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The map label for this gene is ilvD [H]

Identifier: 218711017

GI number: 218711017

Start: 3280400

End: 3282241

Strand: Direct

Name: ilvD [H]

Synonym: VS_3146

Alternate gene names: 218711017

Gene position: 3280400-3282241 (Clockwise)

Preceding gene: 218711016

Following gene: 218711018

Centisome position: 99.43

GC content: 48.91

Gene sequence:

>1842_bases
ATGCCAATCTATCGTTCAGCAACGACTACCCACGGACGCAACATGGCTGGTGCGCGCGCTTTATGGCGTGCAACTGGTGT
TAAAGATGATGATTTCGGTAAGCCAATCATCGCGGTTGTAAACTCTTTCACTCAATTCGTACCAGGCCACGTTCACCTTA
AAGATATGGGTCAACTGGTTGCGGGTGAAATCGAGAAAGCGGGCGGTATCGCTAAAGAATTCAACACCATCGCAGTCGAT
GATGGTATCGCAATGGGCCACGGCGGTATGCTGTACTCATTGCCATCACGTGAGCTTATCGCAGACTCGGTAGAGTACAT
GGTCAATGCACACTGTGCAGATGCGATGGTGTGTATCTCTAACTGTGACAAAATCACTCCGGGAATGATGATGGCAGCTA
TGCGCCTAAACATCCCAGTGATCTTTGTATCTGGCGGCCCAATGGAAGCAGGTAAAACCAAGCTTTCAGATCAAATCATC
AAGCTCGACCTTGTTGATGCTATGATTCAAGGTGCCGATCCAACCATTTCAGATGAGCAAAGTGAGCAAGTAGAGCGTTC
TGCATGTCCGACATGTGGTTCATGTTCAGGTATGTTCACAGCGAACTCAATGAACTGTCTAACAGAAGCACTTGGCCTAT
CTCAGCCTGGTAACGGTTCTATGCTAGCAACCCACGCAGACCGTGAAGAGCTATTCATCAATGCAGGTAAACGTATCGTT
GACCTAACTAAGCGTTACTACGAGCAAGACGACGAATCAGCACTGCCACGCAACATCGCAAATCGCGCAGCCTTTGATAA
TGCAATGGCGTTAGATATCGCGATGGGTGGTTCAAGTAACACCGTTCTTCACCTTTTAGCAGCCGCTCAAGAAGGCGACA
TTGACTTTGATATGGGTGATATCGACGAGATGTCTCGCCGCGTTCCACACCTATGTAAAGTTGCTCCTTCGACGCCTAAA
TACCACATGGAAGACGTTCACCGTGCTGGTGGCGTAATGGCTATCCTAGGTGAGCTTGATCGTGCAGGTCTACTCAATAA
CCAAACTCGCACCGTGCTTGGTCTAAGCATGCAAGAGCAACTTGCACAGTACGACATCATGCAGACAGAAGACGAAGCGG
TGCTTAAGTTCTTCCGTGCTGGCCCTGCGGGCATCCGAACAACCAAAGCATTCTCACAAGATTGCCGTTGGGATCGTCTT
GATGACGACCGTAAAGAAGGTTGTATTCGTACTAAAGAAAACGCATTCAGCCAAGAAGGTGGTCTAGCGGTACTTTCAGG
TAACATCGCGGTTGATGGTTGTATCGTTAAGACCGCGGGTGTTGATGAAGAAAACCTTAAATTCCAAGGCCCTGCAATCG
TATTCGAAAGCCAAGATACGGCAGTAGACGGCATCTTAGCGGGTAAAGTAAAAGCCGGCGAAGTGGTTGTTATTCGTTAC
GAAGGTCCTAAAGGTGGTCCGGGCATGCAAGAGATGCTTTACCCAACGACTTACCTAAAATCGATGGGGCTAGGAAAGTC
GTGTGCGCTTCTAACTGACGGACGTTTCTCTGGTGGTACATCAGGCCTGTCTATCGGTCATGCATCTCCAGAAGCTGCAA
GTGGCGGTGTGATAGGTCTAGTAAACACTGGCGATATCATCACTATCGACATCCCTAGCCGCTCAATCACACTTGATGTG
CCAGAAGCAGAGCTTGAAGCACGTCGCGTTAAACAAGATGCACTAGGCTGGAAACCAGAAAACCGTCAGCGTGAAGTGTC
TTTCGCACTGAAAGCTTATGCAAGCATGGCGACCAGTGCCGACAAAGGCGCTGTACGTGATAAGTCTAAACTTGAGGGCT
AA

Upstream 100 bases:

>100_bases
GAAGATAAGTGGGGCTGGTTAGATTATGTTTACCCAGAACACCAAACTTCAGCAAACAACTAAGTAAGTAACAGCCAAAT
ATTTTATAAGGATTTAAGCA

Downstream 100 bases:

>100_bases
CTATGAGTGATGACACCTCCAGCCCCCAAAAACAAACTGGCGCAGATTATCTGCGTCAGATCCTGAGAGCGCCGGTTTAC
GAAGCGGCAATCGTGACACC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MPIYRSATTTHGRNMAGARALWRATGVKDDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAGEIEKAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQII
KLDLVDAMIQGADPTISDEQSEQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREELFINAGKRIV
DLTKRYYEQDDESALPRNIANRAAFDNAMALDIAMGGSSNTVLHLLAAAQEGDIDFDMGDIDEMSRRVPHLCKVAPSTPK
YHMEDVHRAGGVMAILGELDRAGLLNNQTRTVLGLSMQEQLAQYDIMQTEDEAVLKFFRAGPAGIRTTKAFSQDCRWDRL
DDDRKEGCIRTKENAFSQEGGLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDTAVDGILAGKVKAGEVVVIRY
EGPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHASPEAASGGVIGLVNTGDIITIDIPSRSITLDV
PEAELEARRVKQDALGWKPENRQREVSFALKAYASMATSADKGAVRDKSKLEG

Sequences:

>Translated_613_residues
MPIYRSATTTHGRNMAGARALWRATGVKDDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAGEIEKAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQII
KLDLVDAMIQGADPTISDEQSEQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREELFINAGKRIV
DLTKRYYEQDDESALPRNIANRAAFDNAMALDIAMGGSSNTVLHLLAAAQEGDIDFDMGDIDEMSRRVPHLCKVAPSTPK
YHMEDVHRAGGVMAILGELDRAGLLNNQTRTVLGLSMQEQLAQYDIMQTEDEAVLKFFRAGPAGIRTTKAFSQDCRWDRL
DDDRKEGCIRTKENAFSQEGGLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDTAVDGILAGKVKAGEVVVIRY
EGPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHASPEAASGGVIGLVNTGDIITIDIPSRSITLDV
PEAELEARRVKQDALGWKPENRQREVSFALKAYASMATSADKGAVRDKSKLEG
>Mature_612_residues
PIYRSATTTHGRNMAGARALWRATGVKDDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAGEIEKAGGIAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQIIK
LDLVDAMIQGADPTISDEQSEQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREELFINAGKRIVD
LTKRYYEQDDESALPRNIANRAAFDNAMALDIAMGGSSNTVLHLLAAAQEGDIDFDMGDIDEMSRRVPHLCKVAPSTPKY
HMEDVHRAGGVMAILGELDRAGLLNNQTRTVLGLSMQEQLAQYDIMQTEDEAVLKFFRAGPAGIRTTKAFSQDCRWDRLD
DDRKEGCIRTKENAFSQEGGLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDTAVDGILAGKVKAGEVVVIRYE
GPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHASPEAASGGVIGLVNTGDIITIDIPSRSITLDVP
EAELEARRVKQDALGWKPENRQREVSFALKAYASMATSADKGAVRDKSKLEG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=81.3311688311688, Blast_Score=1053, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=573, Percent_Identity=28.7958115183246, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI2367371, Length=555, Percent_Identity=28.1081081081081, Blast_Score=169, Evalue=6e-43,
Organism=Escherichia coli, GI1786464, Length=527, Percent_Identity=28.4629981024668, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322476, Length=609, Percent_Identity=36.6174055829228, Blast_Score=328, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65560; Mature: 65429

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIYRSATTTHGRNMAGARALWRATGVKDDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AGEIEKAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPTISDEQ
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHEEHHHHHHHHCCCCCCCCCCH
SEQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREELFINAGKRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHCCHHHH
DLTKRYYEQDDESALPRNIANRAAFDNAMALDIAMGGSSNTVLHLLAAAQEGDIDFDMGD
HHHHHHHCCCCCHHCHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCCCC
IDEMSRRVPHLCKVAPSTPKYHMEDVHRAGGVMAILGELDRAGLLNNQTRTVLGLSMQEQ
HHHHHHHCCHHHHCCCCCCCHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCEEEECCHHHH
LAQYDIMQTEDEAVLKFFRAGPAGIRTTKAFSQDCRWDRLDDDRKEGCIRTKENAFSQEG
HHHHHCCCCCHHHHHHHHHCCCCCCEEHHHHHHCCCCCCCCCHHHHCCEECHHHCCCCCC
GLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDTAVDGILAGKVKAGEVVVIRY
CEEEEECCEEEEEEEEEECCCCCCCCEECCCEEEEECCCCCCCCEEECCCCCCCEEEEEE
EGPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHASPEAASGGVIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VNTGDIITIDIPSRSITLDVPEAELEARRVKQDALGWKPENRQREVSFALKAYASMATSA
EECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
DKGAVRDKSKLEG
CCCCCCCHHHCCC
>Mature Secondary Structure 
PIYRSATTTHGRNMAGARALWRATGVKDDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AGEIEKAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPTISDEQ
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHEEHHHHHHHHCCCCCCCCCCH
SEQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREELFINAGKRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHCCHHHH
DLTKRYYEQDDESALPRNIANRAAFDNAMALDIAMGGSSNTVLHLLAAAQEGDIDFDMGD
HHHHHHHCCCCCHHCHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCCCC
IDEMSRRVPHLCKVAPSTPKYHMEDVHRAGGVMAILGELDRAGLLNNQTRTVLGLSMQEQ
HHHHHHHCCHHHHCCCCCCCHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCEEEECCHHHH
LAQYDIMQTEDEAVLKFFRAGPAGIRTTKAFSQDCRWDRLDDDRKEGCIRTKENAFSQEG
HHHHHCCCCCHHHHHHHHHCCCCCCEEHHHHHHCCCCCCCCCHHHHCCEECHHHCCCCCC
GLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDTAVDGILAGKVKAGEVVVIRY
CEEEEECCEEEEEEEEEECCCCCCCCEECCCEEEEECCCCCCCCEEECCCCCCCEEEEEE
EGPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHASPEAASGGVIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VNTGDIITIDIPSRSITLDVPEAELEARRVKQDALGWKPENRQREVSFALKAYASMATSA
EECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
DKGAVRDKSKLEG
CCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA