BacMap

Definition	Desulfurococcus kamchatkensis 1221n chromosome, complete genome.
Accession	NC_011766
Length	1,365,223

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The map label for this gene is psmA [H]

Identifier: 218884638

GI number: 218884638

Start: 1238423

End: 1239163

Strand: Reverse

Name: psmA [H]

Synonym: DKAM_1327

Alternate gene names: 218884638

Gene position: 1239163-1238423 (Counterclockwise)

Preceding gene: 218884639

Following gene: 218884637

Centisome position: 90.77

GC content: 42.38

Gene sequence:

>741_bases
ATGGGTTTCTCAATGGCTGCAGCGTATGATAGGGCAATCACAATATTTTCGCCTGATGGGAGGATATATCAGGTTGAATA
CGCGTTCGAAGCCGTGAGGAGAGGCTGGACCACTATAGGTATAAGAACAAAGAGCGCCTCTATCGTTGCAGCTGAAAAGA
GGAAGATAACCCAGCTCATCGATGAGAAGGCGATTCAGAAAATATTCAAGATAGATGATCATATAGGCGCCAGCTATGCT
GGAATGGCTGGAGATGGAAGGATATTGATAAGCTACGCTATAAACCAGGCACTACTTCATAGGTTCTACTATGATGAACC
AGCTCTGGTAGAATATATAACTAAACTAGTATGCGATGTCAAGCAGGCATACACGCAGCATGCTGGTGTAAGGCCCTTCG
GCGTGGCAATGATTTTTGCCGGGGTAGATGAAAAAGGCACACAGTTATTTATGACTGAACCTAGTGGGAGATACCTTAGT
TATTACGCGACAGCTATAGGTGAGAAAAGCAATAATGTAATAGAATTCCTGGAGAAAAACTACAAGTATGATTTAGATAC
TAGCGAATCCCTTAAACTAGCAATACAAGCACTTGCAGGGATAGTAGAGGGCAAGCCTTTCGAGGACTACATGGAGATAG
GTTATGTAGATGTTGAGTCACGTCGATTCAGAATACTTATGCCGAATGAAATAAGGAAGTATATTGAGGAATTGGAGAAA
GAAGGAAAGCTAAAGATGTAG

Upstream 100 bases:

>100_bases
TGAACGGTTCAGTTGTAACGGGAATTAACATGGATGCATTAAGAGTTAAAAACACTTAGATGTATTTAAATGATGAGTAG
GATGCGGGGAGTGTGAAAAC

Downstream 100 bases:

>100_bases
AATATATCACGGAGCCAAACCCTATATGAGGTTTTTAAGCCATGAAAGATAAACTAGTCATCGCACGCTACGAGGCTAAA
GGACATAGATTCGAGATCCT

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MGFSMAAAYDRAITIFSPDGRIYQVEYAFEAVRRGWTTIGIRTKSASIVAAEKRKITQLIDEKAIQKIFKIDDHIGASYA
GMAGDGRILISYAINQALLHRFYYDEPALVEYITKLVCDVKQAYTQHAGVRPFGVAMIFAGVDEKGTQLFMTEPSGRYLS
YYATAIGEKSNNVIEFLEKNYKYDLDTSESLKLAIQALAGIVEGKPFEDYMEIGYVDVESRRFRILMPNEIRKYIEELEK
EGKLKM

Sequences:

>Translated_246_residues
MGFSMAAAYDRAITIFSPDGRIYQVEYAFEAVRRGWTTIGIRTKSASIVAAEKRKITQLIDEKAIQKIFKIDDHIGASYA
GMAGDGRILISYAINQALLHRFYYDEPALVEYITKLVCDVKQAYTQHAGVRPFGVAMIFAGVDEKGTQLFMTEPSGRYLS
YYATAIGEKSNNVIEFLEKNYKYDLDTSESLKLAIQALAGIVEGKPFEDYMEIGYVDVESRRFRILMPNEIRKYIEELEK
EGKLKM
>Mature_245_residues
GFSMAAAYDRAITIFSPDGRIYQVEYAFEAVRRGWTTIGIRTKSASIVAAEKRKITQLIDEKAIQKIFKIDDHIGASYAG
MAGDGRILISYAINQALLHRFYYDEPALVEYITKLVCDVKQAYTQHAGVRPFGVAMIFAGVDEKGTQLFMTEPSGRYLSY
YATAIGEKSNNVIEFLEKNYKYDLDTSESLKLAIQALAGIVEGKPFEDYMEIGYVDVESRRFRILMPNEIRKYIEELEKE
GKLKM

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation [H]

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family [H]

Homologues:

Organism=Homo sapiens, GI68303563, Length=209, Percent_Identity=44.4976076555024, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI4506189, Length=233, Percent_Identity=41.6309012875536, Blast_Score=184, Evalue=5e-47,
Organism=Homo sapiens, GI68303561, Length=215, Percent_Identity=43.2558139534884, Blast_Score=184, Evalue=5e-47,
Organism=Homo sapiens, GI23110944, Length=244, Percent_Identity=36.4754098360656, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI4506181, Length=228, Percent_Identity=37.280701754386, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI23110942, Length=241, Percent_Identity=35.2697095435685, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI156713442, Length=237, Percent_Identity=36.2869198312236, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI4506185, Length=237, Percent_Identity=36.2869198312236, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI68303565, Length=209, Percent_Identity=39.2344497607655, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI4506179, Length=243, Percent_Identity=32.5102880658436, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI23110935, Length=243, Percent_Identity=32.5102880658436, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4506183, Length=244, Percent_Identity=31.9672131147541, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI23110939, Length=243, Percent_Identity=32.0987654320988, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI221316716, Length=109, Percent_Identity=38.5321100917431, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI156713444, Length=166, Percent_Identity=32.5301204819277, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17508491, Length=197, Percent_Identity=43.1472081218274, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17508493, Length=207, Percent_Identity=40.0966183574879, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25143215, Length=220, Percent_Identity=36.8181818181818, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17562792, Length=204, Percent_Identity=33.8235294117647, Blast_Score=133, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17562788, Length=244, Percent_Identity=30.7377049180328, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562790, Length=236, Percent_Identity=31.3559322033898, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71998965, Length=237, Percent_Identity=32.4894514767932, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324535, Length=203, Percent_Identity=43.8423645320197, Blast_Score=175, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6321692, Length=247, Percent_Identity=36.8421052631579, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321574, Length=232, Percent_Identity=35.3448275862069, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323547, Length=251, Percent_Identity=33.0677290836653, Blast_Score=134, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6323974, Length=195, Percent_Identity=35.8974358974359, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324938, Length=194, Percent_Identity=37.1134020618557, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6321427, Length=176, Percent_Identity=36.9318181818182, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324731, Length=176, Percent_Identity=30.1136363636364, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17933602, Length=197, Percent_Identity=42.6395939086294, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19922898, Length=201, Percent_Identity=42.2885572139304, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21356137, Length=202, Percent_Identity=40.0990099009901, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI17737927, Length=230, Percent_Identity=35.2173913043478, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281360341, Length=242, Percent_Identity=32.6446280991736, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24586406, Length=242, Percent_Identity=32.6446280991736, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24586400, Length=242, Percent_Identity=32.6446280991736, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24586402, Length=242, Percent_Identity=32.6446280991736, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24654391, Length=243, Percent_Identity=32.5102880658436, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24654389, Length=243, Percent_Identity=32.5102880658436, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17136420, Length=193, Percent_Identity=39.8963730569948, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24651571, Length=241, Percent_Identity=34.8547717842324, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI17737405, Length=196, Percent_Identity=35.2040816326531, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19921232, Length=231, Percent_Identity=31.6017316017316, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24652204, Length=230, Percent_Identity=32.1739130434783, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI20130281, Length=166, Percent_Identity=24.6987951807229, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353 [H]

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N [H]

EC number: =3.4.25.1 [H]

Molecular weight: Translated: 27930; Mature: 27799

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00388 PROTEASOME_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFSMAAAYDRAITIFSPDGRIYQVEYAFEAVRRGWTTIGIRTKSASIVAAEKRKITQLI
CCCCHHHHHHCEEEEECCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEEHHHHHHHHHHH
DEKAIQKIFKIDDHIGASYAGMAGDGRILISYAINQALLHRFYYDEPALVEYITKLVCDV
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KQAYTQHAGVRPFGVAMIFAGVDEKGTQLFMTEPSGRYLSYYATAIGEKSNNVIEFLEKN
HHHHHHHCCCCHHHHEEEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHC
YKYDLDTSESLKLAIQALAGIVEGKPFEDYMEIGYVDVESRRFRILMPNEIRKYIEELEK
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCEEECCCEEEEECCHHHHHHHHHHHH
EGKLKM
CCCCCC
>Mature Secondary Structure 
GFSMAAAYDRAITIFSPDGRIYQVEYAFEAVRRGWTTIGIRTKSASIVAAEKRKITQLI
CCCHHHHHHCEEEEECCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEEHHHHHHHHHHH
DEKAIQKIFKIDDHIGASYAGMAGDGRILISYAINQALLHRFYYDEPALVEYITKLVCDV
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KQAYTQHAGVRPFGVAMIFAGVDEKGTQLFMTEPSGRYLSYYATAIGEKSNNVIEFLEKN
HHHHHHHCCCCHHHHEEEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHC
YKYDLDTSESLKLAIQALAGIVEGKPFEDYMEIGYVDVESRRFRILMPNEIRKYIEELEK
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCEEECCCEEEEECCHHHHHHHHHHHH
EGKLKM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA