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The map label for this gene is ppiD [H]

Identifier: 220905632

GI number: 220905632

Start: 2859312

End: 2861231

Strand: Reverse

Name: ppiD [H]

Synonym: Ddes_2372

Alternate gene names: 220905632

Gene position: 2861231-2859312 (Counterclockwise)

Preceding gene: 220905633

Following gene: 220905631

Centisome position: 99.58

GC content: 59.27

Gene sequence:

>1920_bases
ATGCTTGAGTATATTCGCGACAAATCGCAGTCCCTGGGTGTCAAACTGGCCTTTGGTCTTATCATCCTTGTCTTTGTTTT
CTGGGGCGTTGGCAACTTCAACGACCGCAGTTCGGGTACGCTTGTGGCCGTGGTCAACGGCGACCCCATCTCCATGCGGG
AGTTTGAGCTGGCCTACCGCAACGCAGAGGAAAACCTGCTGCGCAGCAATCCCGGCCTGACCCGCGAGCAACTGAAGCAG
CAACAGCTGGGTCGCCAGATTCTGCGTGACCTTATTACCCAGGTGCTGCTGTCGCAGGAAGCGGCCCGCACGGGCGTGAG
CATCACCCCGCTGGAACTGCGCATGGCCGTGGGCAACATCAAGGGCTTCCAGAACGAAAAGGGGCAGTTTGACCCCGAGG
TCTATACCCGCGTTCTTGCTGCCCAGCGCATGGCTCCTGCCCAGTTCGAGCAGGATATGTCGCGCGATCTGCTGCGTCAG
AAGATTTTTGCCATGGTAACGGCCCCCGCCTGGGTTGACCCCGCCGAATCCCAGAAGCGGTTTGAATTTTTGCGCGAAAA
GCGTGATGTGGACTATATTTTTATCCCTGCCTCGGATTTTGCCGCTTCCGTCAAGCCGTCGGATGAAGAGGTGCAGGCCT
ATTATGAAAGCCACAAGGCGCAGTTTGCCATTCCTGCCAGGGCGGATGTTGCGTACGTGCTTGTAAGCCCGCAGGATCTT
GTGAAGGCTAGTGGCATCAGTTCCGCCGCTGCCGAAAAATGGTATGCAGACAATGCCGCCCGTTTCGAACAGCAGGAAGA
AGTGAAGGCCGCCCACATTCTTGTGCCTCTGGCTGAAGATGCCTCTGAGGCCGATGTGAAAAAAGCGCAGGAACAGGCCG
CCGCCATTGAAGCCGAACTTAAGGCCGGAAAAAGCTTTGCTGCCGTGGCCGATGCGCATAACGGTCCCAATGCCGCAGGG
CCGGGCGGCGAGCTTGGCTGGCTCAAGCGCGGCACTACCGTAAAGCCTTTTGAGGACGCGGCGTTCGCCCTTGCTCCCGG
CAAGGTTTCCGCCCCGGTTCGCAGTCAGTTTGGCCTGCATATCATCAAGGTTGAAGAAAAGAAGGACGGCGGCTTGCCGC
CTTTCAAGCAGGTTGAAGCTGAAGTTCTTGCGGCCATGGCCCAGGAACAGGGGGCGGACAAGCTGCATGACGTGGTCGAC
AACCTGATTGAAGACAATATTCTGGGCCGTTCCCTGAAGGACAGCGCGGAAAAATACGGTCTCAAGTGGGGTGAAACCGG
TCTGCTTTCCGCTGCCGAGCTTGAAAAAACGCTGGGAGTCACGGCCCAGGGCGCGGCCACTCTTGTGGCAACCCCGGCGG
GCAATCCTGTCGATACGGCCCTTGAAGCCGGAAAAGCCTACGTGGTTGCCCGCGTGATCAAGTCCGAACCCGCGTCCACA
GCGTCACTTGAAGCTGTCAAGGAGCGTATTGTGGCCGGGCTTGTGGAAGAAAAAGCGCTTGCAGCCGCCCTGGAATCTGC
CGCAGCCCTGCGCAAGGAGCTTGAAAACGCCCCCCTGGGCGCCGCAGGCCTCAAGGGGCGCACGGTCAAGACCGTCAAGG
GGATGGAGCGCAACGGCGCACTGGCTTCGTTCGGTCCCAATCCGGTCATGGCCGAGGCCCTGTTTGAAGCCCGCGCCGGG
CAGTGGCTGCCTGTGGCCTATGCCGTGGAAGACGGCAGCGGTTCCGGTGCCGTTGTGGTGCGCGTCAAGGGCGTTCAGCC
CCCTGATGCCGCCGAATGGGATATGGTCAAGGACATCATGGCCAACGCCGTGGCCCGTGACCGCGCGGACGGCCTGTTTG
AAATATTCATGCAGCGTCTGGCTTCCGGCGCCAAGGTCGAAGTGTACAACGAAGATTTCATAGACAGAAAAAATATGTAG

Upstream 100 bases:

>100_bases
AGCAGCACGTCAAAATCAGCCATGACCTTTCTTGAGTTTCCGCTGGATTGCGCATATGATGCCGCTCTACGTCAAGAGCA
ATTACGCAGTCGGAGTTCGC

Downstream 100 bases:

>100_bases
CAAGGCCCGCGCGCCTGGAACAGGAATATACTGGCCGGGGCCGCTTGACGGTTCCGGCCTTCTTTGTCAGAGCAAGGCAG
ACCGCCCGAAGGCGGAGACG

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MLEYIRDKSQSLGVKLAFGLIILVFVFWGVGNFNDRSSGTLVAVVNGDPISMREFELAYRNAEENLLRSNPGLTREQLKQ
QQLGRQILRDLITQVLLSQEAARTGVSITPLELRMAVGNIKGFQNEKGQFDPEVYTRVLAAQRMAPAQFEQDMSRDLLRQ
KIFAMVTAPAWVDPAESQKRFEFLREKRDVDYIFIPASDFAASVKPSDEEVQAYYESHKAQFAIPARADVAYVLVSPQDL
VKASGISSAAAEKWYADNAARFEQQEEVKAAHILVPLAEDASEADVKKAQEQAAAIEAELKAGKSFAAVADAHNGPNAAG
PGGELGWLKRGTTVKPFEDAAFALAPGKVSAPVRSQFGLHIIKVEEKKDGGLPPFKQVEAEVLAAMAQEQGADKLHDVVD
NLIEDNILGRSLKDSAEKYGLKWGETGLLSAAELEKTLGVTAQGAATLVATPAGNPVDTALEAGKAYVVARVIKSEPAST
ASLEAVKERIVAGLVEEKALAAALESAAALRKELENAPLGAAGLKGRTVKTVKGMERNGALASFGPNPVMAEALFEARAG
QWLPVAYAVEDGSGSGAVVVRVKGVQPPDAAEWDMVKDIMANAVARDRADGLFEIFMQRLASGAKVEVYNEDFIDRKNM

Sequences:

>Translated_639_residues
MLEYIRDKSQSLGVKLAFGLIILVFVFWGVGNFNDRSSGTLVAVVNGDPISMREFELAYRNAEENLLRSNPGLTREQLKQ
QQLGRQILRDLITQVLLSQEAARTGVSITPLELRMAVGNIKGFQNEKGQFDPEVYTRVLAAQRMAPAQFEQDMSRDLLRQ
KIFAMVTAPAWVDPAESQKRFEFLREKRDVDYIFIPASDFAASVKPSDEEVQAYYESHKAQFAIPARADVAYVLVSPQDL
VKASGISSAAAEKWYADNAARFEQQEEVKAAHILVPLAEDASEADVKKAQEQAAAIEAELKAGKSFAAVADAHNGPNAAG
PGGELGWLKRGTTVKPFEDAAFALAPGKVSAPVRSQFGLHIIKVEEKKDGGLPPFKQVEAEVLAAMAQEQGADKLHDVVD
NLIEDNILGRSLKDSAEKYGLKWGETGLLSAAELEKTLGVTAQGAATLVATPAGNPVDTALEAGKAYVVARVIKSEPAST
ASLEAVKERIVAGLVEEKALAAALESAAALRKELENAPLGAAGLKGRTVKTVKGMERNGALASFGPNPVMAEALFEARAG
QWLPVAYAVEDGSGSGAVVVRVKGVQPPDAAEWDMVKDIMANAVARDRADGLFEIFMQRLASGAKVEVYNEDFIDRKNM
>Mature_639_residues
MLEYIRDKSQSLGVKLAFGLIILVFVFWGVGNFNDRSSGTLVAVVNGDPISMREFELAYRNAEENLLRSNPGLTREQLKQ
QQLGRQILRDLITQVLLSQEAARTGVSITPLELRMAVGNIKGFQNEKGQFDPEVYTRVLAAQRMAPAQFEQDMSRDLLRQ
KIFAMVTAPAWVDPAESQKRFEFLREKRDVDYIFIPASDFAASVKPSDEEVQAYYESHKAQFAIPARADVAYVLVSPQDL
VKASGISSAAAEKWYADNAARFEQQEEVKAAHILVPLAEDASEADVKKAQEQAAAIEAELKAGKSFAAVADAHNGPNAAG
PGGELGWLKRGTTVKPFEDAAFALAPGKVSAPVRSQFGLHIIKVEEKKDGGLPPFKQVEAEVLAAMAQEQGADKLHDVVD
NLIEDNILGRSLKDSAEKYGLKWGETGLLSAAELEKTLGVTAQGAATLVATPAGNPVDTALEAGKAYVVARVIKSEPAST
ASLEAVKERIVAGLVEEKALAAALESAAALRKELENAPLGAAGLKGRTVKTVKGMERNGALASFGPNPVMAEALFEARAG
QWLPVAYAVEDGSGSGAVVVRVKGVQPPDAAEWDMVKDIMANAVARDRADGLFEIFMQRLASGAKVEVYNEDFIDRKNM

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein; Periplasmic side (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=655, Percent_Identity=23.6641221374046, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1786238, Length=100, Percent_Identity=34, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17537235, Length=109, Percent_Identity=40.3669724770642, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 68891; Mature: 68891

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEYIRDKSQSLGVKLAFGLIILVFVFWGVGNFNDRSSGTLVAVVNGDPISMREFELAYR
CCCHHHCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHH
NAEENLLRSNPGLTREQLKQQQLGRQILRDLITQVLLSQEAARTGVSITPLELRMAVGNI
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
KGFQNEKGQFDPEVYTRVLAAQRMAPAQFEQDMSRDLLRQKIFAMVTAPAWVDPAESQKR
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
FEFLREKRDVDYIFIPASDFAASVKPSDEEVQAYYESHKAQFAIPARADVAYVLVSPQDL
HHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCEEEEEECCHHH
VKASGISSAAAEKWYADNAARFEQQEEVKAAHILVPLAEDASEADVKKAQEQAAAIEAEL
HHHCCCCHHHHHHHHCCCHHHHHHHHHHCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHH
KAGKSFAAVADAHNGPNAAGPGGELGWLKRGTTVKPFEDAAFALAPGKVSAPVRSQFGLH
HCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHCCCEE
IIKVEEKKDGGLPPFKQVEAEVLAAMAQEQGADKLHDVVDNLIEDNILGRSLKDSAEKYG
EEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
LKWGETGLLSAAELEKTLGVTAQGAATLVATPAGNPVDTALEAGKAYVVARVIKSEPAST
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHCCHHHHHHHHHHCCCCCH
ASLEAVKERIVAGLVEEKALAAALESAAALRKELENAPLGAAGLKGRTVKTVKGMERNGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHCCCCCCCC
LASFGPNPVMAEALFEARAGQWLPVAYAVEDGSGSGAVVVRVKGVQPPDAAEWDMVKDIM
EECCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHH
ANAVARDRADGLFEIFMQRLASGAKVEVYNEDFIDRKNM
HHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MLEYIRDKSQSLGVKLAFGLIILVFVFWGVGNFNDRSSGTLVAVVNGDPISMREFELAYR
CCCHHHCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHH
NAEENLLRSNPGLTREQLKQQQLGRQILRDLITQVLLSQEAARTGVSITPLELRMAVGNI
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
KGFQNEKGQFDPEVYTRVLAAQRMAPAQFEQDMSRDLLRQKIFAMVTAPAWVDPAESQKR
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
FEFLREKRDVDYIFIPASDFAASVKPSDEEVQAYYESHKAQFAIPARADVAYVLVSPQDL
HHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCEEEEEECCHHH
VKASGISSAAAEKWYADNAARFEQQEEVKAAHILVPLAEDASEADVKKAQEQAAAIEAEL
HHHCCCCHHHHHHHHCCCHHHHHHHHHHCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHH
KAGKSFAAVADAHNGPNAAGPGGELGWLKRGTTVKPFEDAAFALAPGKVSAPVRSQFGLH
HCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHCCCEE
IIKVEEKKDGGLPPFKQVEAEVLAAMAQEQGADKLHDVVDNLIEDNILGRSLKDSAEKYG
EEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
LKWGETGLLSAAELEKTLGVTAQGAATLVATPAGNPVDTALEAGKAYVVARVIKSEPAST
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHCCHHHHHHHHHHCCCCCH
ASLEAVKERIVAGLVEEKALAAALESAAALRKELENAPLGAAGLKGRTVKTVKGMERNGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHCCCCCCCC
LASFGPNPVMAEALFEARAGQWLPVAYAVEDGSGSGAVVVRVKGVQPPDAAEWDMVKDIM
EECCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHH
ANAVARDRADGLFEIFMQRLASGAKVEVYNEDFIDRKNM
HHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]