTGAACATGCGTCTGGGCATGCCCGAGGCTCCGGCTCCCGGGCTTGCCCCCCGGCGTATCACGCGTCAATTGATGGTCGG
CAACGTTGGGGTCGGTAGTGATCACCAGATCTCCGTGCAGTCGATGTGCATCACCAAGACTCATGACGTCAATGCGACGT
TGCAGCAGATTGCGGAGTTGACCACTGCCGGCTGTGACATCGTTCGGGTGGCCTGCCCGCGTCAAGAGGATGCTGACGCA
CTTGCCGAAATCGCCCGGCACAGCAAGATTCCGGTGATTGTCGACATACATTTCCAGCCGAAATACATCTTTGCCGCCAT
TGACGCCGGGTGTGCCGCGGTGCGGGTCAACCCCGGCAACATCAAGGAATTCGACGGCCGGGTCGGTGAGGTTGCCAAAG
CCGCGGCCGCGGCCGGTATCCCGATCCGCATCGGCGTCAACGCCGGCTCGCTGGATAAACGGTTCATGGACAAGTACGGC
AAGGCCACGTCCGAAGCACTGGTGGAGTCTGCGCTGTGGGAGGCATCACTGTTCGAAGAGCACGGCTTCGGCAACATCAA
GATCAGCGTCAAGCACCATGACCCCGTCGTGATGGTCGCCGCCTACGAGCAACTGGCCGCCCAGTGCGACTACCCCTTGC
ACCTCGGTGTCACCGAGGCCGGTCCTGTTTTCCAGGGCACCGTCAAGTCCGCGGTCGCCTTCGGAGCACTTTTGTCGAAG
GGCATCGGCGACACCATCCGGGTTTCGCTATCGGCGCCGCCGGTCGAAGAGATCAAGGTTGGCAACCAAATTCTCGAGTC
GCTCAACCTTCGGCCACGTTCACACGAGATTGTGTCCTGCCCGTCGTGCGGCCGTGCGCAGGTCGACGTCTACAAGCTGG
CCAATGAAGTCAGCGCTGGGTTGGACGGACTCGAGGTGCCGTTGCGGATCGCCGTGATGGGGTGCGTCGTCAACGGGCCT
GGTGAGGCCCGCGACGCCGACCTGGGTGTCGCGTCCGGAAACGGCAAGGGCCAGATCTTTGTCAAGGGTGAAGTGATCAA
GACCGTACCCGAAGCCCAGATTGTCGAGACGCTGATCGAGGAGGCCATGCGGCTTGTCTCCGAGATGGGGACCGAGAAAG
GCAGTGATCACTGTTCAGAAACGACAAGGAGCGGTTCACCGGTTGTGACCGTAAACTGA

Upstream 100 bases:

>100_bases
TTGACCGTGACCGCCGATCTGGTAAACCCAATCAGGCTTTTTCAATAGCCAATAGTGAAAAACGAGAAAGCCAATAGTGA
AAACCGAGAAATGGGGAACA

Downstream 100 bases:

>100_bases
GGTGGGGCTAGCCTGCTTGACTTGGCTTCGAGTTAGCCTTATAGAGAGTTCGCCAGATATCGGCTACATCCAATATTTCT
TTCGTTTTGTCGGTGAGCCA

Product: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

Products: NA

Alternate protein names: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNMRLGMPEAPAPGLAPRRITRQLMVGNVGVGSDHQISVQSMCITKTHDVNATLQQIAELTTAGCDIVRVACPRQEDADA
LAEIARHSKIPVIVDIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAAAAGIPIRIGVNAGSLDKRFMDKYG
KATSEALVESALWEASLFEEHGFGNIKISVKHHDPVVMVAAYEQLAAQCDYPLHLGVTEAGPVFQGTVKSAVAFGALLSK
GIGDTIRVSLSAPPVEEIKVGNQILESLNLRPRSHEIVSCPSCGRAQVDVYKLANEVSAGLDGLEVPLRIAVMGCVVNGP
GEARDADLGVASGNGKGQIFVKGEVIKTVPEAQIVETLIEEAMRLVSEMGTEKGSDHCSETTRSGSPVVTVN

Sequences:

>Translated_392_residues
MNMRLGMPEAPAPGLAPRRITRQLMVGNVGVGSDHQISVQSMCITKTHDVNATLQQIAELTTAGCDIVRVACPRQEDADA
LAEIARHSKIPVIVDIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAAAAGIPIRIGVNAGSLDKRFMDKYG
KATSEALVESALWEASLFEEHGFGNIKISVKHHDPVVMVAAYEQLAAQCDYPLHLGVTEAGPVFQGTVKSAVAFGALLSK
GIGDTIRVSLSAPPVEEIKVGNQILESLNLRPRSHEIVSCPSCGRAQVDVYKLANEVSAGLDGLEVPLRIAVMGCVVNGP
GEARDADLGVASGNGKGQIFVKGEVIKTVPEAQIVETLIEEAMRLVSEMGTEKGSDHCSETTRSGSPVVTVN
>Mature_392_residues
MNMRLGMPEAPAPGLAPRRITRQLMVGNVGVGSDHQISVQSMCITKTHDVNATLQQIAELTTAGCDIVRVACPRQEDADA
LAEIARHSKIPVIVDIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAAAAGIPIRIGVNAGSLDKRFMDKYG
KATSEALVESALWEASLFEEHGFGNIKISVKHHDPVVMVAAYEQLAAQCDYPLHLGVTEAGPVFQGTVKSAVAFGALLSK
GIGDTIRVSLSAPPVEEIKVGNQILESLNLRPRSHEIVSCPSCGRAQVDVYKLANEVSAGLDGLEVPLRIAVMGCVVNGP
GEARDADLGVASGNGKGQIFVKGEVIKTVPEAQIVETLIEEAMRLVSEMGTEKGSDHCSETTRSGSPVVTVN

Specific function: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate

COG id: COG0821

COG function: function code I; Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispG family

Homologues:

Organism=Escherichia coli, GI1788863, Length=326, Percent_Identity=45.398773006135, Blast_Score=281, Evalue=5e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPG_MYCLB (B8ZRU5)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503722.1
- ProteinModelPortal:   B8ZRU5
- EnsemblBacteria:   EBMYCT00000086008
- GeneID:   7325751
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017148
- HOGENOM:   HBG335271
- OMA:   APIVVQS
- ProtClustDB:   PRK00366
- HAMAP:   MF_00159
- InterPro:   IPR013785
- InterPro:   IPR011005
- InterPro:   IPR016425
- InterPro:   IPR004588
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF004640
- TIGRFAMs:   TIGR00612

Pfam domain/function: PF04551 GcpE; SSF51717 DHP_synth_like

EC number: =1.17.7.1

Molecular weight: Translated: 41415; Mature: 41415

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MNMRLGMPEAPAPGLAPRRITRQLMVGNVGVGSDHQISVQSMCITKTHDVNATLQQIAEL
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHH
TTAGCDIVRVACPRQEDADALAEIARHSKIPVIVDIHFQPKYIFAAIDAGCAAVRVNPGN
HHCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCCCEEEEECCCC
IKEFDGRVGEVAKAAAAAGIPIRIGVNAGSLDKRFMDKYGKATSEALVESALWEASLFEE
CHHHCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
HGFGNIKISVKHHDPVVMVAAYEQLAAQCDYPLHLGVTEAGPVFQGTVKSAVAFGALLSK
CCCCEEEEEEEECCCEEEEEEHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHC
GIGDTIRVSLSAPPVEEIKVGNQILESLNLRPRSHEIVSCPSCGRAQVDVYKLANEVSAG
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCC
LDGLEVPLRIAVMGCVVNGPGEARDADLGVASGNGKGQIFVKGEVIKTVPEAQIVETLIE
CCCCCCCEEEEEEEEEECCCCCCCCCCCEEECCCCCEEEEEECHHHHHCCHHHHHHHHHH
EAMRLVSEMGTEKGSDHCSETTRSGSPVVTVN
HHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEC
>Mature Secondary Structure
MNMRLGMPEAPAPGLAPRRITRQLMVGNVGVGSDHQISVQSMCITKTHDVNATLQQIAEL
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHH
TTAGCDIVRVACPRQEDADALAEIARHSKIPVIVDIHFQPKYIFAAIDAGCAAVRVNPGN
HHCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCCCEEEEECCCC
IKEFDGRVGEVAKAAAAAGIPIRIGVNAGSLDKRFMDKYGKATSEALVESALWEASLFEE
CHHHCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
HGFGNIKISVKHHDPVVMVAAYEQLAAQCDYPLHLGVTEAGPVFQGTVKSAVAFGALLSK
CCCCEEEEEEEECCCEEEEEEHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHC
GIGDTIRVSLSAPPVEEIKVGNQILESLNLRPRSHEIVSCPSCGRAQVDVYKLANEVSAG
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCC
LDGLEVPLRIAVMGCVVNGPGEARDADLGVASGNGKGQIFVKGEVIKTVPEAQIVETLIE
CCCCCCCEEEEEEEEEECCCCCCCCCCCEEECCCCCEEEEEECHHHHHCCHHHHHHHHHH
EAMRLVSEMGTEKGSDHCSETTRSGSPVVTVN
HHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA