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The map label for this gene is ahcY [H]

Identifier: 220915295

GI number: 220915295

Start: 191286

End: 192761

Strand: Direct

Name: ahcY [H]

Synonym: A2cp1_0174

Alternate gene names: 220915295

Gene position: 191286-192761 (Clockwise)

Preceding gene: 220915294

Following gene: 220915296

Centisome position: 3.8

GC content: 69.65

Gene sequence:

>1476_bases
ATGGCCGTGTCCGCCGCGAAGAAGAAGCCCACCCCGAGCGCCCCTGCGCCGCTCGAGCACAAGGTGAAGGACCTCTCCCT
GGCGGGCTGGGGACGCAAGGAGATCGAGCTCGCCGAGAAGGAGATGCCGGGCCTGATGGCGCTCCGGCGCGAGCACGCGC
GGCAGCGCCCGCTCGCCGGCCAGCGGATCACCGGCTCGCTGCACATGACCATCCAGACCGCGGTGCTGATCGAGACGCTG
GTGGACCTCGGCGCCGACGTCCGCTGGGCGAGCTGCAACATCTTCTCGACGCAGGACCACGCCGCCGCCGCCATCGTGGT
GGGCCGCGAGGGGACGCCCGAGGCGCCGCGCGGGGTGCCGGTGTTCGCCTGGAAGGGCGAGACGCTGGAGGAGTACTGGG
ACTGCACCGAGCGCGCGCTCGACTTCGGCGGCGGCAAGGGCCCCACGCAGATCGTCGACGACGGCGGCGACGCCACCCTG
CTCATCCACAAGGGCGTCGAGTACGAGAAGGCGGGCAAGGTGCCGCCGCCCTCCAGCGCCGACTCCGAGGAGCTGGAGGT
GGTGCTGCGCCTGCTCGCCCGCGAGCAGAAGAAGGACCCGCGCCGCTGGACCCGGGTGGCGAAGGCCTGCGCCGGCGTGA
CCGAGGAGACCACCACCGGCGTGCACCGGCTCTACGAGATGCAGAAGGCCGGGACGCTGCTGTTCCCCGCCATCAACGTG
AACGACTCGGTCACGAAGTCCAAGTTCGACAACCTGTACGGCTGCCGCCACTCGCTGGTGGACGGGCTGAACCGCGCCAC
CGACGTGATGCTGGCCGGGAAGCTCTGCGTGGTCTGCGGTTACGGCGACGTGGGCAAGGGCTGCGCCCAGGCGCTGCGCG
GCCAGGGCGCGCGGGTGGTGGTCACCGAGATCGACCCCATCAACGCGCTGCAGGCGTCGATGGAGGGGTACCAGGTGGTG
CGGCTCGAGGACGTGGTGAAGGACGCCGACGTGTTCGTCACCGCGACCGGCAACCTGGACGTCGTCACCGTGGAGCACAT
GAAGGCGATGAAGGACTGCGCCATCGTCGGCAACATCGGCCACTTCGACAACGAGATCGACATGGCCGGGCTGCGCAAGC
TCACCACCCGGGTGAACATCAAGCCGCAGTACGACGCGTTCGTGTTCCCGGACGGCCACCGGGTGCTGGTGCTGGCCGAG
GGGCGGCTCCTCAACCTGGGCTGCGCCACCGGCCACCCGTCGTTCGTGATGTCGAACTCGTTCACCAACCAGACGCTGGC
GCAGATCGAGCTGGCGGTGAACCGCGCCGCCTACGCGAAGCAGGTGTACGTGCTCCCGAAGCACCTCGACGAGAAGGTGG
CCGCGCTGCACCTCGAGCAGATCGGCGCCCGCCTGACGAAGCTCACCAAGAAGCAGGCGGCCTACATCGGCGTGCCGCAG
TCCGGCCCGTTCAAGCCCGACCACTACCGCTACTAG

Upstream 100 bases:

>100_bases
GGCCCGGGGCTGGTCGCCTGCACCGGCGAGCGGCCCGCCCGGCCCTGACCGCGCCTCACCACCGACCTTCGACCCTCGTT
CCACGCAAAGGAGAAGCACC

Downstream 100 bases:

>100_bases
GCCGGGCGGACGATGAGCCTCGTCTCCGCGGCGCTGTTCGGGCTGCTCCAGGCGCTCACCGAGTTCCTCCCGGTGAGCTC
CACCGCGCACCTGCTGGTGT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MAVSAAKKKPTPSAPAPLEHKVKDLSLAGWGRKEIELAEKEMPGLMALRREHARQRPLAGQRITGSLHMTIQTAVLIETL
VDLGADVRWASCNIFSTQDHAAAAIVVGREGTPEAPRGVPVFAWKGETLEEYWDCTERALDFGGGKGPTQIVDDGGDATL
LIHKGVEYEKAGKVPPPSSADSEELEVVLRLLAREQKKDPRRWTRVAKACAGVTEETTTGVHRLYEMQKAGTLLFPAINV
NDSVTKSKFDNLYGCRHSLVDGLNRATDVMLAGKLCVVCGYGDVGKGCAQALRGQGARVVVTEIDPINALQASMEGYQVV
RLEDVVKDADVFVTATGNLDVVTVEHMKAMKDCAIVGNIGHFDNEIDMAGLRKLTTRVNIKPQYDAFVFPDGHRVLVLAE
GRLLNLGCATGHPSFVMSNSFTNQTLAQIELAVNRAAYAKQVYVLPKHLDEKVAALHLEQIGARLTKLTKKQAAYIGVPQ
SGPFKPDHYRY

Sequences:

>Translated_491_residues
MAVSAAKKKPTPSAPAPLEHKVKDLSLAGWGRKEIELAEKEMPGLMALRREHARQRPLAGQRITGSLHMTIQTAVLIETL
VDLGADVRWASCNIFSTQDHAAAAIVVGREGTPEAPRGVPVFAWKGETLEEYWDCTERALDFGGGKGPTQIVDDGGDATL
LIHKGVEYEKAGKVPPPSSADSEELEVVLRLLAREQKKDPRRWTRVAKACAGVTEETTTGVHRLYEMQKAGTLLFPAINV
NDSVTKSKFDNLYGCRHSLVDGLNRATDVMLAGKLCVVCGYGDVGKGCAQALRGQGARVVVTEIDPINALQASMEGYQVV
RLEDVVKDADVFVTATGNLDVVTVEHMKAMKDCAIVGNIGHFDNEIDMAGLRKLTTRVNIKPQYDAFVFPDGHRVLVLAE
GRLLNLGCATGHPSFVMSNSFTNQTLAQIELAVNRAAYAKQVYVLPKHLDEKVAALHLEQIGARLTKLTKKQAAYIGVPQ
SGPFKPDHYRY
>Mature_490_residues
AVSAAKKKPTPSAPAPLEHKVKDLSLAGWGRKEIELAEKEMPGLMALRREHARQRPLAGQRITGSLHMTIQTAVLIETLV
DLGADVRWASCNIFSTQDHAAAAIVVGREGTPEAPRGVPVFAWKGETLEEYWDCTERALDFGGGKGPTQIVDDGGDATLL
IHKGVEYEKAGKVPPPSSADSEELEVVLRLLAREQKKDPRRWTRVAKACAGVTEETTTGVHRLYEMQKAGTLLFPAINVN
DSVTKSKFDNLYGCRHSLVDGLNRATDVMLAGKLCVVCGYGDVGKGCAQALRGQGARVVVTEIDPINALQASMEGYQVVR
LEDVVKDADVFVTATGNLDVVTVEHMKAMKDCAIVGNIGHFDNEIDMAGLRKLTTRVNIKPQYDAFVFPDGHRVLVLAEG
RLLNLGCATGHPSFVMSNSFTNQTLAQIELAVNRAAYAKQVYVLPKHLDEKVAALHLEQIGARLTKLTKKQAAYIGVPQS
GPFKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=475, Percent_Identity=55.578947368421, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI239937451, Length=451, Percent_Identity=55.6541019955654, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI298286489, Length=490, Percent_Identity=46.734693877551, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI195539337, Length=472, Percent_Identity=48.3050847457627, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI24308043, Length=472, Percent_Identity=48.3050847457627, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI195539349, Length=490, Percent_Identity=46.734693877551, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI21361647, Length=491, Percent_Identity=46.4358452138493, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17506425, Length=483, Percent_Identity=55.2795031055901, Blast_Score=503, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6320882, Length=495, Percent_Identity=56.7676767676768, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24642172, Length=473, Percent_Identity=58.3509513742072, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24656245, Length=464, Percent_Identity=48.7068965517241, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553387, Length=471, Percent_Identity=47.9830148619958, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI45553385, Length=470, Percent_Identity=47.8723404255319, Blast_Score=419, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 53452; Mature: 53321

