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The map label for this gene is thiL [H]

Identifier: 220903356

GI number: 220903356

Start: 90458

End: 91528

Strand: Reverse

Name: thiL [H]

Synonym: Ddes_0070

Alternate gene names: 220903356

Gene position: 91528-90458 (Counterclockwise)

Preceding gene: 220903357

Following gene: 220903355

Centisome position: 3.19

GC content: 65.83

Gene sequence:

>1071_bases
ATGGTCCCGTCCCCTGTTCCGGGCGGCTCTGCCGCCACCAGCGCGGTCCCACTTTCAGAAGATCGCATCCTGGCCTGCCT
GGCGGGATACTTTCCGCAGACGCACCCTTCCCTGCTGCTTGGCCGTGGCGATGACTGCGCTGTGCTCAAGGCGGAAAAGC
CCCTTTGCGTGAGCAGCGACCTTTTTCTGGAAGACATCCACTTCCGGCGAAACTACTTTACCCCCGAAGACACGGGCTAC
AAGGCGCTGGCCGTCAACGTGAGCGATCTTGCGGGCTGCGGCGCCCGCCCCCTGGCCTTTACCCTCTGCCTGGGCTTGCC
CGCATGGGTGGACATGGACTGGCTCAACAGGTTTTTCAGCGGCATGGCCGAACTGGCGGGCAAGCACCGCATCGCCCTGG
CTGGCGGCGACCTGTCCCGCAGCACAAGCCTGCACATCTCCATCACTGTCTGGGGCGAAGCGGCGGAACCCGGCAGTTTT
CTGGCGCGCGGAGGCAGCATGCCGGGCGACATTCTTTTTCTTGTGGGGCCGCTGGGTCTTGCCCGCGCAGGCCTTGCCCT
GCTTGAGGAGCAGGGCCGCGAAGCCCTGCACCACTGGCCCGCCGTCTGCGCCGCGCATCTGCGCCCCGTTCCCCAGGTGG
ATGCGGGACTCATGCTGTCCAGAGCAGGGTACAATGCCCGGCCCCCGGCCCTTATGGACCTTTCGGACGGGATACTGCGC
GACCTGCCCCGCCTGCTGGGCCTCAGCGGCGAACTGAGCGCCACCTGCCCGGAGAAATGCACGGGCCTTGGAGCCGAAAT
CGTGCTGCCGCGAGGCCGCCTGCACCCGGAAGTACTGCACTACGCGGCGGCTACGGGTAAAAATCCTGTTTATGAGGCCC
TGCTCGGCGGCGAGGATTACGCCCTGCTCGGCTCATGCGCCCCCGACATGCTGCCGCCCCTGCATGCGGCCATACCGGGG
CTGTTCAGCATCGGCGTCGTCACCTCCGGCGGCGGCATTGTATGCAATAACGAACCGCTGGAAAAACTCGGCGGCGGTTT
TGACCACTTTGATGCCGGGCAGGACGCCTGA

Upstream 100 bases:

>100_bases
AAAATAATCAGGCACATCTCGCCCGAAAAGGTGCAGGTGAATTTTCCCGGTTTTGGACTCAAGATCATTCTGAGCGAATA
TCTGCTCATGGAGAACTGAT

Downstream 100 bases:

>100_bases
CATGCGCGCCCATATCGGCGTTGTTACCTGGAACCGGCTGGACCTTACCCGCCGGTGCCTCACAAGCCTGCTTGCGCAGA
CGCCGCCCGGCTACAGCCTT

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MVPSPVPGGSAATSAVPLSEDRILACLAGYFPQTHPSLLLGRGDDCAVLKAEKPLCVSSDLFLEDIHFRRNYFTPEDTGY
KALAVNVSDLAGCGARPLAFTLCLGLPAWVDMDWLNRFFSGMAELAGKHRIALAGGDLSRSTSLHISITVWGEAAEPGSF
LARGGSMPGDILFLVGPLGLARAGLALLEEQGREALHHWPAVCAAHLRPVPQVDAGLMLSRAGYNARPPALMDLSDGILR
DLPRLLGLSGELSATCPEKCTGLGAEIVLPRGRLHPEVLHYAAATGKNPVYEALLGGEDYALLGSCAPDMLPPLHAAIPG
LFSIGVVTSGGGIVCNNEPLEKLGGGFDHFDAGQDA

Sequences:

>Translated_356_residues
MVPSPVPGGSAATSAVPLSEDRILACLAGYFPQTHPSLLLGRGDDCAVLKAEKPLCVSSDLFLEDIHFRRNYFTPEDTGY
KALAVNVSDLAGCGARPLAFTLCLGLPAWVDMDWLNRFFSGMAELAGKHRIALAGGDLSRSTSLHISITVWGEAAEPGSF
LARGGSMPGDILFLVGPLGLARAGLALLEEQGREALHHWPAVCAAHLRPVPQVDAGLMLSRAGYNARPPALMDLSDGILR
DLPRLLGLSGELSATCPEKCTGLGAEIVLPRGRLHPEVLHYAAATGKNPVYEALLGGEDYALLGSCAPDMLPPLHAAIPG
LFSIGVVTSGGGIVCNNEPLEKLGGGFDHFDAGQDA
>Mature_356_residues
MVPSPVPGGSAATSAVPLSEDRILACLAGYFPQTHPSLLLGRGDDCAVLKAEKPLCVSSDLFLEDIHFRRNYFTPEDTGY
KALAVNVSDLAGCGARPLAFTLCLGLPAWVDMDWLNRFFSGMAELAGKHRIALAGGDLSRSTSLHISITVWGEAAEPGSF
LARGGSMPGDILFLVGPLGLARAGLALLEEQGREALHHWPAVCAAHLRPVPQVDAGLMLSRAGYNARPPALMDLSDGILR
DLPRLLGLSGELSATCPEKCTGLGAEIVLPRGRLHPEVLHYAAATGKNPVYEALLGGEDYALLGSCAPDMLPPLHAAIPG
LFSIGVVTSGGGIVCNNEPLEKLGGGFDHFDAGQDA

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=348, Percent_Identity=32.7586206896552, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 37271; Mature: 37271

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPSPVPGGSAATSAVPLSEDRILACLAGYFPQTHPSLLLGRGDDCAVLKAEKPLCVSSD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCEEECCC
LFLEDIHFRRNYFTPEDTGYKALAVNVSDLAGCGARPLAFTLCLGLPAWVDMDWLNRFFS
HHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHCCCHHCCHHHHHHHHH
GMAELAGKHRIALAGGDLSRSTSLHISITVWGEAAEPGSFLARGGSMPGDILFLVGPLGL
HHHHHCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCHHHHCCCCCCCCEEEEECCHHH
ARAGLALLEEQGREALHHWPAVCAAHLRPVPQVDAGLMLSRAGYNARPPALMDLSDGILR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCEEECCCHHHHH
DLPRLLGLSGELSATCPEKCTGLGAEIVLPRGRLHPEVLHYAAATGKNPVYEALLGGEDY
HHHHHHCCCCCCCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCCCE
ALLGSCAPDMLPPLHAAIPGLFSIGVVTSGGGIVCNNEPLEKLGGGFDHFDAGQDA
EEECCCCCHHCCHHHHHHCCHHEEEEEECCCCEEECCCCHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MVPSPVPGGSAATSAVPLSEDRILACLAGYFPQTHPSLLLGRGDDCAVLKAEKPLCVSSD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCEEECCC
LFLEDIHFRRNYFTPEDTGYKALAVNVSDLAGCGARPLAFTLCLGLPAWVDMDWLNRFFS
HHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHCCCHHCCHHHHHHHHH
GMAELAGKHRIALAGGDLSRSTSLHISITVWGEAAEPGSFLARGGSMPGDILFLVGPLGL
HHHHHCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCHHHHCCCCCCCCEEEEECCHHH
ARAGLALLEEQGREALHHWPAVCAAHLRPVPQVDAGLMLSRAGYNARPPALMDLSDGILR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCEEECCCHHHHH
DLPRLLGLSGELSATCPEKCTGLGAEIVLPRGRLHPEVLHYAAATGKNPVYEALLGGEDY
HHHHHHCCCCCCCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCCCE
ALLGSCAPDMLPPLHAAIPGLFSIGVVTSGGGIVCNNEPLEKLGGGFDHFDAGQDA
EEECCCCCHHCCHHHHHHCCHHEEEEEECCCCEEECCCCHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]