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The map label for this gene is hemH [H]

Identifier: 220916324

GI number: 220916324

Start: 1367426

End: 1368388

Strand: Direct

Name: hemH [H]

Synonym: A2cp1_1218

Alternate gene names: 220916324

Gene position: 1367426-1368388 (Clockwise)

Preceding gene: 220916323

Following gene: 220916326

Centisome position: 27.19

GC content: 73.52

Gene sequence:

>963_bases
ATGAGCCACACGGCCGTCTTCCTCATGAACCTCGGCGGGCCGAGGAACCTCGCGGAGGTCGAGCCGTACCTCTACGAGCT
GTTCTCCGACCCGCTGGTGATCACGGCGCCGTTCGGCCCGTTCCGCAAGGTGATCGCGAAGCTCATCTCGCGCACGCGCG
CGCCGTCCTCGGCGGAGAAGTACCAGCTCATCGGCGGGAAGTCGCCGCTGGTGGAGGGCACCGAGGCCCAGGCGCGCGCG
CTCCAGGCCGCGCTCGGTCCCGGGTACTCGTGCCACCTGGCCATGCGCTGCGGGCACCCCAACACCGAGGAGGGCGTCCG
CGAGGCGCTCGCCGCCGGGGCCACCCGCGCGGTGGCGCTGCCGCTGTACCCGCAGTACGCGAACGCCACCACGCTCAGCT
CGCTCCTGGAGCTGCGCCGCCTCTGGCCGAAGGATCGTCCGCTCGCCGAGGTCTGCACCTGGCACGATCACGAGGGCTAC
CTGGAGGCCTCGGCCGCGGCGCTGCGCGAGACGCTGGAGCGGGTCCCGGCCGCGCTGCGCGGGCGCACGCGCGTGGTGTT
CAGCGCGCACGGCCTGCCCATGAGCCAGGTGCGCAAGGGCGACCCGTACCCCGGCTACGTGGAGCACTCCGCCCGCGAGA
CCGCGCGCCGCGCCGGCGCCGCCGACTGGCAGCTCACCTACCAGAGCCGCGTCGGCCCGGCGAAGTGGCTCGGCCCGGAC
ACCGTGAAGTACCTCGAGGCCAGCGCGAAGGACCTCGCCGTCGTGGCCGTGCCCATCGCGTTCGTCTCGGAGCACCTCGA
GACGCTCTACGACATGGACATCCTCGCGAAGGAGGCCGCGGAGAAGGCCGGCGCGGCGGCGTACCTGCGCGTGCCCGCGC
TCGGCACCCGCCCCGACTTCATCACCGCGCTCGCCGACGTGGTCCGCGAGGGAGAGAAGGCGTCGCGGACGGTGGCGGCG
TAG

Upstream 100 bases:

>100_bases
CCATGCTGTTCGACGCCTACCTGAAGAAGGAAGGCGGCAAGAAGCAGTTCTCGCGCACGGTGTAGCCGCGCGCGCGGGCG
CGCCGCCGCCGGGGAGCCGC

Downstream 100 bases:

>100_bases
CTCGGGCGTGGAGGGGCCTGCGGCGGTCGGGGACGGGTGCCCGGCCGCGGGGATCGGCTCACGAGATGCCCGAGGGTGGG
ACGTGGGGCGCTGAGCGGAC

Product: Ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSHTAVFLMNLGGPRNLAEVEPYLYELFSDPLVITAPFGPFRKVIAKLISRTRAPSSAEKYQLIGGKSPLVEGTEAQARA
LQAALGPGYSCHLAMRCGHPNTEEGVREALAAGATRAVALPLYPQYANATTLSSLLELRRLWPKDRPLAEVCTWHDHEGY
LEASAAALRETLERVPAALRGRTRVVFSAHGLPMSQVRKGDPYPGYVEHSARETARRAGAADWQLTYQSRVGPAKWLGPD
TVKYLEASAKDLAVVAVPIAFVSEHLETLYDMDILAKEAAEKAGAAAYLRVPALGTRPDFITALADVVREGEKASRTVAA

Sequences:

>Translated_320_residues
MSHTAVFLMNLGGPRNLAEVEPYLYELFSDPLVITAPFGPFRKVIAKLISRTRAPSSAEKYQLIGGKSPLVEGTEAQARA
LQAALGPGYSCHLAMRCGHPNTEEGVREALAAGATRAVALPLYPQYANATTLSSLLELRRLWPKDRPLAEVCTWHDHEGY
LEASAAALRETLERVPAALRGRTRVVFSAHGLPMSQVRKGDPYPGYVEHSARETARRAGAADWQLTYQSRVGPAKWLGPD
TVKYLEASAKDLAVVAVPIAFVSEHLETLYDMDILAKEAAEKAGAAAYLRVPALGTRPDFITALADVVREGEKASRTVAA
>Mature_319_residues
SHTAVFLMNLGGPRNLAEVEPYLYELFSDPLVITAPFGPFRKVIAKLISRTRAPSSAEKYQLIGGKSPLVEGTEAQARAL
QAALGPGYSCHLAMRCGHPNTEEGVREALAAGATRAVALPLYPQYANATTLSSLLELRRLWPKDRPLAEVCTWHDHEGYL
EASAAALRETLERVPAALRGRTRVVFSAHGLPMSQVRKGDPYPGYVEHSARETARRAGAADWQLTYQSRVGPAKWLGPDT
VKYLEASAKDLAVVAVPIAFVSEHLETLYDMDILAKEAAEKAGAAAYLRVPALGTRPDFITALADVVREGEKASRTVAA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=324, Percent_Identity=34.8765432098765, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI60499025, Length=324, Percent_Identity=34.8765432098765, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=30, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324750, Length=326, Percent_Identity=31.5950920245399, Blast_Score=161, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=30.952380952381, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24651774, Length=254, Percent_Identity=29.5275590551181, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45552018, Length=197, Percent_Identity=31.9796954314721, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 34672; Mature: 34541

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHTAVFLMNLGGPRNLAEVEPYLYELFSDPLVITAPFGPFRKVIAKLISRTRAPSSAEK
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHH
YQLIGGKSPLVEGTEAQARALQAALGPGYSCHLAMRCGHPNTEEGVREALAAGATRAVAL
EEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEE
PLYPQYANATTLSSLLELRRLWPKDRPLAEVCTWHDHEGYLEASAAALRETLERVPAALR
ECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GRTRVVFSAHGLPMSQVRKGDPYPGYVEHSARETARRAGAADWQLTYQSRVGPAKWLGPD
CCEEEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCH
TVKYLEASAKDLAVVAVPIAFVSEHLETLYDMDILAKEAAEKAGAAAYLRVPALGTRPDF
HHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
ITALADVVREGEKASRTVAA
HHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure 
SHTAVFLMNLGGPRNLAEVEPYLYELFSDPLVITAPFGPFRKVIAKLISRTRAPSSAEK
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHH
YQLIGGKSPLVEGTEAQARALQAALGPGYSCHLAMRCGHPNTEEGVREALAAGATRAVAL
EEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEE
PLYPQYANATTLSSLLELRRLWPKDRPLAEVCTWHDHEGYLEASAAALRETLERVPAALR
ECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GRTRVVFSAHGLPMSQVRKGDPYPGYVEHSARETARRAGAADWQLTYQSRVGPAKWLGPD
CCEEEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCH
TVKYLEASAKDLAVVAVPIAFVSEHLETLYDMDILAKEAAEKAGAAAYLRVPALGTRPDF
HHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
ITALADVVREGEKASRTVAA
HHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA