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The map label for this gene is atoC [H]

Identifier: 220918955

GI number: 220918955

Start: 4306789

End: 4308243

Strand: Direct

Name: atoC [H]

Synonym: A2cp1_3870

Alternate gene names: 220918955

Gene position: 4306789-4308243 (Clockwise)

Preceding gene: 220918954

Following gene: 220918956

Centisome position: 85.63

GC content: 77.18

Gene sequence:

>1455_bases
ATGAGCGCGGGGACGGCGGAGGCGGCGGCGCCGCGGGCGGGCGCGCTGCGGGTGCTGGTGGTCGAGGACGACCCGCGCCT
GCTCGACATCCTCACCCGGCACCTCGACCGCATGGGCTACGCGGTGCGCGGCGCCGGCGGCGCGGCGGCCGCGCTCCAGC
TCCTCGAGGCCGCGCCCGCCGACGTGGTGCTCTCCGACGTGCGCATGCCGGGGATGGACGGGCGCACGCTCCTCGCCGAG
GTGCGGGCGCGCCACCCGGACGCGAAGGTGATCCTCATGACCGCGTTCGGCAGCGTGGACGACGCGGTCGAGGCGATGCA
GGCCGGCGCGTACAGCTACGTGGTGAAGCCGTTCAAGGTGGAGACGGTCGCGGCCGTCCTCCGCAACGCGGCGCGGGAGC
TGGAGCTGCACCGGGAGGTGGACGGGCTGCGCCGCGCGGTGGCGGAGCGCTTCTCCGCCGACCGGCTCATCGGCGGCTCC
GCCCGGATGCGCGAGGTGCGCCGGGCGCTGCGCGAGGCCGCCGAGGTGGGCGCGACCGTGCTCGTCACCGGCCGGAGCGG
CACCGGCAAGGAGATGGCCGCCCGCGCCATCCACTACGGCGGCCCGCGCGCCGCCGGCCCGTTCGTGGCGGTGAACTGCG
CCGCCATCCCCGAGCCGCTGTTCGAGAGCGCGATGTTCGGCCACCGCCGCGGCGCGTTCACCGGCGCGGTCGAGTCGCAG
GCCGGCTTCGTGGAGCAGTCGTCCGGCGGCACGCTGTTCCTCGACGAGGTCGCGGAGATCCCGCCCGCGCAGCAGGCCAA
GCTGCTGCGCGTGCTGCAGGAGGGCGAGGTCACGCCGGTGGGCGCCGCCCGGCCCGTGAAGGTGGACCTGCGGGTGGTGG
CGGCGGCGAACCGCGACCTCGAGCAGATGGTGGCGAAGGGCGCGTTCCGCGAGGACCTGTTCTACCGGCTCAACGTGCTG
CGCATCGAGCTCCCCACGCTCGCCGAGCGCGCCGAGGACGTGCCGGCGCTGGCGGAGCACCTCCTGCTCGACATCGCGCG
CGGCCACGGCGTGCCCGCGCTGGGCTTCACGCCCGAGGCGCTCGCCGCGCTGGAGCGCCACCGGTGGCCGGGCAACGTGC
GCGAGCTGCGCAACGCGGTCGAGCGCGCGCTGCTCGCCGCGCGCGGCCGGCGCATCGACGCCGCCGACCTTCCCGCCGCG
GTCGTGCGGGCCCCGACCGGCGCCGAGGCGGTGCCGCCGCCCGGCGAGGGCGGGCTCACGCTCGCCGAGGTGGAGCGCGC
GCACGTCGAGAAGGTCCTCGCCATGGTGGGCTGGAACCGCTCGCTCGCGGCGCGGCTGCTCGGCATCGACCGCCGCACGC
TGTTCACGAAGATCCAGCGCTACGGGCTCATCGGCCCGCTGCGCCCCGGCCCGGGCGGCGGCGGGGACGCGGACGACGAG
GACGCGCCGGGCTGA

Upstream 100 bases:

>100_bases
TGGCGCGCATCGTGGCCGACCACGGCGGCGACCTCCGGGTCGGCACCGGGCCGCTCGGCGGCGCGTCCTTCACCGTGCAG
CTCCCGGCCGAGGAGGGGCG

Downstream 100 bases:

>100_bases
GAGCACGTGAACCCATCCCCTCCCGTCGCCGCGGCGGCCGATCCGCGTCGCATCGCGTCGTTGCTCCTCCCTCACATGCC
TCGGGGCATGCTCGGTCGTC

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSAGTAEAAAPRAGALRVLVVEDDPRLLDILTRHLDRMGYAVRGAGGAAAALQLLEAAPADVVLSDVRMPGMDGRTLLAE
VRARHPDAKVILMTAFGSVDDAVEAMQAGAYSYVVKPFKVETVAAVLRNAARELELHREVDGLRRAVAERFSADRLIGGS
ARMREVRRALREAAEVGATVLVTGRSGTGKEMAARAIHYGGPRAAGPFVAVNCAAIPEPLFESAMFGHRRGAFTGAVESQ
AGFVEQSSGGTLFLDEVAEIPPAQQAKLLRVLQEGEVTPVGAARPVKVDLRVVAAANRDLEQMVAKGAFREDLFYRLNVL
RIELPTLAERAEDVPALAEHLLLDIARGHGVPALGFTPEALAALERHRWPGNVRELRNAVERALLAARGRRIDAADLPAA
VVRAPTGAEAVPPPGEGGLTLAEVERAHVEKVLAMVGWNRSLAARLLGIDRRTLFTKIQRYGLIGPLRPGPGGGGDADDE
DAPG

Sequences:

>Translated_484_residues
MSAGTAEAAAPRAGALRVLVVEDDPRLLDILTRHLDRMGYAVRGAGGAAAALQLLEAAPADVVLSDVRMPGMDGRTLLAE
VRARHPDAKVILMTAFGSVDDAVEAMQAGAYSYVVKPFKVETVAAVLRNAARELELHREVDGLRRAVAERFSADRLIGGS
ARMREVRRALREAAEVGATVLVTGRSGTGKEMAARAIHYGGPRAAGPFVAVNCAAIPEPLFESAMFGHRRGAFTGAVESQ
AGFVEQSSGGTLFLDEVAEIPPAQQAKLLRVLQEGEVTPVGAARPVKVDLRVVAAANRDLEQMVAKGAFREDLFYRLNVL
RIELPTLAERAEDVPALAEHLLLDIARGHGVPALGFTPEALAALERHRWPGNVRELRNAVERALLAARGRRIDAADLPAA
VVRAPTGAEAVPPPGEGGLTLAEVERAHVEKVLAMVGWNRSLAARLLGIDRRTLFTKIQRYGLIGPLRPGPGGGGDADDE
DAPG
>Mature_483_residues
SAGTAEAAAPRAGALRVLVVEDDPRLLDILTRHLDRMGYAVRGAGGAAAALQLLEAAPADVVLSDVRMPGMDGRTLLAEV
RARHPDAKVILMTAFGSVDDAVEAMQAGAYSYVVKPFKVETVAAVLRNAARELELHREVDGLRRAVAERFSADRLIGGSA
RMREVRRALREAAEVGATVLVTGRSGTGKEMAARAIHYGGPRAAGPFVAVNCAAIPEPLFESAMFGHRRGAFTGAVESQA
GFVEQSSGGTLFLDEVAEIPPAQQAKLLRVLQEGEVTPVGAARPVKVDLRVVAAANRDLEQMVAKGAFREDLFYRLNVLR
IELPTLAERAEDVPALAEHLLLDIARGHGVPALGFTPEALAALERHRWPGNVRELRNAVERALLAARGRRIDAADLPAAV
VRAPTGAEAVPPPGEGGLTLAEVERAHVEKVLAMVGWNRSLAARLLGIDRRTLFTKIQRYGLIGPLRPGPGGGGDADDED
APG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=41.3716814159292, Blast_Score=354, Evalue=6e-99,
Organism=Escherichia coli, GI1790437, Length=449, Percent_Identity=42.0935412026726, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=41.025641025641, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI1788905, Length=450, Percent_Identity=38.6666666666667, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=40.8668730650155, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87082117, Length=344, Percent_Identity=42.1511627906977, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1789087, Length=406, Percent_Identity=37.6847290640394, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=40.0630914826498, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1787583, Length=327, Percent_Identity=37.9204892966361, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1786524, Length=337, Percent_Identity=38.5756676557863, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=44.3965517241379, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789828, Length=327, Percent_Identity=32.7217125382263, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI87081858, Length=293, Percent_Identity=30.7167235494881, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789402, Length=117, Percent_Identity=35.042735042735, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082012, Length=145, Percent_Identity=31.0344827586207, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789809, Length=122, Percent_Identity=32.7868852459016, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788394, Length=124, Percent_Identity=31.4516129032258, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790552, Length=117, Percent_Identity=34.1880341880342, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51353; Mature: 51221

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGTAEAAAPRAGALRVLVVEDDPRLLDILTRHLDRMGYAVRGAGGAAAALQLLEAAPA
CCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHCCH
DVVLSDVRMPGMDGRTLLAEVRARHPDAKVILMTAFGSVDDAVEAMQAGAYSYVVKPFKV
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHEEECCHHH
ETVAAVLRNAARELELHREVDGLRRAVAERFSADRLIGGSARMREVRRALREAAEVGATV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
LVTGRSGTGKEMAARAIHYGGPRAAGPFVAVNCAAIPEPLFESAMFGHRRGAFTGAVESQ
EEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHHHCCCCCCCCCHHHC
AGFVEQSSGGTLFLDEVAEIPPAQQAKLLRVLQEGEVTPVGAARPVKVDLRVVAAANRDL
CCCEEECCCCEEEEHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCH
EQMVAKGAFREDLFYRLNVLRIELPTLAERAEDVPALAEHLLLDIARGHGVPALGFTPEA
HHHHHCCCHHHHHHHHHEEEEEECHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHH
LAALERHRWPGNVRELRNAVERALLAARGRRIDAADLPAAVVRAPTGAEAVPPPGEGGLT
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHCCCCCCCCCCCCCCCCCC
LAEVERAHVEKVLAMVGWNRSLAARLLGIDRRTLFTKIQRYGLIGPLRPGPGGGGDADDE
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DAPG
CCCC
>Mature Secondary Structure 
SAGTAEAAAPRAGALRVLVVEDDPRLLDILTRHLDRMGYAVRGAGGAAAALQLLEAAPA
CCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHCCH
DVVLSDVRMPGMDGRTLLAEVRARHPDAKVILMTAFGSVDDAVEAMQAGAYSYVVKPFKV
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHEEECCHHH
ETVAAVLRNAARELELHREVDGLRRAVAERFSADRLIGGSARMREVRRALREAAEVGATV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
LVTGRSGTGKEMAARAIHYGGPRAAGPFVAVNCAAIPEPLFESAMFGHRRGAFTGAVESQ
EEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHHHCCCCCCCCCHHHC
AGFVEQSSGGTLFLDEVAEIPPAQQAKLLRVLQEGEVTPVGAARPVKVDLRVVAAANRDL
CCCEEECCCCEEEEHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCH
EQMVAKGAFREDLFYRLNVLRIELPTLAERAEDVPALAEHLLLDIARGHGVPALGFTPEA
HHHHHCCCHHHHHHHHHEEEEEECHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHH
LAALERHRWPGNVRELRNAVERALLAARGRRIDAADLPAAVVRAPTGAEAVPPPGEGGLT
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHCCCCCCCCCCCCCCCCCC
LAEVERAHVEKVLAMVGWNRSLAARLLGIDRRTLFTKIQRYGLIGPLRPGPGGGGDADDE
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DAPG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]