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The map label for this gene is yrhE [H]

Identifier: 220904812

GI number: 220904812

Start: 1847420

End: 1848544

Strand: Direct

Name: yrhE [H]

Synonym: Ddes_1544

Alternate gene names: 220904812

Gene position: 1847420-1848544 (Clockwise)

Preceding gene: 220904811

Following gene: 220904813

Centisome position: 64.29

GC content: 60.18

Gene sequence:

>1125_bases
ATGCCGTTTGTCACCATCAACGGAAAACAGGCTGCTTTTCAACCCGGGCAGACCATTCTTGACGTTGCCGAAACGCTCGG
CATCTTCATCCCCACGCTGTGCTGGCTACCCAAAACGGGACACAGCAAGGTCTGCCGCATCTGCTCGGTAGAAGTGCATG
GGCATGACCGGCTTCTCACGGCCTGCTCTTCTCCCGCTGAAGACGGCATGGTCATTGAAACCGAATCACCCCGCGTACTG
GCCGCGCGTAAAAACATCCTTTCGATGCTGGTGGCCGAAGGTCGTCATGACTGCTTCCTGCGCAAGTTGCCCACAGACCT
CTGGCCGCCCTATCAAAAGGCCGCGGCCGCCATGCCCCATCGCGAGCATCCCTGCCCCGCCGACGGCACATGCCGCCTTC
AGGCTCTGGTCATGAAGTGCAACGTCCCTGTCAAAGACCTGCTTCCCGAGCCGGGCAGCTTTCCCCTGGATAACGATCAC
CCGATGATTACACGCGACTTCAGCCGCTGTGTGCAGTGCGGACGCTGCGCCTCGGTCTGCTCCGCCGTGCAGGTAAACGA
CGCCATCCCCCCCCAGTTCGGCCGCCGTGCCGAAAAAGAAGCATGGTGGCCGGTGGTGGATTACCAGCGCTGTACCCACT
GCGGCGAATGTGTGCAGGTATGCCCTACCGGCGCGCTGACAGCCAAAAAATCCTATGGGCTCGCCGCCCGTGAAGACAGG
GTGGACAGCGTGCGCACAACCTGCCCCTACTGCGGCGTGGGATGTCAGTTGAACCTGTCTGTCAGGGACGGCCGCATCAT
TGAGGTCAACGGCGTTGAAGACGCGCAGCCCAACAAGGGCAGCCTGTGCGTCAAGGGGCGCTTCGGCTATGACTTCATCT
ACAGTGAAGACCGGCTCACCGAGCCGCTCATCCGCCAGCAGGACGGATCGTTCAAAGCCGCCTCCTGGGATGAAGCCCTG
GATCTTATTGCGGCCAGATTTTCCGGCGCCATTGAAAAGCACGGGCCCGACTCCGTGGCCGGAGTGGCCTGTGCCCGCAG
CATCAACGAAGACAATTACCAGATGCAAAAACTCTTTCGCGCGGTGTTCAAGACTAATAATATTGATCACTGCGCGCGTA
CCTGA

Upstream 100 bases:

>100_bases
CACAGCAGACAGCAAAAGCAGGGCCGCCGCCCTTTGACTCAAAGCCCCGTATGGGGTCAAGCCGCACGACAATCCGCTGC
GGAGCGGAACGGGAGACTTT

Downstream 100 bases:

>100_bases
CACGCCCCCACCGTGGCCGGTCTGGCCACATCGTTTGGTTCGGGAGCTATGACCAACAGCTTTGCCCACATGGGCGGGGC
AAAAATGATTTTTCTCATCG

Product: molybdopterin oxidoreductase Fe4S4 region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MPFVTINGKQAAFQPGQTILDVAETLGIFIPTLCWLPKTGHSKVCRICSVEVHGHDRLLTACSSPAEDGMVIETESPRVL
AARKNILSMLVAEGRHDCFLRKLPTDLWPPYQKAAAAMPHREHPCPADGTCRLQALVMKCNVPVKDLLPEPGSFPLDNDH
PMITRDFSRCVQCGRCASVCSAVQVNDAIPPQFGRRAEKEAWWPVVDYQRCTHCGECVQVCPTGALTAKKSYGLAAREDR
VDSVRTTCPYCGVGCQLNLSVRDGRIIEVNGVEDAQPNKGSLCVKGRFGYDFIYSEDRLTEPLIRQQDGSFKAASWDEAL
DLIAARFSGAIEKHGPDSVAGVACARSINEDNYQMQKLFRAVFKTNNIDHCART

Sequences:

>Translated_374_residues
MPFVTINGKQAAFQPGQTILDVAETLGIFIPTLCWLPKTGHSKVCRICSVEVHGHDRLLTACSSPAEDGMVIETESPRVL
AARKNILSMLVAEGRHDCFLRKLPTDLWPPYQKAAAAMPHREHPCPADGTCRLQALVMKCNVPVKDLLPEPGSFPLDNDH
PMITRDFSRCVQCGRCASVCSAVQVNDAIPPQFGRRAEKEAWWPVVDYQRCTHCGECVQVCPTGALTAKKSYGLAAREDR
VDSVRTTCPYCGVGCQLNLSVRDGRIIEVNGVEDAQPNKGSLCVKGRFGYDFIYSEDRLTEPLIRQQDGSFKAASWDEAL
DLIAARFSGAIEKHGPDSVAGVACARSINEDNYQMQKLFRAVFKTNNIDHCART
>Mature_373_residues
PFVTINGKQAAFQPGQTILDVAETLGIFIPTLCWLPKTGHSKVCRICSVEVHGHDRLLTACSSPAEDGMVIETESPRVLA
ARKNILSMLVAEGRHDCFLRKLPTDLWPPYQKAAAAMPHREHPCPADGTCRLQALVMKCNVPVKDLLPEPGSFPLDNDHP
MITRDFSRCVQCGRCASVCSAVQVNDAIPPQFGRRAEKEAWWPVVDYQRCTHCGECVQVCPTGALTAKKSYGLAAREDRV
DSVRTTCPYCGVGCQLNLSVRDGRIIEVNGVEDAQPNKGSLCVKGRFGYDFIYSEDRLTEPLIRQQDGSFKAASWDEALD
LIAARFSGAIEKHGPDSVAGVACARSINEDNYQMQKLFRAVFKTNNIDHCART

Specific function: Decomposes Formic Acid To Hydrogen And Carbon Dioxide Under Anaerobic Conditions In The Absence Of Exogenous Electron Acceptors. [C]

COG id: COG3383

COG function: function code R; Uncharacterized anaerobic dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=340, Percent_Identity=25.2941176470588, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI3868721, Length=139, Percent_Identity=44.6043165467626, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI145693161, Length=372, Percent_Identity=22.3118279569892, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788534, Length=146, Percent_Identity=32.1917808219178, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI3868720, Length=166, Percent_Identity=33.7349397590361, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17565758, Length=330, Percent_Identity=26.6666666666667, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI32566231, Length=330, Percent_Identity=26.6666666666667, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI193209088, Length=272, Percent_Identity=25.3676470588235, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640559, Length=310, Percent_Identity=25.4838709677419, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24640557, Length=310, Percent_Identity=25.4838709677419, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR009010
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006478
- InterPro:   IPR012285
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR019574 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 41196; Mature: 41064

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
5.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFVTINGKQAAFQPGQTILDVAETLGIFIPTLCWLPKTGHSKVCRICSVEVHGHDRLLT
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEEECCCCHHHH
ACSSPAEDGMVIETESPRVLAARKNILSMLVAEGRHDCFLRKLPTDLWPPYQKAAAAMPH
HHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCHHCCCCHHHHHHCCCC
REHPCPADGTCRLQALVMKCNVPVKDLLPEPGSFPLDNDHPMITRDFSRCVQCGRCASVC
CCCCCCCCCCCEEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SAVQVNDAIPPQFGRRAEKEAWWPVVDYQRCTHCGECVQVCPTGALTAKKSYGLAAREDR
HHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECHHCCCCCHHHHH
VDSVRTTCPYCGVGCQLNLSVRDGRIIEVNGVEDAQPNKGSLCVKGRFGYDFIYSEDRLT
HHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHH
EPLIRQQDGSFKAASWDEALDLIAARFSGAIEKHGPDSVAGVACARSINEDNYQMQKLFR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHH
AVFKTNNIDHCART
HHHHCCCCHHHHCC
>Mature Secondary Structure 
PFVTINGKQAAFQPGQTILDVAETLGIFIPTLCWLPKTGHSKVCRICSVEVHGHDRLLT
CEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEEECCCCHHHH
ACSSPAEDGMVIETESPRVLAARKNILSMLVAEGRHDCFLRKLPTDLWPPYQKAAAAMPH
HHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCHHCCCCHHHHHHCCCC
REHPCPADGTCRLQALVMKCNVPVKDLLPEPGSFPLDNDHPMITRDFSRCVQCGRCASVC
CCCCCCCCCCCEEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SAVQVNDAIPPQFGRRAEKEAWWPVVDYQRCTHCGECVQVCPTGALTAKKSYGLAAREDR
HHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECHHCCCCCHHHHH
VDSVRTTCPYCGVGCQLNLSVRDGRIIEVNGVEDAQPNKGSLCVKGRFGYDFIYSEDRLT
HHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHH
EPLIRQQDGSFKAASWDEALDLIAARFSGAIEKHGPDSVAGVACARSINEDNYQMQKLFR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHH
AVFKTNNIDHCART
HHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]