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The map label for this gene is glmS [H]

Identifier: 220905631

GI number: 220905631

Start: 2857321

End: 2859147

Strand: Reverse

Name: glmS [H]

Synonym: Ddes_2371

Alternate gene names: 220905631

Gene position: 2859147-2857321 (Counterclockwise)

Preceding gene: 220905632

Following gene: 220905630

Centisome position: 99.5

GC content: 61.14

Gene sequence:

>1827_bases
ATGTGCGGTATTATAGGTTATGCAGGACACAGGCCGGCCGTTCCCGTTGTAGTGGAAGGGCTGCGCAGGCTTGAATACCG
GGGTTATGATTCCGCCGGCGTGGCCTTTGTGCGCCAGAATGACATCCATGTCGTGCGTGCCATGGGCAAGCTGGCCGCAC
TTGAAGAAAAACTCGCCCATGAGCCGGTGACCACGCCTACCTGCGCCATGGGGCATACCCGCTGGGCCACGCACGGCGTA
CCCGCCGAGCGCAACGCCCATCCCCACCGCAGCAATGACGGCTCCCTGGCCCTCGTGCATAACGGCATTATCGAAAACTA
TCAGGAAATAAAGGCGGACCTTTCGGCCAAGGGCTATACGTTCAGCTCTGAAACCGACACGGAAGTGCTGGTCAATCTTA
TTGCCGAACGCCGCAAGACCGAGCCGGACCTTCTGCACGCTTTTGCCGCCGCCCTGCGCGAGGCCCACGGGGCCTACGCT
GTCTGCCTTATGGACAGGACGGAACCCGGCGTTATCTATGCGGCCCGCATGTCCGCCCCGCTTATTTTCGGCCAGGGAAC
AGGCGAAAATTTTGTGGCTTCGGATATTCCGGCATTTCTGCCGTACACCCGGCAGGTGGTCTTTTTGCAGGACGGGGATC
TTGTGCGTGCCACGGCCGACAGTTACGAGATACTCCGGCTTGAGGACCTCAGCCCCGTAAGCCACGAAACGCAGACCATC
CAGTGGGATATGCAGGCCGCGCAAAAGGGCGGGTACCGCCACTTCATGCTCAAGGAAATCTTCGAGCAGCCGCGCGTCAT
CACCGATGGCCTCACCGGCCGCGCACATGCGCAGCAAGGGCAGGTGCGCCTGCCCGAGCTGGATGCACTGCCTGTGCCGC
GCCGCCTGCACATTGTGGCCTGCGGCACGTCGTACCACTCCGGCCTGTGGGGACGGCACCTGCTGGAGCACTGGGCGCGT
GTTCCTGTGCAGGTGGAAATAGCCTCGGAATTCCGCTACCGCGATACCCTGCTGCTGGACAAGGACGACATGGTGCTTGT
CATCAGCCAGAGCGGTGAAACGGCCGACACCCTTGCGGCCCTGCGCATTGCGCGCCAGAGCGGCGTCACCGTGCTCGGCC
TGTGCAATGTGGTAGGCTCGTCCATTGCCCGTGAGGCCTCAGCCGTGCTTTACACCCAGGCCGGGCCTGAAATCAGCGTG
GCATCCACCAAGGCCATGTGCAGCCAGATGCTCATGCTGACCCTCATGGCGCTCTATTGGGGTACGCGCAGGGGTTGCCT
GTCTGCCGGGGAGTGCCGTGAACATCTTACGGTTCTTGAAAACCTGCCCGCCCTGCTGGACGACAGCCTGCCCGCCCTGC
ACGAACGTGCTAAAGAAATCGCGCGCAAGTACTCCCAGGTGCGCAACTTCTTCTATCTCGGGCGGGGGCATTGCTATCCG
CTGGCTCTGGAGGGGGCGCTCAAGCTCAAGGAGCTTTCCTACATCCATGCTGAAGGCTATGCCGCGGGCGAGATGAAGCA
CGGTCCCATCGCCCTCATTGATCCGGATTTTCCCACTTTTGCCCTGGCCCTGAATGACGCACTGCTGCCCAAGGTCAAGT
CCAACATGGTAGAGGTGCAGGCCCGGCAGGGCAAGGTTATTGCCCTGACCAACAAAGGGGTGGAGCTGGATGCTGAAGAC
AGGTGGGATATTCCCGAGCTGCCCGCGCCGCTTTCCGCCTTTGCGGCGTTGCCTGCGCTGCAGCTTTTCAGCTACGAAAC
CGCGGATTATCTCGGCAAGGATGTGGATCAGCCCCGAAATCTTGCCAAAAGTGTAACGGTTGAATAG

Upstream 100 bases:

>100_bases
TGTCAGAGCAAGGCAGACCGCCCGAAGGCGGAGACGTTCCAGTGCCGCCCTGCCCGCGCCACCCGGCCGGAAGCTTTGGC
GGTATACAAGGAGGCACGTT

Downstream 100 bases:

>100_bases
CATATAGATATTAAAATATTATAAATTCTATTTGCCGGCCCGGAGTTTTCCGGGTCGGCTTTTTTGTTATTCTAATGGAT
TATGAAAATTTCTCTTTGCG

Product: glucosamine/fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIIGYAGHRPAVPVVVEGLRRLEYRGYDSAGVAFVRQNDIHVVRAMGKLAALEEKLAHEPVTTPTCAMGHTRWATHGV
PAERNAHPHRSNDGSLALVHNGIIENYQEIKADLSAKGYTFSSETDTEVLVNLIAERRKTEPDLLHAFAAALREAHGAYA
VCLMDRTEPGVIYAARMSAPLIFGQGTGENFVASDIPAFLPYTRQVVFLQDGDLVRATADSYEILRLEDLSPVSHETQTI
QWDMQAAQKGGYRHFMLKEIFEQPRVITDGLTGRAHAQQGQVRLPELDALPVPRRLHIVACGTSYHSGLWGRHLLEHWAR
VPVQVEIASEFRYRDTLLLDKDDMVLVISQSGETADTLAALRIARQSGVTVLGLCNVVGSSIAREASAVLYTQAGPEISV
ASTKAMCSQMLMLTLMALYWGTRRGCLSAGECREHLTVLENLPALLDDSLPALHERAKEIARKYSQVRNFFYLGRGHCYP
LALEGALKLKELSYIHAEGYAAGEMKHGPIALIDPDFPTFALALNDALLPKVKSNMVEVQARQGKVIALTNKGVELDAED
RWDIPELPAPLSAFAALPALQLFSYETADYLGKDVDQPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIIGYAGHRPAVPVVVEGLRRLEYRGYDSAGVAFVRQNDIHVVRAMGKLAALEEKLAHEPVTTPTCAMGHTRWATHGV
PAERNAHPHRSNDGSLALVHNGIIENYQEIKADLSAKGYTFSSETDTEVLVNLIAERRKTEPDLLHAFAAALREAHGAYA
VCLMDRTEPGVIYAARMSAPLIFGQGTGENFVASDIPAFLPYTRQVVFLQDGDLVRATADSYEILRLEDLSPVSHETQTI
QWDMQAAQKGGYRHFMLKEIFEQPRVITDGLTGRAHAQQGQVRLPELDALPVPRRLHIVACGTSYHSGLWGRHLLEHWAR
VPVQVEIASEFRYRDTLLLDKDDMVLVISQSGETADTLAALRIARQSGVTVLGLCNVVGSSIAREASAVLYTQAGPEISV
ASTKAMCSQMLMLTLMALYWGTRRGCLSAGECREHLTVLENLPALLDDSLPALHERAKEIARKYSQVRNFFYLGRGHCYP
LALEGALKLKELSYIHAEGYAAGEMKHGPIALIDPDFPTFALALNDALLPKVKSNMVEVQARQGKVIALTNKGVELDAED
RWDIPELPAPLSAFAALPALQLFSYETADYLGKDVDQPRNLAKSVTVE
>Mature_608_residues
MCGIIGYAGHRPAVPVVVEGLRRLEYRGYDSAGVAFVRQNDIHVVRAMGKLAALEEKLAHEPVTTPTCAMGHTRWATHGV
PAERNAHPHRSNDGSLALVHNGIIENYQEIKADLSAKGYTFSSETDTEVLVNLIAERRKTEPDLLHAFAAALREAHGAYA
VCLMDRTEPGVIYAARMSAPLIFGQGTGENFVASDIPAFLPYTRQVVFLQDGDLVRATADSYEILRLEDLSPVSHETQTI
QWDMQAAQKGGYRHFMLKEIFEQPRVITDGLTGRAHAQQGQVRLPELDALPVPRRLHIVACGTSYHSGLWGRHLLEHWAR
VPVQVEIASEFRYRDTLLLDKDDMVLVISQSGETADTLAALRIARQSGVTVLGLCNVVGSSIAREASAVLYTQAGPEISV
ASTKAMCSQMLMLTLMALYWGTRRGCLSAGECREHLTVLENLPALLDDSLPALHERAKEIARKYSQVRNFFYLGRGHCYP
LALEGALKLKELSYIHAEGYAAGEMKHGPIALIDPDFPTFALALNDALLPKVKSNMVEVQARQGKVIALTNKGVELDAED
RWDIPELPAPLSAFAALPALQLFSYETADYLGKDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=37.2634643377001, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=34.1605839416058, Blast_Score=381, Evalue=1e-106,
Organism=Escherichia coli, GI1790167, Length=623, Percent_Identity=45.4253611556982, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1788651, Length=173, Percent_Identity=29.4797687861272, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI87082251, Length=256, Percent_Identity=22.65625, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=41.3394919168591, Blast_Score=286, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17532899, Length=480, Percent_Identity=38.5416666666667, Blast_Score=282, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17532897, Length=480, Percent_Identity=38.5416666666667, Blast_Score=281, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6322745, Length=435, Percent_Identity=40.2298850574713, Blast_Score=273, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6323731, Length=434, Percent_Identity=30.8755760368664, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=33.8164251207729, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357745, Length=695, Percent_Identity=36.2589928057554, Blast_Score=402, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66872; Mature: 66872

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGYAGHRPAVPVVVEGLRRLEYRGYDSAGVAFVRQNDIHVVRAMGKLAALEEKLAH
CCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
EPVTTPTCAMGHTRWATHGVPAERNAHPHRSNDGSLALVHNGIIENYQEIKADLSAKGYT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCEE
FSSETDTEVLVNLIAERRKTEPDLLHAFAAALREAHGAYAVCLMDRTEPGVIYAARMSAP
ECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCC
LIFGQGTGENFVASDIPAFLPYTRQVVFLQDGDLVRATADSYEILRLEDLSPVSHETQTI
EEEECCCCCCCCHHCCCHHCCCCEEEEEEECCCEEEEECCCEEEEEEECCCCCCCCCEEE
QWDMQAAQKGGYRHFMLKEIFEQPRVITDGLTGRAHAQQGQVRLPELDALPVPRRLHIVA
EEEHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCEECCCCCCCCCCCEEEEEE
CGTSYHSGLWGRHLLEHWARVPVQVEIASEFRYRDTLLLDKDDMVLVISQSGETADTLAA
ECCCHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCCCEEEEEECCCCCHHHHHH
LRIARQSGVTVLGLCNVVGSSIAREASAVLYTQAGPEISVASTKAMCSQMLMLTLMALYW
HHHHHHCCCEEEEHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHH
GTRRGCLSAGECREHLTVLENLPALLDDSLPALHERAKEIARKYSQVRNFFYLGRGHCYP
CCCCCCCCHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCEEE
LALEGALKLKELSYIHAEGYAAGEMKHGPIALIDPDFPTFALALNDALLPKVKSNMVEVQ
EEECCCHHHHHHHEEECCCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHEEEE
ARQGKVIALTNKGVELDAEDRWDIPELPAPLSAFAALPALQLFSYETADYLGKDVDQPRN
ECCCCEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCHHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIIGYAGHRPAVPVVVEGLRRLEYRGYDSAGVAFVRQNDIHVVRAMGKLAALEEKLAH
CCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
EPVTTPTCAMGHTRWATHGVPAERNAHPHRSNDGSLALVHNGIIENYQEIKADLSAKGYT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCEE
FSSETDTEVLVNLIAERRKTEPDLLHAFAAALREAHGAYAVCLMDRTEPGVIYAARMSAP
ECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCC
LIFGQGTGENFVASDIPAFLPYTRQVVFLQDGDLVRATADSYEILRLEDLSPVSHETQTI
EEEECCCCCCCCHHCCCHHCCCCEEEEEEECCCEEEEECCCEEEEEEECCCCCCCCCEEE
QWDMQAAQKGGYRHFMLKEIFEQPRVITDGLTGRAHAQQGQVRLPELDALPVPRRLHIVA
EEEHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCEECCCCCCCCCCCEEEEEE
CGTSYHSGLWGRHLLEHWARVPVQVEIASEFRYRDTLLLDKDDMVLVISQSGETADTLAA
ECCCHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCCCEEEEEECCCCCHHHHHH
LRIARQSGVTVLGLCNVVGSSIAREASAVLYTQAGPEISVASTKAMCSQMLMLTLMALYW
HHHHHHCCCEEEEHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHH
GTRRGCLSAGECREHLTVLENLPALLDDSLPALHERAKEIARKYSQVRNFFYLGRGHCYP
CCCCCCCCHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCEEE
LALEGALKLKELSYIHAEGYAAGEMKHGPIALIDPDFPTFALALNDALLPKVKSNMVEVQ
EEECCCHHHHHHHEEECCCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHEEEE
ARQGKVIALTNKGVELDAEDRWDIPELPAPLSAFAALPALQLFSYETADYLGKDVDQPRN
ECCCCEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCHHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA