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The map label for this gene is fumC [H]

Identifier: 218710853

GI number: 218710853

Start: 3091251

End: 3092636

Strand: Direct

Name: fumC [H]

Synonym: VS_2937

Alternate gene names: 218710853

Gene position: 3091251-3092636 (Clockwise)

Preceding gene: 218710852

Following gene: 218710856

Centisome position: 93.69

GC content: 48.48

Gene sequence:

>1386_bases
ATGACCCTACAATTTCGGATTGAAAAAGACAGCATGGGGGAAGTTAAAGTCCCTGCTGATGCGCTATATCAAGCACAAAC
TCAACGTGCTGTGGATAACTTCGCGTTTAGTTCGCACAAGATGCCAGCCAGTTTCATTCAAGCACTGGCGCTGATTAAGC
AGGCCGCCGCCGATACCAACGCTCAGTTAGGTTTATTAGAAGGTGATATTGCCAACGCGATAGCCGAAGCTAGCCAAGAG
ATCATTGAGGGTAAACACCTCGAGCAATTCCCTATTGATGTTTACCAAACCGGTTCTGGTACAAGCTCCAACATGAATGC
CAACGAAGTGATTGCGACACTCGCTTCAAGAAGCCTGCAAGGAGACGTGAACCCGAATGATCACGTAAACATGGGACAAA
GCAGTAACGATGTCGTGCCAACAGCAATCCAAGTCAGTGTCGCTTTGATGGCAGAAAATAAGCTGCTGCCTGCGCTTACC
CACCTTTCTGCGGCGCTTACCGTAAAACAGCATGAACTTGCTGAGGTAGTCAAAACTGGCCGTACTCATCTAATGGATGC
AATGCCGATTACCTTTGCTCAAGAGCTTGGTGGTTGGAAATATCAGATTGAACATGCCAAGCAAGCGATAGAAAGCAGCT
TGCCAGCAGTCAAGGCGCTTGCTCAAGGTGGTACAGCGGTAGGTACCGGGATTAATGCCGACCCACGCTTTGCCGATAAG
TTTGCAAGCAACCTGTCTCAATCGACAAAGATCAGTTTTACTTCGAGTGAAAACTTCTTTTTTAACCTCAGCAGCCAAGA
CGCGATCGTTGCACTGTCAGGTCAGCTCAAAACTGCAGCAGTAGCGATCATGAAGATCTCAAACGATCTTCGTTGGATGA
ACTCAGGCCCACTGGCTGGCTTAGGGGAAATTGAGTTGCAGGCTCTACAGCCGGGTTCGTCTATCATGCCTGGCAAGGTA
AACCCTGTAATTCCAGAAGCTGCAGCCATGGCGGCGGCTCAAGTAATAGGTAATGACACCACCATTACGATTGCAGGCCA
ATCGGGTAACTTCCAATTGAATGTGATGCTGCCCGTTATTGCTCATAACGTATTAGAAAGCATAGAGTTGTTAGCAAACA
GTTCAGTCGCACTGGCTGATAAAGCGATTTCCACCTTCACGGTACGCCAAGACAACCTCGATTTGGCACTGTCAAAGAAT
CCAATTCTGGTGACCGCACTTAACCCTGTGATTGGCTACCTAAAAGCAGCGGACATCGCCAAGAAAGCCTACAAAGAGGG
CTTACCAATTCTGGATGTTGCCGAAAGAGAAACGGATCTCAGCCGAGAAGAACTTAGCAAGCTACTTGATCCAACCGCAC
TGACGCAGGGTGGTATTGCGGGCTAG

Upstream 100 bases:

>100_bases
ACGACACTACTGCCAGCAGCCACAAGGCCAAGCGCGTTTCTTGAATCTCAGCCAAACACTACAACAAGTCCAAGCCCCAC
TTGGCTAACAAGGATAGAAG

Downstream 100 bases:

>100_bases
TTAGTTAAAAAGCGAATAGGCATTAACGATCCTTACTGAAACAAAAAAGGCCTCATCCGAGGCCTTTTTTACATCCGTTC
ATTAATTAGGAATTCGAGCT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTLQFRIEKDSMGEVKVPADALYQAQTQRAVDNFAFSSHKMPASFIQALALIKQAAADTNAQLGLLEGDIANAIAEASQE
IIEGKHLEQFPIDVYQTGSGTSSNMNANEVIATLASRSLQGDVNPNDHVNMGQSSNDVVPTAIQVSVALMAENKLLPALT
HLSAALTVKQHELAEVVKTGRTHLMDAMPITFAQELGGWKYQIEHAKQAIESSLPAVKALAQGGTAVGTGINADPRFADK
FASNLSQSTKISFTSSENFFFNLSSQDAIVALSGQLKTAAVAIMKISNDLRWMNSGPLAGLGEIELQALQPGSSIMPGKV
NPVIPEAAAMAAAQVIGNDTTITIAGQSGNFQLNVMLPVIAHNVLESIELLANSSVALADKAISTFTVRQDNLDLALSKN
PILVTALNPVIGYLKAADIAKKAYKEGLPILDVAERETDLSREELSKLLDPTALTQGGIAG

Sequences:

>Translated_461_residues
MTLQFRIEKDSMGEVKVPADALYQAQTQRAVDNFAFSSHKMPASFIQALALIKQAAADTNAQLGLLEGDIANAIAEASQE
IIEGKHLEQFPIDVYQTGSGTSSNMNANEVIATLASRSLQGDVNPNDHVNMGQSSNDVVPTAIQVSVALMAENKLLPALT
HLSAALTVKQHELAEVVKTGRTHLMDAMPITFAQELGGWKYQIEHAKQAIESSLPAVKALAQGGTAVGTGINADPRFADK
FASNLSQSTKISFTSSENFFFNLSSQDAIVALSGQLKTAAVAIMKISNDLRWMNSGPLAGLGEIELQALQPGSSIMPGKV
NPVIPEAAAMAAAQVIGNDTTITIAGQSGNFQLNVMLPVIAHNVLESIELLANSSVALADKAISTFTVRQDNLDLALSKN
PILVTALNPVIGYLKAADIAKKAYKEGLPILDVAERETDLSREELSKLLDPTALTQGGIAG
>Mature_460_residues
TLQFRIEKDSMGEVKVPADALYQAQTQRAVDNFAFSSHKMPASFIQALALIKQAAADTNAQLGLLEGDIANAIAEASQEI
IEGKHLEQFPIDVYQTGSGTSSNMNANEVIATLASRSLQGDVNPNDHVNMGQSSNDVVPTAIQVSVALMAENKLLPALTH
LSAALTVKQHELAEVVKTGRTHLMDAMPITFAQELGGWKYQIEHAKQAIESSLPAVKALAQGGTAVGTGINADPRFADKF
ASNLSQSTKISFTSSENFFFNLSSQDAIVALSGQLKTAAVAIMKISNDLRWMNSGPLAGLGEIELQALQPGSSIMPGKVN
PVIPEAAAMAAAQVIGNDTTITIAGQSGNFQLNVMLPVIAHNVLESIELLANSSVALADKAISTFTVRQDNLDLALSKNP
ILVTALNPVIGYLKAADIAKKAYKEGLPILDVAERETDLSREELSKLLDPTALTQGGIAG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=455, Percent_Identity=44.3956043956044, Blast_Score=376, Evalue=1e-104,
Organism=Escherichia coli, GI1787896, Length=462, Percent_Identity=46.969696969697, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI87082375, Length=460, Percent_Identity=37.6086956521739, Blast_Score=286, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17553882, Length=456, Percent_Identity=44.5175438596491, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI32565146, Length=321, Percent_Identity=44.2367601246106, Blast_Score=281, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6324993, Length=458, Percent_Identity=42.5764192139738, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=44.7826086956522, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24640179, Length=457, Percent_Identity=44.6389496717724, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24640177, Length=457, Percent_Identity=44.6389496717724, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=42.2077922077922, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=38.3947939262473, Blast_Score=338, Evalue=4e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 48749; Mature: 48618

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQFRIEKDSMGEVKVPADALYQAQTQRAVDNFAFSSHKMPASFIQALALIKQAAADTN
CEEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
AQLGLLEGDIANAIAEASQEIIEGKHLEQFPIDVYQTGSGTSSNMNANEVIATLASRSLQ
CEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
GDVNPNDHVNMGQSSNDVVPTAIQVSVALMAENKLLPALTHLSAALTVKQHELAEVVKTG
CCCCCCCCCCCCCCCCCCCCHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
RTHLMDAMPITFAQELGGWKYQIEHAKQAIESSLPAVKALAQGGTAVGTGINADPRFADK
HHHHHHCCCHHHHHHCCCEEEEHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCCHHHHH
FASNLSQSTKISFTSSENFFFNLSSQDAIVALSGQLKTAAVAIMKISNDLRWMNSGPLAG
HHHCCCCCCEEEEEECCCEEEEECCCCEEEEECCCCHHHHEEEEEECCCCEECCCCCCCC
LGEIELQALQPGSSIMPGKVNPVIPEAAAMAAAQVIGNDTTITIAGQSGNFQLNVMLPVI
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEHHHH
AHNVLESIELLANSSVALADKAISTFTVRQDNLDLALSKNPILVTALNPVIGYLKAADIA
HHHHHHHHHHHHCCCHHHHHHHHEEEEEEECCCEEEECCCCEEEEECCHHHHHHHHHHHH
KKAYKEGLPILDVAERETDLSREELSKLLDPTALTQGGIAG
HHHHHCCCCEEECCCCCCCCCHHHHHHHHCCHHHCCCCCCC
>Mature Secondary Structure 
TLQFRIEKDSMGEVKVPADALYQAQTQRAVDNFAFSSHKMPASFIQALALIKQAAADTN
EEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
AQLGLLEGDIANAIAEASQEIIEGKHLEQFPIDVYQTGSGTSSNMNANEVIATLASRSLQ
CEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
GDVNPNDHVNMGQSSNDVVPTAIQVSVALMAENKLLPALTHLSAALTVKQHELAEVVKTG
CCCCCCCCCCCCCCCCCCCCHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
RTHLMDAMPITFAQELGGWKYQIEHAKQAIESSLPAVKALAQGGTAVGTGINADPRFADK
HHHHHHCCCHHHHHHCCCEEEEHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCCHHHHH
FASNLSQSTKISFTSSENFFFNLSSQDAIVALSGQLKTAAVAIMKISNDLRWMNSGPLAG
HHHCCCCCCEEEEEECCCEEEEECCCCEEEEECCCCHHHHEEEEEECCCCEECCCCCCCC
LGEIELQALQPGSSIMPGKVNPVIPEAAAMAAAQVIGNDTTITIAGQSGNFQLNVMLPVI
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEHHHH
AHNVLESIELLANSSVALADKAISTFTVRQDNLDLALSKNPILVTALNPVIGYLKAADIA
HHHHHHHHHHHHCCCHHHHHHHHEEEEEEECCCEEEECCCCEEEEECCHHHHHHHHHHHH
KKAYKEGLPILDVAERETDLSREELSKLLDPTALTQGGIAG
HHHHHCCCCEEECCCCCCCCCHHHHHHHHCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8806672; 10984043 [H]