Click here to switch to the map view.

The map label for this gene is pbpA [H]

Identifier: 221230305

GI number: 221230305

Start: 1901860

End: 1903686

Strand: Reverse

Name: pbpA [H]

Synonym: MLBr_01577

Alternate gene names: 221230305

Gene position: 1903686-1901860 (Counterclockwise)

Preceding gene: 221230306

Following gene: 221230304

Centisome position: 58.25

GC content: 62.01

Gene sequence:

>1827_bases
ATGATGGTCACAAGAACCTCACCAGGGTCATTCGTTTCGGTAGTGGCGGGTCTGTGCTTTGTCGCAGTTATCGCCGTGTC
GGGCTGCACCCCACGGCCCAACGGCCCGGGCCCGGCCGCTGCGAAGTTCTTTGACGCACTGGCCATCGGCGATACCGCGA
CGGCTGCCCAACTTAGTGACAATCCCAACGAGGCCCATGAAGCGCTCAACGCAGCCTGGGCTGGACTACAAGCTGGCCGC
CTGGATGCACAGCTCATCAGTGCGAGATACGTCGAGGACACTGGCACCATTGCTTACCGCTTCACTTGGCACCTGCCGAA
GAACCGGACGTGGAGCTATGATGGGCAGCTGAAGATGGTGCGCTACGAGGGGCGCTGGCAGGTTCGGTGGACTGCAACCG
GGCTGCATCCCAGATTGGGCGAGCATCAGACGTTTGCTTTGCGCGCGAATCCGCCGCGGCGCGCTTCAGTGAACGAACTC
GGGGGCAGCGATGTGTTGGTGCCGGGCTACCTGCACCACTACGCGCTGGACGCCACTTTGGCCGGGTCCAGCCTGATTGG
GACGGCACGTGCGGTGGTCGAAGCCTTACACCCTTTTGATGACACCCTCAACGATCCGCAGCTGCTAGCCGAAAAAGCCA
GCTCGGTGACGGAGCCACTGAGTTTGGTCACGCTGCGCCCTGATGACAACGACCGGGTCGCTTCGGTGATCGGCAGGCTG
CCTGGCGTTGTGGTTACGCTCCAAGCCGACTTACTGCCGACCGACTCGCATTTCGCCCCGTCGGTCATCGCCGAGGTGAA
GAAAGCCGTGATCGACGAACTCGACGGTCAGCCGGGTTGGCGAGTGGTCAGTGTCAACCGTAATGGCGTCGACGTCGCGG
TGCTGCACGAGGTCGAACCGTCCCCGGCATCGTCGGTCTCGATCACGCTAGACCGGTTCGTGCAGAATGCCGCTCAACAC
GCGGTAGATAGCCGCGGCGGTAAGGCGATGATAGTCGTACTCAAACCGTCGACTGGGCAGATCCTTGCGATCGCGCAGAA
TGCGGGGGCAAACGCTGACGGCCCGCTTGCTACTACCGGTCTGTTCCCACCTGGGTCGACCTTCAAGATGGTCACCGCCG
GCGCGGCCATCGACCGGGATATGTCTACCCCCAATACGATGTTAGGTTGCCCTGGCCGCATTGACATTGGGCACCGCACT
ATCCTCAACTACGGGGGTTTTGATCTTGGCGTGGTGCCGATGTCACGTGCATTCGCCAGTTCCTGCAACACCACGTTCGC
CGAATTAAGCAGCAGGATGCCACCCCGCGGTCTGACACAGGCCGCCAACCAGTACGGGATCGGGCTTGACTATCAGGTGG
ACGGCATCGCCACGGTAACCGGGTCGGTGCCGCCAACGGTGGACCTGGCTGAGCGCACCGAGGACGGCTTCGGTCAAGGC
CGGGTGCTGGTCAGTCCGTTCGGGATGTCCTTGGTGGCGGCCACCGTAGCTGCTGGCAAAACCCCGGTTCCGCAGCTGAT
CGTCGGACGGCCAACGAGAGTCGAAGGAGACAGCACGCCGATCCTCCCGAAGGTGATCGATTCGCTGCGACCGATGATGC
GGCTGGTGGTGACTAACGGGACCGCTAAAGAGATCGCCGGCTGTTGCGGTGCGATCTTCGGGAAGACCGGTGAAGCTGAG
TTCGTAGGCGGATCGCATTCCTGGTTTGTCGGATATCGCGGCGATCTGGCGTTTGCAGCGCTGATCGTGGGGGGCGGAAG
CTCGGAATACGCGGTCCGGATGACCAAAGTCATGTTCGAATCGTTGCCGCCAGACTACCTGACCTAG

Upstream 100 bases:

>100_bases
TAATATACGCGTATGTCTCGTATATCGACTCTACGTCCGATAATTGGTGGGTTTCGGTGTGTCGATGCTGTAGTTCAGGT
TTCAGTTCTTAACATCAGCG

Downstream 100 bases:

>100_bases
CGCGATTAGCGGCGCTTTCGGCGCGCCTCGGCATCCAGCCTGCGTCACCAAACCGGTGCGCAGACATACGGCGCAAGGTT
TGTTTGCCTGGTTTGCTCCC

Product: putative penicillin binding protein

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MMVTRTSPGSFVSVVAGLCFVAVIAVSGCTPRPNGPGPAAAKFFDALAIGDTATAAQLSDNPNEAHEALNAAWAGLQAGR
LDAQLISARYVEDTGTIAYRFTWHLPKNRTWSYDGQLKMVRYEGRWQVRWTATGLHPRLGEHQTFALRANPPRRASVNEL
GGSDVLVPGYLHHYALDATLAGSSLIGTARAVVEALHPFDDTLNDPQLLAEKASSVTEPLSLVTLRPDDNDRVASVIGRL
PGVVVTLQADLLPTDSHFAPSVIAEVKKAVIDELDGQPGWRVVSVNRNGVDVAVLHEVEPSPASSVSITLDRFVQNAAQH
AVDSRGGKAMIVVLKPSTGQILAIAQNAGANADGPLATTGLFPPGSTFKMVTAGAAIDRDMSTPNTMLGCPGRIDIGHRT
ILNYGGFDLGVVPMSRAFASSCNTTFAELSSRMPPRGLTQAANQYGIGLDYQVDGIATVTGSVPPTVDLAERTEDGFGQG
RVLVSPFGMSLVAATVAAGKTPVPQLIVGRPTRVEGDSTPILPKVIDSLRPMMRLVVTNGTAKEIAGCCGAIFGKTGEAE
FVGGSHSWFVGYRGDLAFAALIVGGGSSEYAVRMTKVMFESLPPDYLT

Sequences:

>Translated_608_residues
MMVTRTSPGSFVSVVAGLCFVAVIAVSGCTPRPNGPGPAAAKFFDALAIGDTATAAQLSDNPNEAHEALNAAWAGLQAGR
LDAQLISARYVEDTGTIAYRFTWHLPKNRTWSYDGQLKMVRYEGRWQVRWTATGLHPRLGEHQTFALRANPPRRASVNEL
GGSDVLVPGYLHHYALDATLAGSSLIGTARAVVEALHPFDDTLNDPQLLAEKASSVTEPLSLVTLRPDDNDRVASVIGRL
PGVVVTLQADLLPTDSHFAPSVIAEVKKAVIDELDGQPGWRVVSVNRNGVDVAVLHEVEPSPASSVSITLDRFVQNAAQH
AVDSRGGKAMIVVLKPSTGQILAIAQNAGANADGPLATTGLFPPGSTFKMVTAGAAIDRDMSTPNTMLGCPGRIDIGHRT
ILNYGGFDLGVVPMSRAFASSCNTTFAELSSRMPPRGLTQAANQYGIGLDYQVDGIATVTGSVPPTVDLAERTEDGFGQG
RVLVSPFGMSLVAATVAAGKTPVPQLIVGRPTRVEGDSTPILPKVIDSLRPMMRLVVTNGTAKEIAGCCGAIFGKTGEAE
FVGGSHSWFVGYRGDLAFAALIVGGGSSEYAVRMTKVMFESLPPDYLT
>Mature_608_residues
MMVTRTSPGSFVSVVAGLCFVAVIAVSGCTPRPNGPGPAAAKFFDALAIGDTATAAQLSDNPNEAHEALNAAWAGLQAGR
LDAQLISARYVEDTGTIAYRFTWHLPKNRTWSYDGQLKMVRYEGRWQVRWTATGLHPRLGEHQTFALRANPPRRASVNEL
GGSDVLVPGYLHHYALDATLAGSSLIGTARAVVEALHPFDDTLNDPQLLAEKASSVTEPLSLVTLRPDDNDRVASVIGRL
PGVVVTLQADLLPTDSHFAPSVIAEVKKAVIDELDGQPGWRVVSVNRNGVDVAVLHEVEPSPASSVSITLDRFVQNAAQH
AVDSRGGKAMIVVLKPSTGQILAIAQNAGANADGPLATTGLFPPGSTFKMVTAGAAIDRDMSTPNTMLGCPGRIDIGHRT
ILNYGGFDLGVVPMSRAFASSCNTTFAELSSRMPPRGLTQAANQYGIGLDYQVDGIATVTGSVPPTVDLAERTEDGFGQG
RVLVSPFGMSLVAATVAAGKTPVPQLIVGRPTRVEGDSTPILPKVIDSLRPMMRLVVTNGTAKEIAGCCGAIFGKTGEAE
FVGGSHSWFVGYRGDLAFAALIVGGGSSEYAVRMTKVMFESLPPDYLT

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=290, Percent_Identity=25.1724137931034, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786272, Length=336, Percent_Identity=25.5952380952381, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 64051; Mature: 64051

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVTRTSPGSFVSVVAGLCFVAVIAVSGCTPRPNGPGPAAAKFFDALAIGDTATAAQLSD
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHCCC
NPNEAHEALNAAWAGLQAGRLDAQLISARYVEDTGTIAYRFTWHLPKNRTWSYDGQLKMV
CHHHHHHHHHHHHHCCCCCCCHHHHHHHEEEECCCCEEEEEEEECCCCCCCCCCCCEEEE
RYEGRWQVRWTATGLHPRLGEHQTFALRANPPRRASVNELGGSDVLVPGYLHHYALDATL
EECCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHCCCCCEECCCHHHHHHHHHHH
AGSSLIGTARAVVEALHPFDDTLNDPQLLAEKASSVTEPLSLVTLRPDDNDRVASVIGRL
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCC
PGVVVTLQADLLPTDSHFAPSVIAEVKKAVIDELDGQPGWRVVSVNRNGVDVAVLHEVEP
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCC
SPASSVSITLDRFVQNAAQHAVDSRGGKAMIVVLKPSTGQILAIAQNAGANADGPLATTG
CCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCEEECC
LFPPGSTFKMVTAGAAIDRDMSTPNTMLGCPGRIDIGHRTILNYGGFDLGVVPMSRAFAS
CCCCCCCEEEEEECCHHCCCCCCCCCEECCCCCEECCCEEEEECCCCEEEHHHHHHHHHH
SCNTTFAELSSRMPPRGLTQAANQYGIGLDYQVDGIATVTGSVPPTVDLAERTEDGFGQG
HCCHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCEEEEECCCCCCCCHHHHCCCCCCCC
RVLVSPFGMSLVAATVAAGKTPVPQLIVGRPTRVEGDSTPILPKVIDSLRPMMRLVVTNG
EEEEECCCHHHHHHHHHCCCCCCCHHEECCCCCCCCCCCCCHHHHHHHHHHHHHEEECCC
TAKEIAGCCGAIFGKTGEAEFVGGSHSWFVGYRGDLAFAALIVGGGSSEYAVRMTKVMFE
CHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHH
SLPPDYLT
HCCCCCCC
>Mature Secondary Structure
MMVTRTSPGSFVSVVAGLCFVAVIAVSGCTPRPNGPGPAAAKFFDALAIGDTATAAQLSD
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHCCC
NPNEAHEALNAAWAGLQAGRLDAQLISARYVEDTGTIAYRFTWHLPKNRTWSYDGQLKMV
CHHHHHHHHHHHHHCCCCCCCHHHHHHHEEEECCCCEEEEEEEECCCCCCCCCCCCEEEE
RYEGRWQVRWTATGLHPRLGEHQTFALRANPPRRASVNELGGSDVLVPGYLHHYALDATL
EECCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHCCCCCEECCCHHHHHHHHHHH
AGSSLIGTARAVVEALHPFDDTLNDPQLLAEKASSVTEPLSLVTLRPDDNDRVASVIGRL
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCC
PGVVVTLQADLLPTDSHFAPSVIAEVKKAVIDELDGQPGWRVVSVNRNGVDVAVLHEVEP
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCC
SPASSVSITLDRFVQNAAQHAVDSRGGKAMIVVLKPSTGQILAIAQNAGANADGPLATTG
CCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCEEECC
LFPPGSTFKMVTAGAAIDRDMSTPNTMLGCPGRIDIGHRTILNYGGFDLGVVPMSRAFAS
CCCCCCCEEEEEECCHHCCCCCCCCCEECCCCCEECCCEEEEECCCCEEEHHHHHHHHHH
SCNTTFAELSSRMPPRGLTQAANQYGIGLDYQVDGIATVTGSVPPTVDLAERTEDGFGQG
HCCHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCEEEEECCCCCCCCHHHHCCCCCCCC
RVLVSPFGMSLVAATVAAGKTPVPQLIVGRPTRVEGDSTPILPKVIDSLRPMMRLVVTNG
EEEEECCCHHHHHHHHHCCCCCCCHHEECCCCCCCCCCCCCHHHHHHHHHHHHHEEECCC
TAKEIAGCCGAIFGKTGEAEFVGGSHSWFVGYRGDLAFAALIVGGGSSEYAVRMTKVMFE
CHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHH
SLPPDYLT
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA