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The map label for this gene is ntrC [H]

Identifier: 220919485

GI number: 220919485

Start: 4903211

End: 4904662

Strand: Direct

Name: ntrC [H]

Synonym: A2cp1_4406

Alternate gene names: 220919485

Gene position: 4903211-4904662 (Clockwise)

Preceding gene: 220919484

Following gene: 220919487

Centisome position: 97.49

GC content: 74.59

Gene sequence:

>1452_bases
TTGCGAAAGGTCCTCATCGTCGACGACGAGCCCTCGGTCCGCTTCGTGCTCGCGCGGACCTGCGAGCGCGCCGGCGTGCC
CTACGAGGAGGCGGGGAGCGCCGAGGAGGCGCGCACGAAGCTCCGCGCGTCCGGCGGCGGCAAGGACGGCGTCGGGCTGG
TGCTGCTCGACGTGCGCCTCCCCGGCGACGACGGGTTCAAGCTGCTCGGCGAGATCGGCGGGCGGGTGGACTCGCCGTTC
ATCGTGGTGATGACCGCCGAGGACACCATGCGCTCGGCGGTGGAGGCGATGAAGCGCGGCGCCGCCGACTACCTCGGCAA
GCCGTTCGACCTCGAGCGCGTGGAGCGGATCGTGCGCGACCTCTCGGCCGCGCCGCCGCCGGGCCACGCCGACGACCCCG
CCGCGCAGGCGGAGGAGCGGGGCGAGGCGGGCGCCGAGGCGCGGCGGCTGCGCGAGGGCGGCGTGGCGCTGCCGGAGACG
CTCATCGGCCGCTCCGCCGCCATGGTCGAGGTCTACAAGGAGATCGGGCGGGTGGCGCGCACGGAGATGACCGTGCTGCT
CATGGGCGAGTCCGGCACCGGCAAGGAGCTGGTGGCGCGCGCCATCCACGCGAACTCCACCCGCGCGCGCGGCCCGTTCG
TCACCGTGAACATGGCCGCCATCCCGCGCGATCTCATCGAGAGCGAGCTGTACGGCCACGAGAAGGGCTCCTTCACCGGC
GCGGTGGAGCGGCGGCCCGGCAAGTTCGAGCTGGCGAGCGGCGGCACCCTGTTCCTGGACGAGATCGGCGAGATGCCGAT
CGAGCTGCAGGCGAAGCTGCTGCGCGTGCTGCAGGAGCGCGAGATCGATCGCGTCGGCGGCACGCGCCCGCTCGCGGTCG
ACGTGCGCATCGTCGCCGCCACCAACGCGGACCTGGCGCGCTCGGTCGAGGAGGGGCGGTTCCGCCGCGACCTGTACTAC
CGGCTCGCGGTGGTGCCCATCCGCCTGCCGCCGCTCCGCGAGCGCGAGGGCGACGTGATCCTGCTCGCGCGCCACTTCGT
CGCGAAGTTCGGCGAGCAGCTGAAGGGGCGGCCGGTCCAGCTCGGCAAGGACGCCGAGGCGGTGCTGCTCGCGCACCCGT
GGCCCGGCAACGTCCGCGAGCTGCAGAACGTGCTGCAGCGCGCGCTGCTGAAGCTCACCGGGAACCGGGTGGGCGCGCGC
GACGTCGCCACCCTGGTGCCGGCCGCGGCCGCCAGCGAGCGCGCGCTCACCGGCCTCGTGGAGGGGCTGCTCGACGCCGA
GCCTCCGGAGGGCGGGCGCTACCAGGCGGCCATCGCGGCCATCGAGGTGCCGCTCATCGCGGCCGCCCTGGCGCGGACCC
ACGGCAACCAGCTGCGGGCGGCGGAGCTGCTCGGGATGAACCGGAACACGCTGCGCGAGCGCATGCGCGCGCTCGGGATG
AAGCCGCGCTAG

Upstream 100 bases:

>100_bases
GCCGCGGGCCCCGCGCTTGCCGGCGCGAGTTGGCCCCGCGCTTGCTATGAGGTACCGGGATCGGCGGATCATCACGGGAT
CCCACAGCCAGGAGCGAGCG

Downstream 100 bases:

>100_bases
CGGGCCCACGCCTGCCCGGAACCCGGGCAACCCGGTGCCAGGAAACCGGGCACCCCGCCGCTACATCGCCTCGACCAGGA
TCGACGCCTGGCGGGTGCCC

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MRKVLIVDDEPSVRFVLARTCERAGVPYEEAGSAEEARTKLRASGGGKDGVGLVLLDVRLPGDDGFKLLGEIGGRVDSPF
IVVMTAEDTMRSAVEAMKRGAADYLGKPFDLERVERIVRDLSAAPPPGHADDPAAQAEERGEAGAEARRLREGGVALPET
LIGRSAAMVEVYKEIGRVARTEMTVLLMGESGTGKELVARAIHANSTRARGPFVTVNMAAIPRDLIESELYGHEKGSFTG
AVERRPGKFELASGGTLFLDEIGEMPIELQAKLLRVLQEREIDRVGGTRPLAVDVRIVAATNADLARSVEEGRFRRDLYY
RLAVVPIRLPPLREREGDVILLARHFVAKFGEQLKGRPVQLGKDAEAVLLAHPWPGNVRELQNVLQRALLKLTGNRVGAR
DVATLVPAAAASERALTGLVEGLLDAEPPEGGRYQAAIAAIEVPLIAAALARTHGNQLRAAELLGMNRNTLRERMRALGM
KPR

Sequences:

>Translated_483_residues
MRKVLIVDDEPSVRFVLARTCERAGVPYEEAGSAEEARTKLRASGGGKDGVGLVLLDVRLPGDDGFKLLGEIGGRVDSPF
IVVMTAEDTMRSAVEAMKRGAADYLGKPFDLERVERIVRDLSAAPPPGHADDPAAQAEERGEAGAEARRLREGGVALPET
LIGRSAAMVEVYKEIGRVARTEMTVLLMGESGTGKELVARAIHANSTRARGPFVTVNMAAIPRDLIESELYGHEKGSFTG
AVERRPGKFELASGGTLFLDEIGEMPIELQAKLLRVLQEREIDRVGGTRPLAVDVRIVAATNADLARSVEEGRFRRDLYY
RLAVVPIRLPPLREREGDVILLARHFVAKFGEQLKGRPVQLGKDAEAVLLAHPWPGNVRELQNVLQRALLKLTGNRVGAR
DVATLVPAAAASERALTGLVEGLLDAEPPEGGRYQAAIAAIEVPLIAAALARTHGNQLRAAELLGMNRNTLRERMRALGM
KPR
>Mature_483_residues
MRKVLIVDDEPSVRFVLARTCERAGVPYEEAGSAEEARTKLRASGGGKDGVGLVLLDVRLPGDDGFKLLGEIGGRVDSPF
IVVMTAEDTMRSAVEAMKRGAADYLGKPFDLERVERIVRDLSAAPPPGHADDPAAQAEERGEAGAEARRLREGGVALPET
LIGRSAAMVEVYKEIGRVARTEMTVLLMGESGTGKELVARAIHANSTRARGPFVTVNMAAIPRDLIESELYGHEKGSFTG
AVERRPGKFELASGGTLFLDEIGEMPIELQAKLLRVLQEREIDRVGGTRPLAVDVRIVAATNADLARSVEEGRFRRDLYY
RLAVVPIRLPPLREREGDVILLARHFVAKFGEQLKGRPVQLGKDAEAVLLAHPWPGNVRELQNVLQRALLKLTGNRVGAR
DVATLVPAAAASERALTGLVEGLLDAEPPEGGRYQAAIAAIEVPLIAAALARTHGNQLRAAELLGMNRNTLRERMRALGM
KPR

