Click here to switch to the map view.

The map label for this gene is hemD [H]

Identifier: 218710950

GI number: 218710950

Start: 3200861

End: 3201589

Strand: Direct

Name: hemD [H]

Synonym: VS_3053

Alternate gene names: 218710950

Gene position: 3200861-3201589 (Clockwise)

Preceding gene: 218710949

Following gene: 218710951

Centisome position: 97.02

GC content: 42.66

Gene sequence:

>729_bases
ATGACAGTGTTGGTGACTCGTCCCGGTTCAGAGGGACAATCGCTTTGCCAACAACTAGCGGATGAAGGGATTCAAGCAAT
CCATCATCCGCTTATTCGTATCGTTGATAATCCACACTCATCGGATTTAAGCACCCAGCTTAATAACAGCGATATCATTA
TTGCAGTCAGTCACCACGCCGTGACCGCTGCCCAAAACATCCTTTCGAAAACTTCATCTATTTGGCCAACTTCGCCGCTT
TATCTTGGCGTTGGTCAAAAAACTGCGCACGTTTTAAGCAAAGTTAGTAAACAAAAAGTAAACTATCCCAAAGTGAGTGA
TAGTGAACATCTTCTCAAACTTACTGAACTTAATGGCGTAGATAATAAATCCATTTTGATACTGCGTGGAAATGGTGGGC
GTGAGCTCATTCGAGATTCTTTACTCAATCGAGGTGCACAAGTCTCTTATTGTGAGACCTACCGTAGAGAATATATTCCC
ATTAACGATCACAATATCTATCAAACATGGATAAACAAAAAAACGTCCAAAGTTGTCATCACTAGTCAGGAACAATTGGA
GTATCTCTGCTCAATTACCCCTGATGAGTATTTGGCTTGGCTTTCAACGAGACAACTATTTGTCCCAAGCCAGCGCATAG
TAGAACGAGCACAACAACTCGGTTTCTCGAACGTGACCAATACTCAAAGTGCTACGAACCAAATATTACTGGCTGCTCTC
CAGCCCTAG

Upstream 100 bases:

>100_bases
GCAAAGATGCAGAAGCACTTGGCGTTACTCTGGCAAATCAATTGCTGGATGATGGCGCGAGAGAAATCTTAACCAAGCTC
TACGCTGACCAAGAATAACT

Downstream 100 bases:

>100_bases
CTAGAAACAGGAAATAAGCATGACAAGCAAAAAAAATAATGAGCATATTGAACCTGAAAAGAAACAAGACACTCAGCCAG
TAGTTGTTGAAAACGAAAAA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTVLVTRPGSEGQSLCQQLADEGIQAIHHPLIRIVDNPHSSDLSTQLNNSDIIIAVSHHAVTAAQNILSKTSSIWPTSPL
YLGVGQKTAHVLSKVSKQKVNYPKVSDSEHLLKLTELNGVDNKSILILRGNGGRELIRDSLLNRGAQVSYCETYRREYIP
INDHNIYQTWINKKTSKVVITSQEQLEYLCSITPDEYLAWLSTRQLFVPSQRIVERAQQLGFSNVTNTQSATNQILLAAL
QP

Sequences:

>Translated_242_residues
MTVLVTRPGSEGQSLCQQLADEGIQAIHHPLIRIVDNPHSSDLSTQLNNSDIIIAVSHHAVTAAQNILSKTSSIWPTSPL
YLGVGQKTAHVLSKVSKQKVNYPKVSDSEHLLKLTELNGVDNKSILILRGNGGRELIRDSLLNRGAQVSYCETYRREYIP
INDHNIYQTWINKKTSKVVITSQEQLEYLCSITPDEYLAWLSTRQLFVPSQRIVERAQQLGFSNVTNTQSATNQILLAAL
QP
>Mature_241_residues
TVLVTRPGSEGQSLCQQLADEGIQAIHHPLIRIVDNPHSSDLSTQLNNSDIIIAVSHHAVTAAQNILSKTSSIWPTSPLY
LGVGQKTAHVLSKVSKQKVNYPKVSDSEHLLKLTELNGVDNKSILILRGNGGRELIRDSLLNRGAQVSYCETYRREYIPI
NDHNIYQTWINKKTSKVVITSQEQLEYLCSITPDEYLAWLSTRQLFVPSQRIVERAQQLGFSNVTNTQSATNQILLAALQ
P

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=246, Percent_Identity=40.650406504065, Blast_Score=170, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 26980; Mature: 26849

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLVTRPGSEGQSLCQQLADEGIQAIHHPLIRIVDNPHSSDLSTQLNNSDIIIAVSHHA
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEECHH
VTAAQNILSKTSSIWPTSPLYLGVGQKTAHVLSKVSKQKVNYPKVSDSEHLLKLTELNGV
HHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHEEEECCCCC
DNKSILILRGNGGRELIRDSLLNRGAQVSYCETYRREYIPINDHNIYQTWINKKTSKVVI
CCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCEEEE
TSQEQLEYLCSITPDEYLAWLSTRQLFVPSQRIVERAQQLGFSNVTNTQSATNQILLAAL
ECHHHHHHHHCCCHHHHHHHHHHHHEECCHHHHHHHHHHCCCCCCCCCHHHHCEEEEEEE
QP
CC
>Mature Secondary Structure 
TVLVTRPGSEGQSLCQQLADEGIQAIHHPLIRIVDNPHSSDLSTQLNNSDIIIAVSHHA
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEECHH
VTAAQNILSKTSSIWPTSPLYLGVGQKTAHVLSKVSKQKVNYPKVSDSEHLLKLTELNGV
HHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHEEEECCCCC
DNKSILILRGNGGRELIRDSLLNRGAQVSYCETYRREYIPINDHNIYQTWINKKTSKVVI
CCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCEEEE
TSQEQLEYLCSITPDEYLAWLSTRQLFVPSQRIVERAQQLGFSNVTNTQSATNQILLAAL
ECHHHHHHHHCCCHHHHHHHHHHHHEECCHHHHHHHHHHCCCCCCCCCHHHHCEEEEEEE
QP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3054815; 3320969; 3277628; 3040684; 1379743; 9278503 [H]