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The map label for this gene is capL [H]

Identifier: 220905172

GI number: 220905172

Start: 2299691

End: 2301004

Strand: Direct

Name: capL [H]

Synonym: Ddes_1910

Alternate gene names: 220905172

Gene position: 2299691-2301004 (Clockwise)

Preceding gene: 220905170

Following gene: 220905173

Centisome position: 80.03

GC content: 61.8

Gene sequence:

>1314_bases
ATGGTGACATTCGAGGCCCTGCAACAAGGCAAAGAAACCCTGGCCGTCGTCGGCCTCGGCTATGTGGGTCTGCCCCTGGC
CGTTGCCCTCTCGCGCCAGATGAGCGTACTGGGGTTTGATATCAGCGCCCCGCGCATCAAGGAACTGCAAGACGGGCACG
ACCGCACACGCGAAGTGGACGACCACAGGCTGCAGGCCGCCAATGTGCGTTATTCCTGCGACCCGGCCGACCTCAGGGAG
GCCGCCGTCATTATTGTGGCTGTTCCCACCCCCATAGACGATCACCGCTCGCCGGACCTGACTCCCGTGGTGGGAGCCAG
CACCACCGTGGGACGCCACATGGGCAAGGGCTGCGTGGTGGTGTACGAATCCACCGTATATCCGGGTCTTACCGAAGAAA
TCTGCGTCCCCATCCTTGAGCGCGAGTCCGGCCTCACATTCGGCCGTGACTTCACCGTGGGCTACTCGCCCGAGCGCATC
AACCCCGGCGACAAGGTACATACCCTTGAAACCATCACCAAGGTTGTTTCCGGCTCCGACGACGCTACCACGGACCTGCT
CGTTCAGGTTTACGGCTCTGTGGTCACGGCGGGCATACACCGCGCTTCCAGCATCAAGGTGGCCGAGGCCGCCAAGGTTA
TCGAAAACACCCAGCGCGACCTCAATATCGCACTCATGAACGAGCTTGCCATCATCTTCGGCCGCCTCGGCATTGATACC
CTTGAAGTGCTGCAGGCCGCGGGCAGCAAGTGGAACTTCCTGCCCTTCCGGCCCGGTCTTGTGGGCGGCCACTGCATTGG
CGTGGACCCCTACTATCTCACCTACAAGGCAGAAGAACTGGGCTTTCACCCCGAGGTCATCCTGGCGGGCCGCCGCATCA
ATGACAACATGGGCAAATACCTGGCCGAATGCACGGTCAAACGCCTGATCAAGAGCGGCCGCGTCATCAGCGGCGCGCGC
GTGGGCATTCTCGGCTTTACCTTCAAGGAAAACGTGCCGGACCTGCGCAATACCCGCGTGGTGGACGTCATCCGCGAACT
TGAAGACTACGGCGTGCAGGTGCTCGTGAGCGATGCCGAGGCCGATCCCGCCGAAGCCCTGCACGAGTACGGCCAGGCCC
TGCTGCCGCAGAGCGACCTGCGCGACCTGGACGCTCTTATCCTGGCAGTGGGACACGATGCGTACAAGGTATTGTCCCCC
GATGCCATAAAAAGTCTTTTCGCCCAGCCGGACAAGGCCGTGGTGCTGGACGTAAAAAGCTTTCTCGACCCCGCTGCCAT
GCGCAGCGCGGGCATAGATTACTGGAGGCTGTAA

Upstream 100 bases:

>100_bases
AGCACGATGGCAAGGCCCAGGGCGCGGAAAAAAAGTTCGATATCAAAGTCCATGCTTTTCTTGGTGACGAAAAAAGCCTG
TTTTGTAAAGGAATGAAATT

Downstream 100 bases:

>100_bases
ACCGCGTGAGCCTGCTCATCTGCGCTGCCACTGGCCCGGAACTGGGGGGCCTTCTGCCGGGTTTTGCCCCGCCTTCCGCG
TCTGGGGGGCATGGCGGAGC

Product: nucleotide sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MVTFEALQQGKETLAVVGLGYVGLPLAVALSRQMSVLGFDISAPRIKELQDGHDRTREVDDHRLQAANVRYSCDPADLRE
AAVIIVAVPTPIDDHRSPDLTPVVGASTTVGRHMGKGCVVVYESTVYPGLTEEICVPILERESGLTFGRDFTVGYSPERI
NPGDKVHTLETITKVVSGSDDATTDLLVQVYGSVVTAGIHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFGRLGIDT
LEVLQAAGSKWNFLPFRPGLVGGHCIGVDPYYLTYKAEELGFHPEVILAGRRINDNMGKYLAECTVKRLIKSGRVISGAR
VGILGFTFKENVPDLRNTRVVDVIRELEDYGVQVLVSDAEADPAEALHEYGQALLPQSDLRDLDALILAVGHDAYKVLSP
DAIKSLFAQPDKAVVLDVKSFLDPAAMRSAGIDYWRL

Sequences:

>Translated_437_residues
MVTFEALQQGKETLAVVGLGYVGLPLAVALSRQMSVLGFDISAPRIKELQDGHDRTREVDDHRLQAANVRYSCDPADLRE
AAVIIVAVPTPIDDHRSPDLTPVVGASTTVGRHMGKGCVVVYESTVYPGLTEEICVPILERESGLTFGRDFTVGYSPERI
NPGDKVHTLETITKVVSGSDDATTDLLVQVYGSVVTAGIHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFGRLGIDT
LEVLQAAGSKWNFLPFRPGLVGGHCIGVDPYYLTYKAEELGFHPEVILAGRRINDNMGKYLAECTVKRLIKSGRVISGAR
VGILGFTFKENVPDLRNTRVVDVIRELEDYGVQVLVSDAEADPAEALHEYGQALLPQSDLRDLDALILAVGHDAYKVLSP
DAIKSLFAQPDKAVVLDVKSFLDPAAMRSAGIDYWRL
>Mature_437_residues
MVTFEALQQGKETLAVVGLGYVGLPLAVALSRQMSVLGFDISAPRIKELQDGHDRTREVDDHRLQAANVRYSCDPADLRE
AAVIIVAVPTPIDDHRSPDLTPVVGASTTVGRHMGKGCVVVYESTVYPGLTEEICVPILERESGLTFGRDFTVGYSPERI
NPGDKVHTLETITKVVSGSDDATTDLLVQVYGSVVTAGIHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFGRLGIDT
LEVLQAAGSKWNFLPFRPGLVGGHCIGVDPYYLTYKAEELGFHPEVILAGRRINDNMGKYLAECTVKRLIKSGRVISGAR
VGILGFTFKENVPDLRNTRVVDVIRELEDYGVQVLVSDAEADPAEALHEYGQALLPQSDLRDLDALILAVGHDAYKVLSP
DAIKSLFAQPDKAVVLDVKSFLDPAAMRSAGIDYWRL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=432, Percent_Identity=28.7037037037037, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17560350, Length=457, Percent_Identity=24.2888402625821, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17136908, Length=460, Percent_Identity=23.4782608695652, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47516; Mature: 47516

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTFEALQQGKETLAVVGLGYVGLPLAVALSRQMSVLGFDISAPRIKELQDGHDRTREVD
CCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHEEEECCCCCHHHHHHCCHHHHHCCH
DHRLQAANVRYSCDPADLREAAVIIVAVPTPIDDHRSPDLTPVVGASTTVGRHMGKGCVV
HHHHEECCCEEECCHHHCCCEEEEEEEECCCCCCCCCCCCCEECCCCHHHHHHCCCCEEE
VYESTVYPGLTEEICVPILERESGLTFGRDFTVGYSPERINPGDKVHTLETITKVVSGSD
EEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
DATTDLLVQVYGSVVTAGIHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFGRLGIDT
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHH
LEVLQAAGSKWNFLPFRPGLVGGHCIGVDPYYLTYKAEELGFHPEVILAGRRINDNMGKY
HHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEEEHHHHCCCCCEEEECCCCCCHHHHH
LAECTVKRLIKSGRVISGARVGILGFTFKENVPDLRNTRVVDVIRELEDYGVQVLVSDAE
HHHHHHHHHHHCCCEECCCEEEEEEEEHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECCC
ADPAEALHEYGQALLPQSDLRDLDALILAVGHDAYKVLSPDAIKSLFAQPDKAVVLDVKS
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCCCEEEEEHHH
FLDPAAMRSAGIDYWRL
HCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MVTFEALQQGKETLAVVGLGYVGLPLAVALSRQMSVLGFDISAPRIKELQDGHDRTREVD
CCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHEEEECCCCCHHHHHHCCHHHHHCCH
DHRLQAANVRYSCDPADLREAAVIIVAVPTPIDDHRSPDLTPVVGASTTVGRHMGKGCVV
HHHHEECCCEEECCHHHCCCEEEEEEEECCCCCCCCCCCCCEECCCCHHHHHHCCCCEEE
VYESTVYPGLTEEICVPILERESGLTFGRDFTVGYSPERINPGDKVHTLETITKVVSGSD
EEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
DATTDLLVQVYGSVVTAGIHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFGRLGIDT
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHH
LEVLQAAGSKWNFLPFRPGLVGGHCIGVDPYYLTYKAEELGFHPEVILAGRRINDNMGKY
HHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEEEHHHHCCCCCEEEECCCCCCHHHHH
LAECTVKRLIKSGRVISGARVGILGFTFKENVPDLRNTRVVDVIRELEDYGVQVLVSDAE
HHHHHHHHHHHCCCEECCCEEEEEEEEHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECCC
ADPAEALHEYGQALLPQSDLRDLDALILAVGHDAYKVLSPDAIKSLFAQPDKAVVLDVKS
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCCCEEEEEHHH
FLDPAAMRSAGIDYWRL
HCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]