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The map label for this gene is clpP2 [H]

Identifier: 221230254

GI number: 221230254

Start: 1782133

End: 1782777

Strand: Reverse

Name: clpP2 [H]

Synonym: MLBr_01479

Alternate gene names: 221230254

Gene position: 1782777-1782133 (Counterclockwise)

Preceding gene: 221230255

Following gene: 221230252

Centisome position: 54.55

GC content: 57.52

Gene sequence:

>645_bases
GTGAAACTGCAGAATTCTCAGCTCCAACCTCAGGCGCGATACATCCTGCCATCATTCATCGAGCACTCCAGTTTCGGCGT
CAAGGAGTCCAACCCTTACAACAAGCTGTTTGAGGAACGCATCATCTTTCTCGGCGTCCAAGTTGACGATGCGTCGGCAA
ACGACATCATGGCCCAGCTGCTGGTGTTGGAGTCGCTGGATCCCGACCGCGATATCACTATGTACATCAACTCACCGGGC
GGTGGTTTCACCTCGTTGATGGCGATCTACGACACGATGCAGTATGTACGGGCCGACATCCAGACGGTGTGTTTGGGTCA
GGCTGCTTCGGCGGCGGCGGTGCTGCTGGCTGCCGGAACCCCGGGTAAGCGGATGGCGCTACCCAACGCGCGCGTGCTGA
TCCACCAGCCGTCGCTGGCCGGTGTGATCCAAGGTCAATTCTCCGATCTGGAGATCCAGGCTGCCGAAATCGAACGGATG
CGCACCCTGATGGAGACGACGCTGTCCCGGCACACCGGCAAGGATGCCGCGGTGATCCGTAAGGACACGGACAGGGATAA
AATCCTGACCGCCGAAGAAGCCAAGGATTACGGTATTATCGACACTGTGTTGGAATACCGTAAGCTTTCCGCGCAGACCG
TTTAA

Upstream 100 bases:

>100_bases
CGGATTCTGACCGCGACCGCTGGTTCACTGCCTCGGAAGCCCTGGAATACGGTTTTGTCGACCACATCATTACCCGCGCC
CACGTCAACGGAGAAGTGCA

Downstream 100 bases:

>100_bases
CGGCTCGCCAGTGCCTTCGTCAATTCGGCGATATCCGCCGGCCGCACCCGGCAGCATCCGCCGACGATGCGTGCCCCGGC
CGCCGTCCACTGCAGGGCGA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKLQNSQLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPG
GGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSLAGVIQGQFSDLEIQAAEIERM
RTLMETTLSRHTGKDAAVIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTV

Sequences:

>Translated_214_residues
MKLQNSQLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPG
GGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSLAGVIQGQFSDLEIQAAEIERM
RTLMETTLSRHTGKDAAVIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTV
>Mature_214_residues
MKLQNSQLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPG
GGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSLAGVIQGQFSDLEIQAAEIERM
RTLMETTLSRHTGKDAAVIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTV

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=43.6842105263158, Blast_Score=168, Evalue=4e-42,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=48.4536082474227, Blast_Score=200, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17538017, Length=193, Percent_Identity=41.4507772020725, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=43.2291666666667, Blast_Score=161, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23622; Mature: 23622

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQNSQLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQL
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEEEEEEEECCCCHHHHHHHH
LVLESLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGT
HHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
PGKRMALPNARVLIHQPSLAGVIQGQFSDLEIQAAEIERMRTLMETTLSRHTGKDAAVIR
CCCEEECCCCEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEE
KDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTV
CCCCCCCEEEHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLQNSQLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQL
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEEEEEEEECCCCHHHHHHHH
LVLESLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGT
HHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
PGKRMALPNARVLIHQPSLAGVIQGQFSDLEIQAAEIERMRTLMETTLSRHTGKDAAVIR
CCCEEECCCCEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEE
KDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTV
CCCCCCCEEEHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]