Click here to switch to the map view.

The map label for this gene is ycbL [C]

Identifier: 221229647

GI number: 221229647

Start: 599089

End: 599745

Strand: Direct

Name: ycbL [C]

Synonym: MLBr_00493

Alternate gene names: 221229647

Gene position: 599089-599745 (Clockwise)

Preceding gene: 221229645

Following gene: 221229648

Centisome position: 18.33

GC content: 61.04

Gene sequence:

>657_bases
GTGTTAATCACCGGATTTCCCGCCGGGATGCTGCAGTGCAACTGTTACGTGCTGGCCGACCGGGCGGGTACGGATGCCGT
CATAGTGGACCCCGGCCAGCGTGCGATGGGCCCGCTGCGGCGCATCCTTGACGAGAATCGTTTGACTCCATCGGCGGTGC
TGCTCACCCACGGCCACATCGATCACATGTGGTCGGCCCAGAAAGTGTCCGACACCTATGGTTGTCCGACGTACATTCAT
CCCGAGGACCGGTTCATGTTGACCGATCCGCTCTTCGGCTTCGGTCCGCGGGTGGCGCAGGTCGTCACGGGAGCGTTCTT
TCGTGAGCCCAAGCAGGTCGTCGAGCTGGACCGGGATGGCGATAAGCTCGATTTGGGCAGTGTGACCGTCAACGTCGACC
ATACCCCCGGACATACCCGCGGCTCGGTGTGTTTTTGGGTCGCCGCAGATACCGACGTGGTGTTGACCGGCGACACGCTG
TTCGAGCGCACCATCGGTCGCACCGATCTGTTTGGTGGCAGTGGTCGTGACCTATACCGTTCCATCGTCGAAAAATTGTT
GGTACTCGACGACAAGACCGTGGTACTACCCGGGCATGGCAACTCCACCACCATCGGTGCCGAGCGTCGTTTCAATCCGT
TCCTCGAGGGCCTGTAG

Upstream 100 bases:

>100_bases
AACGCCTCGACCTGTGTCAAGTTTTTGTTTCGCGGCGTCTGTCTCGGCTGCTGAGTGGACCGCATTGTCGTCGACGGCTA
AGGGATGGGAAACTGGGGGT

Downstream 100 bases:

>100_bases
CTTGTGACGGAGTCATGCACTGTGTTTTCGTTTTCTGGGCCCAAGGGGATACCGGATTATTTTCCTCCGGACTCGGCGCA
ATTTGTCGCGGTACGTGATG

Product: putative hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MLITGFPAGMLQCNCYVLADRAGTDAVIVDPGQRAMGPLRRILDENRLTPSAVLLTHGHIDHMWSAQKVSDTYGCPTYIH
PEDRFMLTDPLFGFGPRVAQVVTGAFFREPKQVVELDRDGDKLDLGSVTVNVDHTPGHTRGSVCFWVAADTDVVLTGDTL
FERTIGRTDLFGGSGRDLYRSIVEKLLVLDDKTVVLPGHGNSTTIGAERRFNPFLEGL

Sequences:

>Translated_218_residues
MLITGFPAGMLQCNCYVLADRAGTDAVIVDPGQRAMGPLRRILDENRLTPSAVLLTHGHIDHMWSAQKVSDTYGCPTYIH
PEDRFMLTDPLFGFGPRVAQVVTGAFFREPKQVVELDRDGDKLDLGSVTVNVDHTPGHTRGSVCFWVAADTDVVLTGDTL
FERTIGRTDLFGGSGRDLYRSIVEKLLVLDDKTVVLPGHGNSTTIGAERRFNPFLEGL
>Mature_218_residues
MLITGFPAGMLQCNCYVLADRAGTDAVIVDPGQRAMGPLRRILDENRLTPSAVLLTHGHIDHMWSAQKVSDTYGCPTYIH
PEDRFMLTDPLFGFGPRVAQVVTGAFFREPKQVVELDRDGDKLDLGSVTVNVDHTPGHTRGSVCFWVAADTDVVLTGDTL
FERTIGRTDLFGGSGRDLYRSIVEKLLVLDDKTVVLPGHGNSTTIGAERRFNPFLEGL

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family

Homologues:

Organism=Escherichia coli, GI1787158, Length=215, Percent_Identity=34.4186046511628, Blast_Score=113, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17538952, Length=147, Percent_Identity=31.2925170068027, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221330176, Length=207, Percent_Identity=27.536231884058, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y493_MYCLE (Q49649)

Other databases:

- EMBL:   U00011
- EMBL:   AL023591
- EMBL:   AL583918
- PIR:   S72738
- RefSeq:   NP_301432.1
- ProteinModelPortal:   Q49649
- SMR:   Q49649
- EnsemblBacteria:   EBMYCT00000028643
- GeneID:   909236
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0493
- NMPDR:   fig|272631.1.peg.304
- Leproma:   ML0493
- GeneTree:   EBGT00050000015466
- HOGENOM:   HBG753931
- OMA:   PGHGDKT
- ProtClustDB:   CLSK872078
- BioCyc:   MLEP272631:ML0493-MONOMER
- InterPro:   IPR001279
- SMART:   SM00849

Pfam domain/function: PF00753 Lactamase_B

EC number: NA

Molecular weight: Translated: 23915; Mature: 23915

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLITGFPAGMLQCNCYVLADRAGTDAVIVDPGQRAMGPLRRILDENRLTPSAVLLTHGHI
CEEECCCCCCEEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCH
DHMWSAQKVSDTYGCPTYIHPEDRFMLTDPLFGFGPRVAQVVTGAFFREPKQVVELDRDG
HHHCCCHHCCCCCCCCCEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCHHHHEECCCC
DKLDLGSVTVNVDHTPGHTRGSVCFWVAADTDVVLTGDTLFERTIGRTDLFGGSGRDLYR
CEEEECEEEEEEECCCCCCCCCEEEEEECCCCEEEECCHHHHHHCCCCCCCCCCCHHHHH
SIVEKLLVLDDKTVVLPGHGNSTTIGAERRFNPFLEGL
HHHHHHHHCCCCEEEEECCCCCCEECCCCCCCHHHCCC
>Mature Secondary Structure
MLITGFPAGMLQCNCYVLADRAGTDAVIVDPGQRAMGPLRRILDENRLTPSAVLLTHGHI
CEEECCCCCCEEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCH
DHMWSAQKVSDTYGCPTYIHPEDRFMLTDPLFGFGPRVAQVVTGAFFREPKQVVELDRDG
HHHCCCHHCCCCCCCCCEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCHHHHEECCCC
DKLDLGSVTVNVDHTPGHTRGSVCFWVAADTDVVLTGDTLFERTIGRTDLFGGSGRDLYR
CEEEECEEEEEEECCCCCCCCCEEEEEECCCCEEEECCHHHHHHCCCCCCCCCCCHHHHH
SIVEKLLVLDDKTVVLPGHGNSTTIGAERRFNPFLEGL
HHHHHHHHCCCCEEEEECCCCCCEECCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002