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSAAKKKPTPSAPAPLEHKVKDLSLAGWGRKEIELAEKEMPGLMALRREHARQRPLAG
CCCCCCCCCCCCCCCCCHHHHHHHCEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCC
QRITGSLHMTIQTAVLIETLVDLGADVRWASCNIFSTQDHAAAAIVVGREGTPEAPRGVP
CEECCEEEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCE
VFAWKGETLEEYWDCTERALDFGGGKGPTQIVDDGGDATLLIHKGVEYEKAGKVPPPSSA
EEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEECCCCHHHCCCCCCCCCC
DSEELEVVLRLLAREQKKDPRRWTRVAKACAGVTEETTTGVHRLYEMQKAGTLLFPAINV
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEECC
NDSVTKSKFDNLYGCRHSLVDGLNRATDVMLAGKLCVVCGYGDVGKGCAQALRGQGARVV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCCHHHHHHHHCCCCEEE
VTEIDPINALQASMEGYQVVRLEDVVKDADVFVTATGNLDVVTVEHMKAMKDCAIVGNIG
EEECCCHHHHHHHCCCEEEEEHHHHHCCCCEEEEECCCEEEEEHHHHHHHHHHEEECCCC
HFDNEIDMAGLRKLTTRVNIKPQYDAFVFPDGHRVLVLAEGRLLNLGCATGHPSFVMSNS
CCCCCCCHHHHHHHHHEEECCCCCCEEEECCCCEEEEEECCEEEEEEECCCCCCEEEECC
FTNQTLAQIELAVNRAAYAKQVYVLPKHLDEKVAALHLEQIGARLTKLTKKQAAYIGVPQ
CCCHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
SGPFKPDHYRY
CCCCCCCCCCC
>Mature Secondary Structure 
AVSAAKKKPTPSAPAPLEHKVKDLSLAGWGRKEIELAEKEMPGLMALRREHARQRPLAG
CCCCCCCCCCCCCCCCHHHHHHHCEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCC
QRITGSLHMTIQTAVLIETLVDLGADVRWASCNIFSTQDHAAAAIVVGREGTPEAPRGVP
CEECCEEEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCE
VFAWKGETLEEYWDCTERALDFGGGKGPTQIVDDGGDATLLIHKGVEYEKAGKVPPPSSA
EEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEECCCCHHHCCCCCCCCCC
DSEELEVVLRLLAREQKKDPRRWTRVAKACAGVTEETTTGVHRLYEMQKAGTLLFPAINV
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEECC
NDSVTKSKFDNLYGCRHSLVDGLNRATDVMLAGKLCVVCGYGDVGKGCAQALRGQGARVV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCCHHHHHHHHCCCCEEE
VTEIDPINALQASMEGYQVVRLEDVVKDADVFVTATGNLDVVTVEHMKAMKDCAIVGNIG
EEECCCHHHHHHHCCCEEEEEHHHHHCCCCEEEEECCCEEEEEHHHHHHHHHHEEECCCC
HFDNEIDMAGLRKLTTRVNIKPQYDAFVFPDGHRVLVLAEGRLLNLGCATGHPSFVMSNS
CCCCCCCHHHHHHHHHEEECCCCCCEEEECCCCEEEEEECCEEEEEEECCCCCCEEEECC
FTNQTLAQIELAVNRAAYAKQVYVLPKHLDEKVAALHLEQIGARLTKLTKKQAAYIGVPQ
CCCHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
SGPFKPDHYRY
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]