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The map label for this gene is xseA [H]

Identifier: 220904225

GI number: 220904225

Start: 1109492

End: 1110982

Strand: Direct

Name: xseA [H]

Synonym: Ddes_0952

Alternate gene names: 220904225

Gene position: 1109492-1110982 (Clockwise)

Preceding gene: 220904224

Following gene: 220904226

Centisome position: 38.61

GC content: 62.44

Gene sequence:

>1491_bases
ATGCAGGAAGCCATACTGACCGTCCGTGAACTTACGGAACAACTACGCAAAAGCCTTGAAGGGCGTTTTCCCTTTGTCTG
GGTACGGGGTGAGGTGACCAACTTCTCACGCCCCGGCTCGGGACATGTCTATTTCAGTCTCAAAGACCAGGATGCGCAGT
TGCAGTGTGTCTGGTTCCGGCACATGCAGCGGCAGGCAGACCAGGGGTTTGATCCGCTTACAGGGGAAGTTTTTGACGAG
CCGCGACCTTCTCCTCTTGAGCTTTTGCGCAATGGGCTGGATGTGCTTTGCGCCGGGCGCATCAGCGTATATGCGCCGCG
CGGGCAGTATCAGCTTGCAGTGGAACTGGTGCAGCCCGCAGGCGAAGGGCTGCTTGCGCAGGCTTTTGAAGAAAGCAAGC
GCAAGCTGGCCGCCCTGGGGTATTTTGACCACGGGCGCAAACGCCCTTTGCCCAGGGACCCGCAGCGAGTGGCTCTTGTT
ACTTCGCCCACCGGGGCGGCCATTCACGATTTTCTTGAACTGGCGCGCGACCGCGGCAGCGGTTCGTGCATCCGCCTTTT
CCCGTCGCTGGTGCAGGGGGCGGAGGCGGCTCCGGCCATTGTGCGCGCTCTGGCCGAAGCCAATAGCCAGGCCGGGCAGA
ATGACGGGCCGCAGGTCATCGTTCTTGTGCGCGGCGGCGGTTCGCTGGAAGATTTGTGGGCCTTTAACGAAGAAAGCGTG
GCAAAAGCCGTCTTTGAATCCCGGCTGCCTGTTCTTGCGGGCATCGGTCATGAAGTGGACATGACACTGGCGGACATGAC
CGCCGATATGCGCGCCGCCACGCCGAGCCATGCGGCCCAGTTGCTCTGGCCACCGCGCCTTGAGTTGCACCAGCGGGTGG
ACGAGGCCCGGGCGGCCCTGCGGCGCGCTATGGAGCGACGCCTCGAATCTGCCGGGCAGCGGCTGCGTGAATACGAAAAA
GCACTGGCCTGGTTTTCGCCACAGCGGCACCACGAGCGTCTGTACGAGCGCCTGGCTGTTCTGGACGCTGCGCTTGCCAG
GGCCGCGCGGCACTGGCTGGAAAGTAGGGAAGCGCAGACAGTCCGGCTCGAATGTGCTTTGCGTGGCTCTTTCGGCCTGG
AAAAACTCGATATTTTTGATGCCCGTCTGAAACACCTGCATGCGCGTCTGCATGCGGCTCTGCCGCGTCTGACGGACGAG
CGGCAGCGTGCCCTGAATTATGCCGCCCTGCGCCTGCAAAGCGCAGCCAGAAACCATGTGGCGCAGCACGAACGTAGCCT
GGATGTTCTTGGGGCGGCCCTTGATGCGGGCGATCCCCTCATGCCGCTTTCTCGCGGTTATGCTTTGGTAAGCGCCGGCG
GCAGCCTTGTGCGCTCTGTGGAAACAGCGCCCCCCGGTACGGAAATTCAGGTGCGCCTGGCTGACGGCAGCCTGGCAGCC
GTGGTCGGCAGCGTGAACCACGCCGGACGCGGAAAAAGGAAAAAAACGTGA

Upstream 100 bases:

>100_bases
GCTGTTATCGGCGGGCGTTCGGCCGGGTGATCCCCCGGGTATTTCTCCGGCCCGCCGTCTTCCCTCCGTGGCGTCAAAAA
GATATGCTGGCAAAAATATC

Downstream 100 bases:

>100_bases
AAAATATCTTCTATATACATCTTGCGTACAGGGCTTTTGCCGCACTGCTGCCTGTGCTGCTTGCATTGGTGGTTTTTTCC
GGCGGCCCGGCTCTGGCTGC

Product: exodeoxyribonuclease VII, large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MQEAILTVRELTEQLRKSLEGRFPFVWVRGEVTNFSRPGSGHVYFSLKDQDAQLQCVWFRHMQRQADQGFDPLTGEVFDE
PRPSPLELLRNGLDVLCAGRISVYAPRGQYQLAVELVQPAGEGLLAQAFEESKRKLAALGYFDHGRKRPLPRDPQRVALV
TSPTGAAIHDFLELARDRGSGSCIRLFPSLVQGAEAAPAIVRALAEANSQAGQNDGPQVIVLVRGGGSLEDLWAFNEESV
AKAVFESRLPVLAGIGHEVDMTLADMTADMRAATPSHAAQLLWPPRLELHQRVDEARAALRRAMERRLESAGQRLREYEK
ALAWFSPQRHHERLYERLAVLDAALARAARHWLESREAQTVRLECALRGSFGLEKLDIFDARLKHLHARLHAALPRLTDE
RQRALNYAALRLQSAARNHVAQHERSLDVLGAALDAGDPLMPLSRGYALVSAGGSLVRSVETAPPGTEIQVRLADGSLAA
VVGSVNHAGRGKRKKT

Sequences:

>Translated_496_residues
MQEAILTVRELTEQLRKSLEGRFPFVWVRGEVTNFSRPGSGHVYFSLKDQDAQLQCVWFRHMQRQADQGFDPLTGEVFDE
PRPSPLELLRNGLDVLCAGRISVYAPRGQYQLAVELVQPAGEGLLAQAFEESKRKLAALGYFDHGRKRPLPRDPQRVALV
TSPTGAAIHDFLELARDRGSGSCIRLFPSLVQGAEAAPAIVRALAEANSQAGQNDGPQVIVLVRGGGSLEDLWAFNEESV
AKAVFESRLPVLAGIGHEVDMTLADMTADMRAATPSHAAQLLWPPRLELHQRVDEARAALRRAMERRLESAGQRLREYEK
ALAWFSPQRHHERLYERLAVLDAALARAARHWLESREAQTVRLECALRGSFGLEKLDIFDARLKHLHARLHAALPRLTDE
RQRALNYAALRLQSAARNHVAQHERSLDVLGAALDAGDPLMPLSRGYALVSAGGSLVRSVETAPPGTEIQVRLADGSLAA
VVGSVNHAGRGKRKKT
>Mature_496_residues
MQEAILTVRELTEQLRKSLEGRFPFVWVRGEVTNFSRPGSGHVYFSLKDQDAQLQCVWFRHMQRQADQGFDPLTGEVFDE
PRPSPLELLRNGLDVLCAGRISVYAPRGQYQLAVELVQPAGEGLLAQAFEESKRKLAALGYFDHGRKRPLPRDPQRVALV
TSPTGAAIHDFLELARDRGSGSCIRLFPSLVQGAEAAPAIVRALAEANSQAGQNDGPQVIVLVRGGGSLEDLWAFNEESV
AKAVFESRLPVLAGIGHEVDMTLADMTADMRAATPSHAAQLLWPPRLELHQRVDEARAALRRAMERRLESAGQRLREYEK
ALAWFSPQRHHERLYERLAVLDAALARAARHWLESREAQTVRLECALRGSFGLEKLDIFDARLKHLHARLHAALPRLTDE
RQRALNYAALRLQSAARNHVAQHERSLDVLGAALDAGDPLMPLSRGYALVSAGGSLVRSVETAPPGTEIQVRLADGSLAA
VVGSVNHAGRGKRKKT

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=492, Percent_Identity=35.3658536585366, Blast_Score=269, Evalue=4e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 54762; Mature: 54762

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEAILTVRELTEQLRKSLEGRFPFVWVRGEVTNFSRPGSGHVYFSLKDQDAQLQCVWFR
CCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCEEHHHHH
HMQRQADQGFDPLTGEVFDEPRPSPLELLRNGLDVLCAGRISVYAPRGQYQLAVELVQPA
HHHHHHHCCCCCCCCHHCCCCCCCHHHHHHCCCCEEEECCEEEEECCCCHHHHHHHHHCC
GEGLLAQAFEESKRKLAALGYFDHGRKRPLPRDPQRVALVTSPTGAAIHDFLELARDRGS
CCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCC
GSCIRLFPSLVQGAEAAPAIVRALAEANSQAGQNDGPQVIVLVRGGGSLEDLWAFNEESV
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHCCCHHHH
AKAVFESRLPVLAGIGHEVDMTLADMTADMRAATPSHAAQLLWPPRLELHQRVDEARAAL
HHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHH
RRAMERRLESAGQRLREYEKALAWFSPQRHHERLYERLAVLDAALARAARHWLESREAQT
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VRLECALRGSFGLEKLDIFDARLKHLHARLHAALPRLTDERQRALNYAALRLQSAARNHV
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQHERSLDVLGAALDAGDPLMPLSRGYALVSAGGSLVRSVETAPPGTEIQVRLADGSLAA
HHHHHHHHHHHHHHCCCCCCCCHHCCEEEEECCHHHHHHHCCCCCCCEEEEEEECCCHHH
VVGSVNHAGRGKRKKT
HHHCCCCCCCCCCCCC
>Mature Secondary Structure
MQEAILTVRELTEQLRKSLEGRFPFVWVRGEVTNFSRPGSGHVYFSLKDQDAQLQCVWFR
CCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCEEHHHHH
HMQRQADQGFDPLTGEVFDEPRPSPLELLRNGLDVLCAGRISVYAPRGQYQLAVELVQPA
HHHHHHHCCCCCCCCHHCCCCCCCHHHHHHCCCCEEEECCEEEEECCCCHHHHHHHHHCC
GEGLLAQAFEESKRKLAALGYFDHGRKRPLPRDPQRVALVTSPTGAAIHDFLELARDRGS
CCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCC
GSCIRLFPSLVQGAEAAPAIVRALAEANSQAGQNDGPQVIVLVRGGGSLEDLWAFNEESV
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHCCCHHHH
AKAVFESRLPVLAGIGHEVDMTLADMTADMRAATPSHAAQLLWPPRLELHQRVDEARAAL
HHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHH
RRAMERRLESAGQRLREYEKALAWFSPQRHHERLYERLAVLDAALARAARHWLESREAQT
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VRLECALRGSFGLEKLDIFDARLKHLHARLHAALPRLTDERQRALNYAALRLQSAARNHV
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQHERSLDVLGAALDAGDPLMPLSRGYALVSAGGSLVRSVETAPPGTEIQVRLADGSLAA
HHHHHHHHHHHHHHCCCCCCCCHHCCEEEEECCHHHHHHHCCCCCCCEEEEEEECCCHHH
VVGSVNHAGRGKRKKT
HHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA