Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 221229771

GI number: 221229771

Start: 834675

End: 836429

Strand: Reverse

Name: sdhA [H]

Synonym: MLBr_00697

Alternate gene names: 221229771

Gene position: 836429-834675 (Counterclockwise)

Preceding gene: 221229772

Following gene: 221229770

Centisome position: 25.59

GC content: 60.91

Gene sequence:

>1755_bases
TTGATCCAGCAACACCGATACGACGTGGTGATCGTCGGCGCAGGCGGTGCCGGAATGCGGGCAGCCGTAGAAGCCGGCCC
CCGAGTGCGAACCGCGGTCTTGACGAAACTTTATCCGACCCGCAGCCACACCGGTGCCGCCCAAGGGGGCATGTGCGCGG
CGCTGGCTAACGTCGAAGATGACAACTGGGAATGGCACGCCTTCGACACCGTCAAGGGTGGCGACTACCTTGCGGACCAG
GACGCAGTGGAGATTATGTGCAAGGAAGCTATCGACGCGGTGCTCGACCTAGAGAAGATGGGGATGCCATTCAATCGTAC
CCCCGAAGGCCGCATCGATCAGCGCCGCTTCGGCGGTCACACTCGCGACCACGGCAAAGCGCCGGTCCGCAGGGCCTGCT
ACGCGGCCGACCGCACCGGCCACATGATCCTGCAGACGCTCTACCAGAACTGCGTCAAGCACGACGTGGAGTTCTTCAAC
GAGTTCTACGCACTCGACTTGGTCCTGACCCAAACCCCGAGCGGCCCAGTTACCACCGGGGTAGTGGCCTACGAGTTGGC
GACCGGCGATATTCACGTCTTCCACACCAAGGCCGTCGTGATCGCGACCGGCGGTTCGGGCCGAATGTACAAGACCACCT
CCAATGCGCACACGCTGACAGGAGACGGCATCGGGATTGTGTTCCGTAAGGGACTTCCTTTGGAGGACATGGAGTTTCAT
CAGTTTCACCCGACAGGCCTGGCAGGGCTGGGCATCCTAATATCCGAGGCGGTGCGCGGCGAAGGCGGACGGCTGCTCAA
CGGCGAGAACGAACGGTTCATGGAGCACTATGCCCCGACAATCGTCGACCTGGCTCCGCGTGACATCGTGGCCCGCTCAA
TGGTGCTCGAGGTCCTGGAGGGCCGCGGCGCTGGCCCGCATAAGGACTACGTCTACATCGATGTCCGTCACCTCGGCGAG
GAGGTGCTAGAATCCAAACTTCCCGATATCACCGAATTCTCCCGCACCTATTTGGGTGTGGACCCGGTCCACGAGCTGGT
CCCAGTCTATCCGACCTGCCATTACGTGATGGGCGGGATCCCGACCACCGTGACCGGGCAGGTGCTGCGGGACAATACCT
CGACCGTCCCCGGCCTGTACGCGGCCGGCGAATGCGCATGTGTGTCCGTGCACGGCGCCAACCGGCTGGGCACCAACTCG
CTGCTAGACATCAACGTCTTCGGTCGCCGGTCCGGCATCGCAGCGGCCAGTTATGCTTCAGCCAACGACTTCGTCGATAT
GCCACCGAACCCAGCGGAGATGGTCATCAGCTGGGTAGCTAACATCTTATCCGAGCACGGCAACGAGCGCGTCGCCGATA
TTCGTGGCGCGCTACAACAGACGATGGACAACAATGCGGCGGTGTTTCGTACCGAAGAAACACTCAAGCAAGCGCTCACC
GATATTCATTCGCTCAAGGAGCGATACTCCCGAATAACCGTGCACGACAAGGGAAAAAGTTTCAACAGCGACTTGTTGGA
AGCCATCGAGCTGGGCTTTTTGCTGGAACTGGCTGAAGTCACGGTGGTTGGCGCGCTGAACCGCAAGGAATCCCGTGGCG
GGCATGCCCGCGAAGACTATCCGCACCGGGATGACACCAACTACATGCGCCACACCATGGCGTACAAGCAAGGCACCGAT
CTGCTCAGCGATATCGCGCTGGATTTCAAACCCGTCGTGCAGACTCGCTACGAGCCCCAAGAACGGAAGTACTGA

Upstream 100 bases:

>100_bases
GCTTGCTGCTGTTGTCAATGGGGTTCACGCTGGTGCTGGGCAGCTACGTGCTGTTGTCATTCGATCCCAACATCTCCTGA
AAGTCTGCGAAAGGCAAGCT

Downstream 100 bases:

>100_bases
TGGCCGTTGAACCTGTCGAGGTCAAGTCGCTCGAACCTCCCCGACCGCCGATTTCGGATGACGCGGTGATGGTGACCGTG
AAGATCGCACGATTCAACCC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEDDNWEWHAFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN
EFYALDLVLTQTPSGPVTTGVVAYELATGDIHVFHTKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGENERFMEHYAPTIVDLAPRDIVARSMVLEVLEGRGAGPHKDYVYIDVRHLGE
EVLESKLPDITEFSRTYLGVDPVHELVPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRSGIAAASYASANDFVDMPPNPAEMVISWVANILSEHGNERVADIRGALQQTMDNNAAVFRTEETLKQALT
DIHSLKERYSRITVHDKGKSFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPHRDDTNYMRHTMAYKQGTD
LLSDIALDFKPVVQTRYEPQERKY

Sequences:

>Translated_584_residues
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEDDNWEWHAFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN
EFYALDLVLTQTPSGPVTTGVVAYELATGDIHVFHTKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGENERFMEHYAPTIVDLAPRDIVARSMVLEVLEGRGAGPHKDYVYIDVRHLGE
EVLESKLPDITEFSRTYLGVDPVHELVPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRSGIAAASYASANDFVDMPPNPAEMVISWVANILSEHGNERVADIRGALQQTMDNNAAVFRTEETLKQALT
DIHSLKERYSRITVHDKGKSFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPHRDDTNYMRHTMAYKQGTD
LLSDIALDFKPVVQTRYEPQERKY
>Mature_584_residues
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEDDNWEWHAFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN
EFYALDLVLTQTPSGPVTTGVVAYELATGDIHVFHTKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGENERFMEHYAPTIVDLAPRDIVARSMVLEVLEGRGAGPHKDYVYIDVRHLGE
EVLESKLPDITEFSRTYLGVDPVHELVPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRSGIAAASYASANDFVDMPPNPAEMVISWVANILSEHGNERVADIRGALQQTMDNNAAVFRTEETLKQALT
DIHSLKERYSRITVHDKGKSFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPHRDDTNYMRHTMAYKQGTD
LLSDIALDFKPVVQTRYEPQERKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=573, Percent_Identity=46.5968586387435, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI1786942, Length=559, Percent_Identity=47.7638640429338, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1790597, Length=572, Percent_Identity=38.4615384615385, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1788928, Length=554, Percent_Identity=32.4909747292419, Blast_Score=221, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17550100, Length=577, Percent_Identity=46.1005199306759, Blast_Score=511, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17505833, Length=524, Percent_Identity=48.2824427480916, Blast_Score=497, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322701, Length=592, Percent_Identity=47.2972972972973, Blast_Score=527, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6322416, Length=591, Percent_Identity=48.5617597292724, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI17137288, Length=572, Percent_Identity=46.8531468531469, Blast_Score=502, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24655642, Length=572, Percent_Identity=46.8531468531469, Blast_Score=502, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24655647, Length=572, Percent_Identity=46.8531468531469, Blast_Score=502, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24663005, Length=600, Percent_Identity=44.6666666666667, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64239; Mature: 64239

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVED
CCCCCCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCC
DNWEWHAFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGH
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
TRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDLVLTQTPSGPVTTG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCC
VVAYELATGDIHVFHTKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
EEEEEEECCCEEEEEEEEEEEEECCCCCEEEECCCCEEECCCCEEEEEECCCCCCCCCCC
QFHPTGLAGLGILISEAVRGEGGRLLNGENERFMEHYAPTIVDLAPRDIVARSMVLEVLE
CCCCCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHCCHHEECCCHHHHHHHHHHHHHH
GRGAGPHKDYVYIDVRHLGEEVLESKLPDITEFSRTYLGVDPVHELVPVYPTCHYVMGGI
CCCCCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCHHHHHCCC
PTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRSGIAAASYAS
CCCEECHHEECCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEEEEECCCCCCCEECCCC
ANDFVDMPPNPAEMVISWVANILSEHGNERVADIRGALQQTMDNNAAVFRTEETLKQALT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHH
DIHSLKERYSRITVHDKGKSFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDY
HHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCC
PHRDDTNYMRHTMAYKQGTDLLSDIALDFKPVVQTRYEPQERKY
CCCCCCHHHHHHHHHHHCHHHHHHHHHCCHHHHHCCCCHHHCCC
>Mature Secondary Structure
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVED
CCCCCCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCC
DNWEWHAFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGH
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
TRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDLVLTQTPSGPVTTG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCC
VVAYELATGDIHVFHTKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
EEEEEEECCCEEEEEEEEEEEEECCCCCEEEECCCCEEECCCCEEEEEECCCCCCCCCCC
QFHPTGLAGLGILISEAVRGEGGRLLNGENERFMEHYAPTIVDLAPRDIVARSMVLEVLE
CCCCCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHCCHHEECCCHHHHHHHHHHHHHH
GRGAGPHKDYVYIDVRHLGEEVLESKLPDITEFSRTYLGVDPVHELVPVYPTCHYVMGGI
CCCCCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCHHHHHCCC
PTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRSGIAAASYAS
CCCEECHHEECCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEEEEECCCCCCCEECCCC
ANDFVDMPPNPAEMVISWVANILSEHGNERVADIRGALQQTMDNNAAVFRTEETLKQALT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHH
DIHSLKERYSRITVHDKGKSFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDY
HHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCC
PHRDDTNYMRHTMAYKQGTDLLSDIALDFKPVVQTRYEPQERKY
CCCCCCHHHHHHHHHHHCHHHHHHHHHCCHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA