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The map label for this gene is hflC [H]

Identifier: 220904140

GI number: 220904140

Start: 1017082

End: 1017930

Strand: Direct

Name: hflC [H]

Synonym: Ddes_0867

Alternate gene names: 220904140

Gene position: 1017082-1017930 (Clockwise)

Preceding gene: 220904139

Following gene: 220904141

Centisome position: 35.4

GC content: 56.18

Gene sequence:

>849_bases
ATGCGTACCAATCCTCTGCCGGCTGTCATCGTGCTGCTGCTGATCGTTGTGGTGGGTAGCCAGTGCTTTTTTACTGTCCA
TCAGACGCAAACGGCTCTTGTGCTTCAGCTGGGTGATCCCCTGGACAGGGTGTATGGCCCCGGCCTGCATTTCAAGATGC
CTTTTATCCAGAACGTGGTGTATTTTGATTCGCGGGTGCTGGATTATGAAGCCCGCTCGCGTGAAGCCTTTACGGTAGAC
AAGAAAGCCATTGTGCTTGACAACTACGCCCGCTGGAAAATTATCGATCCCCTGCAATTTTACCGTACCATGCGCACCAT
ACCTGGAGCGCAGGCGCGGCTTGACGACGTTGTCTACTCCCAGCTGCGGGCGCTGGTGGGCGCATACACCCTCACCGAGG
TTGTCTCCTCCCACCGTGCGGCCATCATGAAGGAAGTGACAAACAAGGTTTCAGCCTTGATGCATAGTTACGGTGTTGAA
GTGCTGGACGTGCGTATAAAACGCACCGACCTGCCGCCGGAAAACCAGCGTGCCATCTTCGGGCGCATGCGGGCGGAGCG
TGAGCGCCAGGCCAAGCAGTACCGTTCCGAAGGTGAGGAAGAATCCACGCGTATCCGTTCCGACGCTGACCGTCAACGTG
CAGTTATATTGGCTGAAGCCGCGCGCGAGGCTCAGATAAAACGCGGTGAAGGCGACGCCAGCGCCGCATCCATCTACGCC
CAATCCTATAATAAGGCGCCTCAGTTCTATGCGTACCAACGCTGGCTGGAGGCCATGCGCAAATCTCTCAAGGAGAACAG
CAAGATGGTGCTGGCCAACGAAGCGCCTCTTCTTAATCCTCAACATTGA

Upstream 100 bases:

>100_bases
AAGTGCTTATGGATGCCCCGGCGGCATCCCGTGCCTTGCCTTATCTGAATCTGCCCAGCCTGGGCGCCCCTGTTGCCCCC
AAGGCGTTGGAGAGAAAATA

Downstream 100 bases:

>100_bases
TGATGCGGCTTGTCCGCATTATGGAGTTCAAGATCATGCCTGCCTTTGCAGAAATATACGAACGTATCAAACTGGCGACA
AACAGCCGCACTCAGGTGGA

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MRTNPLPAVIVLLLIVVVGSQCFFTVHQTQTALVLQLGDPLDRVYGPGLHFKMPFIQNVVYFDSRVLDYEARSREAFTVD
KKAIVLDNYARWKIIDPLQFYRTMRTIPGAQARLDDVVYSQLRALVGAYTLTEVVSSHRAAIMKEVTNKVSALMHSYGVE
VLDVRIKRTDLPPENQRAIFGRMRAERERQAKQYRSEGEEESTRIRSDADRQRAVILAEAAREAQIKRGEGDASAASIYA
QSYNKAPQFYAYQRWLEAMRKSLKENSKMVLANEAPLLNPQH

Sequences:

>Translated_282_residues
MRTNPLPAVIVLLLIVVVGSQCFFTVHQTQTALVLQLGDPLDRVYGPGLHFKMPFIQNVVYFDSRVLDYEARSREAFTVD
KKAIVLDNYARWKIIDPLQFYRTMRTIPGAQARLDDVVYSQLRALVGAYTLTEVVSSHRAAIMKEVTNKVSALMHSYGVE
VLDVRIKRTDLPPENQRAIFGRMRAERERQAKQYRSEGEEESTRIRSDADRQRAVILAEAAREAQIKRGEGDASAASIYA
QSYNKAPQFYAYQRWLEAMRKSLKENSKMVLANEAPLLNPQH
>Mature_282_residues
MRTNPLPAVIVLLLIVVVGSQCFFTVHQTQTALVLQLGDPLDRVYGPGLHFKMPFIQNVVYFDSRVLDYEARSREAFTVD
KKAIVLDNYARWKIIDPLQFYRTMRTIPGAQARLDDVVYSQLRALVGAYTLTEVVSSHRAAIMKEVTNKVSALMHSYGVE
VLDVRIKRTDLPPENQRAIFGRMRAERERQAKQYRSEGEEESTRIRSDADRQRAVILAEAAREAQIKRGEGDASAASIYA
QSYNKAPQFYAYQRWLEAMRKSLKENSKMVLANEAPLLNPQH

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=305, Percent_Identity=31.4754098360656, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790616, Length=257, Percent_Identity=24.9027237354086, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1786697, Length=244, Percent_Identity=23.7704918032787, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193209764, Length=191, Percent_Identity=27.7486910994764, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17569493, Length=191, Percent_Identity=27.7486910994764, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32564147, Length=254, Percent_Identity=22.4409448818898, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 32193; Mature: 32193

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTNPLPAVIVLLLIVVVGSQCFFTVHQTQTALVLQLGDPLDRVYGPGLHFKMPFIQNVV
CCCCCHHHHHHHHHHHHHCCHHEEEEECCCEEEEEECCCHHHHHHCCCCEEECHHHHHHH
YFDSRVLDYEARSREAFTVDKKAIVLDNYARWKIIDPLQFYRTMRTIPGAQARLDDVVYS
HHHHHHCCHHHCCCCEEEECCCEEEEECCCCEEEECHHHHHHHHHHCCCCHHHHHHHHHH
QLRALVGAYTLTEVVSSHRAAIMKEVTNKVSALMHSYGVEVLDVRIKRTDLPPENQRAIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHH
GRMRAERERQAKQYRSEGEEESTRIRSDADRQRAVILAEAAREAQIKRGEGDASAASIYA
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
QSYNKAPQFYAYQRWLEAMRKSLKENSKMVLANEAPLLNPQH
HHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MRTNPLPAVIVLLLIVVVGSQCFFTVHQTQTALVLQLGDPLDRVYGPGLHFKMPFIQNVV
CCCCCHHHHHHHHHHHHHCCHHEEEEECCCEEEEEECCCHHHHHHCCCCEEECHHHHHHH
YFDSRVLDYEARSREAFTVDKKAIVLDNYARWKIIDPLQFYRTMRTIPGAQARLDDVVYS
HHHHHHCCHHHCCCCEEEECCCEEEEECCCCEEEECHHHHHHHHHHCCCCHHHHHHHHHH
QLRALVGAYTLTEVVSSHRAAIMKEVTNKVSALMHSYGVEVLDVRIKRTDLPPENQRAIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHH
GRMRAERERQAKQYRSEGEEESTRIRSDADRQRAVILAEAAREAQIKRGEGDASAASIYA
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
QSYNKAPQFYAYQRWLEAMRKSLKENSKMVLANEAPLLNPQH
HHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]