Specific function: Member of the two-component regulatory system ntrB/ntrC involved in the activation of nitrogen assimilatory genes such as glnA. NtrC is phosphorylated by ntrB and interacts with sigma-54 [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=486, Percent_Identity=40.1234567901235, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI1790299, Length=500, Percent_Identity=40.8, Blast_Score=330, Evalue=9e-92,
Organism=Escherichia coli, GI1790437, Length=472, Percent_Identity=40.8898305084746, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI87082117, Length=329, Percent_Identity=46.5045592705167, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1788905, Length=467, Percent_Identity=35.3319057815846, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789087, Length=345, Percent_Identity=44.3478260869565, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI87082152, Length=325, Percent_Identity=45.8461538461538, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081872, Length=316, Percent_Identity=41.7721518987342, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI1789233, Length=326, Percent_Identity=41.1042944785276, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1786524, Length=336, Percent_Identity=41.0714285714286, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1787583, Length=325, Percent_Identity=37.2307692307692, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI87081858, Length=310, Percent_Identity=33.8709677419355, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI1789828, Length=244, Percent_Identity=35.655737704918, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR010114
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52265; Mature: 52265

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKVLIVDDEPSVRFVLARTCERAGVPYEEAGSAEEARTKLRASGGGKDGVGLVLLDVRL
CCEEEEECCCCCEEHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCCCCEEEEEEEEE
PGDDGFKLLGEIGGRVDSPFIVVMTAEDTMRSAVEAMKRGAADYLGKPFDLERVERIVRD
CCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHH
LSAAPPPGHADDPAAQAEERGEAGAEARRLREGGVALPETLIGRSAAMVEVYKEIGRVAR
HHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHH
TEMTVLLMGESGTGKELVARAIHANSTRARGPFVTVNMAAIPRDLIESELYGHEKGSFTG
CEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHCCCCCCCCCC
AVERRPGKFELASGGTLFLDEIGEMPIELQAKLLRVLQEREIDRVGGTRPLAVDVRIVAA
HHCCCCCCEEECCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEE
TNADLARSVEEGRFRRDLYYRLAVVPIRLPPLREREGDVILLARHFVAKFGEQLKGRPVQ
CCHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEE
LGKDAEAVLLAHPWPGNVRELQNVLQRALLKLTGNRVGARDVATLVPAAAASERALTGLV
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EGLLDAEPPEGGRYQAAIAAIEVPLIAAALARTHGNQLRAAELLGMNRNTLRERMRALGM
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCC
KPR
CCC
>Mature Secondary Structure
MRKVLIVDDEPSVRFVLARTCERAGVPYEEAGSAEEARTKLRASGGGKDGVGLVLLDVRL
CCEEEEECCCCCEEHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCCCCEEEEEEEEE
PGDDGFKLLGEIGGRVDSPFIVVMTAEDTMRSAVEAMKRGAADYLGKPFDLERVERIVRD
CCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHH
LSAAPPPGHADDPAAQAEERGEAGAEARRLREGGVALPETLIGRSAAMVEVYKEIGRVAR
HHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHH
TEMTVLLMGESGTGKELVARAIHANSTRARGPFVTVNMAAIPRDLIESELYGHEKGSFTG
CEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHCCCCCCCCCC
AVERRPGKFELASGGTLFLDEIGEMPIELQAKLLRVLQEREIDRVGGTRPLAVDVRIVAA
HHCCCCCCEEECCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEE
TNADLARSVEEGRFRRDLYYRLAVVPIRLPPLREREGDVILLARHFVAKFGEQLKGRPVQ
CCHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEE
LGKDAEAVLLAHPWPGNVRELQNVLQRALLKLTGNRVGARDVATLVPAAAASERALTGLV
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EGLLDAEPPEGGRYQAAIAAIEVPLIAAALARTHGNQLRAAELLGMNRNTLRERMRALGM
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCC
KPR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2881918; 11481430; 8478331 [H]