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The map label for this gene is trxA [H]

Identifier: 220903403

GI number: 220903403

Start: 151657

End: 151974

Strand: Direct

Name: trxA [H]

Synonym: Ddes_0117

Alternate gene names: 220903403

Gene position: 151657-151974 (Clockwise)

Preceding gene: 220903402

Following gene: 220903404

Centisome position: 5.28

GC content: 60.38

Gene sequence:

>318_bases
ATGATTATTGTCGACAAGGAAAACTTTGAAGCCGAAGTGCAGCAGAGCGCCATGCCCTGCGTGGTGGACCTGTGGGGTCC
GCAGTGCGGTCCCTGCCTGGCCCTTATGCCCGCTGTGGAAGAGCTGGCCGCAACCTATGAAGGCAAGGTCAAGTTCTGCA
AGCTCAATGTGGCGGAAAACCGCCGCCTGGTCATCGGCCTGCGCGTCATGGCCGTGCCGACCATCCTGTTTTACAAGGGT
GGCGAGTGCGTGGCCCGCCTGACCGGCGATGCCGTGTCCGTTGAATCCATCAAGGCTGAAGCGGACAAGCTGCTGTAG

Upstream 100 bases:

>100_bases
CCGGCAGGCGGGCCGCCCTGAGTCGGAGCCGTCCGGCACAGGCCCCGGCCCGCCTTTATCTATAAAGTTTCAACCATCCG
CAAGCAAAGCGAGGTGCATG

Downstream 100 bases:

>100_bases
CAGTTTCGCGTCGGGGCGGGCCGGTACGGCCTGCCCGGCGCCTGGATGAGGATGACGGGCCGCCGCATGGCCCGTATTGG
CAGAACGCCCATAATCTCAA

Product: Thioredoxin domain-containing protein

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 105; Mature: 105

Protein sequence:

>105_residues
MIIVDKENFEAEVQQSAMPCVVDLWGPQCGPCLALMPAVEELAATYEGKVKFCKLNVAENRRLVIGLRVMAVPTILFYKG
GECVARLTGDAVSVESIKAEADKLL

Sequences:

>Translated_105_residues
MIIVDKENFEAEVQQSAMPCVVDLWGPQCGPCLALMPAVEELAATYEGKVKFCKLNVAENRRLVIGLRVMAVPTILFYKG
GECVARLTGDAVSVESIKAEADKLL
>Mature_105_residues
MIIVDKENFEAEVQQSAMPCVVDLWGPQCGPCLALMPAVEELAATYEGKVKFCKLNVAENRRLVIGLRVMAVPTILFYKG
GECVARLTGDAVSVESIKAEADKLL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=87, Percent_Identity=37.9310344827586, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788936, Length=75, Percent_Identity=37.3333333333333, Blast_Score=69, Evalue=8e-14,
Organism=Escherichia coli, GI87082331, Length=89, Percent_Identity=31.4606741573034, Blast_Score=65, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=83, Percent_Identity=37.3493975903614, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 11415; Mature: 11415

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
8.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVDKENFEAEVQQSAMPCVVDLWGPQCGPCLALMPAVEELAATYEGKVKFCKLNVAEN
CEEECCCCCHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCC
RRLVIGLRVMAVPTILFYKGGECVARLTGDAVSVESIKAEADKLL
CEEEEEEEHHHHCEEEEECCCCEEEEECCCEECHHHHHHHHHHCC
>Mature Secondary Structure
MIIVDKENFEAEVQQSAMPCVVDLWGPQCGPCLALMPAVEELAATYEGKVKFCKLNVAEN
CEEECCCCCHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCC
RRLVIGLRVMAVPTILFYKGGECVARLTGDAVSVESIKAEADKLL
CEEEEEEEHHHHCEEEEECCCCEEEEECCCEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8223622; 1995593 [H]