Click here to switch to the map view.

The map label for this gene is sdhB [H]

Identifier: 221229770

GI number: 221229770

Start: 833881

End: 834675

Strand: Reverse

Name: sdhB [H]

Synonym: MLBr_00696

Alternate gene names: 221229770

Gene position: 834675-833881 (Counterclockwise)

Preceding gene: 221229771

Following gene: 221229769

Centisome position: 25.54

GC content: 60.88

Gene sequence:

>795_bases
ATGGCCGTTGAACCTGTCGAGGTCAAGTCGCTCGAACCTCCCCGACCGCCGATTTCGGATGACGCGGTGATGGTGACCGT
GAAGATCGCACGATTCAACCCAGACAACCCCGATGCATTTGCGGAAACCGGTGGCTGGCAGAGCTTCCGGGTGCCCTGCC
TGCCCACCGACCGGCTGCTAAACCTGCTGATCTACATCAAGGGTTACCTGGACGGCACACTCACCTTCCGGAGATCCTGC
GCGCACGGGGTGTGCGGCTCTGATGCTATGCGGGTTAACGGCGTCAACCGGCTGGCCTGCAAGGTACTGATGCGCGACCT
ACTACCAAAAAAAGCGGGCAAGAACCTGACCATCACAGTCGAACCGATCCGCGGGCTGCCGGTGGAAAAGGACCTGGTGG
TCGACATGGAACCATTCTTCGACGCCTACCGCGCGGTGAAACCCTACCTGATTACCAGCGGCAACCCGCCGACCCGAGAG
CGCATCCAAAGCCCGACCGACCGCGCTCGCTACGACGACACCACCAAATGTATCCTGTGCGCATGCTGCACCACCAGCTG
CCCGGTGTTCTGGAGCGAGGGCACCTACTACGGTCCCGCTGCGATCGTCAACGCGCATCGCTTCATTTTCGACAGCCGCG
ATGAGGGTGCCGGCGAACGCCTGACCCTCCTCAACGAGGTCGACGGAGTATGGCGGTGCCGAACCACGTTCAACTGCACC
GAATCCTGCCCACGCAACATAGAGGTGACCAAAGCGATCCAAGAAGTCAAGCGCGCGCTAATGTTCTCGCGCTAA

Upstream 100 bases:

>100_bases
CCATGGCGTACAAGCAAGGCACCGATCTGCTCAGCGATATCGCGCTGGATTTCAAACCCGTCGTGCAGACTCGCTACGAG
CCCCAAGAACGGAAGTACTG

Downstream 100 bases:

>100_bases
CCGCGCTGGTGCTTGGCAGCCCTTGCAGCAACATTCACCCCCCAGGAGTACCGTGCCGCGACCGCCAGACGATCCACTGA
TGCGATATCGCATTTCGAAA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MAVEPVEVKSLEPPRPPISDDAVMVTVKIARFNPDNPDAFAETGGWQSFRVPCLPTDRLLNLLIYIKGYLDGTLTFRRSC
AHGVCGSDAMRVNGVNRLACKVLMRDLLPKKAGKNLTITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITSGNPPTRE
RIQSPTDRARYDDTTKCILCACCTTSCPVFWSEGTYYGPAAIVNAHRFIFDSRDEGAGERLTLLNEVDGVWRCRTTFNCT
ESCPRNIEVTKAIQEVKRALMFSR

Sequences:

>Translated_264_residues
MAVEPVEVKSLEPPRPPISDDAVMVTVKIARFNPDNPDAFAETGGWQSFRVPCLPTDRLLNLLIYIKGYLDGTLTFRRSC
AHGVCGSDAMRVNGVNRLACKVLMRDLLPKKAGKNLTITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITSGNPPTRE
RIQSPTDRARYDDTTKCILCACCTTSCPVFWSEGTYYGPAAIVNAHRFIFDSRDEGAGERLTLLNEVDGVWRCRTTFNCT
ESCPRNIEVTKAIQEVKRALMFSR
>Mature_263_residues
AVEPVEVKSLEPPRPPISDDAVMVTVKIARFNPDNPDAFAETGGWQSFRVPCLPTDRLLNLLIYIKGYLDGTLTFRRSCA
HGVCGSDAMRVNGVNRLACKVLMRDLLPKKAGKNLTITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITSGNPPTRER
IQSPTDRARYDDTTKCILCACCTTSCPVFWSEGTYYGPAAIVNAHRFIFDSRDEGAGERLTLLNEVDGVWRCRTTFNCTE
SCPRNIEVTKAIQEVKRALMFSR

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=231, Percent_Identity=38.961038961039, Blast_Score=164, Evalue=8e-41,
Organism=Escherichia coli, GI1786943, Length=244, Percent_Identity=41.8032786885246, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1790596, Length=237, Percent_Identity=38.8185654008439, Blast_Score=164, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17533915, Length=239, Percent_Identity=39.7489539748954, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322987, Length=242, Percent_Identity=38.4297520661157, Blast_Score=178, Evalue=9e-46,
Organism=Drosophila melanogaster, GI17137106, Length=257, Percent_Identity=38.5214007782101, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24643156, Length=207, Percent_Identity=40.0966183574879, Blast_Score=161, Evalue=5e-40,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 29544; Mature: 29413

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVEPVEVKSLEPPRPPISDDAVMVTVKIARFNPDNPDAFAETGGWQSFRVPCLPTDRLL
CCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCHHHHCCCCCCEECCCCCHHHHH
NLLIYIKGYLDGTLTFRRSCAHGVCGSDAMRVNGVNRLACKVLMRDLLPKKAGKNLTITV
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCEEEEEE
EPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITSGNPPTRERIQSPTDRARYDDTTKCILC
ECCCCCCCCCCEEEECHHHHHHHHHCCCEEEECCCCCHHHHHCCCCHHHCCCCCHHEEEE
ACCTTSCPVFWSEGTYYGPAAIVNAHRFIFDSRDEGAGERLTLLNEVDGVWRCRTTFNCT
EECCCCCCEEECCCCEECCHHHHHHHHHEEECCCCCCCCEEEHHHHCCCEEEEEEECCCH
ESCPRNIEVTKAIQEVKRALMFSR
HCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVEPVEVKSLEPPRPPISDDAVMVTVKIARFNPDNPDAFAETGGWQSFRVPCLPTDRLL
CCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCHHHHCCCCCCEECCCCCHHHHH
NLLIYIKGYLDGTLTFRRSCAHGVCGSDAMRVNGVNRLACKVLMRDLLPKKAGKNLTITV
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCEEEEEE
EPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITSGNPPTRERIQSPTDRARYDDTTKCILC
ECCCCCCCCCCEEEECHHHHHHHHHCCCEEEECCCCCHHHHHCCCCHHHCCCCCHHEEEE
ACCTTSCPVFWSEGTYYGPAAIVNAHRFIFDSRDEGAGERLTLLNEVDGVWRCRTTFNCT
EECCCCCCEEECCCCEECCHHHHHHHHHEEECCCCCCCCEEEHHHHCCCEEEEEEECCCH
ESCPRNIEVTKAIQEVKRALMFSR
HCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]