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The map label for this gene is coaX

Identifier: 221229507

GI number: 221229507

Start: 302850

End: 303674

Strand: Direct

Name: coaX

Synonym: MLBr_00232

Alternate gene names: 221229507

Gene position: 302850-303674 (Clockwise)

Preceding gene: 221229506

Following gene: 221229508

Centisome position: 9.27

GC content: 62.18

Gene sequence:

>825_bases
GTGCTGCTGGCCATCGACGTTCGCAACACGCATACCGTCGTCGGATTGCTGTCCGGATCCAAGGAGCATGCAAAGGTCGT
GCAGCAATGGCGGATCCGCACTGAATCCGAGGTTACCGCGGACGAACTGGCCTTGATTATCGACGGCTTGATCGGTGATG
ATTCCGAGCGACTCGCCGGAGCTGCCGCATTGTCGACCGTCCCGTCGGTGCTGCACGAGGTGCGGATCATGCTCGATCAG
TACTGGCCGTCGGTGCCGCACGTACTGATCGAACCGGGGGTGCGCACCGGTATCCCGCTGCTGGTAGATAATCCGAAAGA
AGTGGGTGCCGACCGGATCGTGAACTGCCTGGCGGCGTTCCACAAGTTCGGTCAAGCTGCCATCGTGGTCGATTTCGGGT
CGTCGATCTGCGTGGATGTGGTGTCGGCCAAAGGGGAGTTTCTGGGCGGTGCCATTGCGCCCGGAGTGCAGGTGTCTTCG
GATGCCGCGGCTGCCCGCTCTGCCGCGTTGCGCCGCGTTGAGCTGGCCAGACCCCGCTCGGTGGTTGGTAAAAACACGGT
CGAATGTATGCAGGCCGGTGTGGTGTTCGGTTTTGCTGGGCTGGTCGATGGCTTAGTCGGCCGCATGCGCCAGGACGTGG
AGGAATTTTCCGGCGACTTAGGTAATCGGGTTGCGGTCGTGGCTACCGGGCATACCGCGCCGCTGTTGCTGCCCGAGCTG
CATACCGTTGACCACTACGATCGGCACCTGACCCTTCATGGTCTGCGACTGGTCTTCGAACGCAATCGGGAAGCGCAGCG
TGGCCGGTTGAAGACGGCGCGCTGA

Upstream 100 bases:

>100_bases
ATAACAAACCGATCGATCTGGGCCACGATCCAGGCTCCGTGCCCTTGGACATATCTGTCGCGGCTGAACTATTTGATCCC
CGGATCGGTGCGCGGTAACT

Downstream 100 bases:

>100_bases
CGACGTCTGGCAGTGCGCACGTGAAGTTGTTCGACGCCACTGAACAGTGCCCGGCGTGAGGTCATTTAAGCTGGCACGTC
GTGAACGCTGACCCGTTGGA

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-III; Pantothenic acid kinase

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MLLAIDVRNTHTVVGLLSGSKEHAKVVQQWRIRTESEVTADELALIIDGLIGDDSERLAGAAALSTVPSVLHEVRIMLDQ
YWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAFHKFGQAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSS
DAAAARSAALRRVELARPRSVVGKNTVECMQAGVVFGFAGLVDGLVGRMRQDVEEFSGDLGNRVAVVATGHTAPLLLPEL
HTVDHYDRHLTLHGLRLVFERNREAQRGRLKTAR

Sequences:

>Translated_274_residues
MLLAIDVRNTHTVVGLLSGSKEHAKVVQQWRIRTESEVTADELALIIDGLIGDDSERLAGAAALSTVPSVLHEVRIMLDQ
YWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAFHKFGQAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSS
DAAAARSAALRRVELARPRSVVGKNTVECMQAGVVFGFAGLVDGLVGRMRQDVEEFSGDLGNRVAVVATGHTAPLLLPEL
HTVDHYDRHLTLHGLRLVFERNREAQRGRLKTAR
>Mature_274_residues
MLLAIDVRNTHTVVGLLSGSKEHAKVVQQWRIRTESEVTADELALIIDGLIGDDSERLAGAAALSTVPSVLHEVRIMLDQ
YWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAFHKFGQAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSS
DAAAARSAALRRVELARPRSVVGKNTVECMQAGVVFGFAGLVDGLVGRMRQDVEEFSGDLGNRVAVVATGHTAPLLLPEL
HTVDHYDRHLTLHGLRLVFERNREAQRGRLKTAR

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG1521

COG function: function code K; Putative transcriptional regulator, homolog of Bvg accessory factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type III pantothenate kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAX_MYCLB (B8ZU51)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002502923.1
- ProteinModelPortal:   B8ZU51
- SMR:   B8ZU51
- EnsemblBacteria:   EBMYCT00000087507
- GeneID:   7327350
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017438
- HOGENOM:   HBG634537
- OMA:   PAIVVDF
- ProtClustDB:   PRK13318
- GO:   GO:0005737
- HAMAP:   MF_01274
- InterPro:   IPR004619
- TIGRFAMs:   TIGR00671

Pfam domain/function: PF03309 Bvg_acc_factor

EC number: =2.7.1.33

Molecular weight: Translated: 29421; Mature: 29421

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: ACT_SITE 111-111 BINDING 134-134 BINDING 186-186

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLAIDVRNTHTVVGLLSGSKEHAKVVQQWRIRTESEVTADELALIIDGLIGDDSERLAG
CEEEEEECCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
AAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAF
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEECCHHHHCHHHHHHHHHHH
HKFGQAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRS
HHCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCHH
VVGKNTVECMQAGVVFGFAGLVDGLVGRMRQDVEEFSGDLGNRVAVVATGHTAPLLLPEL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCH
HTVDHYDRHLTLHGLRLVFERNREAQRGRLKTAR
HHCCHHHCCHHHHHHHHHHHHCCHHHHCCCCCCC
>Mature Secondary Structure
MLLAIDVRNTHTVVGLLSGSKEHAKVVQQWRIRTESEVTADELALIIDGLIGDDSERLAG
CEEEEEECCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
AAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAF
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEECCHHHHCHHHHHHHHHHH
HKFGQAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRS
HHCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCHH
VVGKNTVECMQAGVVFGFAGLVDGLVGRMRQDVEEFSGDLGNRVAVVATGHTAPLLLPEL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCH
HTVDHYDRHLTLHGLRLVFERNREAQRGRLKTAR
HHCCHHHCCHHHHHHHHHHHHCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA