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The map label for this gene is yngE [H]

Identifier: 220917400

GI number: 220917400

Start: 2549805

End: 2551346

Strand: Reverse

Name: yngE [H]

Synonym: A2cp1_2300

Alternate gene names: 220917400

Gene position: 2551346-2549805 (Counterclockwise)

Preceding gene: 220917401

Following gene: 220917399

Centisome position: 50.73

GC content: 72.83

Gene sequence:

>1542_bases
GTGGCCCGAGACGAGTCGCCGGACGCGCGCATCGCGCGGGAGCTGCGGCGGGTGGAGCAGGGCGGCGCGGCGAAGTACCA
CGCCAAGAACGCCGAGCAGGGCAAGCGCTTCGCGCGGGAGCGGATCGCGCTCCTGCTCGACCCGGGGAGCTTCGTCGAGG
ACGGCGCGCTCGCGAACGCGCTCGACCCGGAGCTGCCCGCCGACGGCGTCGTCACCGGCATGGGCCGGATGGACGGCCGC
CCGGTGTGCGTCATGGCGAACGACTCCACCGTGAAGGCGGGGAGCTGGGGCGCGCGCACGGTCGAGAAGATCCTGCGCAT
CCAGGAGGTCGCGGCGGCGCAGCGCCTGCCGCTGCTCTACCTGGTGGACTCGGCCGGCGCGCGCATCACCGACCAGGTGG
AGATGTTCCCGGGGCGCCGCGGCGCCGGGCGCATCTTCCACAACGAGGTGCACCTCTCCGGCGTGGTCCCCCAGATCTGC
CTGCTGTTCGGTCCGTCGGCGGCGGGCGGCGCGTACATCCCGGCGTTCTGCGACGTGGTCGTGATGGTGGAGGGGAACGC
CTCCATGTACCTGGGCTCCCCGCGGATGGCCGAGATGGTCATCGGCGAGAAGGTGACGCTGGAGGAGCTGGGCGGCGCGC
GCATGCACTGCTCGGTGTCCGGCTGCGGCGACTTCCTGGTGAAGACCGAGGAGGAGGCCATCGCGCTGGCGCGCCGCTGG
CTCTCGTACCTGCCCTCCAGCCACCGTGGCCTGCCGCCCGAGGCGCCGGCCCGGCCGCCGCGCCCCGGCGCCCGCGCGCC
CGCCGACGTGGTGCCGCGCGACCAGAACAAGCCGTTCGACATGCTCGAGCTCGTCGACGCGATCGTGGACGAGGGCTCGT
TCCTGGAGGTGAAGCGCCTCTGGGCCGGCGAGCTCGTCACCGGGCTCGCCCGCATCGACGGCCAGGTGGTGGGGATCGTC
GCGAACCAGCCCAAGGTGAAGGGCGGGGTGCTGTTCGTGGACTCCGCCGACAAGGCCACCCGCTTCATCTGGCTGTGCGA
CGCGTTCAACGTGCCGCTGCTCTACCTCGCCGACGTGCCCGGGTTCATGATCGGCACGAAGGTCGAGCGGGCCGGGATCA
TCCGGGCGGGGGCCAAGATGATCAGCGCGGTCTCGGAGGCCACCGTCCCGCGCATCTGCGTGGTGGTGCGCAAGGCGTAC
GGCGCCGGCCTCTACGCGATGGACGGCCCGGCGTTCGGCCCGTCCGCCACGCTGGCGCTGCCGGAGGCCATGATCGCGGT
GATGGGGCCGGAGGCGGCGGTGAACGCGGTCTTCTTCAACAAGATCCAGGAGCGACCCGAGGCCGAGCGGGCCGCCTACG
TACAGGCCCTGCGCGAGGAGTACCGGGCCGACATCGACCTGCTCAAGCTGGCGAGCGAGCTGGTGGTGGACGCGGTGGTG
CCCGGCGAGCGGCTGCGCGAGGAGCTCTCCCGCCGGTTCCGGATCTACGCGGCCGGCCACGAGCCGACCCGCGAGCGCAA
GCGCGGCGTCCTCCCGGTCTAG

Upstream 100 bases:

>100_bases
CCGGTGTTCACGGGCGAGTGAGCCGGGGCGCGCAGCGCGCCGCGAGGACACGACGGGGGAAGGCACCATGGACGCGGACG
GAACGCCCGGAGGTGGCGCA

Downstream 100 bases:

>100_bases
GAGCCCACATGGACTTCGAACTCCCCGCGGAGCTGGTCGAGATCCAGCGGACCGTGCGCGCGTTCTGCGAGGCGGAGGTG
CGGCCGCACGCCGCCGCGTG

Product: Sigma 54 interacting domain-containing protein

Products: ADP; H+; Malonyl-CoA; Phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MARDESPDARIARELRRVEQGGAAKYHAKNAEQGKRFARERIALLLDPGSFVEDGALANALDPELPADGVVTGMGRMDGR
PVCVMANDSTVKAGSWGARTVEKILRIQEVAAAQRLPLLYLVDSAGARITDQVEMFPGRRGAGRIFHNEVHLSGVVPQIC
LLFGPSAAGGAYIPAFCDVVVMVEGNASMYLGSPRMAEMVIGEKVTLEELGGARMHCSVSGCGDFLVKTEEEAIALARRW
LSYLPSSHRGLPPEAPARPPRPGARAPADVVPRDQNKPFDMLELVDAIVDEGSFLEVKRLWAGELVTGLARIDGQVVGIV
ANQPKVKGGVLFVDSADKATRFIWLCDAFNVPLLYLADVPGFMIGTKVERAGIIRAGAKMISAVSEATVPRICVVVRKAY
GAGLYAMDGPAFGPSATLALPEAMIAVMGPEAAVNAVFFNKIQERPEAERAAYVQALREEYRADIDLLKLASELVVDAVV
PGERLREELSRRFRIYAAGHEPTRERKRGVLPV

Sequences:

>Translated_513_residues
MARDESPDARIARELRRVEQGGAAKYHAKNAEQGKRFARERIALLLDPGSFVEDGALANALDPELPADGVVTGMGRMDGR
PVCVMANDSTVKAGSWGARTVEKILRIQEVAAAQRLPLLYLVDSAGARITDQVEMFPGRRGAGRIFHNEVHLSGVVPQIC
LLFGPSAAGGAYIPAFCDVVVMVEGNASMYLGSPRMAEMVIGEKVTLEELGGARMHCSVSGCGDFLVKTEEEAIALARRW
LSYLPSSHRGLPPEAPARPPRPGARAPADVVPRDQNKPFDMLELVDAIVDEGSFLEVKRLWAGELVTGLARIDGQVVGIV
ANQPKVKGGVLFVDSADKATRFIWLCDAFNVPLLYLADVPGFMIGTKVERAGIIRAGAKMISAVSEATVPRICVVVRKAY
GAGLYAMDGPAFGPSATLALPEAMIAVMGPEAAVNAVFFNKIQERPEAERAAYVQALREEYRADIDLLKLASELVVDAVV
PGERLREELSRRFRIYAAGHEPTRERKRGVLPV
>Mature_512_residues
ARDESPDARIARELRRVEQGGAAKYHAKNAEQGKRFARERIALLLDPGSFVEDGALANALDPELPADGVVTGMGRMDGRP
VCVMANDSTVKAGSWGARTVEKILRIQEVAAAQRLPLLYLVDSAGARITDQVEMFPGRRGAGRIFHNEVHLSGVVPQICL
LFGPSAAGGAYIPAFCDVVVMVEGNASMYLGSPRMAEMVIGEKVTLEELGGARMHCSVSGCGDFLVKTEEEAIALARRWL
SYLPSSHRGLPPEAPARPPRPGARAPADVVPRDQNKPFDMLELVDAIVDEGSFLEVKRLWAGELVTGLARIDGQVVGIVA
NQPKVKGGVLFVDSADKATRFIWLCDAFNVPLLYLADVPGFMIGTKVERAGIIRAGAKMISAVSEATVPRICVVVRKAYG
AGLYAMDGPAFGPSATLALPEAMIAVMGPEAAVNAVFFNKIQERPEAERAAYVQALREEYRADIDLLKLASELVVDAVVP
GERLREELSRRFRIYAAGHEPTRERKRGVLPV

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=470, Percent_Identity=38.5106382978723, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI295821216, Length=490, Percent_Identity=37.1428571428571, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI11545863, Length=433, Percent_Identity=38.7990762124711, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI310133460, Length=119, Percent_Identity=39.4957983193277, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17552936, Length=511, Percent_Identity=36.0078277886497, Blast_Score=301, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI25147359, Length=501, Percent_Identity=36.3273453093812, Blast_Score=291, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI25147362, Length=501, Percent_Identity=36.3273453093812, Blast_Score=291, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI71997163, Length=394, Percent_Identity=24.3654822335025, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133931226, Length=269, Percent_Identity=24.5353159851301, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24586065, Length=443, Percent_Identity=40.1805869074492, Blast_Score=300, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.2 [C]

Molecular weight: Translated: 55372; Mature: 55240

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50045 SIGMA54_INTERACT_4 ; PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARDESPDARIARELRRVEQGGAAKYHAKNAEQGKRFARERIALLLDPGSFVEDGALANA
CCCCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHCC
LDPELPADGVVTGMGRMDGRPVCVMANDSTVKAGSWGARTVEKILRIQEVAAAQRLPLLY
CCCCCCCCCEEECCCCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEE
LVDSAGARITDQVEMFPGRRGAGRIFHNEVHLSGVVPQICLLFGPSAAGGAYIPAFCDVV
EEECCCCCCCHHHHHCCCCCCCCCEEECEEEHHHHHHHHHHHCCCCCCCCCCHHCCCCEE
VMVEGNASMYLGSPRMAEMVIGEKVTLEELGGARMHCSVSGCGDFLVKTEEEAIALARRW
EEEECCCEEEECCCHHHHHHHCCCEEHHHCCCCEEEEEECCCCCCEEECHHHHHHHHHHH
LSYLPSSHRGLPPEAPARPPRPGARAPADVVPRDQNKPFDMLELVDAIVDEGSFLEVKRL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHH
WAGELVTGLARIDGQVVGIVANQPKVKGGVLFVDSADKATRFIWLCDAFNVPLLYLADVP
HHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFMIGTKVERAGIIRAGAKMISAVSEATVPRICVVVRKAYGAGLYAMDGPAFGPSATLAL
CCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHH
PEAMIAVMGPEAAVNAVFFNKIQERPEAERAAYVQALREEYRADIDLLKLASELVVDAVV
HHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
PGERLREELSRRFRIYAAGHEPTRERKRGVLPV
CCHHHHHHHHHCEEEEECCCCCHHHHHCCCCCC
>Mature Secondary Structure 
ARDESPDARIARELRRVEQGGAAKYHAKNAEQGKRFARERIALLLDPGSFVEDGALANA
CCCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHCC
LDPELPADGVVTGMGRMDGRPVCVMANDSTVKAGSWGARTVEKILRIQEVAAAQRLPLLY
CCCCCCCCCEEECCCCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEE
LVDSAGARITDQVEMFPGRRGAGRIFHNEVHLSGVVPQICLLFGPSAAGGAYIPAFCDVV
EEECCCCCCCHHHHHCCCCCCCCCEEECEEEHHHHHHHHHHHCCCCCCCCCCHHCCCCEE
VMVEGNASMYLGSPRMAEMVIGEKVTLEELGGARMHCSVSGCGDFLVKTEEEAIALARRW
EEEECCCEEEECCCHHHHHHHCCCEEHHHCCCCEEEEEECCCCCCEEECHHHHHHHHHHH
LSYLPSSHRGLPPEAPARPPRPGARAPADVVPRDQNKPFDMLELVDAIVDEGSFLEVKRL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHH
WAGELVTGLARIDGQVVGIVANQPKVKGGVLFVDSADKATRFIWLCDAFNVPLLYLADVP
HHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFMIGTKVERAGIIRAGAKMISAVSEATVPRICVVVRKAYGAGLYAMDGPAFGPSATLAL
CCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHH
PEAMIAVMGPEAAVNAVFFNKIQERPEAERAAYVQALREEYRADIDLLKLASELVVDAVV
HHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
PGERLREELSRRFRIYAAGHEPTRERKRGVLPV
CCHHHHHHHHHCEEEEECCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; ATP; Bicarbonate [C]

Specific reaction: Acetyl-CoA + ATP + Bicarbonate <==> ADP + H+ + Malonyl-CoA + Phosphate [C]

General reaction: Carboxylation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]