Click here to switch to the map view.

The map label for this gene is aroB

Identifier: 221229658

GI number: 221229658

Start: 629577

End: 630662

Strand: Direct

Name: aroB

Synonym: MLBr_00518

Alternate gene names: 221229658

Gene position: 629577-630662 (Clockwise)

Preceding gene: 221229657

Following gene: 221229659

Centisome position: 19.26

GC content: 60.13

Gene sequence:

>1086_bases
ATGACAAATATCGACGCACCGGTCACTGTGCAGGTGGCTGTCGACCCGCCATACCCAGTGGTGATCGGCACCGGGTTGTC
GGATCAATTGGATGAACTGCTTGCCAACCGACATCGGGTCGCGATACTGCATCAACCGGTACTGACCCAAACTGCGGAGG
CGATCCGAAGCCACTTGGCCGGCAAGGGGGTCGACGCGCACCGCATCGAAATACCTGACGCCGAGGCCGGCAAGGATCTT
TCTGTCATGGATTTCATATGGGAAGTATTGGGCCGCATCGGAATTGGACGTAAAGATGCACTGGTCAGTTTTGGCGGCGG
CGCCGCTACCGATGTAGCTGGGTTCGCGGCGGCTACCTGGTTACGCGGTGTCTCTATCGTACATGTGCCGACCACGTTGT
TAGGTATGGTCGACGCAGCGGTTGGGGGCAAGACTGGTATCAACACCGAGGCTGGCAAGAACCTGGTCGGCGCATTTCAT
CAACCTCTCGCCGTGTTGGCTGACCTGGCGACTTTGGAAACTTTGCCGCGCAAAGAAATTGCGTCCGGTATGGCCGAAGT
AGTCAAGGCCGGATTTATTGCTGACCCGATCATCCTCGACCTCATCGAAGCCGACCCACAGGCCTCCTTGGACCCGATGG
GTGGCGTGTTGCCGGAGCTGATCCGCCGGGCCGTCACCGTCAAGGCGGGCGTCGTCTCCGCCGATGAGAAGGAATCCGAG
TTGCGCGAAATCCTGAACTATGGCCACACTTTGGCACACGCAATCGAGCGCCGGGAGCGCTATGAATGGCGTCATGGCGC
CGCCGTGTCGGTGGGCTTGGTGTTCGCAGCCGAACTGGCCCGAGTTGCGGGGCGGCTCGACGATGCCACGGCGCAGCGAC
ATCACACCATTCTGACCTCGCTTGGCTTGCCGGTCAGCTATGACGCTGATGCGTTGCCGCAGCTGCTGGAATATATGGCC
GGGGACAAGAAAACCCGGGCTGGCGTGCTTAGATTCGTGATCCTCGATGGGCTGGCTAAGCCGGGGCGGTTAGTGGGGCC
GGACCCAGGGCTGTTAGTGACTGCTTACGCAGGATTGAGTGCCTGA

Upstream 100 bases:

>100_bases
TGCAGGCTCAACTAGCCACTCCTGTCTCTGGTGGTGATCGCAAGAGTAGCGAAGCCGAGCGTAGTGGGGCGCCACTTCGC
AAATCTAGTGAGGTCGTCAA

Downstream 100 bases:

>100_bases
TGACGATGGTTAACATCATCAACGGTCCGAACCTGGGCCGGCTGGGTCGGCGTGAACCCGATGTCTATGGCAGCACCACC
CACGAACAGCTGTCGGCTCT

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTNIDAPVTVQVAVDPPYPVVIGTGLSDQLDELLANRHRVAILHQPVLTQTAEAIRSHLAGKGVDAHRIEIPDAEAGKDL
SVMDFIWEVLGRIGIGRKDALVSFGGGAATDVAGFAAATWLRGVSIVHVPTTLLGMVDAAVGGKTGINTEAGKNLVGAFH
QPLAVLADLATLETLPRKEIASGMAEVVKAGFIADPIILDLIEADPQASLDPMGGVLPELIRRAVTVKAGVVSADEKESE
LREILNYGHTLAHAIERRERYEWRHGAAVSVGLVFAAELARVAGRLDDATAQRHHTILTSLGLPVSYDADALPQLLEYMA
GDKKTRAGVLRFVILDGLAKPGRLVGPDPGLLVTAYAGLSA

Sequences:

>Translated_361_residues
MTNIDAPVTVQVAVDPPYPVVIGTGLSDQLDELLANRHRVAILHQPVLTQTAEAIRSHLAGKGVDAHRIEIPDAEAGKDL
SVMDFIWEVLGRIGIGRKDALVSFGGGAATDVAGFAAATWLRGVSIVHVPTTLLGMVDAAVGGKTGINTEAGKNLVGAFH
QPLAVLADLATLETLPRKEIASGMAEVVKAGFIADPIILDLIEADPQASLDPMGGVLPELIRRAVTVKAGVVSADEKESE
LREILNYGHTLAHAIERRERYEWRHGAAVSVGLVFAAELARVAGRLDDATAQRHHTILTSLGLPVSYDADALPQLLEYMA
GDKKTRAGVLRFVILDGLAKPGRLVGPDPGLLVTAYAGLSA
>Mature_360_residues
TNIDAPVTVQVAVDPPYPVVIGTGLSDQLDELLANRHRVAILHQPVLTQTAEAIRSHLAGKGVDAHRIEIPDAEAGKDLS
VMDFIWEVLGRIGIGRKDALVSFGGGAATDVAGFAAATWLRGVSIVHVPTTLLGMVDAAVGGKTGINTEAGKNLVGAFHQ
PLAVLADLATLETLPRKEIASGMAEVVKAGFIADPIILDLIEADPQASLDPMGGVLPELIRRAVTVKAGVVSADEKESEL
REILNYGHTLAHAIERRERYEWRHGAAVSVGLVFAAELARVAGRLDDATAQRHHTILTSLGLPVSYDADALPQLLEYMAG
DKKTRAGVLRFVILDGLAKPGRLVGPDPGLLVTAYAGLSA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=322, Percent_Identity=40.0621118012422, Blast_Score=211, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6320332, Length=285, Percent_Identity=37.5438596491228, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_MYCLE (Q9CCS4)

Other databases:

- EMBL:   AL583918
- PIR:   F86973
- RefSeq:   NP_301443.1
- ProteinModelPortal:   Q9CCS4
- SMR:   Q9CCS4
- EnsemblBacteria:   EBMYCT00000029116
- GeneID:   909275
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0518
- NMPDR:   fig|272631.1.peg.315
- Leproma:   ML0518
- GeneTree:   EBGT00050000016995
- HOGENOM:   HBG632303
- OMA:   FAAYQEI
- ProtClustDB:   PRK00002
- BioCyc:   MLEP272631:ML0518-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 38032; Mature: 37901

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIDAPVTVQVAVDPPYPVVIGTGLSDQLDELLANRHRVAILHQPVLTQTAEAIRSHLA
CCCCCCCEEEEEEECCCCCEEEECCCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHC
GKGVDAHRIEIPDAEAGKDLSVMDFIWEVLGRIGIGRKDALVSFGGGAATDVAGFAAATW
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHEEECCCCCHHHHHHHHHHHH
LRGVSIVHVPTTLLGMVDAAVGGKTGINTEAGKNLVGAFHQPLAVLADLATLETLPRKEI
HHCCEEEEHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
ASGMAEVVKAGFIADPIILDLIEADPQASLDPMGGVLPELIRRAVTVKAGVVSADEKESE
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
LREILNYGHTLAHAIERRERYEWRHGAAVSVGLVFAAELARVAGRLDDATAQRHHTILTS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LGLPVSYDADALPQLLEYMAGDKKTRAGVLRFVILDGLAKPGRLVGPDPGLLVTAYAGLS
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCC
A
C
>Mature Secondary Structure 
TNIDAPVTVQVAVDPPYPVVIGTGLSDQLDELLANRHRVAILHQPVLTQTAEAIRSHLA
CCCCCCEEEEEEECCCCCEEEECCCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHC
GKGVDAHRIEIPDAEAGKDLSVMDFIWEVLGRIGIGRKDALVSFGGGAATDVAGFAAATW
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHEEECCCCCHHHHHHHHHHHH
LRGVSIVHVPTTLLGMVDAAVGGKTGINTEAGKNLVGAFHQPLAVLADLATLETLPRKEI
HHCCEEEEHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
ASGMAEVVKAGFIADPIILDLIEADPQASLDPMGGVLPELIRRAVTVKAGVVSADEKESE
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
LREILNYGHTLAHAIERRERYEWRHGAAVSVGLVFAAELARVAGRLDDATAQRHHTILTS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LGLPVSYDADALPQLLEYMAGDKKTRAGVLRFVILDGLAKPGRLVGPDPGLLVTAYAGLS
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002