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The map label for this gene is algC [H]

Identifier: 220915299

GI number: 220915299

Start: 195494

End: 196864

Strand: Direct

Name: algC [H]

Synonym: A2cp1_0178

Alternate gene names: 220915299

Gene position: 195494-196864 (Clockwise)

Preceding gene: 220915298

Following gene: 220915300

Centisome position: 3.89

GC content: 71.04

Gene sequence:

>1371_bases
ATGGCCAAGCTCTCCCCGACCATCTTCCGCGAGTACGACATCCGCGGGCTGGTGGACCAGGATCTCCCCGAGGAGGCGGT
CTCGCTCGTCGGCAAGGCGCTCGGCACGCGCATCCGGGGCGCGGGCGGGAAGCGTGCCGCGGTGGGGTGGGACGCGCGCC
TCTCCGGGCCGAAGTTCGCGAAGGCCATGATCGAGGCGCTCACCTCCACCGGCGTGGACGTGGTGAGCCTCGGGGTGGTG
CCGACGCCCCTGACCTACTTCGCCGCCCACACGCTCGACGTGGACGGCATCTGCATGATCACCGGCTCGCACAACCCGCC
GGAGTACAACGGCCTCAAGGTCGGGCTCGGCTCGGCCACCTACTACGGCGAGGAGATCCAGGCGCTGCGCCGCGAGGCGG
AGGCCGGGCGCTTCGCCACGGGCCAGGGGACCGTCCGCGCGCACGACATCGTCACGCCCTACCGCGAGCACGTCCGGCAG
AACCTCCGGCTCGGGAAGCGCCGGCTGAAGGTGGTGGTGGACGCCGGCAACGGGACCGGCGGCGTGGTGGCGGTGCCGCT
GTTCGAGGCGCTCGGGTTCGAGGTGGTGCCGCTGTTCATCGAGATGGACGGCAACTTCCCGAACCACCACCCCGACCCGA
CCGTGGAGAAGAACCTCGAGCACCTGCGGCGCAAGGTGCTGGAGACCGGGGCGGACGTGGGCATCGCCTACGACGGCGAC
GCCGACCGGGTGGGCGCGGTGGACGAGAAGGGCAACGTGCTCTGGGGCGACCAGATCATGATCCTGTTCTCCCGGGCCCT
GCTCGCCGAGGAGCCGGGCGCCGCCATCGTGGGCGAGGTGAAGTGCTCCTTCACGCTCTACGACGACATCGCCGCCCGCG
GCGGGCGGGCCATCATGTGGAAGGCCGGGCACAGCCTCATCAAGGCGAAGATGAAGGAGGAGCACGCGCTCCTCGCCGGC
GAGATGAGCGGCCACATCTTCTTCGCCCACCGCTGGTTCGGGTTCGACGACGGCATCTACTCGTCGGCGCGGCTGCTCGA
GCTGCTCACCCACACCGACCTGCCGATGTCGGCGCTGCTCGCCGACGTGCCGCGGACGTTCTCCACGCCCGAGCTCCGGG
TGGACTGCCCCGAGGAGAAGAAGTTCGAGGTGGTGCGCCGCGCCCAGGAGTTCTTCGCCGCCCGCTACGACGCGGTGACG
GTGGACGGCGTCCGGGTGGTCTTCCCCGACGGGTGGGGCCTGGTGCGCGCCTCCAACACGCAGCCGCTGCTGGTCCTGCG
CTTCGAGGCGAAGACCGAGGCGCGGCTCGCCGAGATCCAGGCGCTGGTGCGCGGCAAGGTCGACGAGCTGCTGCGCGAGC
TGGGGGCGTAG

Upstream 100 bases:

>100_bases
GGCCCGCCCCGGGGGGAACCGGGCGGCGCCGGCGCTCCCCGGGCACGGAGCCTGCCCGCGGCGCCTCACGTCACGACATT
CACGACCGAGGACCGACCCC

Downstream 100 bases:

>100_bases
GCCGTGAAGGGGCTCGCGCTGGGCGTTGACCTGGGGGGCACCAACGCGCGCGCCGCGGTGGTGGACCGCGCCACCGGCGA
GATCGTGGCCTCGCACAAGG

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MAKLSPTIFREYDIRGLVDQDLPEEAVSLVGKALGTRIRGAGGKRAAVGWDARLSGPKFAKAMIEALTSTGVDVVSLGVV
PTPLTYFAAHTLDVDGICMITGSHNPPEYNGLKVGLGSATYYGEEIQALRREAEAGRFATGQGTVRAHDIVTPYREHVRQ
NLRLGKRRLKVVVDAGNGTGGVVAVPLFEALGFEVVPLFIEMDGNFPNHHPDPTVEKNLEHLRRKVLETGADVGIAYDGD
ADRVGAVDEKGNVLWGDQIMILFSRALLAEEPGAAIVGEVKCSFTLYDDIAARGGRAIMWKAGHSLIKAKMKEEHALLAG
EMSGHIFFAHRWFGFDDGIYSSARLLELLTHTDLPMSALLADVPRTFSTPELRVDCPEEKKFEVVRRAQEFFAARYDAVT
VDGVRVVFPDGWGLVRASNTQPLLVLRFEAKTEARLAEIQALVRGKVDELLRELGA

Sequences:

>Translated_456_residues
MAKLSPTIFREYDIRGLVDQDLPEEAVSLVGKALGTRIRGAGGKRAAVGWDARLSGPKFAKAMIEALTSTGVDVVSLGVV
PTPLTYFAAHTLDVDGICMITGSHNPPEYNGLKVGLGSATYYGEEIQALRREAEAGRFATGQGTVRAHDIVTPYREHVRQ
NLRLGKRRLKVVVDAGNGTGGVVAVPLFEALGFEVVPLFIEMDGNFPNHHPDPTVEKNLEHLRRKVLETGADVGIAYDGD
ADRVGAVDEKGNVLWGDQIMILFSRALLAEEPGAAIVGEVKCSFTLYDDIAARGGRAIMWKAGHSLIKAKMKEEHALLAG
EMSGHIFFAHRWFGFDDGIYSSARLLELLTHTDLPMSALLADVPRTFSTPELRVDCPEEKKFEVVRRAQEFFAARYDAVT
VDGVRVVFPDGWGLVRASNTQPLLVLRFEAKTEARLAEIQALVRGKVDELLRELGA
>Mature_455_residues
AKLSPTIFREYDIRGLVDQDLPEEAVSLVGKALGTRIRGAGGKRAAVGWDARLSGPKFAKAMIEALTSTGVDVVSLGVVP
TPLTYFAAHTLDVDGICMITGSHNPPEYNGLKVGLGSATYYGEEIQALRREAEAGRFATGQGTVRAHDIVTPYREHVRQN
LRLGKRRLKVVVDAGNGTGGVVAVPLFEALGFEVVPLFIEMDGNFPNHHPDPTVEKNLEHLRRKVLETGADVGIAYDGDA
DRVGAVDEKGNVLWGDQIMILFSRALLAEEPGAAIVGEVKCSFTLYDDIAARGGRAIMWKAGHSLIKAKMKEEHALLAGE
MSGHIFFAHRWFGFDDGIYSSARLLELLTHTDLPMSALLADVPRTFSTPELRVDCPEEKKFEVVRRAQEFFAARYDAVTV
DGVRVVFPDGWGLVRASNTQPLLVLRFEAKTEARLAEIQALVRGKVDELLRELGA

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=452, Percent_Identity=33.4070796460177, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1789566, Length=442, Percent_Identity=26.6968325791855, Blast_Score=102, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 49770; Mature: 49638

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLSPTIFREYDIRGLVDQDLPEEAVSLVGKALGTRIRGAGGKRAAVGWDARLSGPKFA
CCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHH
KAMIEALTSTGVDVVSLGVVPTPLTYFAAHTLDVDGICMITGSHNPPEYNGLKVGLGSAT
HHHHHHHHHCCCCEEEECCCCCCHHHHHHHEECCCCEEEEECCCCCCCCCCEEEECCCCH
YYGEEIQALRREAEAGRFATGQGTVRAHDIVTPYREHVRQNLRLGKRRLKVVVDAGNGTG
HHHHHHHHHHHHHHCCCEECCCCCEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCCC
GVVAVPLFEALGFEVVPLFIEMDGNFPNHHPDPTVEKNLEHLRRKVLETGADVGIAYDGD
CEEEEHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
ADRVGAVDEKGNVLWGDQIMILFSRALLAEEPGAAIVGEVKCSFTLYDDIAARGGRAIMW
CCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEHHHHHCCCCEEEE
KAGHSLIKAKMKEEHALLAGEMSGHIFFAHRWFGFDDGIYSSARLLELLTHTDLPMSALL
CCCHHHHHHHHHHHHHHEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHH
ADVPRTFSTPELRVDCPEEKKFEVVRRAQEFFAARYDAVTVDGVRVVFPDGWGLVRASNT
HHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCCCEEEEECCC
QPLLVLRFEAKTEARLAEIQALVRGKVDELLRELGA
CCEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure 
AKLSPTIFREYDIRGLVDQDLPEEAVSLVGKALGTRIRGAGGKRAAVGWDARLSGPKFA
CCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHH
KAMIEALTSTGVDVVSLGVVPTPLTYFAAHTLDVDGICMITGSHNPPEYNGLKVGLGSAT
HHHHHHHHHCCCCEEEECCCCCCHHHHHHHEECCCCEEEEECCCCCCCCCCEEEECCCCH
YYGEEIQALRREAEAGRFATGQGTVRAHDIVTPYREHVRQNLRLGKRRLKVVVDAGNGTG
HHHHHHHHHHHHHHCCCEECCCCCEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCCC
GVVAVPLFEALGFEVVPLFIEMDGNFPNHHPDPTVEKNLEHLRRKVLETGADVGIAYDGD
CEEEEHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
ADRVGAVDEKGNVLWGDQIMILFSRALLAEEPGAAIVGEVKCSFTLYDDIAARGGRAIMW
CCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEHHHHHCCCCEEEE
KAGHSLIKAKMKEEHALLAGEMSGHIFFAHRWFGFDDGIYSSARLLELLTHTDLPMSALL
CCCHHHHHHHHHHHHHHEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHH
ADVPRTFSTPELRVDCPEEKKFEVVRRAQEFFAARYDAVTVDGVRVVFPDGWGLVRASNT
HHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCCCEEEEECCC
QPLLVLRFEAKTEARLAEIQALVRGKVDELLRELGA
CCEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]