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The map label for this gene is aroD

Identifier: 221229659

GI number: 221229659

Start: 630662

End: 631099

Strand: Direct

Name: aroD

Synonym: MLBr_00519

Alternate gene names: 221229659

Gene position: 630662-631099 (Clockwise)

Preceding gene: 221229658

Following gene: 221229661

Centisome position: 19.3

GC content: 57.08

Gene sequence:

>438_bases
ATGACGATGGTTAACATCATCAACGGTCCGAACCTGGGCCGGCTGGGTCGGCGTGAACCCGATGTCTATGGCAGCACCAC
CCACGAACAGCTGTCGGCTCTGATTGAGCGTGCGGCTGTCGAATTTGGGATCAAAGCTGTTGTGCGGCAAAGTGATAGTG
AGTCACAGCTACTGGATTGGATCCATCTGGCCGCTGATGCTGGAGAACCGGTTATCCTCAACGCCGGCGGCTTGACGCAC
ACGTCAGTGGCGCTGCGCGACGCGTGCGCTGAATTAAGCGCACCGTTTATTGAGGTGCACATCTCTAATGTGCATGCCCG
CGAGGAGTTTCGGCGTCATTCCTATCTCAGCCCGCTAGCGACAGGAGTGATTACCGGGCTGGGAGTCCAAGGCTACCTGC
TTGCCTTGCGCTATCTGGCTGAGATAGCTGGGAACTAA

Upstream 100 bases:

>100_bases
TGCTTAGATTCGTGATCCTCGATGGGCTGGCTAAGCCGGGGCGGTTAGTGGGGCCGGACCCAGGGCTGTTAGTGACTGCT
TACGCAGGATTGAGTGCCTG

Downstream 100 bases:

>100_bases
TCTTTTTTCGGGATATCACGCGTCTCCTTATTTCGGGATATCATGCGTCGCGGTGGCGTAGGTGCGGATCATCTCGATGG
GAGTGTCGTCACGCTCGCTG

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type II DHQase

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MTMVNIINGPNLGRLGRREPDVYGSTTHEQLSALIERAAVEFGIKAVVRQSDSESQLLDWIHLAADAGEPVILNAGGLTH
TSVALRDACAELSAPFIEVHISNVHAREEFRRHSYLSPLATGVITGLGVQGYLLALRYLAEIAGN

Sequences:

>Translated_145_residues
MTMVNIINGPNLGRLGRREPDVYGSTTHEQLSALIERAAVEFGIKAVVRQSDSESQLLDWIHLAADAGEPVILNAGGLTH
TSVALRDACAELSAPFIEVHISNVHAREEFRRHSYLSPLATGVITGLGVQGYLLALRYLAEIAGN
>Mature_144_residues
TMVNIINGPNLGRLGRREPDVYGSTTHEQLSALIERAAVEFGIKAVVRQSDSESQLLDWIHLAADAGEPVILNAGGLTHT
SVALRDACAELSAPFIEVHISNVHAREEFRRHSYLSPLATGVITGLGVQGYLLALRYLAEIAGN

Specific function: Catalyzes a trans-dehydration via an enolate intermediate

COG id: COG0757

COG function: function code E; 3-dehydroquinate dehydratase II

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-II 3-dehydroquinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROQ_MYCLB (B8ZUK3)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503075.1
- ProteinModelPortal:   B8ZUK3
- SMR:   B8ZUK3
- EnsemblBacteria:   EBMYCT00000086557
- GeneID:   7327231
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017464
- HOGENOM:   HBG284657
- OMA:   GWLHEAA
- ProtClustDB:   PRK05395
- HAMAP:   MF_00169
- InterPro:   IPR001874
- InterPro:   IPR018509
- Gene3D:   G3DSA:3.40.50.9100
- PANTHER:   PTHR21272
- PIRSF:   PIRSF001399
- ProDom:   PD004527
- TIGRFAMs:   TIGR01088

Pfam domain/function: PF01220 DHquinase_II; SSF52304 DHquinase_II

EC number: =4.2.1.10

Molecular weight: Translated: 15643; Mature: 15512

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS01029 DEHYDROQUINASE_II

Important sites: ACT_SITE 23-23 ACT_SITE 100-100 BINDING 74-74 BINDING 80-80 BINDING 87-87 BINDING 111-111

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMVNIINGPNLGRLGRREPDVYGSTTHEQLSALIERAAVEFGIKAVVRQSDSESQLLDW
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IHLAADAGEPVILNAGGLTHTSVALRDACAELSAPFIEVHISNVHAREEFRRHSYLSPLA
HHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHH
TGVITGLGVQGYLLALRYLAEIAGN
HHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TMVNIINGPNLGRLGRREPDVYGSTTHEQLSALIERAAVEFGIKAVVRQSDSESQLLDW
CEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IHLAADAGEPVILNAGGLTHTSVALRDACAELSAPFIEVHISNVHAREEFRRHSYLSPLA
HHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHH
TGVITGLGVQGYLLALRYLAEIAGN
HHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA