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The map label for this gene is pyrC

Identifier: 220917429

GI number: 220917429

Start: 2580412

End: 2581713

Strand: Reverse

Name: pyrC

Synonym: A2cp1_2329

Alternate gene names: 220917429

Gene position: 2581713-2580412 (Counterclockwise)

Preceding gene: 220917430

Following gene: 220917428

Centisome position: 51.33

GC content: 75.04

Gene sequence:

>1302_bases
ATGTCTGACGTGCTCTTCATCGAGGGCGGCCGGGTCATCGACCCGGCGAGCGGCGTGGACGGCGTCCGCACCGTGGTGAT
CCGCGACGGCAAGGTGGCGGAGGTGGCCGAGCGGGTGGAGCGCCCGCGCGACGCCCGCGCGGTCGACGCGCGGAACCGGT
GGGTGACGCCGGGGTTCGTGGACCTGCACGTGCACCTGCGCGAGCCGGGGCAGGAGTACAAGGAGACGGTCGCGACCGGC
GCGCGGGCGGCGGTGGCGGGCGGCTTCACGGCCGTGTGCGCCATGCCGAACACGAAGCCGGTGAACGACTGCGCCGCGGT
GACCGAGCTCGTGCTGGCGCGCGCGGCGGCGGCCGGCCTGGCCCGCGTCTACCCGGTGGGCGCCATCTCCCGCGGCTCGA
ACGGCGAGGAGCTGGCCGAGTACGGCGAGCTGAAGGCCTCGGGCTGCGTGGCGCTCTCCGACGACGGGCGGCCGGTGATG
TCGTCGGCGCTGATGCGCCGCGCGCTGGAGTACGCGCGCGCGTTCGGCCTGCCGCTCACGGTGCACGAGGAGGACCTGCA
CCTGGTGGGCAAGGGCGTGATGCACGAGGGCGCCGCCGCAACGCGGCTCGGCCTGAAGGGCATCCCGTCGCAGGCCGAGG
ACGTGATGGTGCTGCGCGACATCGCGCTGGTGGAGCTCACCGGCGGGCGGCTGCACGTGGCGCACGTCAGCACCGCCGGC
GCGGTCCGCGCCATCCGCGAGGCGAAGCGCCGCGGCCTGCCGGTCACCGGCGAGGTCACCCCGCACCACCTCGCGCTCAC
CGACGACGACGTGGGCGCCTCGGGCTACTCGACCGACTTCAAGATGAACCCCCCGCTGCGCTCGGCGGAGGACGTCCGCG
CCTGCCGCGAGGCGCTCGCGGACGGCACGCTCGACGCGATCGCCACCGACCACGCGCCGCACTCCGCGGTCGAGAAGGAC
GTGGAGTTCGACGCCGCCGCGAACGGCATCGTCGGGCTGGAGACCGCGTTCTCGGTCTGCCTGGGCCTGGTACGGGAGGG
CGCGCTGACCGAGCGTCGGCTCGTCGAGGCGCTCACCGTGGGGCCGGCCAGGGTGTTCGGGCTGCCCGCCGGCACGCTGG
CGCGCGGCGCGGCCGCGGACGTGGCGGTGCTCGACGCCGCCGCGGAGTGGACGGTGGACCCGGCCCGGCTCCACTCCAAG
GGCCGCAACACGCCGTGGAAGGGAAGGCGGCTCGCCGGGCGTTGCACGCACACGATCGTGGGTGGCCGGATCGTCCACGA
GGAGGACAAGGCAGACCGATGA

Upstream 100 bases:

>100_bases
CGGGGTGGCGGTCCGGATGGCGATCCTGTACCTGCTCGCGGGCGGCGCGGGCGAGGAGGCCAGGGCGTGACGGCGCGGCT
CGGGACGGGAGGCAGGCGCG

Downstream 100 bases:

>100_bases
AGCAGGCGATCCTGGCGCTGGCGGACGGCACCACCTTCGAGGGGTTCTCGCTCGGCGCGACCGGCGAGGCCACGGGGGAG
GTCGTCTTCAACACCTCCAT

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MSDVLFIEGGRVIDPASGVDGVRTVVIRDGKVAEVAERVERPRDARAVDARNRWVTPGFVDLHVHLREPGQEYKETVATG
ARAAVAGGFTAVCAMPNTKPVNDCAAVTELVLARAAAAGLARVYPVGAISRGSNGEELAEYGELKASGCVALSDDGRPVM
SSALMRRALEYARAFGLPLTVHEEDLHLVGKGVMHEGAAATRLGLKGIPSQAEDVMVLRDIALVELTGGRLHVAHVSTAG
AVRAIREAKRRGLPVTGEVTPHHLALTDDDVGASGYSTDFKMNPPLRSAEDVRACREALADGTLDAIATDHAPHSAVEKD
VEFDAAANGIVGLETAFSVCLGLVREGALTERRLVEALTVGPARVFGLPAGTLARGAAADVAVLDAAAEWTVDPARLHSK
GRNTPWKGRRLAGRCTHTIVGGRIVHEEDKADR

Sequences:

>Translated_433_residues
MSDVLFIEGGRVIDPASGVDGVRTVVIRDGKVAEVAERVERPRDARAVDARNRWVTPGFVDLHVHLREPGQEYKETVATG
ARAAVAGGFTAVCAMPNTKPVNDCAAVTELVLARAAAAGLARVYPVGAISRGSNGEELAEYGELKASGCVALSDDGRPVM
SSALMRRALEYARAFGLPLTVHEEDLHLVGKGVMHEGAAATRLGLKGIPSQAEDVMVLRDIALVELTGGRLHVAHVSTAG
AVRAIREAKRRGLPVTGEVTPHHLALTDDDVGASGYSTDFKMNPPLRSAEDVRACREALADGTLDAIATDHAPHSAVEKD
VEFDAAANGIVGLETAFSVCLGLVREGALTERRLVEALTVGPARVFGLPAGTLARGAAADVAVLDAAAEWTVDPARLHSK
GRNTPWKGRRLAGRCTHTIVGGRIVHEEDKADR
>Mature_432_residues
SDVLFIEGGRVIDPASGVDGVRTVVIRDGKVAEVAERVERPRDARAVDARNRWVTPGFVDLHVHLREPGQEYKETVATGA
RAAVAGGFTAVCAMPNTKPVNDCAAVTELVLARAAAAGLARVYPVGAISRGSNGEELAEYGELKASGCVALSDDGRPVMS
SALMRRALEYARAFGLPLTVHEEDLHLVGKGVMHEGAAATRLGLKGIPSQAEDVMVLRDIALVELTGGRLHVAHVSTAGA
VRAIREAKRRGLPVTGEVTPHHLALTDDDVGASGYSTDFKMNPPLRSAEDVRACREALADGTLDAIATDHAPHSAVEKDV
EFDAAANGIVGLETAFSVCLGLVREGALTERRLVEALTVGPARVFGLPAGTLARGAAADVAVLDAAAEWTVDPARLHSKG
RNTPWKGRRLAGRCTHTIVGGRIVHEEDKADR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=376, Percent_Identity=33.7765957446808, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI190194363, Length=459, Percent_Identity=25.9259259259259, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI19923821, Length=459, Percent_Identity=24.8366013071895, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786722, Length=445, Percent_Identity=28.314606741573, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI87082175, Length=441, Percent_Identity=26.3038548752834, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193204318, Length=372, Percent_Identity=32.5268817204301, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI86575075, Length=420, Percent_Identity=22.6190476190476, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322218, Length=205, Percent_Identity=27.3170731707317, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24642586, Length=372, Percent_Identity=32.258064516129, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI18859883, Length=452, Percent_Identity=26.7699115044248, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_ANAD2 (B8JAE8)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002492733.1
- ProteinModelPortal:   B8JAE8
- GeneID:   7297583
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2329
- HOGENOM:   HBG724623
- ProtClustDB:   CLSK945757
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 45605; Mature: 45474

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVLFIEGGRVIDPASGVDGVRTVVIRDGKVAEVAERVERPRDARAVDARNRWVTPGFV
CCCEEEECCCEEECCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCEECCCCCCCCCCEE
DLHVHLREPGQEYKETVATGARAAVAGGFTAVCAMPNTKPVNDCAAVTELVLARAAAAGL
EEEEEECCCCHHHHHHHHCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
ARVYPVGAISRGSNGEELAEYGELKASGCVALSDDGRPVMSSALMRRALEYARAFGLPLT
HHHCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEE
VHEEDLHLVGKGVMHEGAAATRLGLKGIPSQAEDVMVLRDIALVELTGGRLHVAHVSTAG
EECCCHHHHHCCHHCCCCHHHHHCCCCCCCCHHHHHHHHHEEEEEECCCEEEEEEECHHH
AVRAIREAKRRGLPVTGEVTPHHLALTDDDVGASGYSTDFKMNPPLRSAEDVRACREALA
HHHHHHHHHHCCCCEECCCCCCEEEECCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHC
DGTLDAIATDHAPHSAVEKDVEFDAAANGIVGLETAFSVCLGLVREGALTERRLVEALTV
CCCHHHHHCCCCCHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
GPARVFGLPAGTLARGAAADVAVLDAAAEWTVDPARLHSKGRNTPWKGRRLAGRCTHTIV
CCHHEEECCCHHHHCCCCCCHHHEECCHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHEEE
GGRIVHEEDKADR
CCEEEECCCCCCC
>Mature Secondary Structure 
SDVLFIEGGRVIDPASGVDGVRTVVIRDGKVAEVAERVERPRDARAVDARNRWVTPGFV
CCEEEECCCEEECCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCEECCCCCCCCCCEE
DLHVHLREPGQEYKETVATGARAAVAGGFTAVCAMPNTKPVNDCAAVTELVLARAAAAGL
EEEEEECCCCHHHHHHHHCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
ARVYPVGAISRGSNGEELAEYGELKASGCVALSDDGRPVMSSALMRRALEYARAFGLPLT
HHHCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEE
VHEEDLHLVGKGVMHEGAAATRLGLKGIPSQAEDVMVLRDIALVELTGGRLHVAHVSTAG
EECCCHHHHHCCHHCCCCHHHHHCCCCCCCCHHHHHHHHHEEEEEECCCEEEEEEECHHH
AVRAIREAKRRGLPVTGEVTPHHLALTDDDVGASGYSTDFKMNPPLRSAEDVRACREALA
HHHHHHHHHHCCCCEECCCCCCEEEECCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHC
DGTLDAIATDHAPHSAVEKDVEFDAAANGIVGLETAFSVCLGLVREGALTERRLVEALTV
CCCHHHHHCCCCCHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
GPARVFGLPAGTLARGAAADVAVLDAAAEWTVDPARLHSKGRNTPWKGRRLAGRCTHTIV
CCHHEEECCCHHHHCCCCCCHHHEECCHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHEEE
GGRIVHEEDKADR
CCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA