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The map label for this gene is zraR [H]

Identifier: 220916905

GI number: 220916905

Start: 2014309

End: 2015724

Strand: Reverse

Name: zraR [H]

Synonym: A2cp1_1801

Alternate gene names: 220916905

Gene position: 2015724-2014309 (Counterclockwise)

Preceding gene: 220916906

Following gene: 220916904

Centisome position: 40.08

GC content: 74.51

Gene sequence:

>1416_bases
ATGAGCGAGCCCGCGTCCACCTACCCCTCCTTCGCCGTGCTGCTGGTGGACGACGAGGCGGCCTGGCTGCGCTCCATGCG
CGTGGCGCTGCAGCGCGCCGGGGTGGACCACGTGCTCGCGACGCAGGAGCCGCGCGAGGTCCCGGAGCTCCTGGCGCGCG
AGCCGGTGGGTCTCGTGCTGCTCGACCTCAACATGCCCCACCTCTCCGGCGAGGCGCTGCTCGAGCGGCTCGCGGCGGAG
CGGCCCGAGGTCGCGGTGATCGTCATCAGCGGCATGAACCAGGTCGAGACGGCGGTGCGCTGCGTGAAGGCCGGGGCGCT
CGACTACTACGTGAAGACCGCCGAGGAGGACCGGCTGGTGGGCGGCGTGCTGCGCGCCATCCGCCTGCTCGAGCTGCAGC
GCGAGAACCGCGAGATGGCGAGCCGGTTCCTCTCCGGCGACCTCCGCCACCCGGAGGCCTTCGCCGGGCTCGTCACCCAG
GACCGCGCCATGCTGGCGATCTTCTCCTACGTGGAGGCGGTGGCGCGCAGTCCGCAGCCCCTGCTCGTCCAGGGCGAGAG
CGGGTCGGGCAAGGAGCTCGTGGCGCGCGCTGCGCACCAGGTCTCGGGCCGGCGCGGGCCGCTCGTGGCGGTGAACGTGG
CCGGGCTCGACGACACGGTGTTCGCCGACACGCTGTTCGGCCACGCCCGCGGCGCGTTCACCGGCGCCGAGCAGGCGCGC
CGGGGCATGGTGGAGGAGGCGGCCGACGGGACGCTGTTCCTCGACGAGATCGGCGACCTCTCGCAGGCGTCGCAGGTGAA
GCTGCTCCGGCTGCTGCAGGAGGGCGAATACTTCCCGCTCGGCAGCGACCGGCCGAAGCGGCTGCTGGCGCGCGTGATCG
TGGCGACGCACCACGACCTCGCGGCCCGGCAGGCGGCGGGCACGTTCCGGCGGGACCTCTACTACCGGCTCGCCACGCAC
CAGGTGCGCATCCCGCCGCTGCGCGAGCGCCGCGGCGACCTCCCGCTGCTGCTCGACCACTTCCTCGCCGAGGCGGCGCG
CGAGCTCGGGAAGAAGCGGCCCACCCCGCCCAGGGAGCTCGTGCCGCTGCTCGGCAGCTACGCGTTCCCCGGCAACGTGC
GCGAGCTGCGCTCGATGGTGCTCGACGCGGTGAGCCTGCACCGCGAGCGCGTGCTCTCCATGGACGCGTTCGTGAAGGCC
ATGGCCCGCGGGGGCGCGGCGGCGCCCGCGCCGGGGGCCCTCCCGGACCGGAACCCGTTCGCCGTGGCCGAGCACCTGCC
CACCATCCACGACGCGGTCGAGCTGCTGGTCGAGGAGGCGCTCTCGCGCGCCGGCGGCAGCCAGACCATCGCGGCGCGCA
CGCTCGGCATCACCCAGTCGGCGCTCTCGAAGCGGCTCAAGGCCGCGCGCGAGTGA

Upstream 100 bases:

>100_bases
AGCACGGGGGGACGCTCGAGTTCCGCTCCGCGCCCGGCGCGGGGACCACCGCCACCGTCACGCTCCCGGCCGCGCCCGAC
GCCGGCCCCCAGGGGATCCC

Downstream 100 bases:

>100_bases
CCCCGCGCGCCGCGGCCCGCGCCGCGGCATCCGGTCGCGCCCGGGAACGGGCATGAGCGGGCTCATGCGCATGAGCCGGC
GCATGCCGCGTGGAATCCGG

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSEPASTYPSFAVLLVDDEAAWLRSMRVALQRAGVDHVLATQEPREVPELLAREPVGLVLLDLNMPHLSGEALLERLAAE
RPEVAVIVISGMNQVETAVRCVKAGALDYYVKTAEEDRLVGGVLRAIRLLELQRENREMASRFLSGDLRHPEAFAGLVTQ
DRAMLAIFSYVEAVARSPQPLLVQGESGSGKELVARAAHQVSGRRGPLVAVNVAGLDDTVFADTLFGHARGAFTGAEQAR
RGMVEEAADGTLFLDEIGDLSQASQVKLLRLLQEGEYFPLGSDRPKRLLARVIVATHHDLAARQAAGTFRRDLYYRLATH
QVRIPPLRERRGDLPLLLDHFLAEAARELGKKRPTPPRELVPLLGSYAFPGNVRELRSMVLDAVSLHRERVLSMDAFVKA
MARGGAAAPAPGALPDRNPFAVAEHLPTIHDAVELLVEEALSRAGGSQTIAARTLGITQSALSKRLKAARE

Sequences:

>Translated_471_residues
MSEPASTYPSFAVLLVDDEAAWLRSMRVALQRAGVDHVLATQEPREVPELLAREPVGLVLLDLNMPHLSGEALLERLAAE
RPEVAVIVISGMNQVETAVRCVKAGALDYYVKTAEEDRLVGGVLRAIRLLELQRENREMASRFLSGDLRHPEAFAGLVTQ
DRAMLAIFSYVEAVARSPQPLLVQGESGSGKELVARAAHQVSGRRGPLVAVNVAGLDDTVFADTLFGHARGAFTGAEQAR
RGMVEEAADGTLFLDEIGDLSQASQVKLLRLLQEGEYFPLGSDRPKRLLARVIVATHHDLAARQAAGTFRRDLYYRLATH
QVRIPPLRERRGDLPLLLDHFLAEAARELGKKRPTPPRELVPLLGSYAFPGNVRELRSMVLDAVSLHRERVLSMDAFVKA
MARGGAAAPAPGALPDRNPFAVAEHLPTIHDAVELLVEEALSRAGGSQTIAARTLGITQSALSKRLKAARE
>Mature_470_residues
SEPASTYPSFAVLLVDDEAAWLRSMRVALQRAGVDHVLATQEPREVPELLAREPVGLVLLDLNMPHLSGEALLERLAAER
PEVAVIVISGMNQVETAVRCVKAGALDYYVKTAEEDRLVGGVLRAIRLLELQRENREMASRFLSGDLRHPEAFAGLVTQD
RAMLAIFSYVEAVARSPQPLLVQGESGSGKELVARAAHQVSGRRGPLVAVNVAGLDDTVFADTLFGHARGAFTGAEQARR
GMVEEAADGTLFLDEIGDLSQASQVKLLRLLQEGEYFPLGSDRPKRLLARVIVATHHDLAARQAAGTFRRDLYYRLATHQ
VRIPPLRERRGDLPLLLDHFLAEAARELGKKRPTPPRELVPLLGSYAFPGNVRELRSMVLDAVSLHRERVLSMDAFVKAM
ARGGAAAPAPGALPDRNPFAVAEHLPTIHDAVELLVEEALSRAGGSQTIAARTLGITQSALSKRLKAARE

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=465, Percent_Identity=37.4193548387097, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788550, Length=460, Percent_Identity=33.9130434782609, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI1790299, Length=475, Percent_Identity=35.1578947368421, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1788905, Length=409, Percent_Identity=36.4303178484108, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI87082117, Length=269, Percent_Identity=42.3791821561338, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789087, Length=334, Percent_Identity=37.4251497005988, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789233, Length=226, Percent_Identity=42.4778761061947, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87082152, Length=226, Percent_Identity=46.4601769911504, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI87081872, Length=250, Percent_Identity=38, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1786524, Length=355, Percent_Identity=33.8028169014084, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1787583, Length=367, Percent_Identity=31.0626702997275, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1789828, Length=220, Percent_Identity=37.7272727272727, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI87081858, Length=236, Percent_Identity=33.8983050847458, Blast_Score=104, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51270; Mature: 51138

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPASTYPSFAVLLVDDEAAWLRSMRVALQRAGVDHVLATQEPREVPELLAREPVGLVL
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHCCCCCEEE
LDLNMPHLSGEALLERLAAERPEVAVIVISGMNQVETAVRCVKAGALDYYVKTAEEDRLV
EECCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHCCCHHHHH
GGVLRAIRLLELQRENREMASRFLSGDLRHPEAFAGLVTQDRAMLAIFSYVEAVARSPQP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
LLVQGESGSGKELVARAAHQVSGRRGPLVAVNVAGLDDTVFADTLFGHARGAFTGAEQAR
EEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHH
RGMVEEAADGTLFLDEIGDLSQASQVKLLRLLQEGEYFPLGSDRPKRLLARVIVATHHDL
HCHHHHHCCCCEEHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
AARQAAGTFRRDLYYRLATHQVRIPPLRERRGDLPLLLDHFLAEAARELGKKRPTPPREL
HHHHHHHHHHHHHHHHHHHCEEECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
VPLLGSYAFPGNVRELRSMVLDAVSLHRERVLSMDAFVKAMARGGAAAPAPGALPDRNPF
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
AVAEHLPTIHDAVELLVEEALSRAGGSQTIAARTLGITQSALSKRLKAARE
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEPASTYPSFAVLLVDDEAAWLRSMRVALQRAGVDHVLATQEPREVPELLAREPVGLVL
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHCCCCCEEE
LDLNMPHLSGEALLERLAAERPEVAVIVISGMNQVETAVRCVKAGALDYYVKTAEEDRLV
EECCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHCCCHHHHH
GGVLRAIRLLELQRENREMASRFLSGDLRHPEAFAGLVTQDRAMLAIFSYVEAVARSPQP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
LLVQGESGSGKELVARAAHQVSGRRGPLVAVNVAGLDDTVFADTLFGHARGAFTGAEQAR
EEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHH
RGMVEEAADGTLFLDEIGDLSQASQVKLLRLLQEGEYFPLGSDRPKRLLARVIVATHHDL
HCHHHHHCCCCEEHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
AARQAAGTFRRDLYYRLATHQVRIPPLRERRGDLPLLLDHFLAEAARELGKKRPTPPREL
HHHHHHHHHHHHHHHHHHHCEEECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
VPLLGSYAFPGNVRELRSMVLDAVSLHRERVLSMDAFVKAMARGGAAAPAPGALPDRNPF
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
AVAEHLPTIHDAVELLVEEALSRAGGSQTIAARTLGITQSALSKRLKAARE
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]