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The map label for this gene is fmt

Identifier: 220919193

GI number: 220919193

Start: 4599744

End: 4600682

Strand: Direct

Name: fmt

Synonym: A2cp1_4113

Alternate gene names: 220919193

Gene position: 4599744-4600682 (Clockwise)

Preceding gene: 220919192

Following gene: 220919194

Centisome position: 91.46

GC content: 78.7

Gene sequence:

>939_bases
ATGCGCATCGCCTTCCTCGGCACCCCCGCCTTCGCGGTCGCCGCGCTCGACGCGCTGGAGCGGGCCGGCCACGCGCTCGT
GACCGTGGTGGCGCAGCCCGACCGCCCGGCCGGCCGCGGCCAGGCGCTGCGCGAGCCGGCCACCAAGGCCTGGGCCCGCG
CGCGCGGCGTCCCGGTGCTCCAGCCGGAGAAGGTCCGCGACGGGACGCTCGCCGCCGCGCTCCGGGCGCTCGCGCCGGAC
GCGCTGGTGGTCGCCGCCTACGGCCGGATCCTGGGCAAGGACCTGCTCACGCTCGCCCCGCACGGCGCCCTCAACGTGCA
CGGCTCGCTGCTCCCGCGCTGGCGCGGCGCCGCGCCCATCCAGTGGGCGGTGGCCGAGGGCGAGCGCGAGACCGGCGTCA
CCATCATGCAGATGGACGAGGGGCTCGACACCGGCGACGTCCTGCTGCAGCGCGCGCTCGAGATCGGCGAGGACGACACC
TCGGAGACGCTGGCGCCGCGGCTGGCGGCGCTGGGGGGCGAGGCGCTGGTCGAGGCGCTCCGCCTGCTCGAGGCCGGCGC
GCTCGTGCCGGTTCGCCAGGACGCGGCGCAGGCCACGCTGGCGCGCATCCTGGAGAAGGAGGACGGGCGCATCGCCTGGA
CCCGCCCGGCCCGCCGCATCTCCGACCGGCTGCGCGGCTTCACGCCCTGGCCCGGCGCGTTCACCACGCTGGAGGGCCGG
ACGCTGAAGGTGCTGGAGGCGCGGCCGGGCGCGGACGTGGCGACGCCGGCGGGCGAGCCCGGCGAGGCCGAGGTGGTCCC
CGGGCGCGGGCTGGCGGTCGCGTGCGGCGGCGGGAGCGCGCTGCTCGTCACGCGCGTGCAGCTGGAGGGCAGGCCGGCGC
AGTCGGCGCTCGACCTCGCGAACGGCCTGCGCAGGAAGCGCTTCCGGCTGGGCACCTGA

Upstream 100 bases:

>100_bases
GCCGCAGCAGGGCTCCACGCGAATGGGCGGCGCTACCGTCCCCGGGCGCGTCCGGTTGGCGCTCGATCTCGCGCCCTCGC
CCGCGTATACAGGGGCGGCC

Downstream 100 bases:

>100_bases
TGGCCGGCCGCCCGACGAACCCGGCCGCGGGCGCGCGCGGCATCGCGTTCGACGTGCTCCGGCGCGTCGAGGAGGGCGGC
GCGTACGCGTCGCGCGCGCT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MRIAFLGTPAFAVAALDALERAGHALVTVVAQPDRPAGRGQALREPATKAWARARGVPVLQPEKVRDGTLAAALRALAPD
ALVVAAYGRILGKDLLTLAPHGALNVHGSLLPRWRGAAPIQWAVAEGERETGVTIMQMDEGLDTGDVLLQRALEIGEDDT
SETLAPRLAALGGEALVEALRLLEAGALVPVRQDAAQATLARILEKEDGRIAWTRPARRISDRLRGFTPWPGAFTTLEGR
TLKVLEARPGADVATPAGEPGEAEVVPGRGLAVACGGGSALLVTRVQLEGRPAQSALDLANGLRRKRFRLGT

Sequences:

>Translated_312_residues
MRIAFLGTPAFAVAALDALERAGHALVTVVAQPDRPAGRGQALREPATKAWARARGVPVLQPEKVRDGTLAAALRALAPD
ALVVAAYGRILGKDLLTLAPHGALNVHGSLLPRWRGAAPIQWAVAEGERETGVTIMQMDEGLDTGDVLLQRALEIGEDDT
SETLAPRLAALGGEALVEALRLLEAGALVPVRQDAAQATLARILEKEDGRIAWTRPARRISDRLRGFTPWPGAFTTLEGR
TLKVLEARPGADVATPAGEPGEAEVVPGRGLAVACGGGSALLVTRVQLEGRPAQSALDLANGLRRKRFRLGT
>Mature_312_residues
MRIAFLGTPAFAVAALDALERAGHALVTVVAQPDRPAGRGQALREPATKAWARARGVPVLQPEKVRDGTLAAALRALAPD
ALVVAAYGRILGKDLLTLAPHGALNVHGSLLPRWRGAAPIQWAVAEGERETGVTIMQMDEGLDTGDVLLQRALEIGEDDT
SETLAPRLAALGGEALVEALRLLEAGALVPVRQDAAQATLARILEKEDGRIAWTRPARRISDRLRGFTPWPGAFTTLEGR
TLKVLEARPGADVATPAGEPGEAEVVPGRGLAVACGGGSALLVTRVQLEGRPAQSALDLANGLRRKRFRLGT

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=301, Percent_Identity=32.2259136212625, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI238814322, Length=301, Percent_Identity=30.2325581395349, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI164663775, Length=190, Percent_Identity=34.7368421052632, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1789683, Length=312, Percent_Identity=45.1923076923077, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788589, Length=312, Percent_Identity=28.8461538461538, Blast_Score=138, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI133930964, Length=313, Percent_Identity=29.3929712460064, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319458, Length=351, Percent_Identity=26.7806267806268, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550868, Length=309, Percent_Identity=30.7443365695793, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28571984, Length=228, Percent_Identity=33.7719298245614, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24585660, Length=245, Percent_Identity=28.1632653061224, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24582400, Length=123, Percent_Identity=32.520325203252, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_ANAD2 (B8J9P3)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002494497.1
- GeneID:   7297538
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_4113
- HOGENOM:   HBG571560
- ProtClustDB:   CLSK946948
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 32826; Mature: 32826

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAFLGTPAFAVAALDALERAGHALVTVVAQPDRPAGRGQALREPATKAWARARGVPVL
CEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCC
QPEKVRDGTLAAALRALAPDALVVAAYGRILGKDLLTLAPHGALNVHGSLLPRWRGAAPI
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCE
QWAVAEGERETGVTIMQMDEGLDTGDVLLQRALEIGEDDTSETLAPRLAALGGEALVEAL
EEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHH
RLLEAGALVPVRQDAAQATLARILEKEDGRIAWTRPARRISDRLRGFTPWPGAFTTLEGR
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCCCEEEECCC
TLKVLEARPGADVATPAGEPGEAEVVPGRGLAVACGGGSALLVTRVQLEGRPAQSALDLA
EEEEEECCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCEEEEEEEEECCCCHHHHHHHH
NGLRRKRFRLGT
HHHHHHHHCCCC
>Mature Secondary Structure
MRIAFLGTPAFAVAALDALERAGHALVTVVAQPDRPAGRGQALREPATKAWARARGVPVL
CEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCC
QPEKVRDGTLAAALRALAPDALVVAAYGRILGKDLLTLAPHGALNVHGSLLPRWRGAAPI
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCE
QWAVAEGERETGVTIMQMDEGLDTGDVLLQRALEIGEDDTSETLAPRLAALGGEALVEAL
EEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHH
RLLEAGALVPVRQDAAQATLARILEKEDGRIAWTRPARRISDRLRGFTPWPGAFTTLEGR
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCCCEEEECCC
TLKVLEARPGADVATPAGEPGEAEVVPGRGLAVACGGGSALLVTRVQLEGRPAQSALDLA
EEEEEECCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCEEEEEEEEECCCCHHHHHHHH
NGLRRKRFRLGT
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA