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The map label for this gene is adhA [H]

Identifier: 218884444

GI number: 218884444

Start: 1065752

End: 1066765

Strand: Reverse

Name: adhA [H]

Synonym: DKAM_1133

Alternate gene names: 218884444

Gene position: 1066765-1065752 (Counterclockwise)

Preceding gene: 218884445

Following gene: 218884441

Centisome position: 78.14

GC content: 49.31

Gene sequence:

>1014_bases
GTGTATACGTTGAGGGCGATGGTTCTCTATTCTCCAGCTCCTGTCGAGTCAAGGCCGTTGAAATACATGGATGTCGAGAA
ACCAAGCCCCGGTAGAGGCGAGGTCTTGATAAGGATCCTCAAATGCGGCGTGTGTAGGACGGATCTCCACATTGTTGAAG
GCGAGTTGAAACCTGTAAAGCTCCCACTGATACCCGGGCACCAGGTAATCGGTGTAGTAGAAGATGTAGGTGAGGGGGTT
GAAGGAGTTAGGAGGGGAGAGCGTGTTGGAGTTCCATGGCTATACTATGCTTGTGGTGAATGCAGGTATTGTAGAAGGGG
TCTCGAGAATCTCTGTGAAAACGCTTTATTCACAGGCTACAGTGTGGACGGCGGGTACGCTGAGTACATGGTTGCAAAGG
CAGGCTTCATACATAGGATACCTGATGGAATAGATGACACCCATGCAGCTCCATTAATGTGTGCTGGTGCAATAGGCTAT
AGATCCCTAAAGCTAACGGGGCTCCTTGGTAAGGGTGATGCAACCCTGGGTCTATTTGGCTACGGTGCAGCCGCACACCT
TGTTCTACAGGTGGCTAGGAGGCTTGGCTTAAGAGTATACGTGTTCACGAGTAATAGGTGGAAGATAGAGAAGGCTCTCG
AGAACGGTGCCGAATGGGCTGGCTCAACAAGTGAGGAGCCCCCGCGTAGACTCGATGCCGCAATAGTGTATGCACCTGTG
TCCAGTGTCTTCATTGAGGCATTGAAGAAGATAGATAAGGGTGGGAGAGTAGTATTGGCTGAGATATATATGACTCCAAT
CGAGCAGCTGGACTACAGCCTCCTATGGCATGAGAAAGAAGTTAAAAGCGTTGCGAATGTAACTAGGAAGGATGTAGGAG
AGTTCCTAGAGGTAGCCAGTAGACACGGTGTGAAGCCTGAAGTGAAAACCTATAGGCTTAGCGAGGCCAATGAGGCATTA
ATAGAGTTAAAGAAGGGAGGACACTTAGGGCAACTAGTACTAGATGTAGCTTAA

Upstream 100 bases:

>100_bases
GTCCGGATATGAATCATATGGATCAAGGTTTTTAAAACATTACTATCCAAGGTTTAAATAGTGTTTCACAGATTAGAGAA
CACAGGCTTGAGATTGTAAG

Downstream 100 bases:

>100_bases
ATCTACTCTTCACACATACTCCAAAGATCCACTGTTAAATCCGGGTTTTCAAGCGCTATGCTGTAGGTTGAGTGGTTAAA
GCTTATCGACACAGCCTTAA

Product: alcohol dehydrogenase, zinc-containing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MYTLRAMVLYSPAPVESRPLKYMDVEKPSPGRGEVLIRILKCGVCRTDLHIVEGELKPVKLPLIPGHQVIGVVEDVGEGV
EGVRRGERVGVPWLYYACGECRYCRRGLENLCENALFTGYSVDGGYAEYMVAKAGFIHRIPDGIDDTHAAPLMCAGAIGY
RSLKLTGLLGKGDATLGLFGYGAAAHLVLQVARRLGLRVYVFTSNRWKIEKALENGAEWAGSTSEEPPRRLDAAIVYAPV
SSVFIEALKKIDKGGRVVLAEIYMTPIEQLDYSLLWHEKEVKSVANVTRKDVGEFLEVASRHGVKPEVKTYRLSEANEAL
IELKKGGHLGQLVLDVA

Sequences:

>Translated_337_residues
MYTLRAMVLYSPAPVESRPLKYMDVEKPSPGRGEVLIRILKCGVCRTDLHIVEGELKPVKLPLIPGHQVIGVVEDVGEGV
EGVRRGERVGVPWLYYACGECRYCRRGLENLCENALFTGYSVDGGYAEYMVAKAGFIHRIPDGIDDTHAAPLMCAGAIGY
RSLKLTGLLGKGDATLGLFGYGAAAHLVLQVARRLGLRVYVFTSNRWKIEKALENGAEWAGSTSEEPPRRLDAAIVYAPV
SSVFIEALKKIDKGGRVVLAEIYMTPIEQLDYSLLWHEKEVKSVANVTRKDVGEFLEVASRHGVKPEVKTYRLSEANEAL
IELKKGGHLGQLVLDVA
>Mature_337_residues
MYTLRAMVLYSPAPVESRPLKYMDVEKPSPGRGEVLIRILKCGVCRTDLHIVEGELKPVKLPLIPGHQVIGVVEDVGEGV
EGVRRGERVGVPWLYYACGECRYCRRGLENLCENALFTGYSVDGGYAEYMVAKAGFIHRIPDGIDDTHAAPLMCAGAIGY
RSLKLTGLLGKGDATLGLFGYGAAAHLVLQVARRLGLRVYVFTSNRWKIEKALENGAEWAGSTSEEPPRRLDAAIVYAPV
SSVFIEALKKIDKGGRVVLAEIYMTPIEQLDYSLLWHEKEVKSVANVTRKDVGEFLEVASRHGVKPEVKTYRLSEANEAL
IELKKGGHLGQLVLDVA

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=234, Percent_Identity=30.7692307692308, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262073058, Length=234, Percent_Identity=30.7692307692308, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501933, Length=225, Percent_Identity=29.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI34577061, Length=225, Percent_Identity=29.3333333333333, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4501929, Length=225, Percent_Identity=28, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71565154, Length=226, Percent_Identity=29.646017699115, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI71565152, Length=264, Percent_Identity=26.1363636363636, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156627571, Length=214, Percent_Identity=29.4392523364486, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI194239676, Length=197, Percent_Identity=26.9035532994924, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI194239674, Length=197, Percent_Identity=26.9035532994924, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI13236495, Length=197, Percent_Identity=26.9035532994924, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4501939, Length=235, Percent_Identity=26.8085106382979, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI156523966, Length=235, Percent_Identity=26.8085106382979, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87081918, Length=316, Percent_Identity=32.9113924050633, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1787863, Length=321, Percent_Identity=28.0373831775701, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786518, Length=336, Percent_Identity=28.2738095238095, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI87082401, Length=309, Percent_Identity=25.8899676375405, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790045, Length=267, Percent_Identity=29.9625468164794, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI226510992, Length=151, Percent_Identity=32.4503311258278, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786552, Length=235, Percent_Identity=30.2127659574468, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788073, Length=187, Percent_Identity=31.5508021390374, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082125, Length=208, Percent_Identity=28.3653846153846, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786825, Length=237, Percent_Identity=25.7383966244726, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=333, Percent_Identity=27.6276276276276, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=326, Percent_Identity=27.3006134969325, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=338, Percent_Identity=25.1479289940828, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=130, Percent_Identity=33.8461538461538, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=235, Percent_Identity=26.8085106382979, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=120, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71997431, Length=237, Percent_Identity=26.5822784810127, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324486, Length=335, Percent_Identity=32.5373134328358, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323961, Length=354, Percent_Identity=31.9209039548023, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=330, Percent_Identity=30, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=351, Percent_Identity=29.3447293447293, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323980, Length=314, Percent_Identity=28.9808917197452, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319949, Length=313, Percent_Identity=29.7124600638978, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=212, Percent_Identity=30.6603773584906, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=228, Percent_Identity=28.9473684210526, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=101, Percent_Identity=36.6336633663366, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221457811, Length=118, Percent_Identity=31.3559322033898, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550770, Length=118, Percent_Identity=31.3559322033898, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551930, Length=118, Percent_Identity=31.3559322033898, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=212, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37037; Mature: 37037

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTLRAMVLYSPAPVESRPLKYMDVEKPSPGRGEVLIRILKCGVCRTDLHIVEGELKPVK
CCEEEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCEEE
LPLIPGHQVIGVVEDVGEGVEGVRRGERVGVPWLYYACGECRYCRRGLENLCENALFTGY
EECCCCCHHHHHHHHHCCCHHHHHCCCCCCCCEEEEHHCCCHHHHHHHHHHHHHHHCCCC
SVDGGYAEYMVAKAGFIHRIPDGIDDTHAAPLMCAGAIGYRSLKLTGLLGKGDATLGLFG
CCCCCHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCEEEEEH
YGAAAHLVLQVARRLGLRVYVFTSNRWKIEKALENGAEWAGSTSEEPPRRLDAAIVYAPV
HHHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHCCHHCCCCCCCCCCHHHCCEEEEHHH
SSVFIEALKKIDKGGRVVLAEIYMTPIEQLDYSLLWHEKEVKSVANVTRKDVGEFLEVAS
HHHHHHHHHHHCCCCCEEEEEEHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHGVKPEVKTYRLSEANEALIELKKGGHLGQLVLDVA
HCCCCCCHHEEEECCHHHHHHHHHCCCCEEHEEEECC
>Mature Secondary Structure
MYTLRAMVLYSPAPVESRPLKYMDVEKPSPGRGEVLIRILKCGVCRTDLHIVEGELKPVK
CCEEEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCEEE
LPLIPGHQVIGVVEDVGEGVEGVRRGERVGVPWLYYACGECRYCRRGLENLCENALFTGY
EECCCCCHHHHHHHHHCCCHHHHHCCCCCCCCEEEEHHCCCHHHHHHHHHHHHHHHCCCC
SVDGGYAEYMVAKAGFIHRIPDGIDDTHAAPLMCAGAIGYRSLKLTGLLGKGDATLGLFG
CCCCCHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCEEEEEH
YGAAAHLVLQVARRLGLRVYVFTSNRWKIEKALENGAEWAGSTSEEPPRRLDAAIVYAPV
HHHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHCCHHCCCCCCCCCCHHHCCEEEEHHH
SSVFIEALKKIDKGGRVVLAEIYMTPIEQLDYSLLWHEKEVKSVANVTRKDVGEFLEVAS
HHHHHHHHHHHCCCCCEEEEEEHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHGVKPEVKTYRLSEANEALIELKKGGHLGQLVLDVA
HCCCCCCHHEEEECCHHHHHHHHHCCCCEEHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]