Click here to switch to the map view.

The map label for this gene is ubiE [H]

Identifier: 220905170

GI number: 220905170

Start: 2298383

End: 2299138

Strand: Direct

Name: ubiE [H]

Synonym: Ddes_1908

Alternate gene names: 220905170

Gene position: 2298383-2299138 (Clockwise)

Preceding gene: 220905169

Following gene: 220905172

Centisome position: 79.99

GC content: 63.49

Gene sequence:

>756_bases
GTGGACTCTTCTCGGCTTTCCGGGCAGCAGGACAGGGCTTCGTCCCCGTCTCCCGTGCCCTCACATGATGCTGCCGTGGC
CGGCATGTTCGGCCGCATTGTACGCTTTTACGACCTGCTCAACCGCGTTCTCAGCCTGGGCCTTGACCAGCACTGGCGCA
AGGTGCTGGCGCGCAACGTGCGGCTGGGTGAAAGCGGTGTGGTGCTCGATCTGGCTGCGGGAACCCTGGATGTATCCCTG
GCCATCCGCCGCCAGTACCCCACGGCTCTCGTGCCTGCGCTGGACTTCTGCCCTCCCATGCTGGTGCAGGGCAGCCGCAA
GCTCAAGGGCGACAATGCCCGGCGCATCCTGCCCGTGGCGGCCGATGCCAAACGCCTGCCTCTGCCCGATGCCTCGGTAG
ACTGCCTGACCATCGCTTTCGGCATACGCAACATCATCCCGCGTGAAACGGCCTTTGCCGAAATGCTGCGTGTGCTGCGC
CCAGGCGGGCGGGCCTGTATCCTGGAGTTCGGCTCCGGCCGCGAGCGCATCTGGGGCGGCCTGTACAATGTGTACCTGAA
CCACCTGCTGCCCCGTGTGGGCCGTATGTTTTCCAAAGATCCCGCAGCCTATGCCTACCTGGCGGGCACTATCCGCGCGT
TTCCCTCTGCCGTTGAGCTGGAAAAAGAAATGCGCAAAGCCGGATTCAGCAAGGCATGGTATCAGAAGCTCACGTCAGGT
ATTGTCTGCCTGCATGTGGGCGAAAAGGCCCGCTAG

Upstream 100 bases:

>100_bases
GGTTTCGCCCGGCAATTTTGCAGAGGTCTTTCCCTCTGTCTACCGGGTGGTCTGCACGGCCATCGGTGTTGACGCGGATC
AGGACAACAAGGGTAAATAA

Downstream 100 bases:

>100_bases
GCGTCCGGCACAGGCGATCCCGGGCAGCGTGCCGGACACCGGAAAAATGGCAAAAAACACGTGACATTCTTACGGCGGCA
AACCATGCGCCGCACAGCCA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MDSSRLSGQQDRASSPSPVPSHDAAVAGMFGRIVRFYDLLNRVLSLGLDQHWRKVLARNVRLGESGVVLDLAAGTLDVSL
AIRRQYPTALVPALDFCPPMLVQGSRKLKGDNARRILPVAADAKRLPLPDASVDCLTIAFGIRNIIPRETAFAEMLRVLR
PGGRACILEFGSGRERIWGGLYNVYLNHLLPRVGRMFSKDPAAYAYLAGTIRAFPSAVELEKEMRKAGFSKAWYQKLTSG
IVCLHVGEKAR

Sequences:

>Translated_251_residues
MDSSRLSGQQDRASSPSPVPSHDAAVAGMFGRIVRFYDLLNRVLSLGLDQHWRKVLARNVRLGESGVVLDLAAGTLDVSL
AIRRQYPTALVPALDFCPPMLVQGSRKLKGDNARRILPVAADAKRLPLPDASVDCLTIAFGIRNIIPRETAFAEMLRVLR
PGGRACILEFGSGRERIWGGLYNVYLNHLLPRVGRMFSKDPAAYAYLAGTIRAFPSAVELEKEMRKAGFSKAWYQKLTSG
IVCLHVGEKAR
>Mature_251_residues
MDSSRLSGQQDRASSPSPVPSHDAAVAGMFGRIVRFYDLLNRVLSLGLDQHWRKVLARNVRLGESGVVLDLAAGTLDVSL
AIRRQYPTALVPALDFCPPMLVQGSRKLKGDNARRILPVAADAKRLPLPDASVDCLTIAFGIRNIIPRETAFAEMLRVLR
PGGRACILEFGSGRERIWGGLYNVYLNHLLPRVGRMFSKDPAAYAYLAGTIRAFPSAVELEKEMRKAGFSKAWYQKLTSG
IVCLHVGEKAR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=288, Percent_Identity=30.9027777777778, Blast_Score=125, Evalue=4e-29,
Organism=Escherichia coli, GI48994983, Length=228, Percent_Identity=37.280701754386, Blast_Score=146, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17557039, Length=234, Percent_Identity=33.7606837606838, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323526, Length=241, Percent_Identity=27.8008298755187, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24641702, Length=242, Percent_Identity=31.8181818181818, Blast_Score=127, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27615; Mature: 27615

Theoretical pI: Translated: 10.55; Mature: 10.55

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSSRLSGQQDRASSPSPVPSHDAAVAGMFGRIVRFYDLLNRVLSLGLDQHWRKVLARNV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
RLGESGVVLDLAAGTLDVSLAIRRQYPTALVPALDFCPPMLVQGSRKLKGDNARRILPVA
CCCCCCEEEEEECCCEEHHHHHHHHCCHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEC
ADAKRLPLPDASVDCLTIAFGIRNIIPRETAFAEMLRVLRPGGRACILEFGSGRERIWGG
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
LYNVYLNHLLPRVGRMFSKDPAAYAYLAGTIRAFPSAVELEKEMRKAGFSKAWYQKLTSG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCC
IVCLHVGEKAR
EEEEECCCCCC
>Mature Secondary Structure
MDSSRLSGQQDRASSPSPVPSHDAAVAGMFGRIVRFYDLLNRVLSLGLDQHWRKVLARNV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
RLGESGVVLDLAAGTLDVSLAIRRQYPTALVPALDFCPPMLVQGSRKLKGDNARRILPVA
CCCCCCEEEEEECCCEEHHHHHHHHCCHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEC
ADAKRLPLPDASVDCLTIAFGIRNIIPRETAFAEMLRVLRPGGRACILEFGSGRERIWGG
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
LYNVYLNHLLPRVGRMFSKDPAAYAYLAGTIRAFPSAVELEKEMRKAGFSKAWYQKLTSG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCC
IVCLHVGEKAR
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA