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The map label for this gene is hemY [H]

Identifier: 218710952

GI number: 218710952

Start: 3202847

End: 3204028

Strand: Direct

Name: hemY [H]

Synonym: VS_3055

Alternate gene names: 218710952

Gene position: 3202847-3204028 (Clockwise)

Preceding gene: 218710951

Following gene: 218710959

Centisome position: 97.08

GC content: 44.67

Gene sequence:

>1182_bases
ATGATTCGTTGGATTTTTCTTTTTCTCGTTCTAGGTGCTGGGTTAATTGTTGGTACTCAGTTCTCTGGTCAACAAGGCTA
CGTTCTGATCTCAATTGCGAATAAGACCATTGAGATGAGCGTGACAACACTGGTTATCTTTGTCATTGCTCTTCTAGCTG
CTCTATTCGGCTTAGAGTACCTATTTAAAAAGCTTATGTACGCAAGCTCGACAACTTGGAACTGGTTCAGTGTTCGTAAA
CTAAAGCGCTCTCGTCGTTATACCAATGAAGGCATCATCAAGCTTCTTGAAGGTGACTGGAAAGGCGCAGAGAAGAAGGT
AACTCGCTGGGCTAACCACCACGACATGCCGCTACTTTGTTATTTAGTCGCATCTCAAGCGGCGCACGAACAAGGCAATA
CAAGTGAGCGTGATAAGTACATCGAGCTTGCTAGCCAACAAGAGGACTCTCTATTGGCCGTTGAGCTAACGAAAGCAAAA
CAACAGATCAGTGAGTCGAACTACGAAGCCGCATTCGATACACTTTCAAATCTAAAAGGTTCGCACCCTAACAACACTGC
GGTACTTGGATTGCTAAAAGCGACCTACATGCAACTTAAGTTATGGCAGCCATTGTTGGAACTAACGCCAAAACTCGCTA
AGAACAAGCTTCTAACAGCTGAGGAGCAAATCGAGTTGGAACAGAAAGCACAATGTGGCTTGCTTCACGATGTGGCACAG
CAGCAAGGTAGCGAAGGATTAATTAGCCATTGGAACAAGCTTTCCAGAAAGCAGAAACAAAGCTCACACCTTGTATCGTG
CTTTGTGAAACAACTGATCGCACGTAAAGCTGATTCAGAAGCCTTCACAGTGATTAAAGAGAACATTGCGAAAAGTGGTT
CAAATGAGCTCTATATGCTGCTTCCTGAGCTTAATCTTCCTGATCACCACCCAGTAGTCGTAATGCTAGAACGCGCTATC
AGTAAAGACAATGGTAATGCAGAAGCACACAGCGCATTGGCTCAGTTCTACCTAAGAGAACAGAAGTGGTCAGAAGCACA
AACCCACTTCGAGAAAGCACTAGCACTTCGCTCAAACGTATCAGATTACGGATACTTATCTGATGCACTAGAAAAGCAAA
ACTTAACGAAGGCTGCTCACGAAGTTTCTCGCAAGGCACTCGCTCTCGTTCAACCAGCGTAA

Upstream 100 bases:

>100_bases
TGAAATACCCTGTGAAACTTGAGTCTCAAAATGAGTTATCAGACGTGATACGTGAGCGCCTACGTCGTGAAGTCACCGTT
ATGACCACGGAGGAAAAATA

Downstream 100 bases:

>100_bases
TTCAAAACGACTCAAACTAAGCCGATGTCTAGCATCGGCTTTTTTGTATCTGTTATTTACCCCTAGATAACTTCTACAAC
ACATCTCATCGAACCCTACG

Product: HemY protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MIRWIFLFLVLGAGLIVGTQFSGQQGYVLISIANKTIEMSVTTLVIFVIALLAALFGLEYLFKKLMYASSTTWNWFSVRK
LKRSRRYTNEGIIKLLEGDWKGAEKKVTRWANHHDMPLLCYLVASQAAHEQGNTSERDKYIELASQQEDSLLAVELTKAK
QQISESNYEAAFDTLSNLKGSHPNNTAVLGLLKATYMQLKLWQPLLELTPKLAKNKLLTAEEQIELEQKAQCGLLHDVAQ
QQGSEGLISHWNKLSRKQKQSSHLVSCFVKQLIARKADSEAFTVIKENIAKSGSNELYMLLPELNLPDHHPVVVMLERAI
SKDNGNAEAHSALAQFYLREQKWSEAQTHFEKALALRSNVSDYGYLSDALEKQNLTKAAHEVSRKALALVQPA

Sequences:

>Translated_393_residues
MIRWIFLFLVLGAGLIVGTQFSGQQGYVLISIANKTIEMSVTTLVIFVIALLAALFGLEYLFKKLMYASSTTWNWFSVRK
LKRSRRYTNEGIIKLLEGDWKGAEKKVTRWANHHDMPLLCYLVASQAAHEQGNTSERDKYIELASQQEDSLLAVELTKAK
QQISESNYEAAFDTLSNLKGSHPNNTAVLGLLKATYMQLKLWQPLLELTPKLAKNKLLTAEEQIELEQKAQCGLLHDVAQ
QQGSEGLISHWNKLSRKQKQSSHLVSCFVKQLIARKADSEAFTVIKENIAKSGSNELYMLLPELNLPDHHPVVVMLERAI
SKDNGNAEAHSALAQFYLREQKWSEAQTHFEKALALRSNVSDYGYLSDALEKQNLTKAAHEVSRKALALVQPA
>Mature_393_residues
MIRWIFLFLVLGAGLIVGTQFSGQQGYVLISIANKTIEMSVTTLVIFVIALLAALFGLEYLFKKLMYASSTTWNWFSVRK
LKRSRRYTNEGIIKLLEGDWKGAEKKVTRWANHHDMPLLCYLVASQAAHEQGNTSERDKYIELASQQEDSLLAVELTKAK
QQISESNYEAAFDTLSNLKGSHPNNTAVLGLLKATYMQLKLWQPLLELTPKLAKNKLLTAEEQIELEQKAQCGLLHDVAQ
QQGSEGLISHWNKLSRKQKQSSHLVSCFVKQLIARKADSEAFTVIKENIAKSGSNELYMLLPELNLPDHHPVVVMLERAI
SKDNGNAEAHSALAQFYLREQKWSEAQTHFEKALALRSNVSDYGYLSDALEKQNLTKAAHEVSRKALALVQPA

Specific function: Involved in a late step of protoheme IX synthesis [H]

COG id: COG3071

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Escherichia coli, GI1790234, Length=379, Percent_Identity=30.0791556728232, Blast_Score=195, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010817
- InterPro:   IPR005254
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR013105
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07219 HemY_N; PF07719 TPR_2 [H]

EC number: NA

Molecular weight: Translated: 44240; Mature: 44240

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRWIFLFLVLGAGLIVGTQFSGQQGYVLISIANKTIEMSVTTLVIFVIALLAALFGLEY
CHHHHHHHHHHHCHHEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFKKLMYASSTTWNWFSVRKLKRSRRYTNEGIIKLLEGDWKGAEKKVTRWANHHDMPLLC
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCHHHH
YLVASQAAHEQGNTSERDKYIELASQQEDSLLAVELTKAKQQISESNYEAAFDTLSNLKG
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHHCCC
SHPNNTAVLGLLKATYMQLKLWQPLLELTPKLAKNKLLTAEEQIELEQKAQCGLLHDVAQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
QQGSEGLISHWNKLSRKQKQSSHLVSCFVKQLIARKADSEAFTVIKENIAKSGSNELYML
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEE
LPELNLPDHHPVVVMLERAISKDNGNAEAHSALAQFYLREQKWSEAQTHFEKALALRSNV
EECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SDYGYLSDALEKQNLTKAAHEVSRKALALVQPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIRWIFLFLVLGAGLIVGTQFSGQQGYVLISIANKTIEMSVTTLVIFVIALLAALFGLEY
CHHHHHHHHHHHCHHEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFKKLMYASSTTWNWFSVRKLKRSRRYTNEGIIKLLEGDWKGAEKKVTRWANHHDMPLLC
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCHHHH
YLVASQAAHEQGNTSERDKYIELASQQEDSLLAVELTKAKQQISESNYEAAFDTLSNLKG
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHHCCC
SHPNNTAVLGLLKATYMQLKLWQPLLELTPKLAKNKLLTAEEQIELEQKAQCGLLHDVAQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
QQGSEGLISHWNKLSRKQKQSSHLVSCFVKQLIARKADSEAFTVIKENIAKSGSNELYML
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEE
LPELNLPDHHPVVVMLERAISKDNGNAEAHSALAQFYLREQKWSEAQTHFEKALALRSNV
EECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SDYGYLSDALEKQNLTKAAHEVSRKALALVQPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]