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The map label for this gene is luxQ [H]

Identifier: 220903475

GI number: 220903475

Start: 241110

End: 243110

Strand: Direct

Name: luxQ [H]

Synonym: Ddes_0191

Alternate gene names: 220903475

Gene position: 241110-243110 (Clockwise)

Preceding gene: 220903473

Following gene: 220903476

Centisome position: 8.39

GC content: 60.72

Gene sequence:

>2001_bases
TTGTTAGAGGCGCGGCGAATTTTTGACGAAGAACTTTCCTGGGGACGCGAGGCGATGGCGGCGGCCAGTGTTGGGCTGTG
GGCCATTTCATATGACACGCGCACGGAAAGAACCGCCATGTTCACCAATGAGGCCATGCGCCGTTTGTTGGGTGTGCCTG
AGGGGCTGGACCCCGAAGCGTGTGCGGCGTTCTGGCTTCGTCATGTGGACAGCCGCGACCTGCCCCTCATCCGGGACAGC
CTGGCGGCGTTTAAAGATGATGCCTCCATGCGTGAAATCCGCTACGCCTACTGCCATCCCGGCATGGGGGCAATGCACGT
GCGCTGCGGGGGCCGGCGCGTGTCTTCTGCCGATGATCCGGTATTGCGTATTACCGGTTTCCATCAGGATATCAGCGAGC
TGCACGCGGCGCATAATGCCCTGCGCGAGAGCCTTTCACGACTTTCGCTGGCGTGCCGCCTGGGTTGGCTCGGCGTGTTC
GAACTGGGCCGTAAAAACGGCAGGCCGGAATTTTCGTGCAACGAGGTTTTTTACGAGCAGTTCGGCCTGCGTGAAAGCGC
GGACGCCGCGGAACGGCTCGTGGCCGTGGAAAAATGCATCCTGCCCGAAGACCGCCACCGCTGGCGCAATCTCTGCCGGG
CCGAAGGCTGGACCCTGGGCTTCCAGGAGCATGTGGAACTGCGCGTGAGCCACCCTTGGCGCGGCCTGTGCTGGTTTGTG
GTGGCCTACGAAGTGGTGGGCACACAGGATGAACCCCGCATCACCGGGTATGTGCATGATGTGACGAAGCAGCGCCAGCA
TGAATGCATGCTGCGCGAGGCCAAGGAAAGCGCCGAGGCGGCCAATGCGGCCAAAAGCATCTTTCTTGCCAACATGAGCC
ACGAAATACGTACGCCCATGAACGGTATTATGGGCATGGCCCATCTGGTGCTCAATACAGATCTCAGCCCGCAGCAGCGG
GACTATGTGGAAAAGATCCATTCCACCTGCGAATCCTTGCTGGACATTATCAATGATCTTCTGGATTTTTCCAAGATAGA
AGCCAATCATATGGATCTGGAGGCCCTGCCGTTTCAGCCTGTCAATGAGATGGAGGCGGTGCTTGCCCTGTTGCGCCCGC
GCACCCAGCACAAGAACTGTGTTCTTGAAAGTCATATCGATCCCGATATTCCCCAGACGCTGGTGGGCGACGCTCTGCGC
CTGCGGCAGATACTGCTGAATCTGGGTGGCAATGCCATCAAGTTTTCAGAGCGCGGCGTGGTGCGCGTGGATCTGCAGCT
TTTGCACCGCGAGGGCAATAGCGTTACCCTCGCATGCCTGGTGAGCGATGAAGGCATCGGCATGAGCGAGGAAGAGCAGG
AACGCATTTTTACGCCGTTTTCCCAGGCAGACACGTCCATCACGCGCCGCTTCGGCGGCACCGGCCTTGGTCTTGCCCTG
TGCCGTCGTCTGGTAGAGCTGATGGGCGGCCGGATACATGTGCAAAGCGCGCCGGGCAAAGGCAGCGTATTCCGGGTGGA
GCTGCCTTTCGGCGTGGGCCGTGATGATGTTTTTGCTCCTGACATGGCAGGGGCGGGACCGGAAGAGCAGCCCGGCTGCC
TGCGGGGGCTGCGGGTGCTCATGGCTGAAGACGGTGATATAAACCGCGAGATTATGGAAGTGCTGTTAAGCGGCATGGGC
GTGCAGTGCACGGCCGTGAGCAATGGGCAGGAAGCGCTTGAGGCGTGGCGGGCGCACGCCGGGGATATAGACCTTATCCT
TATGGACGTGCAGATGCCCGTAATGGACGGCTACACCGCTACGCGCGAGATCAGGGCCGACAGCCGGCCCGAAGCGGCTA
CGGTTCCCATTGTTGCCATGACGGCCTATGCCATGCGGGGAGATGCGGAACGCAGCCTTCAGGCTGGCATGAACGCCCAC
CTGACCAAGCCGGTCGATGTGCGCGAACTCATGCTCACGCTCAAGCGCCTTGCCTGTCCCTGCGAGGGACGGCTCGGGTG
A

Upstream 100 bases:

>100_bases
TGTTGCGCAACACAGGCTGGAGACATCCGGCCTTTACAGAACGGCATTGTCTTGCGGGCATAAAAGCGCTAGCCTGCACG
CCAGCTCTGGAGGCAGTATA

Downstream 100 bases:

>100_bases
TGTCTGTGCGGCGCCTGCCGCCCCTGCGCCGCTGTGTGTCTGCCGTTGTAGCCGGACGGCATGTACCTGGTCTGCACGCG
CCCGCCCTGTATGCGCCCGT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MLEARRIFDEELSWGREAMAAASVGLWAISYDTRTERTAMFTNEAMRRLLGVPEGLDPEACAAFWLRHVDSRDLPLIRDS
LAAFKDDASMREIRYAYCHPGMGAMHVRCGGRRVSSADDPVLRITGFHQDISELHAAHNALRESLSRLSLACRLGWLGVF
ELGRKNGRPEFSCNEVFYEQFGLRESADAAERLVAVEKCILPEDRHRWRNLCRAEGWTLGFQEHVELRVSHPWRGLCWFV
VAYEVVGTQDEPRITGYVHDVTKQRQHECMLREAKESAEAANAAKSIFLANMSHEIRTPMNGIMGMAHLVLNTDLSPQQR
DYVEKIHSTCESLLDIINDLLDFSKIEANHMDLEALPFQPVNEMEAVLALLRPRTQHKNCVLESHIDPDIPQTLVGDALR
LRQILLNLGGNAIKFSERGVVRVDLQLLHREGNSVTLACLVSDEGIGMSEEEQERIFTPFSQADTSITRRFGGTGLGLAL
CRRLVELMGGRIHVQSAPGKGSVFRVELPFGVGRDDVFAPDMAGAGPEEQPGCLRGLRVLMAEDGDINREIMEVLLSGMG
VQCTAVSNGQEALEAWRAHAGDIDLILMDVQMPVMDGYTATREIRADSRPEAATVPIVAMTAYAMRGDAERSLQAGMNAH
LTKPVDVRELMLTLKRLACPCEGRLG

Sequences:

>Translated_666_residues
MLEARRIFDEELSWGREAMAAASVGLWAISYDTRTERTAMFTNEAMRRLLGVPEGLDPEACAAFWLRHVDSRDLPLIRDS
LAAFKDDASMREIRYAYCHPGMGAMHVRCGGRRVSSADDPVLRITGFHQDISELHAAHNALRESLSRLSLACRLGWLGVF
ELGRKNGRPEFSCNEVFYEQFGLRESADAAERLVAVEKCILPEDRHRWRNLCRAEGWTLGFQEHVELRVSHPWRGLCWFV
VAYEVVGTQDEPRITGYVHDVTKQRQHECMLREAKESAEAANAAKSIFLANMSHEIRTPMNGIMGMAHLVLNTDLSPQQR
DYVEKIHSTCESLLDIINDLLDFSKIEANHMDLEALPFQPVNEMEAVLALLRPRTQHKNCVLESHIDPDIPQTLVGDALR
LRQILLNLGGNAIKFSERGVVRVDLQLLHREGNSVTLACLVSDEGIGMSEEEQERIFTPFSQADTSITRRFGGTGLGLAL
CRRLVELMGGRIHVQSAPGKGSVFRVELPFGVGRDDVFAPDMAGAGPEEQPGCLRGLRVLMAEDGDINREIMEVLLSGMG
VQCTAVSNGQEALEAWRAHAGDIDLILMDVQMPVMDGYTATREIRADSRPEAATVPIVAMTAYAMRGDAERSLQAGMNAH
LTKPVDVRELMLTLKRLACPCEGRLG
>Mature_666_residues
MLEARRIFDEELSWGREAMAAASVGLWAISYDTRTERTAMFTNEAMRRLLGVPEGLDPEACAAFWLRHVDSRDLPLIRDS
LAAFKDDASMREIRYAYCHPGMGAMHVRCGGRRVSSADDPVLRITGFHQDISELHAAHNALRESLSRLSLACRLGWLGVF
ELGRKNGRPEFSCNEVFYEQFGLRESADAAERLVAVEKCILPEDRHRWRNLCRAEGWTLGFQEHVELRVSHPWRGLCWFV
VAYEVVGTQDEPRITGYVHDVTKQRQHECMLREAKESAEAANAAKSIFLANMSHEIRTPMNGIMGMAHLVLNTDLSPQQR
DYVEKIHSTCESLLDIINDLLDFSKIEANHMDLEALPFQPVNEMEAVLALLRPRTQHKNCVLESHIDPDIPQTLVGDALR
LRQILLNLGGNAIKFSERGVVRVDLQLLHREGNSVTLACLVSDEGIGMSEEEQERIFTPFSQADTSITRRFGGTGLGLAL
CRRLVELMGGRIHVQSAPGKGSVFRVELPFGVGRDDVFAPDMAGAGPEEQPGCLRGLRVLMAEDGDINREIMEVLLSGMG
VQCTAVSNGQEALEAWRAHAGDIDLILMDVQMPVMDGYTATREIRADSRPEAATVPIVAMTAYAMRGDAERSLQAGMNAH
LTKPVDVRELMLTLKRLACPCEGRLG

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=391, Percent_Identity=35.8056265984655, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI48994928, Length=410, Percent_Identity=32.4390243902439, Blast_Score=203, Evalue=3e-53,
Organism=Escherichia coli, GI1788713, Length=442, Percent_Identity=32.579185520362, Blast_Score=193, Evalue=4e-50,
Organism=Escherichia coli, GI87081816, Length=335, Percent_Identity=36.1194029850746, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=39.8406374501992, Blast_Score=185, Evalue=9e-48,
Organism=Escherichia coli, GI1788549, Length=297, Percent_Identity=26.5993265993266, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=29.2576419213974, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1788393, Length=225, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=27.1929824561404, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=347, Percent_Identity=24.7838616714697, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790346, Length=236, Percent_Identity=27.5423728813559, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=244, Percent_Identity=25.4098360655738, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790300, Length=278, Percent_Identity=27.6978417266187, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=238, Percent_Identity=25.2100840336134, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=33.0578512396694, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=33.8983050847458, Blast_Score=62, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322044, Length=133, Percent_Identity=31.5789473684211, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323034, Length=175, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74219; Mature: 74219

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEARRIFDEELSWGREAMAAASVGLWAISYDTRTERTAMFTNEAMRRLLGVPEGLDPEA
CCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHH
CAAFWLRHVDSRDLPLIRDSLAAFKDDASMREIRYAYCHPGMGAMHVRCGGRRVSSADDP
HHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
VLRITGFHQDISELHAAHNALRESLSRLSLACRLGWLGVFELGRKNGRPEFSCNEVFYEQ
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FGLRESADAAERLVAVEKCILPEDRHRWRNLCRAEGWTLGFQEHVELRVSHPWRGLCWFV
HCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHCEEEEECCCCCHHHHHH
VAYEVVGTQDEPRITGYVHDVTKQRQHECMLREAKESAEAANAAKSIFLANMSHEIRTPM
HHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCH
NGIMGMAHLVLNTDLSPQQRDYVEKIHSTCESLLDIINDLLDFSKIEANHMDLEALPFQP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VNEMEAVLALLRPRTQHKNCVLESHIDPDIPQTLVGDALRLRQILLNLGGNAIKFSERGV
HHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCE
VRVDLQLLHREGNSVTLACLVSDEGIGMSEEEQERIFTPFSQADTSITRRFGGTGLGLAL
EEEEHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
CRRLVELMGGRIHVQSAPGKGSVFRVELPFGVGRDDVFAPDMAGAGPEEQPGCLRGLRVL
HHHHHHHHCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
MAEDGDINREIMEVLLSGMGVQCTAVSNGQEALEAWRAHAGDIDLILMDVQMPVMDGYTA
HCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEEEECCHHCCCCH
TREIRADSRPEAATVPIVAMTAYAMRGDAERSLQAGMNAHLTKPVDVRELMLTLKRLACP
HHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
CEGRLG
CCCCCC
>Mature Secondary Structure
MLEARRIFDEELSWGREAMAAASVGLWAISYDTRTERTAMFTNEAMRRLLGVPEGLDPEA
CCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHH
CAAFWLRHVDSRDLPLIRDSLAAFKDDASMREIRYAYCHPGMGAMHVRCGGRRVSSADDP
HHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
VLRITGFHQDISELHAAHNALRESLSRLSLACRLGWLGVFELGRKNGRPEFSCNEVFYEQ
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FGLRESADAAERLVAVEKCILPEDRHRWRNLCRAEGWTLGFQEHVELRVSHPWRGLCWFV
HCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHCEEEEECCCCCHHHHHH
VAYEVVGTQDEPRITGYVHDVTKQRQHECMLREAKESAEAANAAKSIFLANMSHEIRTPM
HHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCH
NGIMGMAHLVLNTDLSPQQRDYVEKIHSTCESLLDIINDLLDFSKIEANHMDLEALPFQP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VNEMEAVLALLRPRTQHKNCVLESHIDPDIPQTLVGDALRLRQILLNLGGNAIKFSERGV
HHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCE
VRVDLQLLHREGNSVTLACLVSDEGIGMSEEEQERIFTPFSQADTSITRRFGGTGLGLAL
EEEEHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
CRRLVELMGGRIHVQSAPGKGSVFRVELPFGVGRDDVFAPDMAGAGPEEQPGCLRGLRVL
HHHHHHHHCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
MAEDGDINREIMEVLLSGMGVQCTAVSNGQEALEAWRAHAGDIDLILMDVQMPVMDGYTA
HCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEEEECCHHCCCCH
TREIRADSRPEAATVPIVAMTAYAMRGDAERSLQAGMNAHLTKPVDVRELMLTLKRLACP
HHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
CEGRLG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]