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The map label for this gene is murB [H]

Identifier: 218710890

GI number: 218710890

Start: 3136702

End: 3137760

Strand: Reverse

Name: murB [H]

Synonym: VS_2980

Alternate gene names: 218710890

Gene position: 3137760-3136702 (Counterclockwise)

Preceding gene: 218710895

Following gene: 218710889

Centisome position: 95.1

GC content: 43.34

Gene sequence:

>1059_bases
TTGAATATCGCCATGCAATTCCATCTCAATGCTAGTTTAAAAAATGTTCATACTTTTTCCATAGATCAGACGTGTGATAC
GTTAGTTGAAGTCACCACTATCGAAGAATTAATTTCCGTTTACAGAGACCCTAAATGGTCAGCTTTACCTAAGTTAATAC
TGGGTAAAGGCAGTAATATGCTTTTTACTGAGCACTTCGCTGGTCTAGTCATAGTGAATAAATTATCCGGGATTGAGTTG
ACCGAGACGGACAGTCATCACCTACTGCATGTTAGTGGGGGGGAAGATTGGCCAAACTTAGTTGAATGGAGTGTGGATAA
AGGGCTCGGTGGTCTAGAAAACCTAGCAATGATACCTGGCTGTTCAGGTTCGGCTCCGATTCAAAATATTGGTGCGTATG
GTGTTGAGCTACAAGACGTATGCGAGTATGTCGATATCCTGTGTCTGGATACTTATACAGTTAAGCGATTGAGCAAAGAA
GAGTGTCTCTTTGGTTACCGAGATTCTATTTTCAAGCACGCTCTCTACGATAAAGCGATTGTTGTTGCGATTGGTTTAAC
GTTGCCGAAAGAGTGGGAGCCATGCAATCACTATGGCCCGTTAAAAAGCCTAGCAGCCGATACGCTCTCTCCTCGTACTA
TATTTGATGAAGTATGCATTATCCGTTCAAGTAAGTTGCCAGACCCTAGAGTCCAAGGTAATGCGGGCAGCTTCTTCAAA
AACCCTGTGATCACCAAAGATCATTTTGATCGCCTGTTCGCTCTATACCCAAACATTGTAGGCTATGAGAGCAATGACAT
GATCAAAGTCGCTGCAGGCTGGTTGATTGATCAATGCCAGTTCAAAGGCGTGACAGAAGGCGGCGCTCAAGTTCACCCAA
ACCAAGCATTAGTTATCATCAATTATGATAAGGCTTCTGCTGTGGATATCCTTAAGCTTGCAGAGCGAGTACGTCAGTCT
GTCTTGAATAAATTCGATATTCGACTGGAACATGAAGTACGTTTTATGGGACGAGACTGCGAGACAAACCTAGACAAGGC
TTTGGAGTCATTGGCATGA

Upstream 100 bases:

>100_bases
AGGGAACCTTTACTGGGTCTAATTGGGTAATGATGACATTGTTCATTCAGTCACTGCGCCATTGGTTTATCTGCTGTAGA
ATGACTGCAGTGTAAGTTAA

Downstream 100 bases:

>100_bases
GAGAACACAGTACCAAGCTTGCACTATTGAGATGTCTTGCTGACGGTGAGTTTCATTCAGGTGAAGCTCTAGGTGAAATG
ATTGGTGTATCACGAGCGGC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MNIAMQFHLNASLKNVHTFSIDQTCDTLVEVTTIEELISVYRDPKWSALPKLILGKGSNMLFTEHFAGLVIVNKLSGIEL
TETDSHHLLHVSGGEDWPNLVEWSVDKGLGGLENLAMIPGCSGSAPIQNIGAYGVELQDVCEYVDILCLDTYTVKRLSKE
ECLFGYRDSIFKHALYDKAIVVAIGLTLPKEWEPCNHYGPLKSLAADTLSPRTIFDEVCIIRSSKLPDPRVQGNAGSFFK
NPVITKDHFDRLFALYPNIVGYESNDMIKVAAGWLIDQCQFKGVTEGGAQVHPNQALVIINYDKASAVDILKLAERVRQS
VLNKFDIRLEHEVRFMGRDCETNLDKALESLA

Sequences:

>Translated_352_residues
MNIAMQFHLNASLKNVHTFSIDQTCDTLVEVTTIEELISVYRDPKWSALPKLILGKGSNMLFTEHFAGLVIVNKLSGIEL
TETDSHHLLHVSGGEDWPNLVEWSVDKGLGGLENLAMIPGCSGSAPIQNIGAYGVELQDVCEYVDILCLDTYTVKRLSKE
ECLFGYRDSIFKHALYDKAIVVAIGLTLPKEWEPCNHYGPLKSLAADTLSPRTIFDEVCIIRSSKLPDPRVQGNAGSFFK
NPVITKDHFDRLFALYPNIVGYESNDMIKVAAGWLIDQCQFKGVTEGGAQVHPNQALVIINYDKASAVDILKLAERVRQS
VLNKFDIRLEHEVRFMGRDCETNLDKALESLA
>Mature_352_residues
MNIAMQFHLNASLKNVHTFSIDQTCDTLVEVTTIEELISVYRDPKWSALPKLILGKGSNMLFTEHFAGLVIVNKLSGIEL
TETDSHHLLHVSGGEDWPNLVEWSVDKGLGGLENLAMIPGCSGSAPIQNIGAYGVELQDVCEYVDILCLDTYTVKRLSKE
ECLFGYRDSIFKHALYDKAIVVAIGLTLPKEWEPCNHYGPLKSLAADTLSPRTIFDEVCIIRSSKLPDPRVQGNAGSFFK
NPVITKDHFDRLFALYPNIVGYESNDMIKVAAGWLIDQCQFKGVTEGGAQVHPNQALVIINYDKASAVDILKLAERVRQS
VLNKFDIRLEHEVRFMGRDCETNLDKALESLA

Specific function: Cell wall formation [H]

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1790407, Length=345, Percent_Identity=49.2753623188406, Blast_Score=342, Evalue=3e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C [H]

EC number: =1.1.1.158 [H]

Molecular weight: Translated: 39198; Mature: 39198

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAMQFHLNASLKNVHTFSIDQTCDTLVEVTTIEELISVYRDPKWSALPKLILGKGSNM
CCEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHCCCCCE
LFTEHFAGLVIVNKLSGIELTETDSHHLLHVSGGEDWPNLVEWSVDKGLGGLENLAMIPG
EEHHHCCCEEEEECCCCCEEEECCCCEEEEECCCCCCCHHHHEEHHCCCCCHHHEEECCC
CSGSAPIQNIGAYGVELQDVCEYVDILCLDTYTVKRLSKEECLFGYRDSIFKHALYDKAI
CCCCCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCEE
VVAIGLTLPKEWEPCNHYGPLKSLAADTLSPRTIFDEVCIIRSSKLPDPRVQGNAGSFFK
EEEEECCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NPVITKDHFDRLFALYPNIVGYESNDMIKVAAGWLIDQCQFKGVTEGGAQVHPNQALVII
CCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCEECCCCEEEEE
NYDKASAVDILKLAERVRQSVLNKFDIRLEHEVRFMGRDCETNLDKALESLA
ECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHCC
>Mature Secondary Structure
MNIAMQFHLNASLKNVHTFSIDQTCDTLVEVTTIEELISVYRDPKWSALPKLILGKGSNM
CCEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHCCCCCE
LFTEHFAGLVIVNKLSGIELTETDSHHLLHVSGGEDWPNLVEWSVDKGLGGLENLAMIPG
EEHHHCCCEEEEECCCCCEEEECCCCEEEEECCCCCCCHHHHEEHHCCCCCHHHEEECCC
CSGSAPIQNIGAYGVELQDVCEYVDILCLDTYTVKRLSKEECLFGYRDSIFKHALYDKAI
CCCCCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCEE
VVAIGLTLPKEWEPCNHYGPLKSLAADTLSPRTIFDEVCIIRSSKLPDPRVQGNAGSFFK
EEEEECCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NPVITKDHFDRLFALYPNIVGYESNDMIKVAAGWLIDQCQFKGVTEGGAQVHPNQALVII
CCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCEECCCCEEEEE
NYDKASAVDILKLAERVRQSVLNKFDIRLEHEVRFMGRDCETNLDKALESLA
ECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]