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The map label for this gene is patB [H]

Identifier: 220914740

GI number: 220914740

Start: 85807

End: 87045

Strand: Reverse

Name: patB [H]

Synonym: Mnod_7854

Alternate gene names: 220914740

Gene position: 87045-85807 (Counterclockwise)

Preceding gene: 220914741

Following gene: 220914739

Centisome position: 19.0

GC content: 52.3

Gene sequence:

>1239_bases
GTGGAGAATGTCGCCGCGAGATCAGGAAGCCCTGTTTCAAAGGTTATTGACGGTTCGATATTTGATGAAATCATTGAGCG
CAGGGATACAAATTCGCTGAAGTGGACCTACAGCGAGAAGCTGCTTGCTCCTGAAGAAGTGGCGGCCGGACCACTGCCTA
TGTGGGTGGCCGACACCGATTGGAGAGCACCGGCTCCGGTCATCGACGCATTGCAAGACGCGATCAAGCATGGGGTTTTC
GGCTACCCAGCTGGCGCCACCAACGGCTACATGAAAGCGGTCACGGACTGGCAGGCCAGAAGGTTCGGATGGGAGATAGC
GGAAGAGTGGGTCACGCAGACAGCCGGTATCATCACCGCGCTTAAGACGGCCGTACAAGCTTTCTCAAGCCCAGGCGATT
CGATACTGATCCAGCCGCCCGTCTATTCGCACTTCCATGACGATGTGTTGGTAAACGGTCGGCAGTTGGCACTCGCTCCC
TTGCTCCGCTGGGAGAACGGCTATCGATTCGATGAATCCATCTTTGAGGCTGCAATCGGAGAAGGCACCAAACTTTTTAT
TCTGAGCAATCCCCACAACCCGACAGGCAATGTATGGTCCGAAGCCGAACTTCGGGTGATGGGGGAGATCTGTCTGCGCC
ATAACGTTCTAGTGCTTTCTGATGAAATTCATCAGGATCTCATTATCAATCCTGAGAAGCGGCATATTCCATTTGCCTCC
ATCAGTGAGGAGTTTGCGCAAAATAGCATTACCTGCACCGCTCCGAGCAAAACATTCAATTTGGCAGGTCTACAATGTGC
GAATATATTCATCCCAAATGCTAGAATTCGCAATCAATTCGCTAGGCAGTACAATCGTAACGTCTACCCGCGTGTGAACG
TGTTGGGCATGGTCGCGACCGAGGCAGCCTATAGTGAAGGCGAGCCATGGCTGGAAGAGATGTTGATCTATCTCCGGACA
AATCATGACCATTTCGCAAGTTCAATTAACAATAGTCTTTCAAAGATCAAGGTTCTTCCTGCGGACTCGCTCTACCTAGC
TTGGATGGATTGTCGTGGTCTGGGTTTGGATGCAGAGACGCTCGATAAGTTAATGCTTACAAAGGCCAGAGTCTGGCTCG
ACAAGGGTCAGAAGTTCGGGGCTGAAGGCAGGGGCTACATGCGTGCGAATCTTGGATGCCCTCGTTCGACAGTCGACGTG
GCGATAAACCGGCTGATTTCCACGTTCCGTGCTGCGTGA

Upstream 100 bases:

>100_bases
TCGGCGAATTATACGTCGTATCATCTGCGCGCTTGCATCAGTCGTGAAGGGCGATCGGCCCACACGGTAGGTTGCCTAGC
CACGAAGAAGGAAGCAAGTT

Downstream 100 bases:

>100_bases
GTGTCAAACTCGGCGTTGCCAAAACTTGAGGCGGCCTTTGCTGCGGTTTTCCGCCGCAAGGCCCATCGTCGCCGGTTCGC
GGCGTGAGCGCGATCATCGA

Product: aminotransferase class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MENVAARSGSPVSKVIDGSIFDEIIERRDTNSLKWTYSEKLLAPEEVAAGPLPMWVADTDWRAPAPVIDALQDAIKHGVF
GYPAGATNGYMKAVTDWQARRFGWEIAEEWVTQTAGIITALKTAVQAFSSPGDSILIQPPVYSHFHDDVLVNGRQLALAP
LLRWENGYRFDESIFEAAIGEGTKLFILSNPHNPTGNVWSEAELRVMGEICLRHNVLVLSDEIHQDLIINPEKRHIPFAS
ISEEFAQNSITCTAPSKTFNLAGLQCANIFIPNARIRNQFARQYNRNVYPRVNVLGMVATEAAYSEGEPWLEEMLIYLRT
NHDHFASSINNSLSKIKVLPADSLYLAWMDCRGLGLDAETLDKLMLTKARVWLDKGQKFGAEGRGYMRANLGCPRSTVDV
AINRLISTFRAA

Sequences:

>Translated_412_residues
MENVAARSGSPVSKVIDGSIFDEIIERRDTNSLKWTYSEKLLAPEEVAAGPLPMWVADTDWRAPAPVIDALQDAIKHGVF
GYPAGATNGYMKAVTDWQARRFGWEIAEEWVTQTAGIITALKTAVQAFSSPGDSILIQPPVYSHFHDDVLVNGRQLALAP
LLRWENGYRFDESIFEAAIGEGTKLFILSNPHNPTGNVWSEAELRVMGEICLRHNVLVLSDEIHQDLIINPEKRHIPFAS
ISEEFAQNSITCTAPSKTFNLAGLQCANIFIPNARIRNQFARQYNRNVYPRVNVLGMVATEAAYSEGEPWLEEMLIYLRT
NHDHFASSINNSLSKIKVLPADSLYLAWMDCRGLGLDAETLDKLMLTKARVWLDKGQKFGAEGRGYMRANLGCPRSTVDV
AINRLISTFRAA
>Mature_412_residues
MENVAARSGSPVSKVIDGSIFDEIIERRDTNSLKWTYSEKLLAPEEVAAGPLPMWVADTDWRAPAPVIDALQDAIKHGVF
GYPAGATNGYMKAVTDWQARRFGWEIAEEWVTQTAGIITALKTAVQAFSSPGDSILIQPPVYSHFHDDVLVNGRQLALAP
LLRWENGYRFDESIFEAAIGEGTKLFILSNPHNPTGNVWSEAELRVMGEICLRHNVLVLSDEIHQDLIINPEKRHIPFAS
ISEEFAQNSITCTAPSKTFNLAGLQCANIFIPNARIRNQFARQYNRNVYPRVNVLGMVATEAAYSEGEPWLEEMLIYLRT
NHDHFASSINNSLSKIKVLPADSLYLAWMDCRGLGLDAETLDKLMLTKARVWLDKGQKFGAEGRGYMRANLGCPRSTVDV
AINRLISTFRAA

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=227, Percent_Identity=25.9911894273128, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI56713256, Length=227, Percent_Identity=25.9911894273128, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4507369, Length=297, Percent_Identity=24.5791245791246, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI95147551, Length=233, Percent_Identity=25.3218884120172, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI169881279, Length=233, Percent_Identity=25.3218884120172, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787909, Length=393, Percent_Identity=30.7888040712468, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1786816, Length=328, Percent_Identity=23.1707317073171, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994472, Length=215, Percent_Identity=26.5116279069767, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=215, Percent_Identity=26.5116279069767, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322401, Length=194, Percent_Identity=26.8041237113402, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573069, Length=172, Percent_Identity=29.6511627906977, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646114, Length=172, Percent_Identity=29.6511627906977, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573067, Length=172, Percent_Identity=29.6511627906977, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573065, Length=172, Percent_Identity=29.6511627906977, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859735, Length=380, Percent_Identity=21.8421052631579, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45923; Mature: 45923

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVAARSGSPVSKVIDGSIFDEIIERRDTNSLKWTYSEKLLAPEEVAAGPLPMWVADTD
CCCCCCCCCCCHHHHHCHHHHHHHHHHCCCCCEEEEHHCCCCCCHHHCCCCCCEEEECCC
WRAPAPVIDALQDAIKHGVFGYPAGATNGYMKAVTDWQARRFGWEIAEEWVTQTAGIITA
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKTAVQAFSSPGDSILIQPPVYSHFHDDVLVNGRQLALAPLLRWENGYRFDESIFEAAIG
HHHHHHHHCCCCCEEEECCCCHHCCCCCEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHC
EGTKLFILSNPHNPTGNVWSEAELRVMGEICLRHNVLVLSDEIHQDLIINPEKRHIPFAS
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCEECCCHHCCCHHH
ISEEFAQNSITCTAPSKTFNLAGLQCANIFIPNARIRNQFARQYNRNVYPRVNVLGMVAT
HHHHHHCCCEEEECCCCCEECCCEEEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEHHH
EAAYSEGEPWLEEMLIYLRTNHDHFASSINNSLSKIKVLPADSLYLAWMDCRGLGLDAET
HHHCCCCCHHHHHHHHHHCCCCHHHHHHHHCHHHEEEEECCCCEEEEEEECCCCCCCHHH
LDKLMLTKARVWLDKGQKFGAEGRGYMRANLGCPRSTVDVAINRLISTFRAA
HHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MENVAARSGSPVSKVIDGSIFDEIIERRDTNSLKWTYSEKLLAPEEVAAGPLPMWVADTD
CCCCCCCCCCCHHHHHCHHHHHHHHHHCCCCCEEEEHHCCCCCCHHHCCCCCCEEEECCC
WRAPAPVIDALQDAIKHGVFGYPAGATNGYMKAVTDWQARRFGWEIAEEWVTQTAGIITA
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKTAVQAFSSPGDSILIQPPVYSHFHDDVLVNGRQLALAPLLRWENGYRFDESIFEAAIG
HHHHHHHHCCCCCEEEECCCCHHCCCCCEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHC
EGTKLFILSNPHNPTGNVWSEAELRVMGEICLRHNVLVLSDEIHQDLIINPEKRHIPFAS
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCEECCCHHCCCHHH
ISEEFAQNSITCTAPSKTFNLAGLQCANIFIPNARIRNQFARQYNRNVYPRVNVLGMVAT
HHHHHHCCCEEEECCCCCEECCCEEEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEHHH
EAAYSEGEPWLEEMLIYLRTNHDHFASSINNSLSKIKVLPADSLYLAWMDCRGLGLDAET
HHHCCCCCHHHHHHHHHHCCCCHHHHHHHHCHHHEEEEECCCCEEEEEEECCCCCCCHHH
LDKLMLTKARVWLDKGQKFGAEGRGYMRANLGCPRSTVDVAINRLISTFRAA
HHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]