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The map label for this gene is ribA [H]

Identifier: 221229688

GI number: 221229688

Start: 676311

End: 677618

Strand: Direct

Name: ribA [H]

Synonym: MLBr_00559

Alternate gene names: 221229688

Gene position: 676311-677618 (Clockwise)

Preceding gene: 221229687

Following gene: 221229689

Centisome position: 20.69

GC content: 57.65

Gene sequence:

>1308_bases
GTGGGCCCTTTTGATAGCAAGGTGGCAAAGATGACGAGGTTGGACTCCGTCGAGCGGGCAGTTGCCGACATTGCGGCTGG
TAAAGCCGTTGTCGTCATCGACGATGAGGACCGCGAGAACGAAGGCGACCTGATCTTCGCCGCCGAAAAGGCAACGCTGG
AGATGGTGGCCTTTATGGTCCGCTATACCTCGGGATACTTGTGCGCGCCACTGGATGGTGCGATCTGCGACCGGTTGGGA
CTTTTGCCGATGTTTGCGGTGAATCAAGACAAACATGGGACTGCCTACACGGTCACTGTCGATGCGAGAAACGGTGTAGG
AACCGGGATTTCGGCTTCTGATCGGGCTACCACAATGCGATTATTAGCTGACCCGGCTAGTGTCGCTGACGATTTCACCC
GCCCCGGCCATGTGGTTCCGTTGCGTGCCAAGGACGGCGGTGTGTTGCGCCGGCCGGGTCACACAGAGGCCGCCGTCGAC
TTGGCCCGGCTGGCAGGATTGCAGCCCGCAGGAGCGATCTGCGAGATCGTCAGTCAGAAGGACGAAGGCTCGATGGCACA
GACCGACGAGTTGCGGGTCTTCGCTGATGAGCACGATCTGGCGCTGATCACCATTGCCGATCTGATCGCATGGCGGCGCA
AGCATGAGAAGCACATCGAGCGGGTTGCTGAAGCGCGGATCCCAACCCGTCATGGAGAGTTTCGTGCTATTGGCTATACT
AGTATTTACGACGACGTTAAGCATGTGGCACTGGTCCGCGGCGAAATTGCCGGATCAAGCGGTGACGGCGATGACATATT
GGTCCGGGTGCACTCCGAGTGTTTGACGGGTGATGTGTTCGGCTCACGGCGTTGCGATTGTGGGACCCAACTCGATGCCG
CTATGGCTATGGTGGCGCGAGAAGGACGCGGTGTGGTGTTATACATGCGCGGCCATGAAGGTCGAGGTATCGGGCTGATG
CATAAACTGCAAGCATACCAGCTACAGGATGCTGGCGCGGACACCGTGGACGCTAACATCAAGCTTGGATTCCCTTCTGA
TGCAAGGGATTACGGAATTGGTGCGCAGATACTCGTCGATCTCGGAGTGCGCTCGATGCGACTGTTAACCAACAATCCCG
CCAAGCGGGTTGGGCTGGACGGGTACGGACTGCAGATCATCGAGCGGGTGCCGCTTCCGGTGCGGGCCAACGCGGATAAC
ATCCGTTACTTGATGACCAAGCGTGACAAGATGGGTCACGACCTGGGCGGGTTGGATGATTTTCATGAATCAAACTATTT
TCCAGGTGAATTCGGCGGTGCTTTATGA

Upstream 100 bases:

>100_bases
CAACTGTGCGGCTCATGCCACTTAATCTGCCTTGAAAAGCTGTGGCAATGACCGTGGCAGCACGGTGGTTCATACTGAAT
GCAGCGTGTGGGCTGCTTGT

Downstream 100 bases:

>100_bases
GTGGTGGAGCCGGTATTCCGGAGGTTCCGGGGATCGACGCTTCCGGTCTGCGGCTAGGTATTGTCGCAAGCACCTGGCAC
AGCAGAATTTGCGATGCGCT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MGPFDSKVAKMTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEKATLEMVAFMVRYTSGYLCAPLDGAICDRLG
LLPMFAVNQDKHGTAYTVTVDARNGVGTGISASDRATTMRLLADPASVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVD
LARLAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHDLALITIADLIAWRRKHEKHIERVAEARIPTRHGEFRAIGYT
SIYDDVKHVALVRGEIAGSSGDGDDILVRVHSECLTGDVFGSRRCDCGTQLDAAMAMVAREGRGVVLYMRGHEGRGIGLM
HKLQAYQLQDAGADTVDANIKLGFPSDARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLQIIERVPLPVRANADN
IRYLMTKRDKMGHDLGGLDDFHESNYFPGEFGGAL

Sequences:

>Translated_435_residues
MGPFDSKVAKMTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEKATLEMVAFMVRYTSGYLCAPLDGAICDRLG
LLPMFAVNQDKHGTAYTVTVDARNGVGTGISASDRATTMRLLADPASVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVD
LARLAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHDLALITIADLIAWRRKHEKHIERVAEARIPTRHGEFRAIGYT
SIYDDVKHVALVRGEIAGSSGDGDDILVRVHSECLTGDVFGSRRCDCGTQLDAAMAMVAREGRGVVLYMRGHEGRGIGLM
HKLQAYQLQDAGADTVDANIKLGFPSDARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLQIIERVPLPVRANADN
IRYLMTKRDKMGHDLGGLDDFHESNYFPGEFGGAL
>Mature_434_residues
GPFDSKVAKMTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEKATLEMVAFMVRYTSGYLCAPLDGAICDRLGL
LPMFAVNQDKHGTAYTVTVDARNGVGTGISASDRATTMRLLADPASVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDL
ARLAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHDLALITIADLIAWRRKHEKHIERVAEARIPTRHGEFRAIGYTS
IYDDVKHVALVRGEIAGSSGDGDDILVRVHSECLTGDVFGSRRCDCGTQLDAAMAMVAREGRGVVLYMRGHEGRGIGLMH
KLQAYQLQDAGADTVDANIKLGFPSDARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLQIIERVPLPVRANADNI
RYLMTKRDKMGHDLGGLDDFHESNYFPGEFGGAL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=199, Percent_Identity=51.7587939698493, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789420, Length=206, Percent_Identity=47.5728155339806, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=46.5686274509804, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6319438, Length=192, Percent_Identity=45.3125, Blast_Score=138, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 47042; Mature: 46911

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPFDSKVAKMTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEKATLEMVAFMV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHH
RYTSGYLCAPLDGAICDRLGLLPMFAVNQDKHGTAYTVTVDARNGVGTGISASDRATTMR
HHCCCEEEECCCHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCHHHEEH
LLADPASVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARLAGLQPAGAICEIVSQK
HHCCCHHHHHHCCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCC
DEGSMAQTDELRVFADEHDLALITIADLIAWRRKHEKHIERVAEARIPTRHGEFRAIGYT
CCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECH
SIYDDVKHVALVRGEIAGSSGDGDDILVRVHSECLTGDVFGSRRCDCGTQLDAAMAMVAR
HHHHHHHHHHHHHHEECCCCCCCCEEEEEEECHHHCCCCCCCCCCCCCCHHHHHHHHHHH
EGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANIKLGFPSDARDYGIGAQILVD
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECEEEECCCCCCCCCCCCHHHHHH
LGVRSMRLLTNNPAKRVGLDGYGLQIIERVPLPVRANADNIRYLMTKRDKMGHDLGGLDD
HCCHHEEHHCCCCHHHCCCCCCCHHHHHHCCCCEECCCCCEEEEEECCHHCCCCCCCCCH
FHESNYFPGEFGGAL
HHHCCCCCCCCCCCC
>Mature Secondary Structure 
GPFDSKVAKMTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEKATLEMVAFMV
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHH
RYTSGYLCAPLDGAICDRLGLLPMFAVNQDKHGTAYTVTVDARNGVGTGISASDRATTMR
HHCCCEEEECCCHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCHHHEEH
LLADPASVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARLAGLQPAGAICEIVSQK
HHCCCHHHHHHCCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCC
DEGSMAQTDELRVFADEHDLALITIADLIAWRRKHEKHIERVAEARIPTRHGEFRAIGYT
CCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECH
SIYDDVKHVALVRGEIAGSSGDGDDILVRVHSECLTGDVFGSRRCDCGTQLDAAMAMVAR
HHHHHHHHHHHHHHEECCCCCCCCEEEEEEECHHHCCCCCCCCCCCCCCHHHHHHHHHHH
EGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANIKLGFPSDARDYGIGAQILVD
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECEEEECCCCCCCCCCCCHHHHHH
LGVRSMRLLTNNPAKRVGLDGYGLQIIERVPLPVRANADNIRYLMTKRDKMGHDLGGLDD
HCCHHEEHHCCCCHHHCCCCCCCHHHHHHCCCCEECCCCCEEEEEECCHHCCCCCCCCCH
FHESNYFPGEFGGAL
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA