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The map label for this gene is hemX [H]

Identifier: 218710951

GI number: 218710951

Start: 3201609

End: 3202847

Strand: Direct

Name: hemX [H]

Synonym: VS_3054

Alternate gene names: 218710951

Gene position: 3201609-3202847 (Clockwise)

Preceding gene: 218710950

Following gene: 218710952

Centisome position: 97.04

GC content: 44.07

Gene sequence:

>1239_bases
ATGACAAGCAAAAAAAATAATGAGCATATTGAACCTGAAAAGAAACAAGACACTCAGCCAGTAGTTGTTGAAAACGAAAA
AGCTGACTCTACAGAGACAAAACAGCCTGAACAAAAACTTGATGCCTCTGCGTCAAATACTGCTCAAAATGAACCGCCTC
AAGCTGAACATAAAGAGCAAATAGAGAAAGCGGAAAAGCAAGGTAAGCGCGGTGTCAAACTAGGCGCTATTGCGATCGCT
ATTTCTATTATTTTTAGCGGCGGCATCGCGTTTCAAATGCAGCAAAAGAGCGCTGAGTACTCGACTCAAATAGCCGCTCT
TCAAGCACAACTTCAAAATACTCAATCTGCAGTAAATAAAGACCTACAAACCATCAAGCAAGAGACCATCCAAGAAGCAT
CACATGCGGTGGAGAAAACTCAAGTCGTGCAATCTCAGCAACAGAAGAGCATTCAAAGCCTACAGCTAGCGGTTGCTGAT
GTTAAAGGTCGCCGTCCAAATGACTGGTTGCTTGCTGAAGCTGATTACCTTGTGAAACTTGCTGGTCGTAAACTGTTCCT
AGAACATGATGCCGTTAGTGCCACCAAACTAATGGAAAGCGCAGATCAACGTATCGCCGCACTGAATGACCCAAGCTTGG
TCTCTCTTCGTCAATCAATGACCAATGACATTACTAAGCTTCGCACTATCCCTCTAATCGACCGTGATGGCTTAGTTCTT
CGTATCACAAGCCTACAACAACAAGTCGATACTCTACCGCTTGCCAATGCGATTCTTCCAGAAGCTGCGGTTGTTGAGAA
AAAAGCCGTATCGCAAGATATCAATGATTGGCAGAACAACCTGATGACGTCGATGAAAGATTTTTCAGAAAACTTCATCA
CATTCCGCAGTCGTGATGGTGAAGTTATTCCTCTACTCTCTCCTGAACCACCTCCTGAACAACACTTTTACCTGCGTGAG
AATATCAAGGGCAAACTAGAGACCGCAATTCGCGCAGTCTACAAAGAGCAAGGCGAAGTCTATAGCGCAGCTCTTAAGAC
AGCTAACGAGTGGTCGAAGTCGTACCTAAACCAAGATAACAACTCAGTAATCGAGTTTGAAAAGGCGATTAAGCAGCTGA
GCGAGCAGAATATTTCTGTGAAATACCCTGTGAAACTTGAGTCTCAAAATGAGTTATCAGACGTGATACGTGAGCGCCTA
CGTCGTGAAGTCACCGTTATGACCACGGAGGAAAAATAA

Upstream 100 bases:

>100_bases
GCACAACAACTCGGTTTCTCGAACGTGACCAATACTCAAAGTGCTACGAACCAAATATTACTGGCTGCTCTCCAGCCCTA
GCTAGAAACAGGAAATAAGC

Downstream 100 bases:

>100_bases
TGATTCGTTGGATTTTTCTTTTTCTCGTTCTAGGTGCTGGGTTAATTGTTGGTACTCAGTTCTCTGGTCAACAAGGCTAC
GTTCTGATCTCAATTGCGAA

Product: membrane protein HemX

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTSKKNNEHIEPEKKQDTQPVVVENEKADSTETKQPEQKLDASASNTAQNEPPQAEHKEQIEKAEKQGKRGVKLGAIAIA
ISIIFSGGIAFQMQQKSAEYSTQIAALQAQLQNTQSAVNKDLQTIKQETIQEASHAVEKTQVVQSQQQKSIQSLQLAVAD
VKGRRPNDWLLAEADYLVKLAGRKLFLEHDAVSATKLMESADQRIAALNDPSLVSLRQSMTNDITKLRTIPLIDRDGLVL
RITSLQQQVDTLPLANAILPEAAVVEKKAVSQDINDWQNNLMTSMKDFSENFITFRSRDGEVIPLLSPEPPPEQHFYLRE
NIKGKLETAIRAVYKEQGEVYSAALKTANEWSKSYLNQDNNSVIEFEKAIKQLSEQNISVKYPVKLESQNELSDVIRERL
RREVTVMTTEEK

Sequences:

>Translated_412_residues
MTSKKNNEHIEPEKKQDTQPVVVENEKADSTETKQPEQKLDASASNTAQNEPPQAEHKEQIEKAEKQGKRGVKLGAIAIA
ISIIFSGGIAFQMQQKSAEYSTQIAALQAQLQNTQSAVNKDLQTIKQETIQEASHAVEKTQVVQSQQQKSIQSLQLAVAD
VKGRRPNDWLLAEADYLVKLAGRKLFLEHDAVSATKLMESADQRIAALNDPSLVSLRQSMTNDITKLRTIPLIDRDGLVL
RITSLQQQVDTLPLANAILPEAAVVEKKAVSQDINDWQNNLMTSMKDFSENFITFRSRDGEVIPLLSPEPPPEQHFYLRE
NIKGKLETAIRAVYKEQGEVYSAALKTANEWSKSYLNQDNNSVIEFEKAIKQLSEQNISVKYPVKLESQNELSDVIRERL
RREVTVMTTEEK
>Mature_411_residues
TSKKNNEHIEPEKKQDTQPVVVENEKADSTETKQPEQKLDASASNTAQNEPPQAEHKEQIEKAEKQGKRGVKLGAIAIAI
SIIFSGGIAFQMQQKSAEYSTQIAALQAQLQNTQSAVNKDLQTIKQETIQEASHAVEKTQVVQSQQQKSIQSLQLAVADV
KGRRPNDWLLAEADYLVKLAGRKLFLEHDAVSATKLMESADQRIAALNDPSLVSLRQSMTNDITKLRTIPLIDRDGLVLR
ITSLQQQVDTLPLANAILPEAAVVEKKAVSQDINDWQNNLMTSMKDFSENFITFRSRDGEVIPLLSPEPPPEQHFYLREN
IKGKLETAIRAVYKEQGEVYSAALKTANEWSKSYLNQDNNSVIEFEKAIKQLSEQNISVKYPVKLESQNELSDVIRERLR
REVTVMTTEEK

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=254, Percent_Identity=39.3700787401575, Blast_Score=194, Evalue=1e-50,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 46287; Mature: 46156

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKKNNEHIEPEKKQDTQPVVVENEKADSTETKQPEQKLDASASNTAQNEPPQAEHKEQ
CCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHH
IEKAEKQGKRGVKLGAIAIAISIIFSGGIAFQMQQKSAEYSTQIAALQAQLQNTQSAVNK
HHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLQTIKQETIQEASHAVEKTQVVQSQQQKSIQSLQLAVADVKGRRPNDWLLAEADYLVKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHH
AGRKLFLEHDAVSATKLMESADQRIAALNDPSLVSLRQSMTNDITKLRTIPLIDRDGLVL
HCCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCEE
RITSLQQQVDTLPLANAILPEAAVVEKKAVSQDINDWQNNLMTSMKDFSENFITFRSRDG
EEHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
EVIPLLSPEPPPEQHFYLRENIKGKLETAIRAVYKEQGEVYSAALKTANEWSKSYLNQDN
CEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NSVIEFEKAIKQLSEQNISVKYPVKLESQNELSDVIRERLRREVTVMTTEEK
CCHHHHHHHHHHHHHCCCEEEECEEECCCHHHHHHHHHHHHCCEEEEEECCC
>Mature Secondary Structure 
TSKKNNEHIEPEKKQDTQPVVVENEKADSTETKQPEQKLDASASNTAQNEPPQAEHKEQ
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHH
IEKAEKQGKRGVKLGAIAIAISIIFSGGIAFQMQQKSAEYSTQIAALQAQLQNTQSAVNK
HHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLQTIKQETIQEASHAVEKTQVVQSQQQKSIQSLQLAVADVKGRRPNDWLLAEADYLVKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHH
AGRKLFLEHDAVSATKLMESADQRIAALNDPSLVSLRQSMTNDITKLRTIPLIDRDGLVL
HCCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCEE
RITSLQQQVDTLPLANAILPEAAVVEKKAVSQDINDWQNNLMTSMKDFSENFITFRSRDG
EEHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
EVIPLLSPEPPPEQHFYLRENIKGKLETAIRAVYKEQGEVYSAALKTANEWSKSYLNQDN
CEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NSVIEFEKAIKQLSEQNISVKYPVKLESQNELSDVIRERLRREVTVMTTEEK
CCHHHHHHHHHHHHHCCCEEEECEEECCCHHHHHHHHHHHHCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]