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The map label for this gene is hemN [H]

Identifier: 220916323

GI number: 220916323

Start: 1366014

End: 1367390

Strand: Direct

Name: hemN [H]

Synonym: A2cp1_1217

Alternate gene names: 220916323

Gene position: 1366014-1367390 (Clockwise)

Preceding gene: 220916322

Following gene: 220916324

Centisome position: 27.16

GC content: 69.14

Gene sequence:

>1377_bases
GTGATCCAGATCCCGTCCACGCAGCTCATCAAGAAGTACGACCGTCCCGGGCCGCGCTACACCAGCTACCCGACCGCGCC
GGAGTGGACCGAGGCGTTCGGTCCGGCGCAGTACGTCGAGCACCTGGCGCGCGCGAACCAGCAGGGCGGCCCGCTCTCCA
TCTACGTGCACCTCCCGTTCTGCCGGGAGATGTGCCGCTTCTGCGGCTGCAACGTGGTGGCGACGCACGATCGCACCCGC
GCCGACGCCTACCTCGACGTGCTCGAGAAGGAGGTCGCGCTGGTGGCGGCGAAGCTGCCCGACCGGCGCGCGGCCTCGCA
GCTCCACTGGGGCGGCGGGACGCCCACCTTCCTCGACGAGAAGCAGCTGGTGCGCTGCCACGACATCCTGGCGCGCCACT
TCACGTTCACGTCCGACGCCGAGAAGGCGATCGAGATCGACCCGGCCATCACCACCCGCTCGCAGATCGAGGTGCTGGCG
AAGCTCGGGTTCAACCGCATCTCGATGGGCGTGCAGGACTTCGACGCGCGGGTGCAGGAGGTGGTGGGGCGCATCCAGGG
CGAGAAGGAGACCGCCGACCTGGTGCAGGCCGCCCGCGACAACGGCTTCAAGGGCGTCAACCTCGACCTGATCTACGGGC
TGCCCTATCAGACGCCGGACACCTGGAAGAAGACGCTCGAGCGCATCCTCGCCATCCACCCGGACCGCATGGCGGTGTTC
GGCTTCGCCTACGTGCCGTGGTCGAAGCCGCACCAGCGCCTGCTGCCGCAGGAGGCGCTGCCGAAGACCGAGCAGCGCGT
GGAGCTGTTCCTGTCGGCGGTGGAGGCGTTCACCGGCGCCGGGTACCGGCTCATCGGCCTCGACCACTTCGCGCTGGAGT
CGGACGAGCTGGCCGTGGCGCAGAGCGGCGGCTACCTGTACCGCAACTTCCAGGGCTACACCGTCCGCCCCGCCGAGGAC
ACGGTGGCGTTCGGGATGACCTCCATCTCGGACATCGGCGGCGCGTACGCGCAGAACGCGCACAAGCTCAAGGACTGGGA
GGCGAAGGTCGAGGCCGGGATCATCCCGGTGGACCGCGGCGCCTCCATGTCCGCGGACGACGTGATGCGGCGGTTCACCA
TCAACCGCGTCATGTGCCTGCTCCGCCTCGACCTCCGCGAGATCGCGGAGAAGTTCGGGCCGGAGGGCCGGGCCGCCATC
GAGGCCGACCTGCGCGCCGGCGTGAAGGAGCTGGAGGAGGACGGGCTGGTCACCTTCGACGGCGACGTGCTGAAGGTGAC
GCCGCTCGGCCAGCTCCTGGTCCGCAACGTGGCCATGCTGTTCGACGCCTACCTGAAGAAGGAAGGCGGCAAGAAGCAGT
TCTCGCGCACGGTGTAG

Upstream 100 bases:

>100_bases
TTCAACCTCGGCCACGGGATCCAGGTGGGCACCCCGACCGAGAACGTGAAGGCGGTGGTGGACGCGGTCCACGCCTTCGG
CTGGAAGTGAGGCGATCGGC

Downstream 100 bases:

>100_bases
CCGCGCGCGCGGGCGCGCCGCCGCCGGGGAGCCGCATGAGCCACACGGCCGTCTTCCTCATGAACCTCGGCGGGCCGAGG
AACCTCGCGGAGGTCGAGCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MIQIPSTQLIKKYDRPGPRYTSYPTAPEWTEAFGPAQYVEHLARANQQGGPLSIYVHLPFCREMCRFCGCNVVATHDRTR
ADAYLDVLEKEVALVAAKLPDRRAASQLHWGGGTPTFLDEKQLVRCHDILARHFTFTSDAEKAIEIDPAITTRSQIEVLA
KLGFNRISMGVQDFDARVQEVVGRIQGEKETADLVQAARDNGFKGVNLDLIYGLPYQTPDTWKKTLERILAIHPDRMAVF
GFAYVPWSKPHQRLLPQEALPKTEQRVELFLSAVEAFTGAGYRLIGLDHFALESDELAVAQSGGYLYRNFQGYTVRPAED
TVAFGMTSISDIGGAYAQNAHKLKDWEAKVEAGIIPVDRGASMSADDVMRRFTINRVMCLLRLDLREIAEKFGPEGRAAI
EADLRAGVKELEEDGLVTFDGDVLKVTPLGQLLVRNVAMLFDAYLKKEGGKKQFSRTV

Sequences:

>Translated_458_residues
MIQIPSTQLIKKYDRPGPRYTSYPTAPEWTEAFGPAQYVEHLARANQQGGPLSIYVHLPFCREMCRFCGCNVVATHDRTR
ADAYLDVLEKEVALVAAKLPDRRAASQLHWGGGTPTFLDEKQLVRCHDILARHFTFTSDAEKAIEIDPAITTRSQIEVLA
KLGFNRISMGVQDFDARVQEVVGRIQGEKETADLVQAARDNGFKGVNLDLIYGLPYQTPDTWKKTLERILAIHPDRMAVF
GFAYVPWSKPHQRLLPQEALPKTEQRVELFLSAVEAFTGAGYRLIGLDHFALESDELAVAQSGGYLYRNFQGYTVRPAED
TVAFGMTSISDIGGAYAQNAHKLKDWEAKVEAGIIPVDRGASMSADDVMRRFTINRVMCLLRLDLREIAEKFGPEGRAAI
EADLRAGVKELEEDGLVTFDGDVLKVTPLGQLLVRNVAMLFDAYLKKEGGKKQFSRTV
>Mature_458_residues
MIQIPSTQLIKKYDRPGPRYTSYPTAPEWTEAFGPAQYVEHLARANQQGGPLSIYVHLPFCREMCRFCGCNVVATHDRTR
ADAYLDVLEKEVALVAAKLPDRRAASQLHWGGGTPTFLDEKQLVRCHDILARHFTFTSDAEKAIEIDPAITTRSQIEVLA
KLGFNRISMGVQDFDARVQEVVGRIQGEKETADLVQAARDNGFKGVNLDLIYGLPYQTPDTWKKTLERILAIHPDRMAVF
GFAYVPWSKPHQRLLPQEALPKTEQRVELFLSAVEAFTGAGYRLIGLDHFALESDELAVAQSGGYLYRNFQGYTVRPAED
TVAFGMTSISDIGGAYAQNAHKLKDWEAKVEAGIIPVDRGASMSADDVMRRFTINRVMCLLRLDLREIAEKFGPEGRAAI
EADLRAGVKELEEDGLVTFDGDVLKVTPLGQLLVRNVAMLFDAYLKKEGGKKQFSRTV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=262, Percent_Identity=23.2824427480916, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI87082341, Length=450, Percent_Identity=43.1111111111111, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1789325, Length=237, Percent_Identity=27.4261603375527, Blast_Score=99, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51140; Mature: 51140

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIPSTQLIKKYDRPGPRYTSYPTAPEWTEAFGPAQYVEHLARANQQGGPLSIYVHLPF
CCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCEEEEEECHH
CREMCRFCGCNVVATHDRTRADAYLDVLEKEVALVAAKLPDRRAASQLHWGGGTPTFLDE
HHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCH
KQLVRCHDILARHFTFTSDAEKAIEIDPAITTRSQIEVLAKLGFNRISMGVQDFDARVQE
HHHHHHHHHHHHHCCCCCCCCHHEECCCCCCCHHHHHHHHHCCCHHHHCCHHHHHHHHHH
VVGRIQGEKETADLVQAARDNGFKGVNLDLIYGLPYQTPDTWKKTLERILAIHPDRMAVF
HHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEE
GFAYVPWSKPHQRLLPQEALPKTEQRVELFLSAVEAFTGAGYRLIGLDHFALESDELAVA
EEEECCCCCHHHHCCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHCCCCCCEEEE
QSGGYLYRNFQGYTVRPAEDTVAFGMTSISDIGGAYAQNAHKLKDWEAKVEAGIIPVDRG
ECCCEEEEECCCCEECCCCCHHHHCCHHHHHHCCHHHCCCHHHHHHHHHHHCCEEECCCC
ASMSADDVMRRFTINRVMCLLRLDLREIAEKFGPEGRAAIEADLRAGVKELEEDGLVTFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEC
GDVLKVTPLGQLLVRNVAMLFDAYLKKEGGKKQFSRTV
CCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure
MIQIPSTQLIKKYDRPGPRYTSYPTAPEWTEAFGPAQYVEHLARANQQGGPLSIYVHLPF
CCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCEEEEEECHH
CREMCRFCGCNVVATHDRTRADAYLDVLEKEVALVAAKLPDRRAASQLHWGGGTPTFLDE
HHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCH
KQLVRCHDILARHFTFTSDAEKAIEIDPAITTRSQIEVLAKLGFNRISMGVQDFDARVQE
HHHHHHHHHHHHHCCCCCCCCHHEECCCCCCCHHHHHHHHHCCCHHHHCCHHHHHHHHHH
VVGRIQGEKETADLVQAARDNGFKGVNLDLIYGLPYQTPDTWKKTLERILAIHPDRMAVF
HHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEE
GFAYVPWSKPHQRLLPQEALPKTEQRVELFLSAVEAFTGAGYRLIGLDHFALESDELAVA
EEEECCCCCHHHHCCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHCCCCCCEEEE
QSGGYLYRNFQGYTVRPAEDTVAFGMTSISDIGGAYAQNAHKLKDWEAKVEAGIIPVDRG
ECCCEEEEECCCCEECCCCCHHHHCCHHHHHHCCHHHCCCHHHHHHHHHHHCCEEECCCC
ASMSADDVMRRFTINRVMCLLRLDLREIAEKFGPEGRAAIEADLRAGVKELEEDGLVTFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEC
GDVLKVTPLGQLLVRNVAMLFDAYLKKEGGKKQFSRTV
CCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]