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The map label for this gene is rio2 [H]

Identifier: 218883336

GI number: 218883336

Start: 19401

End: 20288

Strand: Direct

Name: rio2 [H]

Synonym: DKAM_0022

Alternate gene names: 218883336

Gene position: 19401-20288 (Clockwise)

Preceding gene: 218883335

Following gene: 218883337

Centisome position: 1.42

GC content: 44.59

Gene sequence:

>888_bases
TTGCTCCCCGGTGAAATATATAAGTCGCTCACAGACAAGGACTTCAAGGTTCTCGCGGCCATCGAAAAAGGGATTTCGAG
GGGAATGGAATATGTTGCCCTAGAGACCATAGAGAGGATCAGTGGCCTGCATGAAGGGGAGGTAATCCTAGTACTTGGCA
AGCTCCATGAGCTTGGGTTAGTTAGGAGGAAGACTATAGCAGGCTATAAGGCGTATAGGTTGACATATATAGGCTATGAT
ATGCTGGCTTTCAGGGCCCTGGTCAACAAGAACATACTTGAGGCACTAGGAAATAAAATAGGGGTTGGCAAGGAGAGTGA
AATATACATAGGGCTTGCACCAGGCGGTTTAAAGGTAGTGGTCAAGGTACTTAGGATCGGGAGAACCAGCTTTCAACGCA
CAAGGCTACTAAGATCTTGGAGTAGCAACAAGGTTTCAACCACATGGTATGAGGAGTCGAAGCTGGCTGCTGAGAGAGAG
TTCAAAGCATTGAAAACCCTGTCCTCGATAAATGCACTTGTACCGGTTCCCCTGGGCTACAATAGACATGTAATTGTCAC
AGAGTACATTGAAGGCGTAGAGCTTTATAAACGCCCTGAGCTTAGGAAACCAGAACAGGTTCTCGAGTATATCATTGATA
CTATTAGTAAAGCATATAGGGAAGCCGGTATTGTACACGGGGATTTAAGCGAGTATAATATAATCGTAACGGTAAGCGAT
GAGAAACCCTATGTAATAGACTGGCCTCAATACATCTACAGGGAGGAACCCAACGCGTTACAGTTGTTGAGGAGGGATGT
TGAATACGTGGTGAAGTTCTTCAATAAGGTATATGGGTTGAACATTGATCATATGGCGATCTATAATAGAATAGTGTCAG
CTGGTTAA

Upstream 100 bases:

>100_bases
CTCTACATGCTTTACGAGTGGTCGTAATGCCGCATGTGAGCCGGCAACACCTTGATAAGTTTATTAATATACTTAAATTA
ATCCATGGAAGTGGTTAATC

Downstream 100 bases:

>100_bases
GTGAGGAGATCTACGGGAGCTTTTGGCTGTTGTTTTGGTTTTTATATGGGCTTGTATTGGTTGGTGTTGTTTGCTGCTGT
GAAGAGTTTATTATAATAAG

Product: RIO-like serine/threonine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MLPGEIYKSLTDKDFKVLAAIEKGISRGMEYVALETIERISGLHEGEVILVLGKLHELGLVRRKTIAGYKAYRLTYIGYD
MLAFRALVNKNILEALGNKIGVGKESEIYIGLAPGGLKVVVKVLRIGRTSFQRTRLLRSWSSNKVSTTWYEESKLAAERE
FKALKTLSSINALVPVPLGYNRHVIVTEYIEGVELYKRPELRKPEQVLEYIIDTISKAYREAGIVHGDLSEYNIIVTVSD
EKPYVIDWPQYIYREEPNALQLLRRDVEYVVKFFNKVYGLNIDHMAIYNRIVSAG

Sequences:

>Translated_295_residues
MLPGEIYKSLTDKDFKVLAAIEKGISRGMEYVALETIERISGLHEGEVILVLGKLHELGLVRRKTIAGYKAYRLTYIGYD
MLAFRALVNKNILEALGNKIGVGKESEIYIGLAPGGLKVVVKVLRIGRTSFQRTRLLRSWSSNKVSTTWYEESKLAAERE
FKALKTLSSINALVPVPLGYNRHVIVTEYIEGVELYKRPELRKPEQVLEYIIDTISKAYREAGIVHGDLSEYNIIVTVSD
EKPYVIDWPQYIYREEPNALQLLRRDVEYVVKFFNKVYGLNIDHMAIYNRIVSAG
>Mature_295_residues
MLPGEIYKSLTDKDFKVLAAIEKGISRGMEYVALETIERISGLHEGEVILVLGKLHELGLVRRKTIAGYKAYRLTYIGYD
MLAFRALVNKNILEALGNKIGVGKESEIYIGLAPGGLKVVVKVLRIGRTSFQRTRLLRSWSSNKVSTTWYEESKLAAERE
FKALKTLSSINALVPVPLGYNRHVIVTEYIEGVELYKRPELRKPEQVLEYIIDTISKAYREAGIVHGDLSEYNIIVTVSD
EKPYVIDWPQYIYREEPNALQLLRRDVEYVVKFFNKVYGLNIDHMAIYNRIVSAG

Specific function: Unknown

COG id: COG0478

COG function: function code T; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI229331971, Length=273, Percent_Identity=35.8974358974359, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI229331967, Length=273, Percent_Identity=35.8974358974359, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI32564178, Length=264, Percent_Identity=34.8484848484849, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17556977, Length=250, Percent_Identity=24.8, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI115532073, Length=124, Percent_Identity=33.0645161290323, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324122, Length=282, Percent_Identity=35.4609929078014, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6324693, Length=267, Percent_Identity=25.8426966292135, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24649986, Length=274, Percent_Identity=32.4817518248175, Blast_Score=154, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR015285
- InterPro:   IPR000687
- InterPro:   IPR018935 [H]

Pfam domain/function: PF01163 RIO1; PF09202 Rio2_N [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 33649; Mature: 33649

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS00109 PROTEIN_KINASE_TYR ; PS01245 RIO1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPGEIYKSLTDKDFKVLAAIEKGISRGMEYVALETIERISGLHEGEVILVLGKLHELGL
CCCHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHH
VRRKTIAGYKAYRLTYIGYDMLAFRALVNKNILEALGNKIGVGKESEIYIGLAPGGLKVV
HHHHHHCCHHHEEEEEHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEEEECCCHHHHH
VKVLRIGRTSFQRTRLLRSWSSNKVSTTWYEESKLAAEREFKALKTLSSINALVPVPLGY
HHHHHHCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
NRHVIVTEYIEGVELYKRPELRKPEQVLEYIIDTISKAYREAGIVHGDLSEYNIIVTVSD
CCCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEEEC
EKPYVIDWPQYIYREEPNALQLLRRDVEYVVKFFNKVYGLNIDHMAIYNRIVSAG
CCCEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLPGEIYKSLTDKDFKVLAAIEKGISRGMEYVALETIERISGLHEGEVILVLGKLHELGL
CCCHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHH
VRRKTIAGYKAYRLTYIGYDMLAFRALVNKNILEALGNKIGVGKESEIYIGLAPGGLKVV
HHHHHHCCHHHEEEEEHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEEEECCCHHHHH
VKVLRIGRTSFQRTRLLRSWSSNKVSTTWYEESKLAAEREFKALKTLSSINALVPVPLGY
HHHHHHCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
NRHVIVTEYIEGVELYKRPELRKPEQVLEYIIDTISKAYREAGIVHGDLSEYNIIVTVSD
CCCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEEEC
EKPYVIDWPQYIYREEPNALQLLRRDVEYVVKFFNKVYGLNIDHMAIYNRIVSAG
CCCEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]