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The map label for this gene is grdA [H]

Identifier: 220903404

GI number: 220903404

Start: 152085

End: 152561

Strand: Direct

Name: grdA [H]

Synonym: Ddes_0118

Alternate gene names: 220903404

Gene position: 152085-152561 (Clockwise)

Preceding gene: 220903403

Following gene: 220903405

Centisome position: 5.29

GC content: 55.35

Gene sequence:

>477_bases
ATGGGTAAGCTTACAGGCAAGAAGCTTCTGCTGCTTGGCGAAAGGGACGGCGTACCCGGCCCGGCCATGGCGGATGTCTT
TGCAAATTCGGGTGCGGAAATACTGTTTTCCGCTACCGAATGCTTTGTCTGAACGGCCGCAGGGGCCATGGATCTGGAAA
ATCAGCAGCGCGTCAAGGACGCGGCTGAGAAGTTTGGTGGCGAGAACGTTGTGGTGATTCTCGGCTCTTCCGACCCTGAA
GGGGCGGAAATTTACGCCGAAACCGTCACCATGGGCGACCCCACCTTCGCCGGACCCTTGGCCGGAGTCCCGTTGGGACT
CTGCGTATATCACATTCTTGAACCCGAAATTAAAGAAGAAGCCGATCCCGCCAAGTGGGAAGAGCAGATCAGCATGATGG
AAATGGTCCTTAACGTGGATGCGCTCGTGGAATCTGTAAGAAAGATGCGCGAAGCCAACAGCAAGTTCAGCCTTTAG

Upstream 100 bases:

>100_bases
TCGGGGCGGGCCGGTACGGCCTGCCCGGCGCCTGGATGAGGATGACGGGCCGCCGCATGGCCCGTATTGGCAGAACGCCC
ATAATCTCAAGGAGTATGCA

Downstream 100 bases:

>100_bases
GAACATTGCCTGCCTGAACTGCCCGCAAGGTTTTGAGGGCGCACCCCCTTTCAGGCCTTGCTCCGGCGGCTGCCGCCGGA
CACAGGGACGGTTCGGAATG

Product: glycine/sarcosine/betaine reductase complex protein A

Products: NA

Alternate protein names: Selenoprotein PA; Thioredoxin reductase complex selenoprotein A [H]

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MGKLTGKKLLLLGERDGVPGPAMADVFANSGAEILFSATECFVUTAAGAMDLENQQRVKDAAEKFGGENVVVILGSSDPE
GAEIYAETVTMGDPTFAGPLAGVPLGLCVYHILEPEIKEEADPAKWEEQISMMEMVLNVDALVESVRKMREANSKFSL

Sequences:

>Translated_158_residues
MGKLTGKKLLLLGERDGVPGPAMADVFANSGAEILFSATECFV*TAAGAMDLENQQRVKDAAEKFGGENVVVILGSSDPE
GAEIYAETVTMGDPTFAGPLAGVPLGLCVYHILEPEIKEEADPAKWEEQISMMEMVLNVDALVESVRKMREANSKFSL
>Mature_157_residues
GKLTGKKLLLLGERDGVPGPAMADVFANSGAEILFSATECFV*TAAGAMDLENQQRVKDAAEKFGGENVVVILGSSDPEG
AEIYAETVTMGDPTFAGPLAGVPLGLCVYHILEPEIKEEADPAKWEEQISMMEMVLNVDALVESVRKMREANSKFSL

Specific function: In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a c

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the grdA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006812 [H]

Pfam domain/function: PF04723 GRDA [H]

EC number: =1.21.4.2; =1.21.4.3; =1.21.4.4 [H]

Molecular weight: Translated: 16746; Mature: 16615

Theoretical pI: Translated: 4.12; Mature: 4.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLTGKKLLLLGERDGVPGPAMADVFANSGAEILFSATECFVTAAGAMDLENQQRVKDA
CCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHH
AEKFGGENVVVILGSSDPEGAEIYAETVTMGDPTFAGPLAGVPLGLCVYHILEPEIKEEA
HHHHCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHCCC
DPAKWEEQISMMEMVLNVDALVESVRKMREANSKFSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GKLTGKKLLLLGERDGVPGPAMADVFANSGAEILFSATECFVTAAGAMDLENQQRVKDA
CCCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHH
AEKFGGENVVVILGSSDPEGAEIYAETVTMGDPTFAGPLAGVPLGLCVYHILEPEIKEEA
HHHHCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHCCC
DPAKWEEQISMMEMVLNVDALVESVRKMREANSKFSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA