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The map label for this gene is fhuB [H]

Identifier: 218904607

GI number: 218904607

Start: 3319525

End: 3320421

Strand: Reverse

Name: fhuB [H]

Synonym: BCAH820_3491

Alternate gene names: 218904607

Gene position: 3320421-3319525 (Counterclockwise)

Preceding gene: 218904609

Following gene: 218904606

Centisome position: 62.62

GC content: 41.03

Gene sequence:

>897_bases
TTGCAAACGGTGTGGACAGCGGTTTTTGATTACAATCCGAAATTAACGCAGCATCAAATCATTTACGAATTAAGGCTCCC
AAGGGTAATTGGCGCAGCAGTTGTAGGAGCGGCTTTTGCGGTCGCTGGGGCTGTTATGCAAGGAGTAACACGAAATCCTT
TAGCTGATGCAGGTGTGCTTGGCATAAATGCAGGTGCGATGTTTGTAGTAGCACTTAGTTTTGCCTTTTTCCCGCATATG
CCGTATTCCTATTTGATGGTTGTTTCCTTTATTGGAGCGGTTTTAAGTACAGTACTCATTTTTATTATCGGATCAGCAAC
AGCAGGCGGATTAACACCGATGAGGTTAACGATCGCTGGGGCAGTTATGGCAGCACTTTTACATTCATTAAGTTCAGGTG
TTGCAATTTATTATGACTTAAGTCAAGATTTAGCGTTTTGGTACGCTGGTGGTGTTGCAGGGGTTAAGTGGGAACACTTG
AAATTTTTAGTTCCTATTATTTTTATAACGATTGTTTTTGCGACAGTGTTAGGGCGGTCTATTTCACTCATATCAATGGG
GGATGATGTCGCTACGAATTTAGGTGTGAAAACGAATCGAACGAGGATACTTGGAATGATTATAGTAGTTATTCTAGCAG
GTGTTTCTGTTTCAGCTGTTGGTTCTATTGGATTTGTAGGACTCGTTATCCCGCATATTGCTAGAAAAATAGTTGGTGTG
AATTATCGACTCATTATTCCTATGTCAGCATTATTAGGAGCTATGTTATTAGTTTTAGCTGACCTAGGGGCAAGAACAGT
AAACCCTCCTAAAGAACTTGCGATAGGGATTATGGTAGCTCTCATTGGAGTTCCGTTTTTCCTATATATAGCACGTAAAG
TTGGGAGGGAACTATAA

Upstream 100 bases:

>100_bases
TGGATACACATTAAGTTTATATGTTTTATGAGCTTAACAATTATATGTTTAATTGGATCTATATTTTTGGCCCGTCGCAT
TTGGTGCAAAGGATATTCAT

Downstream 100 bases:

>100_bases
GTGAAGAAGATTTTAAACACAGATAAGAAGAGAGCTATTACTGTAACGACAATATTTGGTTGTATTGGTATCGCTGTCAT
TTTAATTAGTTTAAATACAG

Product: iron compound ABC transporter, permease protein

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MQTVWTAVFDYNPKLTQHQIIYELRLPRVIGAAVVGAAFAVAGAVMQGVTRNPLADAGVLGINAGAMFVVALSFAFFPHM
PYSYLMVVSFIGAVLSTVLIFIIGSATAGGLTPMRLTIAGAVMAALLHSLSSGVAIYYDLSQDLAFWYAGGVAGVKWEHL
KFLVPIIFITIVFATVLGRSISLISMGDDVATNLGVKTNRTRILGMIIVVILAGVSVSAVGSIGFVGLVIPHIARKIVGV
NYRLIIPMSALLGAMLLVLADLGARTVNPPKELAIGIMVALIGVPFFLYIARKVGREL

Sequences:

>Translated_298_residues
MQTVWTAVFDYNPKLTQHQIIYELRLPRVIGAAVVGAAFAVAGAVMQGVTRNPLADAGVLGINAGAMFVVALSFAFFPHM
PYSYLMVVSFIGAVLSTVLIFIIGSATAGGLTPMRLTIAGAVMAALLHSLSSGVAIYYDLSQDLAFWYAGGVAGVKWEHL
KFLVPIIFITIVFATVLGRSISLISMGDDVATNLGVKTNRTRILGMIIVVILAGVSVSAVGSIGFVGLVIPHIARKIVGV
NYRLIIPMSALLGAMLLVLADLGARTVNPPKELAIGIMVALIGVPFFLYIARKVGREL
>Mature_298_residues
MQTVWTAVFDYNPKLTQHQIIYELRLPRVIGAAVVGAAFAVAGAVMQGVTRNPLADAGVLGINAGAMFVVALSFAFFPHM
PYSYLMVVSFIGAVLSTVLIFIIGSATAGGLTPMRLTIAGAVMAALLHSLSSGVAIYYDLSQDLAFWYAGGVAGVKWEHL
KFLVPIIFITIVFATVLGRSISLISMGDDVATNLGVKTNRTRILGMIIVVILAGVSVSAVGSIGFVGLVIPHIARKIVGV
NYRLIIPMSALLGAMLLVLADLGARTVNPPKELAIGIMVALIGVPFFLYIARKVGREL

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=289, Percent_Identity=35.9861591695502, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1790740, Length=292, Percent_Identity=34.9315068493151, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790741, Length=290, Percent_Identity=33.7931034482759, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786804, Length=238, Percent_Identity=32.7731092436975, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788004, Length=280, Percent_Identity=33.2142857142857, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786347, Length=277, Percent_Identity=30.6859205776173, Blast_Score=114, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 31484; Mature: 31484

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVWTAVFDYNPKLTQHQIIYELRLPRVIGAAVVGAAFAVAGAVMQGVTRNPLADAGVL
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
GINAGAMFVVALSFAFFPHMPYSYLMVVSFIGAVLSTVLIFIIGSATAGGLTPMRLTIAG
EECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AVMAALLHSLSSGVAIYYDLSQDLAFWYAGGVAGVKWEHLKFLVPIIFITIVFATVLGRS
HHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
ISLISMGDDVATNLGVKTNRTRILGMIIVVILAGVSVSAVGSIGFVGLVIPHIARKIVGV
EEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
NYRLIIPMSALLGAMLLVLADLGARTVNPPKELAIGIMVALIGVPFFLYIARKVGREL
CEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQTVWTAVFDYNPKLTQHQIIYELRLPRVIGAAVVGAAFAVAGAVMQGVTRNPLADAGVL
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
GINAGAMFVVALSFAFFPHMPYSYLMVVSFIGAVLSTVLIFIIGSATAGGLTPMRLTIAG
EECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AVMAALLHSLSSGVAIYYDLSQDLAFWYAGGVAGVKWEHLKFLVPIIFITIVFATVLGRS
HHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
ISLISMGDDVATNLGVKTNRTRILGMIIVVILAGVSVSAVGSIGFVGLVIPHIARKIVGV
EEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
NYRLIIPMSALLGAMLLVLADLGARTVNPPKELAIGIMVALIGVPFFLYIARKVGREL
CEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]