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The map label for this gene is fdhA [H]

Identifier: 220904813

GI number: 220904813

Start: 1848593

End: 1850176

Strand: Direct

Name: fdhA [H]

Synonym: Ddes_1545

Alternate gene names: 220904813

Gene position: 1848593-1850176 (Clockwise)

Preceding gene: 220904812

Following gene: 220904814

Centisome position: 64.33

GC content: 59.28

Gene sequence:

>1584_bases
ATGACCAACAGCTTTGCCCACATGGGCGGGGCAAAAATGATTTTTCTCATCGGTTCCAATATCACGGAGGCCCATCCCGT
GGCCGGAACCCTTGTCAAACAGGCTGTGCGCAAGGGCTGCCGCCTTATTGTCGCTGACCCGCGCCGCACCGGCATCGCCA
AGGAAGCGGAAACACACCTGCAATTGCGGGTGGGATCGGACATTGCGCTGCTCAACGCCATCATGCACGTGCTCATCAAG
GAAGATCTGTATGACAGGCACTATGTGGCACGGCACACGCTGGGCTTTGAAGAGCTGCGTGACAATGTGGCAAACTGCAC
GCCCGAGAGCGCGGCCCCCATATGCGGCATAGATGCGGAAACCATCAGGCAGACCGCGCGCACCCTCGCCTCGGTCAAGC
CCGCTATGCTGGCGTACACCCTTGGCATCACTGAACATACCAGCGGCGTCAACAACGTGCTGGCCTGTGCCGCGCTGCAG
ATGCTTCTGGGCAATGTGGGCAAAGCGCTGGGCGGGGTAAATCCCCTGCGCGGGCAAAATAACGTACAGGGTTCGTGCGA
CATGGGCGCTCTGCCGGATACCTACCCAGGCTACGGCAAAGTTGCGGACCCGGCAGCCAGAGAGCACCTTGAGCGCTTCT
GGGGCGTCTCGCTGCCGACGGAACCGGGCATCATGATGCCCGACATGCTGGATGGGCTTAAATCAAAAAAAATCAAGGCA
ATGTATATTTTTGGCGAAAACCTCGCCAATACCGAACCCAATATCAGTCATGTGGAAAGCTGCCTTGCCGCTGCGGATTT
TCTGGTGGTTCAGGATATTTTTCCCAACGAAACGAGCAGATTTGCTCATGTGATTCTGCCCGCCGCCGCCTGGGGTGAAA
AAGACGGCACGTTCACCAACAGCGAACGCCGCGTCAGCCGCGTACGCGCCGCCAGCCCGGCCCCCGGCAACGCCCGGGAA
GACTGGCGTATCTTCAAAGACCTGGCAGCCCGTTTCGGGCACCACTGGCAGGCGGACTCCGCCAGGGAGCTGTGGGACGA
CGAAATAGCGCCCCTGGCTGAGCTGTTTCGTGGCATCCGGTACGACCGCATTGAAGGTGATGGCCTGCAATGGCCCTGCA
CACACGCGGAACATCCCGGCAGCCCCGTGCTGCACAAGGATGGAGCCTTCGCGCGCGGCAAGGGGCTTTTTGTGCCTGTA
CGCTGGACGCCTGCCGCCGAAGTGGCCGATGAGGAGTATCCCTTCGTGCTCAGTTCCGGCAGACGTCTCTACCACTACCA
CACGCGTACGCAAACAGGCCGCAGCAAAGGACTCAACAGCCTGATGGGGCATGACACGGCGGATATTTCCACCGCTGATG
CAGCCCGGCTGGGCATAGCCAATGGTGACAACATCCGCGTGTCTTCACGCCGTGGTTCGGTGACGGTGCAGGCCAAGGTT
ACCGACGACATGCCGCGCGGCATGGTATGGATGGCCTTTCATTTTCGCGAAAGCAACGCCAACTGGCTTACCAATACCGC
TATGGACCCCATTACCAAAACAGCAGAATACAAAGCCTGCGCCGTGAAAATAGAAAAGATCTGA

Upstream 100 bases:

>100_bases
CTTTCGCGCGGTGTTCAAGACTAATAATATTGATCACTGCGCGCGTACCTGACACGCCCCCACCGTGGCCGGTCTGGCCA
CATCGTTTGGTTCGGGAGCT

Downstream 100 bases:

>100_bases
AGCCTTGATGCAAGCTCCGGCGCGGTGGTCCAGAGCCGCGCCGGACAGTCGGGCCTTTTGCAAAAAACTTTCTGCCCCGG
TACTTTCATCCAAACAGATA

Product: molybdopterin oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MTNSFAHMGGAKMIFLIGSNITEAHPVAGTLVKQAVRKGCRLIVADPRRTGIAKEAETHLQLRVGSDIALLNAIMHVLIK
EDLYDRHYVARHTLGFEELRDNVANCTPESAAPICGIDAETIRQTARTLASVKPAMLAYTLGITEHTSGVNNVLACAALQ
MLLGNVGKALGGVNPLRGQNNVQGSCDMGALPDTYPGYGKVADPAAREHLERFWGVSLPTEPGIMMPDMLDGLKSKKIKA
MYIFGENLANTEPNISHVESCLAAADFLVVQDIFPNETSRFAHVILPAAAWGEKDGTFTNSERRVSRVRAASPAPGNARE
DWRIFKDLAARFGHHWQADSARELWDDEIAPLAELFRGIRYDRIEGDGLQWPCTHAEHPGSPVLHKDGAFARGKGLFVPV
RWTPAAEVADEEYPFVLSSGRRLYHYHTRTQTGRSKGLNSLMGHDTADISTADAARLGIANGDNIRVSSRRGSVTVQAKV
TDDMPRGMVWMAFHFRESNANWLTNTAMDPITKTAEYKACAVKIEKI

Sequences:

>Translated_527_residues
MTNSFAHMGGAKMIFLIGSNITEAHPVAGTLVKQAVRKGCRLIVADPRRTGIAKEAETHLQLRVGSDIALLNAIMHVLIK
EDLYDRHYVARHTLGFEELRDNVANCTPESAAPICGIDAETIRQTARTLASVKPAMLAYTLGITEHTSGVNNVLACAALQ
MLLGNVGKALGGVNPLRGQNNVQGSCDMGALPDTYPGYGKVADPAAREHLERFWGVSLPTEPGIMMPDMLDGLKSKKIKA
MYIFGENLANTEPNISHVESCLAAADFLVVQDIFPNETSRFAHVILPAAAWGEKDGTFTNSERRVSRVRAASPAPGNARE
DWRIFKDLAARFGHHWQADSARELWDDEIAPLAELFRGIRYDRIEGDGLQWPCTHAEHPGSPVLHKDGAFARGKGLFVPV
RWTPAAEVADEEYPFVLSSGRRLYHYHTRTQTGRSKGLNSLMGHDTADISTADAARLGIANGDNIRVSSRRGSVTVQAKV
TDDMPRGMVWMAFHFRESNANWLTNTAMDPITKTAEYKACAVKIEKI
>Mature_526_residues
TNSFAHMGGAKMIFLIGSNITEAHPVAGTLVKQAVRKGCRLIVADPRRTGIAKEAETHLQLRVGSDIALLNAIMHVLIKE
DLYDRHYVARHTLGFEELRDNVANCTPESAAPICGIDAETIRQTARTLASVKPAMLAYTLGITEHTSGVNNVLACAALQM
LLGNVGKALGGVNPLRGQNNVQGSCDMGALPDTYPGYGKVADPAAREHLERFWGVSLPTEPGIMMPDMLDGLKSKKIKAM
YIFGENLANTEPNISHVESCLAAADFLVVQDIFPNETSRFAHVILPAAAWGEKDGTFTNSERRVSRVRAASPAPGNARED
WRIFKDLAARFGHHWQADSARELWDDEIAPLAELFRGIRYDRIEGDGLQWPCTHAEHPGSPVLHKDGAFARGKGLFVPVR
WTPAAEVADEEYPFVLSSGRRLYHYHTRTQTGRSKGLNSLMGHDTADISTADAARLGIANGDNIRVSSRRGSVTVQAKVT
DDMPRGMVWMAFHFRESNANWLTNTAMDPITKTAEYKACAVKIEKI

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=534, Percent_Identity=39.7003745318352, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1788534, Length=625, Percent_Identity=24.64, Blast_Score=165, Evalue=8e-42,
Organism=Escherichia coli, GI3868720, Length=448, Percent_Identity=26.3392857142857, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI3868719, Length=480, Percent_Identity=25.8333333333333, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87081797, Length=612, Percent_Identity=23.6928104575163, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1787778, Length=273, Percent_Identity=27.4725274725275, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI171474008, Length=615, Percent_Identity=25.3658536585366, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1787870, Length=611, Percent_Identity=23.5679214402619, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1787231, Length=520, Percent_Identity=23.4615384615385, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693196, Length=512, Percent_Identity=22.265625, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 57699; Mature: 57568

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSFAHMGGAKMIFLIGSNITEAHPVAGTLVKQAVRKGCRLIVADPRRTGIAKEAETHL
CCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHCCCEE
QLRVGSDIALLNAIMHVLIKEDLYDRHYVARHTLGFEELRDNVANCTPESAAPICGIDAE
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHH
TIRQTARTLASVKPAMLAYTLGITEHTSGVNNVLACAALQMLLGNVGKALGGVNPLRGQN
HHHHHHHHHHHCCHHHHHEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NVQGSCDMGALPDTYPGYGKVADPAAREHLERFWGVSLPTEPGIMMPDMLDGLKSKKIKA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHCCCEEE
MYIFGENLANTEPNISHVESCLAAADFLVVQDIFPNETSRFAHVILPAAAWGEKDGTFTN
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCEEEEEEEHHHCCCCCCCCCC
SERRVSRVRAASPAPGNAREDWRIFKDLAARFGHHWQADSARELWDDEIAPLAELFRGIR
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
YDRIEGDGLQWPCTHAEHPGSPVLHKDGAFARGKGLFVPVRWTPAAEVADEEYPFVLSSG
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCHHHHCCCCCCEEECCC
RRLYHYHTRTQTGRSKGLNSLMGHDTADISTADAARLGIANGDNIRVSSRRGSVTVQAKV
CEEEEEECCCCCCHHHCHHHHHCCCCCCCCCCCHHHEECCCCCCEEEECCCCCEEEEEEE
TDDMPRGMVWMAFHFRESNANWLTNTAMDPITKTAEYKACAVKIEKI
CCCCCCCEEEEEEEEECCCCCEEECCCCCCHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
TNSFAHMGGAKMIFLIGSNITEAHPVAGTLVKQAVRKGCRLIVADPRRTGIAKEAETHL
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHCCCEE
QLRVGSDIALLNAIMHVLIKEDLYDRHYVARHTLGFEELRDNVANCTPESAAPICGIDAE
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHH
TIRQTARTLASVKPAMLAYTLGITEHTSGVNNVLACAALQMLLGNVGKALGGVNPLRGQN
HHHHHHHHHHHCCHHHHHEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NVQGSCDMGALPDTYPGYGKVADPAAREHLERFWGVSLPTEPGIMMPDMLDGLKSKKIKA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHCCCEEE
MYIFGENLANTEPNISHVESCLAAADFLVVQDIFPNETSRFAHVILPAAAWGEKDGTFTN
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCEEEEEEEHHHCCCCCCCCCC
SERRVSRVRAASPAPGNAREDWRIFKDLAARFGHHWQADSARELWDDEIAPLAELFRGIR
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
YDRIEGDGLQWPCTHAEHPGSPVLHKDGAFARGKGLFVPVRWTPAAEVADEEYPFVLSSG
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCHHHHCCCCCCEEECCC
RRLYHYHTRTQTGRSKGLNSLMGHDTADISTADAARLGIANGDNIRVSSRRGSVTVQAKV
CEEEEEECCCCCCHHHCHHHHHCCCCCCCCCCCHHHEECCCCCCEEEECCCCCEEEEEEE
TDDMPRGMVWMAFHFRESNANWLTNTAMDPITKTAEYKACAVKIEKI
CCCCCCCEEEEEEEEECCCCCEEECCCCCCHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]