Click here to switch to the map view.

The map label for this gene is hbd [H]

Identifier: 218904159

GI number: 218904159

Start: 2882863

End: 2883717

Strand: Reverse

Name: hbd [H]

Synonym: BCAH820_3043

Alternate gene names: 218904159

Gene position: 2883717-2882863 (Counterclockwise)

Preceding gene: 218904160

Following gene: 218904158

Centisome position: 54.38

GC content: 38.13

Gene sequence:

>855_bases
ATGGTAATTCAAACGATTGGTATTGTCGGTGCAGGATCTATGGGTTCTGGCATTGCAAATTTAGCTGCATTACACGGATT
TACAGTTATTTTACATGATATTGAAGAGCGTTATTTAGATAGTGCAATGCAACGTATGAATAGTTTTATGACGAAAAGTG
TTACGAGAGGAAAAATGACGGAAGAGGGTAAACAAGAGGCACTTAACCGTATTCAAATGACTACAGATTTAGAAGATATG
AAAGATGCGGATGTAGTTATTGAAGCCGTGTTAGAAAAATTAGAGTTGAAGAGAGAAGTGTTTGAAGCACTGGATCGAAT
CGTCCCAGAAGGAGTTATATTGGCAACAAACACTTCATCTATGTCGATAACAGAGATTGCTTCAGCGACGAATCGTCCAG
ATCGTGTAGCAGGTATGCATTTCTTTAATCCTGCACAACTTATGAAACTTGTAGAAGTTGTTCGGGGCTATAAAACGAGT
GATGAAACAGTCGAAGAATTGAAAGCGCTATCCAAAAGACTTTCGAAAGAACCAGTTGAAGTAAAGAAAGATTCACCGGG
TTTTATTGTAAATCGAATTATGATTCCGCAGTTTATTGAAGCAATTAAATTGCTTGAAGATGGTGTTGCATCTGCAGAAG
ATATTGACAAGGCAGTTACACTTGGCCTCAATTATCCGATGGGTCCGTTTACACTACAAGATTTTGCAGGTGTAGACATT
GGTTATCACGTGATGGAGTACTTCAAAGAAGAATTAAACAATGATCAATACGCGCCGCCGCTCCTTTTAAAACAGTTAGT
TAGAGCAGGTAGACATGGTAAAAAAACAGGCGCAGGTTTTTATGATTATGAATAA

Upstream 100 bases:

>100_bases
AATATATGTATTCCCTACACTATGTACATACAAAAACTTTTTACATATAGATATAATTTATTTACAGAATATTTTAAAAA
TTATTTGAGGAGGTAGCAAA

Downstream 100 bases:

>100_bases
AGAATGGGGGATACAGTTATGAATTATGAGTTTTTAATATGTGATATTGAAAATAAAGTTGCGATTGTTACGATTAATCG
ACCACCTGTAAATCCGCTAA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MVIQTIGIVGAGSMGSGIANLAALHGFTVILHDIEERYLDSAMQRMNSFMTKSVTRGKMTEEGKQEALNRIQMTTDLEDM
KDADVVIEAVLEKLELKREVFEALDRIVPEGVILATNTSSMSITEIASATNRPDRVAGMHFFNPAQLMKLVEVVRGYKTS
DETVEELKALSKRLSKEPVEVKKDSPGFIVNRIMIPQFIEAIKLLEDGVASAEDIDKAVTLGLNYPMGPFTLQDFAGVDI
GYHVMEYFKEELNNDQYAPPLLLKQLVRAGRHGKKTGAGFYDYE

Sequences:

>Translated_284_residues
MVIQTIGIVGAGSMGSGIANLAALHGFTVILHDIEERYLDSAMQRMNSFMTKSVTRGKMTEEGKQEALNRIQMTTDLEDM
KDADVVIEAVLEKLELKREVFEALDRIVPEGVILATNTSSMSITEIASATNRPDRVAGMHFFNPAQLMKLVEVVRGYKTS
DETVEELKALSKRLSKEPVEVKKDSPGFIVNRIMIPQFIEAIKLLEDGVASAEDIDKAVTLGLNYPMGPFTLQDFAGVDI
GYHVMEYFKEELNNDQYAPPLLLKQLVRAGRHGKKTGAGFYDYE
>Mature_284_residues
MVIQTIGIVGAGSMGSGIANLAALHGFTVILHDIEERYLDSAMQRMNSFMTKSVTRGKMTEEGKQEALNRIQMTTDLEDM
KDADVVIEAVLEKLELKREVFEALDRIVPEGVILATNTSSMSITEIASATNRPDRVAGMHFFNPAQLMKLVEVVRGYKTS
DETVEELKALSKRLSKEPVEVKKDSPGFIVNRIMIPQFIEAIKLLEDGVASAEDIDKAVTLGLNYPMGPFTLQDFAGVDI
GYHVMEYFKEELNNDQYAPPLLLKQLVRAGRHGKKTGAGFYDYE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=292, Percent_Identity=43.1506849315069, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI296179427, Length=309, Percent_Identity=40.7766990291262, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI20127408, Length=286, Percent_Identity=34.6153846153846, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI68989263, Length=295, Percent_Identity=34.2372881355932, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=34.2372881355932, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI115430219, Length=234, Percent_Identity=30.7692307692308, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=43.9716312056738, Blast_Score=244, Evalue=3e-66,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=34.8314606741573, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788682, Length=264, Percent_Identity=34.8484848484849, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=41.1764705882353, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=39.1003460207612, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=39.2361111111111, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI25144276, Length=287, Percent_Identity=37.9790940766551, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17508951, Length=287, Percent_Identity=37.9790940766551, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17508953, Length=287, Percent_Identity=37.9790940766551, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=36.8794326241135, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=31.5602836879433, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71985930, Length=289, Percent_Identity=31.4878892733564, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI115533614, Length=229, Percent_Identity=30.1310043668122, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI193203623, Length=229, Percent_Identity=30.1310043668122, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19921000, Length=286, Percent_Identity=33.5664335664336, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24583077, Length=286, Percent_Identity=33.5664335664336, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24583079, Length=286, Percent_Identity=33.5664335664336, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI20129993, Length=234, Percent_Identity=32.4786324786325, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45549573, Length=225, Percent_Identity=30.6666666666667, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31552; Mature: 31552

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIQTIGIVGAGSMGSGIANLAALHGFTVILHDIEERYLDSAMQRMNSFMTKSVTRGKMT
CCEEEECEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EEGKQEALNRIQMTTDLEDMKDADVVIEAVLEKLELKREVFEALDRIVPEGVILATNTSS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MSITEIASATNRPDRVAGMHFFNPAQLMKLVEVVRGYKTSDETVEELKALSKRLSKEPVE
CHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCC
VKKDSPGFIVNRIMIPQFIEAIKLLEDGVASAEDIDKAVTLGLNYPMGPFTLQDFAGVDI
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCHH
GYHVMEYFKEELNNDQYAPPLLLKQLVRAGRHGKKTGAGFYDYE
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVIQTIGIVGAGSMGSGIANLAALHGFTVILHDIEERYLDSAMQRMNSFMTKSVTRGKMT
CCEEEECEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EEGKQEALNRIQMTTDLEDMKDADVVIEAVLEKLELKREVFEALDRIVPEGVILATNTSS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MSITEIASATNRPDRVAGMHFFNPAQLMKLVEVVRGYKTSDETVEELKALSKRLSKEPVE
CHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCC
VKKDSPGFIVNRIMIPQFIEAIKLLEDGVASAEDIDKAVTLGLNYPMGPFTLQDFAGVDI
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCHH
GYHVMEYFKEELNNDQYAPPLLLKQLVRAGRHGKKTGAGFYDYE
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]