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The map label for this gene is yggV [C]

Identifier: 218884650

GI number: 218884650

Start: 1248527

End: 1249093

Strand: Reverse

Name: yggV [C]

Synonym: DKAM_1339

Alternate gene names: 218884650

Gene position: 1249093-1248527 (Counterclockwise)

Preceding gene: 218884651

Following gene: 218884649

Centisome position: 91.49

GC content: 44.27

Gene sequence:

>567_bases
ATGTCGGTTAAACTATTGCTTCTCTCAGGTAACAGACACAAGTACCTTGAGATAAAGGACATAGCGAGGGAGTACGGGGT
CAATGTCGCTCCCCTCGAGGGATTAAAAATCGAGATACAGGATGACGACTTATCTAACATAGCGTTAACCGCAGCATTAA
TAGGATACTCCCTCTTAAGGAAACCAGTCCTAGTTGAGGATGCTGGATTATTCATAAGAGCCCTAAATGGATTTCCAGGA
CCCTACAGTAGTTATGTCTTCAAGACGCTTGGATTAAACGGTGTATTGAAACTAATGGAGGGGATCAGTGAAAGAGATGC
ATGCTTTAAATCCGTGGCTGTCGCCGTGATACATGGTGAGATAATAAGGGGAGAAGGAGAAGTATGCGGATACATAACCA
CCACGCCTCGGGGGAATAAGGGATTCGGGTTCGACCCAGTATTCGCTCCAAGGGAACAACCATATAGAACCTTCGGCGAG
ATGGATGTAGAGGAGAAAAATAAGTATAGCCATAGAGCTAAAGCCGTAAAAGCAGTATTTGAAAAAATCAAGGAGAAAGC
AGGATAG

Upstream 100 bases:

>100_bases
AGCGGCAGCTTCGATGAAATCATGTATAAACTAAGGGAGATAAGCACGCGGGGTAGATACATTGATAGGGAGTTAAGGAG
ATCGGTGATGCGTGAGAGAT

Downstream 100 bases:

>100_bases
CAGGAAATAGTTACCACAGGAGTCACATTTAAAATCTGTTCTTAAATATTATGGTGTTTAATAGTGTATTGTTTAACCCG
GGATATAGTGTCAACGGGGT

Product: RdgB/HAM1 family non-canonical purine NTP pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSVKLLLLSGNRHKYLEIKDIAREYGVNVAPLEGLKIEIQDDDLSNIALTAALIGYSLLRKPVLVEDAGLFIRALNGFPG
PYSSYVFKTLGLNGVLKLMEGISERDACFKSVAVAVIHGEIIRGEGEVCGYITTTPRGNKGFGFDPVFAPREQPYRTFGE
MDVEEKNKYSHRAKAVKAVFEKIKEKAG

Sequences:

>Translated_188_residues
MSVKLLLLSGNRHKYLEIKDIAREYGVNVAPLEGLKIEIQDDDLSNIALTAALIGYSLLRKPVLVEDAGLFIRALNGFPG
PYSSYVFKTLGLNGVLKLMEGISERDACFKSVAVAVIHGEIIRGEGEVCGYITTTPRGNKGFGFDPVFAPREQPYRTFGE
MDVEEKNKYSHRAKAVKAVFEKIKEKAG
>Mature_187_residues
SVKLLLLSGNRHKYLEIKDIAREYGVNVAPLEGLKIEIQDDDLSNIALTAALIGYSLLRKPVLVEDAGLFIRALNGFPGP
YSSYVFKTLGLNGVLKLMEGISERDACFKSVAVAVIHGEIIRGEGEVCGYITTTPRGNKGFGFDPVFAPREQPYRTFGEM
DVEEKNKYSHRAKAVKAVFEKIKEKAG

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=178, Percent_Identity=28.6516853932584, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI31657144, Length=123, Percent_Identity=35.7723577235772, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1789324, Length=195, Percent_Identity=28.7179487179487, Blast_Score=70, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17556833, Length=183, Percent_Identity=31.6939890710383, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322529, Length=191, Percent_Identity=32.4607329842932, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19920712, Length=193, Percent_Identity=29.0155440414508, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 20739; Mature: 20608

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKLLLLSGNRHKYLEIKDIAREYGVNVAPLEGLKIEIQDDDLSNIALTAALIGYSLLR
CCEEEEEEECCCCEEEHHHHHHHHHCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHHH
KPVLVEDAGLFIRALNGFPGPYSSYVFKTLGLNGVLKLMEGISERDACFKSVAVAVIHGE
CCCEEECCCHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHCE
IIRGEGEVCGYITTTPRGNKGFGFDPVFAPREQPYRTFGEMDVEEKNKYSHRAKAVKAVF
EEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHH
EKIKEKAG
HHHHHHCC
>Mature Secondary Structure 
SVKLLLLSGNRHKYLEIKDIAREYGVNVAPLEGLKIEIQDDDLSNIALTAALIGYSLLR
CEEEEEEECCCCEEEHHHHHHHHHCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHHH
KPVLVEDAGLFIRALNGFPGPYSSYVFKTLGLNGVLKLMEGISERDACFKSVAVAVIHGE
CCCEEECCCHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHCE
IIRGEGEVCGYITTTPRGNKGFGFDPVFAPREQPYRTFGEMDVEEKNKYSHRAKAVKAVF
EEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHH
EKIKEKAG
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA