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The map label for this gene is carA [H]

Identifier: 220917428

GI number: 220917428

Start: 2579294

End: 2580415

Strand: Reverse

Name: carA [H]

Synonym: A2cp1_2328

Alternate gene names: 220917428

Gene position: 2580415-2579294 (Counterclockwise)

Preceding gene: 220917429

Following gene: 220917427

Centisome position: 51.31

GC content: 72.55

Gene sequence:

>1122_bases
ATGAAGCAGGCGATCCTGGCGCTGGCGGACGGCACCACCTTCGAGGGGTTCTCGCTCGGCGCGACCGGCGAGGCCACGGG
GGAGGTCGTCTTCAACACCTCCATGACCGGGTACCAGGAGATCCTGACCGACCCGTCGTACGTCGATCAGATGATCTGCA
TGACGTATCCGGAGCAGGGGAACTACGGCGTGAACCGCGCCGACGAGGAGTCGGCGCGCCCGCACGCCACCGGCTTCATC
GTGCGCCACGCCACGGAGCAGCCGTCGAACTTCCGCGCGGAGCGGAGCCTCCACGCGTACCTCGCGGCGCACGGCATCGT
CGGGATCTCCGGCATCGACACCCGGCGGCTCACCCGCCACATCCGCACCGCCGGCGCGCAGATGGGCGTCATCGCCACCG
AGGGGAGCGCGAAGGCGCTGGTGGAGCGGGCGCGCGCGCTGCCCGGGATGGAGGGGCAGGACCTCGCCACCCGCATCTCG
ACGGCGGCCCCGTACGAGTGGACCGAGCAGGGCGCCGACTGCTGGACCGACGCGGAGCGCGCGCCGCTCGGGAGGCCGCG
CTTCCACGTGGTGGCGTACGACTGGGGCCTGAAGCGCGCCATGCTCCGCCTGCTGGCCGAGGCCGGCTGCCGCGTGACCG
TGGTGCCGTCGCGGACCAGCGCCGCAGAGGCGCTGGCGCTCCGGCCGGACGGCGTGTTCCTCACCAACGGCCCGGGCGAT
CCGGCGGCGGTGGCCGGCGCGCGCGAGACCGTGGCGGCGCTGCTCGGCAAGGTGCCGGTGTTCGGCATCTGCCTCGGCCA
CCAGATCCTCGCGCTCGCCATCGGCGCGCGCACCTACAAGCTGAAGTTCGGCCACCGCGGCGCGAACCAGCCGGTGAAGG
AGCTGGACACCGGCAAGGTGGACATCACCGCCCAGAACCACGGCTTCGCCGTGGACGACGCCAGCCTGGGCAAGCGCGCC
CGCGTCACCCACGTGAACCTGAACGACGGGACGGTGGAGGGCATCGAGGTGCTCGACGCGCCCGCGTTCAGCGTCCAGTA
CCACCCGGAGTCGTCGCCCGGGCCGCACGACGCGCGCCCGCTGTTCGCGCGCTTCGTGGCGATGATGGAGCGGTCTCGAT
GA

Upstream 100 bases:

>100_bases
AGGGCCGCAACACGCCGTGGAAGGGAAGGCGGCTCGCCGGGCGTTGCACGCACACGATCGTGGGTGGCCGGATCGTCCAC
GAGGAGGACAAGGCAGACCG

Downstream 100 bases:

>100_bases
CGCTGCAGCTGCTGCACGAGCGCCTGCTCGCCTGGGCCACCGACGGCGCGCGCAAGGAGGAGCTCCTCGCCGCGCGCCGG
TTCCACTTCGACCGCTACGG

Product: carbamoyl phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MKQAILALADGTTFEGFSLGATGEATGEVVFNTSMTGYQEILTDPSYVDQMICMTYPEQGNYGVNRADEESARPHATGFI
VRHATEQPSNFRAERSLHAYLAAHGIVGISGIDTRRLTRHIRTAGAQMGVIATEGSAKALVERARALPGMEGQDLATRIS
TAAPYEWTEQGADCWTDAERAPLGRPRFHVVAYDWGLKRAMLRLLAEAGCRVTVVPSRTSAAEALALRPDGVFLTNGPGD
PAAVAGARETVAALLGKVPVFGICLGHQILALAIGARTYKLKFGHRGANQPVKELDTGKVDITAQNHGFAVDDASLGKRA
RVTHVNLNDGTVEGIEVLDAPAFSVQYHPESSPGPHDARPLFARFVAMMERSR

Sequences:

>Translated_373_residues
MKQAILALADGTTFEGFSLGATGEATGEVVFNTSMTGYQEILTDPSYVDQMICMTYPEQGNYGVNRADEESARPHATGFI
VRHATEQPSNFRAERSLHAYLAAHGIVGISGIDTRRLTRHIRTAGAQMGVIATEGSAKALVERARALPGMEGQDLATRIS
TAAPYEWTEQGADCWTDAERAPLGRPRFHVVAYDWGLKRAMLRLLAEAGCRVTVVPSRTSAAEALALRPDGVFLTNGPGD
PAAVAGARETVAALLGKVPVFGICLGHQILALAIGARTYKLKFGHRGANQPVKELDTGKVDITAQNHGFAVDDASLGKRA
RVTHVNLNDGTVEGIEVLDAPAFSVQYHPESSPGPHDARPLFARFVAMMERSR
>Mature_373_residues
MKQAILALADGTTFEGFSLGATGEATGEVVFNTSMTGYQEILTDPSYVDQMICMTYPEQGNYGVNRADEESARPHATGFI
VRHATEQPSNFRAERSLHAYLAAHGIVGISGIDTRRLTRHIRTAGAQMGVIATEGSAKALVERARALPGMEGQDLATRIS
TAAPYEWTEQGADCWTDAERAPLGRPRFHVVAYDWGLKRAMLRLLAEAGCRVTVVPSRTSAAEALALRPDGVFLTNGPGD
PAAVAGARETVAALLGKVPVFGICLGHQILALAIGARTYKLKFGHRGANQPVKELDTGKVDITAQNHGFAVDDASLGKRA
RVTHVNLNDGTVEGIEVLDAPAFSVQYHPESSPGPHDARPLFARFVAMMERSR

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=383, Percent_Identity=39.4255874673629, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI21361331, Length=381, Percent_Identity=34.9081364829396, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI169790915, Length=381, Percent_Identity=34.9081364829396, Blast_Score=205, Evalue=4e-53,
Organism=Escherichia coli, GI1786215, Length=380, Percent_Identity=55, Blast_Score=410, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI193204318, Length=389, Percent_Identity=38.560411311054, Blast_Score=234, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6322331, Length=387, Percent_Identity=37.984496124031, Blast_Score=256, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6324878, Length=386, Percent_Identity=36.7875647668394, Blast_Score=235, Evalue=1e-62,
Organism=Drosophila melanogaster, GI45555749, Length=389, Percent_Identity=38.3033419023136, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24642586, Length=389, Percent_Identity=38.3033419023136, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase [H]

EC number: =6.3.5.5 [H]

Molecular weight: Translated: 39989; Mature: 39989

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQAILALADGTTFEGFSLGATGEATGEVVFNTSMTGYQEILTDPSYVDQMICMTYPEQG
CCCEEEEEECCCEECCEECCCCCCCCCEEEEECCCCHHHHHHCCHHHHHHHHEEECCCCC
NYGVNRADEESARPHATGFIVRHATEQPSNFRAERSLHAYLAAHGIVGISGIDTRRLTRH
CCCCCCCCHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHH
IRTAGAQMGVIATEGSAKALVERARALPGMEGQDLATRISTAAPYEWTEQGADCWTDAER
HHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCCCCCCCCCC
APLGRPRFHVVAYDWGLKRAMLRLLAEAGCRVTVVPSRTSAAEALALRPDGVFLTNGPGD
CCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCCEEEECCCCC
PAAVAGARETVAALLGKVPVFGICLGHQILALAIGARTYKLKFGHRGANQPVKELDTGKV
HHHHCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHCCCCEE
DITAQNHGFAVDDASLGKRARVTHVNLNDGTVEGIEVLDAPAFSVQYHPESSPGPHDARP
EEEECCCCEEECCCCCCCCEEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCCCCCCHH
LFARFVAMMERSR
HHHHHHHHHHCCC
>Mature Secondary Structure
MKQAILALADGTTFEGFSLGATGEATGEVVFNTSMTGYQEILTDPSYVDQMICMTYPEQG
CCCEEEEEECCCEECCEECCCCCCCCCEEEEECCCCHHHHHHCCHHHHHHHHEEECCCCC
NYGVNRADEESARPHATGFIVRHATEQPSNFRAERSLHAYLAAHGIVGISGIDTRRLTRH
CCCCCCCCHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHH
IRTAGAQMGVIATEGSAKALVERARALPGMEGQDLATRISTAAPYEWTEQGADCWTDAER
HHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCCCCCCCCCC
APLGRPRFHVVAYDWGLKRAMLRLLAEAGCRVTVVPSRTSAAEALALRPDGVFLTNGPGD
CCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCCEEEECCCCC
PAAVAGARETVAALLGKVPVFGICLGHQILALAIGARTYKLKFGHRGANQPVKELDTGKV
HHHHCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHCCCCEE
DITAQNHGFAVDDASLGKRARVTHVNLNDGTVEGIEVLDAPAFSVQYHPESSPGPHDARP
EEEECCCCEEECCCCCCCCEEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCCCCCCHH
LFARFVAMMERSR
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA