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The map label for this gene is mfnA [H]

Identifier: 218883335

GI number: 218883335

Start: 18256

End: 19398

Strand: Direct

Name: mfnA [H]

Synonym: DKAM_0021

Alternate gene names: 218883335

Gene position: 18256-19398 (Clockwise)

Preceding gene: 218883334

Following gene: 218883336

Centisome position: 1.34

GC content: 44.09

Gene sequence:

>1143_bases
ATGTATATTGGTGATATTAATAAGGCTAGAGAATGGTTGGAGAAAGCTTTTTCTAAGACCCCCAACCACTTGGATGGCTC
GATACTTGGTTCAATGACGACTATGCCGCATGAATTAGGTGTTGAGGCTTTTCTCAGATTTATCCATATAAATGGTAATG
ATCCCATGGTCTTCCCTATTGTTAAAGAAGCTGAAGAGATCATTGTTAAAGGAATCGGAGGGTTATTTGATGTTGAGCAC
GGTATGTATACCTCGGGTGGCACAGAATCAAATATCATGGCGCTATATGTTGGTAGAAGAGTGAACAAGGGCAAGGAGAA
TACAGTGGTTGTGCCGTCAAGCATCCATAGATCCATAGATAAGGCATGCCTTTTAATGGGTTGTAAACTGGTAAAGATAC
CAGTTGATCCATTGAAACCGGTTGACCCAGCAATCTTGGAGGAGTATATCAGATTATATAAACCTTTCGCGGTAGTCGTA
ACAGCTGGCACTACGGAGGCAGGTGTCATTGATCCGGTTAAAGAAGCCGGGGAGTTAGCTGAAAAATATGGTGTCTACCT
ACACGTCGACGCTGCTTATGGTGGCCTCCTAATACCATTCCTATATAGGAGGGGGTATATTACCGTGGATTTACGGATGT
TCCCAGGAGTATCAAGCCTAAGCGTCGACATGCATAAGAATGGATGTGCGCCGATACCCTCGGGTCTTCTCTTCTTCTCC
AATCGTGGTTTCCTTGAGCAGGCCTGCTTTGATATGGAGTATATGCCGCTTGGTAAATCATGCGGGCTCCTTGGCACGAG
GCCTGGTGGAGCTGTTGTTGCTTCAGCAGCCGTCTTCATGGCAATGGGCATCAAGGGTTATGAGGAGAACGCAGTTAAAA
TGATGGAGAACTCTTATTACCTGTATAATGGCTTGAAAAATATCCCTGAGCTGGTAGTATTCAAGCCGATCCTACCCATA
AATGTGTTTAGGTCCCTGAGATACAGCTATATTGAGCTGTTCAAGGTTTTAGCTGAGAAAGGGGTATACGTGTACAAATC
GCCATCTCTACATGCTTTACGAGTGGTCGTAATGCCGCATGTGAGCCGGCAACACCTTGATAAGTTTATTAATATACTTA
AATTAATCCATGGAAGTGGTTAA

Upstream 100 bases:

>100_bases
GCTAGAAAGCTCTTTATAGATGTATCCATAAGTACCGAGTATCTAAAACAATATGAGAGACTCTTCATGAAGTAAATGAA
CTGGGGATGATGAGTAATAA

Downstream 100 bases:

>100_bases
TCTTGCTCCCCGGTGAAATATATAAGTCGCTCACAGACAAGGACTTCAAGGTTCTCGCGGCCATCGAAAAAGGGATTTCG
AGGGGAATGGAATATGTTGC

Product: Pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: TDC [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MYIGDINKAREWLEKAFSKTPNHLDGSILGSMTTMPHELGVEAFLRFIHINGNDPMVFPIVKEAEEIIVKGIGGLFDVEH
GMYTSGGTESNIMALYVGRRVNKGKENTVVVPSSIHRSIDKACLLMGCKLVKIPVDPLKPVDPAILEEYIRLYKPFAVVV
TAGTTEAGVIDPVKEAGELAEKYGVYLHVDAAYGGLLIPFLYRRGYITVDLRMFPGVSSLSVDMHKNGCAPIPSGLLFFS
NRGFLEQACFDMEYMPLGKSCGLLGTRPGGAVVASAAVFMAMGIKGYEENAVKMMENSYYLYNGLKNIPELVVFKPILPI
NVFRSLRYSYIELFKVLAEKGVYVYKSPSLHALRVVVMPHVSRQHLDKFINILKLIHGSG

Sequences:

>Translated_380_residues
MYIGDINKAREWLEKAFSKTPNHLDGSILGSMTTMPHELGVEAFLRFIHINGNDPMVFPIVKEAEEIIVKGIGGLFDVEH
GMYTSGGTESNIMALYVGRRVNKGKENTVVVPSSIHRSIDKACLLMGCKLVKIPVDPLKPVDPAILEEYIRLYKPFAVVV
TAGTTEAGVIDPVKEAGELAEKYGVYLHVDAAYGGLLIPFLYRRGYITVDLRMFPGVSSLSVDMHKNGCAPIPSGLLFFS
NRGFLEQACFDMEYMPLGKSCGLLGTRPGGAVVASAAVFMAMGIKGYEENAVKMMENSYYLYNGLKNIPELVVFKPILPI
NVFRSLRYSYIELFKVLAEKGVYVYKSPSLHALRVVVMPHVSRQHLDKFINILKLIHGSG
>Mature_380_residues
MYIGDINKAREWLEKAFSKTPNHLDGSILGSMTTMPHELGVEAFLRFIHINGNDPMVFPIVKEAEEIIVKGIGGLFDVEH
GMYTSGGTESNIMALYVGRRVNKGKENTVVVPSSIHRSIDKACLLMGCKLVKIPVDPLKPVDPAILEEYIRLYKPFAVVV
TAGTTEAGVIDPVKEAGELAEKYGVYLHVDAAYGGLLIPFLYRRGYITVDLRMFPGVSSLSVDMHKNGCAPIPSGLLFFS
NRGFLEQACFDMEYMPLGKSCGLLGTRPGGAVVASAAVFMAMGIKGYEENAVKMMENSYYLYNGLKNIPELVVFKPILPI
NVFRSLRYSYIELFKVLAEKGVYVYKSPSLHALRVVVMPHVSRQHLDKFINILKLIHGSG

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine [H]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31982936, Length=329, Percent_Identity=33.7386018237082, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI58331246, Length=260, Percent_Identity=27.3076923076923, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI197276620, Length=256, Percent_Identity=26.171875, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI4503875, Length=256, Percent_Identity=26.171875, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17543922, Length=271, Percent_Identity=30.9963099630996, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17557272, Length=302, Percent_Identity=30.4635761589404, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25148342, Length=352, Percent_Identity=26.4204545454545, Blast_Score=107, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320500, Length=350, Percent_Identity=29.1428571428571, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21355963, Length=336, Percent_Identity=28.8690476190476, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24654344, Length=336, Percent_Identity=28.8690476190476, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115
- InterPro:   IPR020931 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.25 [H]

Molecular weight: Translated: 41988; Mature: 41988

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIGDINKAREWLEKAFSKTPNHLDGSILGSMTTMPHELGVEAFLRFIHINGNDPMVFPI
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHCHHHEEEEEEECCCCCEEEHH
VKEAEEIIVKGIGGLFDVEHGMYTSGGTESNIMALYVGRRVNKGKENTVVVPSSIHRSID
HHHHHHHHHHHCCCCEECCCCCEECCCCCCCEEEEEECCCCCCCCCCEEEECHHHHHHHH
KACLLMGCKLVKIPVDPLKPVDPAILEEYIRLYKPFAVVVTAGTTEAGVIDPVKEAGELA
HHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHH
EKYGVYLHVDAAYGGLLIPFLYRRGYITVDLRMFPGVSSLSVDMHKNGCAPIPSGLLFFS
HHCCEEEEEECCCCCHHHHHHHHCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEC
NRGFLEQACFDMEYMPLGKSCGLLGTRPGGAVVASAAVFMAMGIKGYEENAVKMMENSYY
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCH
LYNGLKNIPELVVFKPILPINVFRSLRYSYIELFKVLAEKGVYVYKSPSLHALRVVVMPH
HHHHHHCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEEECC
VSRQHLDKFINILKLIHGSG
CCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYIGDINKAREWLEKAFSKTPNHLDGSILGSMTTMPHELGVEAFLRFIHINGNDPMVFPI
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHCHHHEEEEEEECCCCCEEEHH
VKEAEEIIVKGIGGLFDVEHGMYTSGGTESNIMALYVGRRVNKGKENTVVVPSSIHRSID
HHHHHHHHHHHCCCCEECCCCCEECCCCCCCEEEEEECCCCCCCCCCEEEECHHHHHHHH
KACLLMGCKLVKIPVDPLKPVDPAILEEYIRLYKPFAVVVTAGTTEAGVIDPVKEAGELA
HHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHH
EKYGVYLHVDAAYGGLLIPFLYRRGYITVDLRMFPGVSSLSVDMHKNGCAPIPSGLLFFS
HHCCEEEEEECCCCCHHHHHHHHCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEC
NRGFLEQACFDMEYMPLGKSCGLLGTRPGGAVVASAAVFMAMGIKGYEENAVKMMENSYY
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCH
LYNGLKNIPELVVFKPILPINVFRSLRYSYIELFKVLAEKGVYVYKSPSLHALRVVVMPH
HHHHHHCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEEECC
VSRQHLDKFINILKLIHGSG
CCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA