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The map label for this gene is acdA [H]

Identifier: 220917399

GI number: 220917399

Start: 2548657

End: 2549796

Strand: Reverse

Name: acdA [H]

Synonym: A2cp1_2299

Alternate gene names: 220917399

Gene position: 2549796-2548657 (Counterclockwise)

Preceding gene: 220917400

Following gene: 220917398

Centisome position: 50.7

GC content: 73.42

Gene sequence:

>1140_bases
ATGGACTTCGAACTCCCCGCGGAGCTGGTCGAGATCCAGCGGACCGTGCGCGCGTTCTGCGAGGCGGAGGTGCGGCCGCA
CGCCGCCGCGTGGGACGCGAGCGAGACGTTCCCGCGCGAGGTGGTGGCGAAGCTCGGCGCCATGGGCCTGCTCGGCATCA
CCGTGCCGGAGCGCTACGGCGGCGCCGGCATGGGCGCGCTGGCGGTGGCGGTGGTGGTGGAGGAGGTCGCGCGCTTCGAC
GGCTCGCTCGCCCTCACCGTGGCGAGCCACAACGGGCTCGGCACCGGCCACATCGCGCGGTTCGGCACCGACGCGCAGAA
GGAGCGGTACCTGCCGTCGCTGGCGACGGGCGAGCGCCTGGCCGCCTGGGCGCTCACCGAGCCGGGGAGCGGCTCGGACG
CCTCGGCCATGCGCACCACCGCGGTGCGACGCGGCGACGCCTGGGCGCTCTCCGGCTCGAAGACGTTCATCACGCAGGGG
ACGGTGGGCGGCAGCTTCGTGGTGCTGGCCCGCACCGACCCGGGGCGACGCCACCACGGGATCACCGCGTTCATCCTCGA
GCCGGGGATGAGCGGGTTCACGCAGCGCCCCATCCACGGCAAGCTCGGCATGCGCAGCTCCGACACCGCGCAGCTGTTCC
TGGACGAGGTCGAGGTCCCGGACGCGCAGCGGCTCGGCGAGGTCGACCACGGCTTCATCGACACGCTGCAGATCCTCGAC
CGCGGCCGGATCACCATCGGCGCGCTCGCGGTGGGCCTGGGCCGGGGCGCGCTGGAGGAGGCCCGGGCGTACGCGAAGGA
GCGCCAGGCGTTCGGCAAGCCCATCGCCGAGTTCCAGGCGATCGGCTTCATGCTCGCCGACATGGCCACCGAGCTCGACG
CGGCGCGGCTGCTGGTCCGGCGGGCGGCCGCCCTGTGCGACGCGGGCGAGCCGTTCGGCACGGCGGCCTCGATGGCGAAG
CTCTACGCGAGCGAGGCCGCCATGCGCGCCACCTCCCGCGCGATCCAGATCCACGGCGGCTACGGCTACACCCGCGACTT
CCCGGTGGAGCGCCATTTTCGCGACGCCAAGCTGACCGAGATCGGCGAGGGGACGAGCGAGGTGCAGCGGATGGTCATCT
CGCGGGAGATTCTGAGGTAG

Upstream 100 bases:

>100_bases
GGCTGCGCGAGGAGCTCTCCCGCCGGTTCCGGATCTACGCGGCCGGCCACGAGCCGACCCGCGAGCGCAAGCGCGGCGTC
CTCCCGGTCTAGGAGCCCAC

Downstream 100 bases:

>100_bases
TCTCTCGCGCGGAAGGGGAGCGCGCCGGACGGGCGGGACGCCCGTGGCGCGCGCGCGTGGGAGACCATGGGCGAAGGCGA
ACACACCATCATCGGAAAGA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MDFELPAELVEIQRTVRAFCEAEVRPHAAAWDASETFPREVVAKLGAMGLLGITVPERYGGAGMGALAVAVVVEEVARFD
GSLALTVASHNGLGTGHIARFGTDAQKERYLPSLATGERLAAWALTEPGSGSDASAMRTTAVRRGDAWALSGSKTFITQG
TVGGSFVVLARTDPGRRHHGITAFILEPGMSGFTQRPIHGKLGMRSSDTAQLFLDEVEVPDAQRLGEVDHGFIDTLQILD
RGRITIGALAVGLGRGALEEARAYAKERQAFGKPIAEFQAIGFMLADMATELDAARLLVRRAAALCDAGEPFGTAASMAK
LYASEAAMRATSRAIQIHGGYGYTRDFPVERHFRDAKLTEIGEGTSEVQRMVISREILR

Sequences:

>Translated_379_residues
MDFELPAELVEIQRTVRAFCEAEVRPHAAAWDASETFPREVVAKLGAMGLLGITVPERYGGAGMGALAVAVVVEEVARFD
GSLALTVASHNGLGTGHIARFGTDAQKERYLPSLATGERLAAWALTEPGSGSDASAMRTTAVRRGDAWALSGSKTFITQG
TVGGSFVVLARTDPGRRHHGITAFILEPGMSGFTQRPIHGKLGMRSSDTAQLFLDEVEVPDAQRLGEVDHGFIDTLQILD
RGRITIGALAVGLGRGALEEARAYAKERQAFGKPIAEFQAIGFMLADMATELDAARLLVRRAAALCDAGEPFGTAASMAK
LYASEAAMRATSRAIQIHGGYGYTRDFPVERHFRDAKLTEIGEGTSEVQRMVISREILR
>Mature_379_residues
MDFELPAELVEIQRTVRAFCEAEVRPHAAAWDASETFPREVVAKLGAMGLLGITVPERYGGAGMGALAVAVVVEEVARFD
GSLALTVASHNGLGTGHIARFGTDAQKERYLPSLATGERLAAWALTEPGSGSDASAMRTTAVRRGDAWALSGSKTFITQG
TVGGSFVVLARTDPGRRHHGITAFILEPGMSGFTQRPIHGKLGMRSSDTAQLFLDEVEVPDAQRLGEVDHGFIDTLQILD
RGRITIGALAVGLGRGALEEARAYAKERQAFGKPIAEFQAIGFMLADMATELDAARLLVRRAAALCDAGEPFGTAASMAK
LYASEAAMRATSRAIQIHGGYGYTRDFPVERHFRDAKLTEIGEGTSEVQRMVISREILR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=44.4148936170213, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI4501859, Length=366, Percent_Identity=40.1639344262295, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=39.2572944297082, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=40.4624277456647, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=36.3395225464191, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=34.3163538873995, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=36.0742705570292, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=36.0742705570292, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI21361497, Length=378, Percent_Identity=38.0952380952381, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI76496475, Length=374, Percent_Identity=37.7005347593583, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI4557235, Length=374, Percent_Identity=37.7005347593583, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI4503943, Length=380, Percent_Identity=31.3157894736842, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI7669494, Length=355, Percent_Identity=32.112676056338, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI211971008, Length=386, Percent_Identity=29.2746113989637, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI48976061, Length=383, Percent_Identity=29.242819843342, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI38505218, Length=359, Percent_Identity=24.2339832869081, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=33.5078534031414, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=28.1578947368421, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI87081702, Length=329, Percent_Identity=26.1398176291793, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=38.4615384615385, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17506239, Length=363, Percent_Identity=38.5674931129477, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=37.5328083989501, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=38.7434554973822, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=37.3655913978495, Blast_Score=257, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=37.5328083989501, Blast_Score=250, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=33.8624338624339, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI71990804, Length=302, Percent_Identity=40.3973509933775, Blast_Score=220, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=34.1880341880342, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17534353, Length=381, Percent_Identity=31.2335958005249, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=33.1521739130435, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=367, Percent_Identity=32.9700272479564, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=39.3939393939394, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=33.5793357933579, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71985192, Length=331, Percent_Identity=31.7220543806647, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=34.4398340248963, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=35.2272727272727, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=332, Percent_Identity=24.3975903614458, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=327, Percent_Identity=29.0519877675841, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=327, Percent_Identity=29.0519877675841, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21356377, Length=368, Percent_Identity=42.9347826086957, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24646207, Length=368, Percent_Identity=43.75, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24666513, Length=368, Percent_Identity=38.3152173913043, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=38.0577427821522, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=36.7724867724868, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI281363737, Length=355, Percent_Identity=34.6478873239437, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=30.7086614173228, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 40573; Mature: 40573

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFELPAELVEIQRTVRAFCEAEVRPHAAAWDASETFPREVVAKLGAMGLLGITVPERYG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCHHCC
GAGMGALAVAVVVEEVARFDGSLALTVASHNGLGTGHIARFGTDAQKERYLPSLATGERL
CCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCHHHHHCCCCCCCCCCE
AAWALTEPGSGSDASAMRTTAVRRGDAWALSGSKTFITQGTVGGSFVVLARTDPGRRHHG
EEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCCEEEEECCCCCEEEEEEECCCCCCCCC
ITAFILEPGMSGFTQRPIHGKLGMRSSDTAQLFLDEVEVPDAQRLGEVDHGFIDTLQILD
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHH
RGRITIGALAVGLGRGALEEARAYAKERQAFGKPIAEFQAIGFMLADMATELDAARLLVR
CCCEEEHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAALCDAGEPFGTAASMAKLYASEAAMRATSRAIQIHGGYGYTRDFPVERHFRDAKLTE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHCCCCHHHH
IGEGTSEVQRMVISREILR
HCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFELPAELVEIQRTVRAFCEAEVRPHAAAWDASETFPREVVAKLGAMGLLGITVPERYG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCHHCC
GAGMGALAVAVVVEEVARFDGSLALTVASHNGLGTGHIARFGTDAQKERYLPSLATGERL
CCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCHHHHHCCCCCCCCCCE
AAWALTEPGSGSDASAMRTTAVRRGDAWALSGSKTFITQGTVGGSFVVLARTDPGRRHHG
EEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCCEEEEECCCCCEEEEEEECCCCCCCCC
ITAFILEPGMSGFTQRPIHGKLGMRSSDTAQLFLDEVEVPDAQRLGEVDHGFIDTLQILD
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHH
RGRITIGALAVGLGRGALEEARAYAKERQAFGKPIAEFQAIGFMLADMATELDAARLLVR
CCCEEEHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAALCDAGEPFGTAASMAKLYASEAAMRATSRAIQIHGGYGYTRDFPVERHFRDAKLTE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHCCCCHHHH
IGEGTSEVQRMVISREILR
HCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]