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The map label for this gene is algA [H]

Identifier: 220915298

GI number: 220915298

Start: 194236

End: 195324

Strand: Direct

Name: algA [H]

Synonym: A2cp1_0177

Alternate gene names: 220915298

Gene position: 194236-195324 (Clockwise)

Preceding gene: 220915297

Following gene: 220915299

Centisome position: 3.86

GC content: 73.46

Gene sequence:

>1089_bases
GTGAAGATCTACCCGGTGATCATGGCGGGCGGCTCGGGCACGCGGTTCTGGCCGCTGTCGCGCCGCAACCGCCCGAAGCA
GTTCCTGGCGCTCGCCGGCGACGCGCCGCTGCTCGCCGCCACGGTGAGCCGGCTCCCGCCGCTGTCGCGGCCCAGGGACA
CGTTCGTGGTGTGCGGGCCGAAGCACGCCGCCGCCGCCCGGCGGATGGTGGCGCAGCTCCCGAAGGAGAACTTCATCGTC
GAGCCGTGCGCGCGGAACACCGCGCCCTGCGTGGGCCTCGCCGCCATCCACGTGGCCGCGAAGGACCCCCGCGGCGTCAT
CGCCATGCTGCCGGCCGACCACCACATCGGCCGGCCCCCGGCGTTCCGCGACGCGCTGGCCGCGGCCGCCCAGCTCGCCG
AGGCCGGCTCCATCGCCACCATCGGCATCCGCCCCTCGCGCCCCGAGACCGGCTACGGCTACCTGAAGCTCGGGCCGCGC
CTGGCCGCGCGCGCGAAGGGCAAGAAGCGGCTGGTGGCGCACAAGGTCGAGCGCTTCGTGGAGAAGCCGGACGTGGTCAC
CGCCGCGCGCTACCTCGCCGACGGCAGCTACCTCTGGAACTCGGGCATCTTCGTGTTCCGCGCCGACGTGATCCTGGACG
AGATCCGCCGCGCCATGCCGGTGCTGGGCGAGCAGCTCGAGGCCATCCGCCGCACGCTCGGCACGCCGAACTACGCGCGC
ACGCTGAAGCGCGTCTTCCCCGACTGCCCGTCCATCTCCATCGACTACGGCGTGATGGAGAAGAGCCAGCGCATCGCGGT
GGTGCCGGCCGAGTTCGGCTGGAGCGACGTGGGCAGCTTCGCCGCGCTCTCCGACGTCCGCGTCACCGACGACCTCGGCA
ACGTGGCGGAGGGCGACGCGCTCGTCATCGACGGCCGCAACAACGTGGTGCTGGCCGGGAAGGACCGGCCCATCGCGCTC
ATCGGCCTCGACGACGTCATCGTGGTGGACTCGGGCGACGCGCTGCTCGTGTGCCGCCGCGACCGGGCCCAGGACGTGCG
CAAGGCGGTCGAGGAGCTGGGCCGCCGCGGCCGCGAGGAGCTCCTCTAG

Upstream 100 bases:

>100_bases
GCCTGAGGCTCGACGTGCACTTCTTCTCGGTCGGCAAGGACGTGATCTGGGGCGCGACGGGTCGCGTGCTCGCCGAGCTC
CTGTCCATCTGGAGGGCGTC

Downstream 100 bases:

>100_bases
CGCGCCCCGCCCCCCGCGTCCCCGAGGGACGCGCGGCCCCCGGTCCGAGGTGCTATACAGCCGCCCGGCGGCCCGCCCCG
GGGGGAACCGGGCGGCGCCG

Product: Mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKIYPVIMAGGSGTRFWPLSRRNRPKQFLALAGDAPLLAATVSRLPPLSRPRDTFVVCGPKHAAAARRMVAQLPKENFIV
EPCARNTAPCVGLAAIHVAAKDPRGVIAMLPADHHIGRPPAFRDALAAAAQLAEAGSIATIGIRPSRPETGYGYLKLGPR
LAARAKGKKRLVAHKVERFVEKPDVVTAARYLADGSYLWNSGIFVFRADVILDEIRRAMPVLGEQLEAIRRTLGTPNYAR
TLKRVFPDCPSISIDYGVMEKSQRIAVVPAEFGWSDVGSFAALSDVRVTDDLGNVAEGDALVIDGRNNVVLAGKDRPIAL
IGLDDVIVVDSGDALLVCRRDRAQDVRKAVEELGRRGREELL

Sequences:

>Translated_362_residues
MKIYPVIMAGGSGTRFWPLSRRNRPKQFLALAGDAPLLAATVSRLPPLSRPRDTFVVCGPKHAAAARRMVAQLPKENFIV
EPCARNTAPCVGLAAIHVAAKDPRGVIAMLPADHHIGRPPAFRDALAAAAQLAEAGSIATIGIRPSRPETGYGYLKLGPR
LAARAKGKKRLVAHKVERFVEKPDVVTAARYLADGSYLWNSGIFVFRADVILDEIRRAMPVLGEQLEAIRRTLGTPNYAR
TLKRVFPDCPSISIDYGVMEKSQRIAVVPAEFGWSDVGSFAALSDVRVTDDLGNVAEGDALVIDGRNNVVLAGKDRPIAL
IGLDDVIVVDSGDALLVCRRDRAQDVRKAVEELGRRGREELL
>Mature_362_residues
MKIYPVIMAGGSGTRFWPLSRRNRPKQFLALAGDAPLLAATVSRLPPLSRPRDTFVVCGPKHAAAARRMVAQLPKENFIV
EPCARNTAPCVGLAAIHVAAKDPRGVIAMLPADHHIGRPPAFRDALAAAAQLAEAGSIATIGIRPSRPETGYGYLKLGPR
LAARAKGKKRLVAHKVERFVEKPDVVTAARYLADGSYLWNSGIFVFRADVILDEIRRAMPVLGEQLEAIRRTLGTPNYAR
TLKRVFPDCPSISIDYGVMEKSQRIAVVPAEFGWSDVGSFAALSDVRVTDDLGNVAEGDALVIDGRNNVVLAGKDRPIAL
IGLDDVIVVDSGDALLVCRRDRAQDVRKAVEELGRRGREELL

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=369, Percent_Identity=41.1924119241192, Blast_Score=253, Evalue=9e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 39230; Mature: 39230

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYPVIMAGGSGTRFWPLSRRNRPKQFLALAGDAPLLAATVSRLPPLSRPRDTFVVCGP
CEEEEEEEECCCCCEEEECCCCCCCHHEEEECCCCCHHHHHHHHCCCCCCCCCCEEEECC
KHAAAARRMVAQLPKENFIVEPCARNTAPCVGLAAIHVAAKDPRGVIAMLPADHHIGRPP
HHHHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCC
AFRDALAAAAQLAEAGSIATIGIRPSRPETGYGYLKLGPRLAARAKGKKRLVAHKVERFV
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHH
EKPDVVTAARYLADGSYLWNSGIFVFRADVILDEIRRAMPVLGEQLEAIRRTLGTPNYAR
CCCCHHHHHHHHCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TLKRVFPDCPSISIDYGVMEKSQRIAVVPAEFGWSDVGSFAALSDVRVTDDLGNVAEGDA
HHHHHCCCCCCCEEECCHHCCCCEEEEEECCCCCCHHCCHHHHCCCEEECCCCCCCCCCE
LVIDGRNNVVLAGKDRPIALIGLDDVIVVDSGDALLVCRRDRAQDVRKAVEELGRRGREE
EEEECCCCEEEECCCCCEEEEECCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCHHH
LL
CC
>Mature Secondary Structure
MKIYPVIMAGGSGTRFWPLSRRNRPKQFLALAGDAPLLAATVSRLPPLSRPRDTFVVCGP
CEEEEEEEECCCCCEEEECCCCCCCHHEEEECCCCCHHHHHHHHCCCCCCCCCCEEEECC
KHAAAARRMVAQLPKENFIVEPCARNTAPCVGLAAIHVAAKDPRGVIAMLPADHHIGRPP
HHHHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCC
AFRDALAAAAQLAEAGSIATIGIRPSRPETGYGYLKLGPRLAARAKGKKRLVAHKVERFV
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHH
EKPDVVTAARYLADGSYLWNSGIFVFRADVILDEIRRAMPVLGEQLEAIRRTLGTPNYAR
CCCCHHHHHHHHCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TLKRVFPDCPSISIDYGVMEKSQRIAVVPAEFGWSDVGSFAALSDVRVTDDLGNVAEGDA
HHHHHCCCCCCCEEECCHHCCCCEEEEEECCCCCCHHCCHHHHCCCEEECCCCCCCCCCE
LVIDGRNNVVLAGKDRPIALIGLDDVIVVDSGDALLVCRRDRAQDVRKAVEELGRRGREE
EEEECCCCEEEECCCCCEEEEECCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCHHH
LL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]