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The map label for this gene is dcuB [H]

Identifier: 220916904

GI number: 220916904

Start: 2012705

End: 2014048

Strand: Reverse

Name: dcuB [H]

Synonym: A2cp1_1800

Alternate gene names: 220916904

Gene position: 2014048-2012705 (Counterclockwise)

Preceding gene: 220916905

Following gene: 220916899

Centisome position: 40.05

GC content: 68.01

Gene sequence:

>1344_bases
ATGCTCATGTTCTGGATCCAGTTCGCCCTCGTGCTCGGCGCCATCCTGCTCGGCATCCGCCGCGGCGGCGTGGCGCTCGG
GATGATCGGCGGCCTGGGCGTCGCCGTGCTGGTGTTCCTGTTCCGCGCCGCGCCGTCGGAGCCGCCCATCGCCGTCATGC
TCATCATCCTGGCGGTGGTCACCACCTCCGCCACGCTGCAGGTGGCGGGCGGGCTCGACTACCTGGTGCAGCTCGCCGAG
AAGCTGCTGCGGGCGCACCCGAAGTACGTGACGATCCTCGCGCCGTTCTGCACGTTCTTCCTGACCATGGCGGTGGGCAC
CGGGCACGCGGTGTACGCGCTGCTGCCGGTGATCGCCGACGTCGCGCTGAAGACGAAGACGCGGCCGGAGCGGCCCATGG
CGGTCTCGAGCGTCGCCTCGCAGATGGGCATCACCGCGAGCCCGGTGGCCGCGGCGGTCACCACCTTCCTCGCGTTCTCC
GCCAAGGCGGGCCAGCCGCTCTCGCTCTACGACATCCTCAAGATCACCATCCCCGCGGGCGTGGTGGGCGTCCTCGCGGC
CGCGCTGTGGAGCATGAACCGCGGCCGGGACCTGTACTCCGACCCGGAGTTCCTGAAGAAGCTCGAGGACCCCGAGTTCC
GCAAGTCGCTCGACGTCTCGGTCACCACCCTCGACAAGCAGCTCCCCCGCGCCGCCAGGCTGTCGGTGCTGCTGTTCTTC
ACCGGCGTCGCCACGATCGTGGTGCTCGCGCTCGACCAGGACTTCCTGCACCTCGGGCTCATCCCGCTCGTGAACGGCGG
GAAGCCCGTGGCCATGACCACGGTGGTGCAGATCGTGATGCTGGCGTTCGGCGCGTTCATCCTGTTCACCGCGAAGGTGA
AGGCCGCCGAGGTGGCGCGCTCGAGCGTGTTCACCGCCGGCATGATCGCGGTGGTGTCCATCTTCGGCATCGCCTGGATG
AGCGACACCTTCGTCACCGCGAACAAGCCGTTCCTCATCGAGAAGATCCAGGCGATGGTGCAGGTGGCGCCCTGGACGTT
CGCCGTCGCCATGTTCTGCGTGTCGGCGTTCGTGAAGAGCCAGGCCGCCACGCTCACCATCATGCTGCCGTTCGGCCTCG
CGCTCGGGCTGCCCGCGACGCTGCTGCTCGGCCTCATGCCGGCGAGCTACGCCTACTTCTTCTTCTGCTTCTACCCGTCG
GATCTCGCCGCCATCAACATGGACCGGACCGGTACCACGCACATCGGCAAGTACCTGCTCAACCACAGCTTCATGATCCC
CGGCTTCATCGGCGTGGGGACCTCCACGGTCGTCGCGTACGCGCTCTCGCGGCTCGCGTTCTGA

Upstream 100 bases:

>100_bases
CCCCCGTGCCGGCGGCGCGCGCGGCCCAGCGATCCCGCGACGTTGCTGCGCCCGGCGCCCTGGCACCGCCCGTGCTCAAG
GACACGGGCGGAGGCCACAC

Downstream 100 bases:

>100_bases
AGGGCGCCGCGGGCGCGGGGCGGGGCCGGCGGTGCGCGCACGGGCGCGCCGCCGGCCTCGGCGGTCGGCCGCAGGCCCTC
GGTTCAGGCCCTCACCACCC

Product: anaerobic C4-dicarboxylate transporter

Products: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLMFWIQFALVLGAILLGIRRGGVALGMIGGLGVAVLVFLFRAAPSEPPIAVMLIILAVVTTSATLQVAGGLDYLVQLAE
KLLRAHPKYVTILAPFCTFFLTMAVGTGHAVYALLPVIADVALKTKTRPERPMAVSSVASQMGITASPVAAAVTTFLAFS
AKAGQPLSLYDILKITIPAGVVGVLAAALWSMNRGRDLYSDPEFLKKLEDPEFRKSLDVSVTTLDKQLPRAARLSVLLFF
TGVATIVVLALDQDFLHLGLIPLVNGGKPVAMTTVVQIVMLAFGAFILFTAKVKAAEVARSSVFTAGMIAVVSIFGIAWM
SDTFVTANKPFLIEKIQAMVQVAPWTFAVAMFCVSAFVKSQAATLTIMLPFGLALGLPATLLLGLMPASYAYFFFCFYPS
DLAAINMDRTGTTHIGKYLLNHSFMIPGFIGVGTSTVVAYALSRLAF

Sequences:

>Translated_447_residues
MLMFWIQFALVLGAILLGIRRGGVALGMIGGLGVAVLVFLFRAAPSEPPIAVMLIILAVVTTSATLQVAGGLDYLVQLAE
KLLRAHPKYVTILAPFCTFFLTMAVGTGHAVYALLPVIADVALKTKTRPERPMAVSSVASQMGITASPVAAAVTTFLAFS
AKAGQPLSLYDILKITIPAGVVGVLAAALWSMNRGRDLYSDPEFLKKLEDPEFRKSLDVSVTTLDKQLPRAARLSVLLFF
TGVATIVVLALDQDFLHLGLIPLVNGGKPVAMTTVVQIVMLAFGAFILFTAKVKAAEVARSSVFTAGMIAVVSIFGIAWM
SDTFVTANKPFLIEKIQAMVQVAPWTFAVAMFCVSAFVKSQAATLTIMLPFGLALGLPATLLLGLMPASYAYFFFCFYPS
DLAAINMDRTGTTHIGKYLLNHSFMIPGFIGVGTSTVVAYALSRLAF
>Mature_447_residues
MLMFWIQFALVLGAILLGIRRGGVALGMIGGLGVAVLVFLFRAAPSEPPIAVMLIILAVVTTSATLQVAGGLDYLVQLAE
KLLRAHPKYVTILAPFCTFFLTMAVGTGHAVYALLPVIADVALKTKTRPERPMAVSSVASQMGITASPVAAAVTTFLAFS
AKAGQPLSLYDILKITIPAGVVGVLAAALWSMNRGRDLYSDPEFLKKLEDPEFRKSLDVSVTTLDKQLPRAARLSVLLFF
TGVATIVVLALDQDFLHLGLIPLVNGGKPVAMTTVVQIVMLAFGAFILFTAKVKAAEVARSSVFTAGMIAVVSIFGIAWM
SDTFVTANKPFLIEKIQAMVQVAPWTFAVAMFCVSAFVKSQAATLTIMLPFGLALGLPATLLLGLMPASYAYFFFCFYPS
DLAAINMDRTGTTHIGKYLLNHSFMIPGFIGVGTSTVVAYALSRLAF

Specific function: Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane [H]

COG id: COG2704

COG function: function code R; Anaerobic C4-dicarboxylate transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dcuA/dcuB transporter (TC 2.A.13.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790565, Length=406, Percent_Identity=45.8128078817734, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1790580, Length=445, Percent_Identity=38.4269662921348, Blast_Score=248, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004668 [H]

Pfam domain/function: PF03605 DcuA_DcuB [H]

EC number: NA

Molecular weight: Translated: 47632; Mature: 47632

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMFWIQFALVLGAILLGIRRGGVALGMIGGLGVAVLVFLFRAAPSEPPIAVMLIILAVV
CHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TTSATLQVAGGLDYLVQLAEKLLRAHPKYVTILAPFCTFFLTMAVGTGHAVYALLPVIAD
HCCCCEEECCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VALKTKTRPERPMAVSSVASQMGITASPVAAAVTTFLAFSAKAGQPLSLYDILKITIPAG
HHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHH
VVGVLAAALWSMNRGRDLYSDPEFLKKLEDPEFRKSLDVSVTTLDKQLPRAARLSVLLFF
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHCCCEEEHHHHHCCHHHHHHHHHHH
TGVATIVVLALDQDFLHLGLIPLVNGGKPVAMTTVVQIVMLAFGAFILFTAKVKAAEVAR
HHHHHHHHHHCCCHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSVFTAGMIAVVSIFGIAWMSDTFVTANKPFLIEKIQAMVQVAPWTFAVAMFCVSAFVKS
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHC
QAATLTIMLPFGLALGLPATLLLGLMPASYAYFFFCFYPSDLAAINMDRTGTTHIGKYLL
CCCEEEEEEHHHHHHCCHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCCHHHHHHHHH
NHSFMIPGFIGVGTSTVVAYALSRLAF
CCCCCCCCHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLMFWIQFALVLGAILLGIRRGGVALGMIGGLGVAVLVFLFRAAPSEPPIAVMLIILAVV
CHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TTSATLQVAGGLDYLVQLAEKLLRAHPKYVTILAPFCTFFLTMAVGTGHAVYALLPVIAD
HCCCCEEECCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VALKTKTRPERPMAVSSVASQMGITASPVAAAVTTFLAFSAKAGQPLSLYDILKITIPAG
HHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHH
VVGVLAAALWSMNRGRDLYSDPEFLKKLEDPEFRKSLDVSVTTLDKQLPRAARLSVLLFF
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHCCCEEEHHHHHCCHHHHHHHHHHH
TGVATIVVLALDQDFLHLGLIPLVNGGKPVAMTTVVQIVMLAFGAFILFTAKVKAAEVAR
HHHHHHHHHHCCCHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSVFTAGMIAVVSIFGIAWMSDTFVTANKPFLIEKIQAMVQVAPWTFAVAMFCVSAFVKS
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHC
QAATLTIMLPFGLALGLPATLLLGLMPASYAYFFFCFYPSDLAAINMDRTGTTHIGKYLL
CCCEEEEEEHHHHHHCCHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCCHHHHHHHHH
NHSFMIPGFIGVGTSTVVAYALSRLAF
CCCCCCCCHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Specific reaction: C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] = C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]